Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation

Circulation

Volumn 126, Issue 3, 2012, Pages 325-334

  Totzeck, Matthias ^a   Hendgen Cotta, Ulrike B ^a   Luedike, Peter ^a   Berenbrink, Michael ^b   Klare, Johann P ^c   Steinhoff, Heinz Juergen ^c   Semmler, Dominik ^a   Shiva, Sruti ^d   Williams, Daryl ^b   Kipar, Anja ^b   Gladwin, Mark T ^d   Schrader, Juergen ^e   Kelm, Malte ^a   Cossins, Andrew R ^b   Rassaf, Tienush ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

hypoxic vasodilation; myoglobin; nitrite

Indexed keywords

CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MYOGLOBIN; NITRIC OXIDE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CELL HYPOXIA; CONTROLLED STUDY; DEOXYGENATION; EX VIVO STUDY; FISH; HEART MUSCLE CELL; HEMODYNAMICS; HYPOXIC VASODILATATION; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; CARDIAC OUTPUT; GUANYLATE CYCLASE; MICE; MICE, MUTANT STRAINS; MUSCLE, SMOOTH, VASCULAR; MYOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; OXYGEN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; VASODILATION;

EID: 84863927306     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.087155     Document Type: Article

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