메뉴 건너뛰기




Volumn 13, Issue 2, 2016, Pages 295-310

Clinical potential of electroporation for gene therapy and DNA vaccine delivery

Author keywords

Clinical trials; DNA vaccines; electroporation; gene delivery; gene electrotransfer; gene therapy; genetic adjuvants

Indexed keywords

DNA VACCINE; INTERLEUKIN 12; INTERLEUKIN 2;

EID: 84957430721     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2016.1121990     Document Type: Review
Times cited : (195)

References (83)
  • 1
    • 84949324433 scopus 로고    scopus 로고
    • Conceptual and technical aspects of transfection and gene delivery
    • Kaestner L, Scholz A, Lipp P. Conceptual and technical aspects of transfection and gene delivery. Bioorg Med Chem Lett. 2015;25(6):1171-1176.
    • (2015) Bioorg Med Chem Lett , vol.25 , Issue.6 , pp. 1171-1176
    • Kaestner, L.1    Scholz, A.2    Lipp, P.3
  • 2
    • 84870909757 scopus 로고    scopus 로고
    • Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis
    • Mali B, Jarm T, Snoj M, et al. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis. Eur J Surg Oncol. 2013;39(1):4-16.
    • (2013) Eur J Surg Oncol , vol.39 , Issue.1 , pp. 4-16
    • Mali, B.1    Jarm, T.2    Snoj, M.3
  • 3
    • 84904351599 scopus 로고    scopus 로고
    • Electroporationbased technologies for medicine: Principles, applications, and challenges
    • Yarmush ML, Golberg A, Sersa G, et al. Electroporationbased technologies for medicine: principles, applications, and challenges. Annu Rev Biomed Eng. 2014;16:295-320.
    • (2014) Annu Rev Biomed Eng , vol.16 , pp. 295-320
    • Yarmush, M.L.1    Golberg, A.2    Sersa, G.3
  • 4
    • 1542328820 scopus 로고    scopus 로고
    • Skin electroporation for transdermal and topical delivery
    • Denet AR, Vanbever R, Preat V. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev. 2004;56(5):659-674.
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.5 , pp. 659-674
    • Denet, A.R.1    Vanbever, R.2    Preat, V.3
  • 5
    • 84891849262 scopus 로고    scopus 로고
    • Atomistic simulations of pore formation and closure in lipid bilayers
    • Bennett WF, Sapay N, Tieleman DP. Atomistic simulations of pore formation and closure in lipid bilayers. Biophys J. 2014;106(1):210-219.
    • (2014) Biophys J , vol.106 , Issue.1 , pp. 210-219
    • Bennett, W.F.1    Sapay, N.2    Tieleman, D.P.3
  • 6
    • 33646510798 scopus 로고    scopus 로고
    • Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells
    • Rols MP. Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells. Biochim Biophys Acta. 2006;1758(3):423-428.
    • (2006) Biochim Biophys Acta , vol.1758 , Issue.3 , pp. 423-428
    • Rols, M.P.1
  • 7
    • 23144463785 scopus 로고    scopus 로고
    • Mechanisms of cell membrane electropermeabilization: A minireview of our present (lack of ?) knowledge
    • Teissie J, Golzio M, Rols MP. Mechanisms of cell membrane electropermeabilization: a minireview of our present (lack of ?) knowledge. Biochim Biophys Acta. 2005;1724(3):270-280.
    • (2005) Biochim Biophys Acta , vol.1724 , Issue.3 , pp. 270-280
    • Teissie, J.1    Golzio, M.2    Rols, M.P.3
  • 8
    • 84869761013 scopus 로고    scopus 로고
    • What you always needed to know about electroporation based DNA vaccines
    • Gothelf A, Gehl J. What you always needed to know about electroporation based DNA vaccines. Hum Vacc Immunother. 2012;8(11):1694-1702.
    • (2012) Hum Vacc Immunother , vol.8 , Issue.11 , pp. 1694-1702
    • Gothelf, A.1    Gehl, J.2
  • 9
    • 0025004010 scopus 로고
    • Schwan equation and transmembrane potential induced by alternating electric field
    • Marszalek P, Liu DS, Tsong TY. Schwan equation and transmembrane potential induced by alternating electric field. Biophys J. 1990;58(4):1053-1058.
    • (1990) Biophys J , vol.58 , Issue.4 , pp. 1053-1058
    • Marszalek, P.1    Liu, D.S.2    Tsong, T.Y.3
  • 10
    • 77955305897 scopus 로고    scopus 로고
    • Induced transmembrane voltage and its correlation with electroporation-mediated molecular transport
    • Kotnik T, Pucihar G, Miklavcic D. Induced transmembrane voltage and its correlation with electroporation-mediated molecular transport. J Membr Biol. 2010;236(1):3-13.
    • (2010) J Membr Biol , vol.236 , Issue.1 , pp. 3-13
    • Kotnik, T.1    Pucihar, G.2    Miklavcic, D.3
  • 11
    • 84855754028 scopus 로고    scopus 로고
    • Induced transmembrane voltage - Theory modeling and experiments
    • Pakhomov AG, Miklavcic D, Markov MS, editors, Boca Raton (FL): CRC Press
    • Kotnik T, Pucihar G. Induced transmembrane voltage - theory, modeling, and experiments. In: Pakhomov AG, Miklavcic D, Markov MS, editors. Advanced electroporation techniques in biology and medicine. Boca Raton (FL): CRC Press; 2010.
    • (2010) Advanced Electroporation Techniques in Biology and Medicine
    • Kotnik, T.1    Pucihar, G.2
  • 12
    • 84937519255 scopus 로고    scopus 로고
    • Electroporation-based applications in biotechnology
    • Kotnik T, Frey W, Sack M, et al. Electroporation-based applications in biotechnology. Trends Biotechnol. 2015;33 (8):480-488.
    • (2015) Trends Biotechnol , vol.33 , Issue.8 , pp. 480-488
    • Kotnik, T.1    Frey, W.2    Sack, M.3
  • 13
    • 0343069846 scopus 로고    scopus 로고
    • The importance of electric field distribution for effective in vivo electroporation of tissues
    • Miklavcic D, Beravs K, Semrov D, et al. The importance of electric field distribution for effective in vivo electroporation of tissues. Biophys J. 1998;74(5):2152-2158.
    • (1998) Biophys J , vol.74 , Issue.5 , pp. 2152-2158
    • Miklavcic, D.1    Beravs, K.2    Semrov, D.3
  • 14
    • 37549037877 scopus 로고    scopus 로고
    • Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques
    • Hirao LA, Wu L, Khan AS, et al. Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques. Vaccine. 2008;26(3):440-448.
    • (2008) Vaccine , vol.26 , Issue.3 , pp. 440-448
    • Hirao, L.A.1    Wu, L.2    Khan, A.S.3
  • 15
    • 4644371368 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Electroporation and other physical methods
    • Wells DJ. Gene therapy progress and prospects: Electroporation and other physical methods. Gene Ther. 2004;11(18):1363-1369.
    • (2004) Gene Ther , vol.11 , Issue.18 , pp. 1363-1369
    • Wells, D.J.1
  • 16
    • 84947037572 scopus 로고    scopus 로고
    • Orafa Z electroporation - Advantages and drawbacks for delivery of drug gene and vaccine
    • Sezer AD, editor, Rijeka: InTech
    • Bolhassani A, Khavari A. Orafa Z electroporation - advantages and drawbacks for delivery of drug, gene and vaccine. In: Sezer AD, editor. Nanotechnology in drug delivery. Rijeka: InTech; 2014.
    • (2014) Nanotechnology in Drug Delivery
    • Bolhassani, A.1    Khavari, A.2
  • 17
    • 84934443234 scopus 로고    scopus 로고
    • Gene electrotransfer in clinical trials
    • Gehl J. Gene electrotransfer in clinical trials. Methods Mol Biol. 2014;1121:241-246.
    • (2014) Methods Mol Biol , vol.1121 , pp. 241-246
    • Gehl, J.1
  • 18
    • 33750626735 scopus 로고    scopus 로고
    • In vivo electroporation for gene therapy
    • Heller LC, Heller R. In vivo electroporation for gene therapy. Human Gene Therapy. 2006;17(9):890-897.
    • (2006) Human Gene Therapy , vol.17 , Issue.9 , pp. 890-897
    • Heller, L.C.1    Heller, R.2
  • 19
    • 84885432340 scopus 로고    scopus 로고
    • Trial watch: DNA vaccines for cancer therapy
    • Senovilla L, Vacchelli E, Garcia P, et al. Trial watch: DNA vaccines for cancer therapy. Oncoimmunology. 2013;2(4): e23803.
    • (2013) Oncoimmunology , vol.2 , Issue.4
    • Senovilla, L.1    Vacchelli, E.2    Garcia, P.3
  • 20
    • 84906899823 scopus 로고    scopus 로고
    • Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination
    • Kobiyama K, Jounai N, Aoshi T, et al. Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination. Vaccines. 2013;1(3):278.
    • (2013) Vaccines , vol.1 , Issue.3 , pp. 278
    • Kobiyama, K.1    Jounai, N.2    Aoshi, T.3
  • 21
    • 1942455782 scopus 로고    scopus 로고
    • Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines
    • Babiuk S, Baca-Estrada ME, Foldvari M, et al. Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J Biotechnol. 2004;110(1):1-10.
    • (2004) J Biotechnol , vol.110 , Issue.1 , pp. 1-10
    • Babiuk, S.1    Baca-Estrada, M.E.2    Foldvari, M.3
  • 22
    • 56249136280 scopus 로고    scopus 로고
    • Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration
    • Chiarella P, Massi E, De Robertis M, et al. Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration. Expert Opin Biol Ther. 2008;8(11):1645-1657.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.11 , pp. 1645-1657
    • Chiarella, P.1    Massi, E.2    De Robertis, M.3
  • 23
    • 0029437811 scopus 로고
    • Electroporation theory Concepts and mechanisms
    • Weaver JC. Electroporation theory Concepts and mechanisms. Methods Mol Biol. 1995;55:3-28.
    • (1995) Methods Mol Biol , vol.55 , pp. 3-28
    • Weaver, J.C.1
  • 24
    • 0027146212 scopus 로고
    • Electroporation as a technique for the transfer of macromolecules into mammalian cell lines
    • Andreason G. Electroporation as a technique for the transfer of macromolecules into mammalian cell lines. J Tissue Culture Methods. 1993;15(2):56-62.
    • (1993) J Tissue Culture Methods , vol.15 , Issue.2 , pp. 56-62
    • Andreason, G.1
  • 25
    • 84869756642 scopus 로고    scopus 로고
    • Generators and applicators: Equipment for electroporation
    • Kee ST, Gehl J, Lee EW, editors, New York (NY): Springer
    • Staal L, Gilbert R. Generators and applicators: equipment for electroporation. In: Kee ST, Gehl J, Lee EW, editors. Clinical aspects of electroporation. New York (NY): Springer; 2011. p. 45-65.
    • (2011) Clinical Aspects of Electroporation , pp. 45-65
    • Staal, L.1    Gilbert, R.2
  • 26
    • 84921459183 scopus 로고    scopus 로고
    • Gene electrotransfer clinical trials
    • Heller R, Heller LC. Gene electrotransfer clinical trials. Adv Genet. 2015;89:235-262.
    • (2015) Adv Genet , vol.89 , pp. 235-262
    • Heller, R.1    Heller, L.C.2
  • 27
    • 84856969117 scopus 로고    scopus 로고
    • Safety and Tolerability of the Easy Vax Clinical Epidermal Electroporation System in Healthy Adults
    • El-Kamary SS, Billington M, Deitz S, et al. Safety and Tolerability of the Easy Vax Clinical Epidermal Electroporation System in Healthy Adults. Mol Ther. 2012;20(1):214-220.
    • (2012) Mol Ther , vol.20 , Issue.1 , pp. 214-220
    • El-Kamary, S.S.1    Billington, M.2    Deitz, S.3
  • 28
    • 84898869622 scopus 로고    scopus 로고
    • Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: Safety and efficacy results of a phase i first-in-man study
    • Spanggaard I, Snoj M, Cavalcanti A, et al. Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study. Hum Gene Ther Clin Dev. 2013;24(3):99-107.
    • (2013) Hum Gene Ther Clin Dev , vol.24 , Issue.3 , pp. 99-107
    • Spanggaard, I.1    Snoj, M.2    Cavalcanti, A.3
  • 29
    • 84881555063 scopus 로고    scopus 로고
    • DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer
    • Eriksson F, Tötterman T, Maltais A-K, et al. DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer. Vaccine. 2013;31(37):3843-3848.
    • (2013) Vaccine , vol.31 , Issue.37 , pp. 3843-3848
    • Eriksson, F.1    Tötterman, T.2    Maltais, A.-K.3
  • 30
    • 67349242763 scopus 로고    scopus 로고
    • Tolerability of Two Sequential Electroporation Treatments Using MedPulser DNA Delivery System (DDS) in Healthy Adults
    • Wallace M, Evans B, Woods S, et al. Tolerability of Two Sequential Electroporation Treatments Using MedPulser DNA Delivery System (DDS) in Healthy Adults. Mol Ther J Am Soc Gene Ther. 2009;17(5):922-928.
    • (2009) Mol Ther J Am Soc Gene Ther , vol.17 , Issue.5 , pp. 922-928
    • Wallace, M.1    Evans, B.2    Woods, S.3
  • 31
    • 84885161878 scopus 로고    scopus 로고
    • Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers
    • Diehl MC, Lee JC, Daniels SE, et al. Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers. Hum Vacc Immunother. 2013;9 (10):2246-2252.
    • (2013) Hum Vacc Immunother , vol.9 , Issue.10 , pp. 2246-2252
    • Diehl, M.C.1    Lee, J.C.2    Daniels, S.E.3
  • 32
    • 79956061128 scopus 로고    scopus 로고
    • In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    • Vasan S, Hurley A, Schlesinger SJ, et al. In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers. PLoS One 2011;6(5): e19252.
    • (2011) PLoS One , vol.6 , Issue.5
    • Vasan, S.1    Hurley, A.2    Schlesinger, S.J.3
  • 33
    • 84991039863 scopus 로고    scopus 로고
    • Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma
    • Yuan J, Ku GY, Adamow M, et al. Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma. J Immunother Cancer. 2013;1:20-20.
    • (2013) J Immunother Cancer , vol.1 , pp. 20
    • Yuan, J.1    Ku, G.Y.2    Adamow, M.3
  • 34
    • 84921357729 scopus 로고    scopus 로고
    • Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients
    • Kim TJ, Jin H-T, Hur S-Y, et al. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients. Nat Commun. 2014;5:5317.
    • (2014) Nat Commun , vol.5 , pp. 5317
    • Kim, T.J.1    Jin, H.-T.2    Hur, S.-Y.3
  • 35
    • 84881623207 scopus 로고    scopus 로고
    • Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery
    • Kalams SA, Parker SD, Elizaga M, et al. Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery. J Infect Dis. 2013;208(5):818-829.
    • (2013) J Infect Dis , vol.208 , Issue.5 , pp. 818-829
    • Kalams, S.A.1    Parker, S.D.2    Elizaga, M.3
  • 36
    • 84941947030 scopus 로고    scopus 로고
    • A Phase i Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of Electroporated HIV DNA with or without Interleukin 12 in Prime-Boost Combinations with an Ad35 HIV Vaccine in Healthy HIVSeronegative African Adults
    • Mpendo J, Mutua G, Nyombayire J, et al. A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of Electroporated HIV DNA with or without Interleukin 12 in Prime-Boost Combinations with an Ad35 HIV Vaccine in Healthy HIVSeronegative African Adults. PLoS One. 2015;10(8): e0134287.
    • (2015) PLoS One , vol.10 , Issue.8
    • Mpendo, J.1    Mutua, G.2    Nyombayire, J.3
  • 37
    • 84883741031 scopus 로고    scopus 로고
    • Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C
    • Weiland O, Ahlen G, Diepolder H, et al. Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C. Mol Ther. 2013;21(9):1796-1805.
    • (2013) Mol Ther , vol.21 , Issue.9 , pp. 1796-1805
    • Weiland, O.1    Ahlen, G.2    Diepolder, H.3
  • 38
    • 84897494777 scopus 로고    scopus 로고
    • A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation
    • Hooper JW, Moon JE, Paolino KM, et al. A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation. Clin Microbiol Infect. 2014;20(Suppl 5):110-117.
    • (2014) Clin Microbiol Infect , vol.20 , pp. 110-117
    • Hooper, J.W.1    Moon, J.E.2    Paolino, K.M.3
  • 39
    • 84921903497 scopus 로고    scopus 로고
    • DNA vaccine for cancer immunotherapy
    • Yang B, Jeang J, Yang A, et al. DNA vaccine for cancer immunotherapy. Hum Vaccin Immunother. 2014;10 (11):3153-3164.
    • (2014) Hum Vaccin Immunother , vol.10 , Issue.11 , pp. 3153-3164
    • Yang, B.1    Jeang, J.2    Yang, A.3
  • 40
    • 84867437406 scopus 로고    scopus 로고
    • Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
    • Bagarazzi ML, Yan J, Morrow MP, et al. Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med. 2012;4 (155):155ra38.
    • (2012) Sci Transl Med , vol.4 , Issue.155 , pp. 155ra38
    • Bagarazzi, M.L.1    Yan, J.2    Morrow, M.P.3
  • 41
    • 84947869406 scopus 로고    scopus 로고
    • Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: A randomised, double-blind, placebo-controlled phase 2b trial
    • 10008
    • Trimble CL, Morrow MP, Kraynyak KA, et al. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. Lancet. 2015;386(10008):2078-2088.
    • (2015) Lancet , vol.386 , pp. 2078-2088
    • Trimble, C.L.1    Morrow, M.P.2    Kraynyak, K.A.3
  • 42
    • 0036594813 scopus 로고    scopus 로고
    • IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma
    • Lucas ML, Heller L, Coppola D, et al. IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma. Mol Ther. 2002;5(6):668-675.
    • (2002) Mol Ther , vol.5 , Issue.6 , pp. 668-675
    • Lucas, M.L.1    Heller, L.2    Coppola, D.3
  • 43
    • 58049200809 scopus 로고    scopus 로고
    • Phase i trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
    • Daud AI, DeConti RC, Andrews S, et al. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol. 2008;26(36):5896-5903.
    • (2008) J Clin Oncol , vol.26 , Issue.36 , pp. 5896-5903
    • Daud, A.I.1    DeConti, R.C.2    Andrews, S.3
  • 44
    • 67650687073 scopus 로고    scopus 로고
    • You're one in a googol: Optimizing genes for protein expression
    • Welch M, Villalobos A, Gustafsson C, et al. You're one in a googol: optimizing genes for protein expression. J Royal Soc Interface. 2009;6(Suppl 4):S467-S76.
    • (2009) J Royal Soc Interface , vol.6 , pp. S467-S476
    • Welch, M.1    Villalobos, A.2    Gustafsson, C.3
  • 45
    • 78650304100 scopus 로고    scopus 로고
    • Synonymous but not the same: The causes and consequences of codon bias
    • Plotkin JB, Kudla G. Synonymous but not the same: the causes and consequences of codon bias. Nat Rev Genet. 2011;12(1):32-42.
    • (2011) Nat Rev Genet , vol.12 , Issue.1 , pp. 32-42
    • Plotkin, J.B.1    Kudla, G.2
  • 46
    • 79957798888 scopus 로고    scopus 로고
    • Codon usage: Nature's roadmap to expression and folding of proteins
    • Angov E. Codon usage: Nature's roadmap to expression and folding of proteins. Biotechnol J. 2011;6(6):650-659.
    • (2011) Biotechnol J , vol.6 , Issue.6 , pp. 650-659
    • Angov, E.1
  • 47
    • 0342699700 scopus 로고    scopus 로고
    • A Rev- Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene
    • Kotsopoulou E, Kim VN, Kingsman AJ, et al. A Rev- Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene. J Virol. 2000;74(10):4839-4852.
    • (2000) J Virol , vol.74 , Issue.10 , pp. 4839-4852
    • Kotsopoulou, E.1    Kim, V.N.2    Kingsman, A.J.3
  • 48
    • 84868484767 scopus 로고    scopus 로고
    • The future of human DNA vaccines
    • Li L, Saade F, Petrovsky N. The future of human DNA vaccines. J Biotechnol. 2012;162(2-3):171-182.
    • (2012) J Biotechnol , vol.162 , Issue.2-3 , pp. 171-182
    • Li, L.1    Saade, F.2    Petrovsky, N.3
  • 49
    • 84856869561 scopus 로고    scopus 로고
    • Technologies for enhanced efficacy of DNA vaccines
    • Saade F, Petrovsky N. Technologies for enhanced efficacy of DNA vaccines. Expert Rev Vaccines. 2012;11(2):189-209.
    • (2012) Expert Rev Vaccines , vol.11 , Issue.2 , pp. 189-209
    • Saade, F.1    Petrovsky, N.2
  • 50
    • 3042786281 scopus 로고    scopus 로고
    • Promoters and control elements: Designing expression cassettes for gene therapy
    • Papadakis ED, Nicklin SA, Baker AH, et al. Promoters and control elements: designing expression cassettes for gene therapy. Curr Gene Ther. 2004;4(1):89-113.
    • (2004) Curr Gene Ther , vol.4 , Issue.1 , pp. 89-113
    • Papadakis, E.D.1    Nicklin, S.A.2    Baker, A.H.3
  • 51
    • 67649484348 scopus 로고    scopus 로고
    • Skin-specific promoters for genetic immunisation by DNA electroporation
    • Vandermeulen G, Richiardi H, Escriou V, et al. Skin-specific promoters for genetic immunisation by DNA electroporation. Vaccine. 2009;27(32):4272-4277.
    • (2009) Vaccine , vol.27 , Issue.32 , pp. 4272-4277
    • Vandermeulen, G.1    Richiardi, H.2    Escriou, V.3
  • 52
    • 84896726768 scopus 로고    scopus 로고
    • Targeted expression of suicide gene by tissue-specific promoter and microRNA regulation for cancer gene therapy
    • Danda R, Krishnan G, Ganapathy K, et al. Targeted expression of suicide gene by tissue-specific promoter and microRNA regulation for cancer gene therapy. Plos One. 2013;8(12):e83398.
    • (2013) Plos One , vol.8 , Issue.12
    • Danda, R.1    Krishnan, G.2    Ganapathy, K.3
  • 53
    • 84941315853 scopus 로고    scopus 로고
    • Improved specificity of gene electrotransfer to skin using pDNA under the control of collagen tissue-specific promoter
    • Kos S, Tesic N, Kamensek U, et al. Improved specificity of gene electrotransfer to skin using pDNA under the control of collagen tissue-specific promoter. J Membr Biol. 2015;248(5):919-928.
    • (2015) J Membr Biol , vol.248 , Issue.5 , pp. 919-928
    • Kos, S.1    Tesic, N.2    Kamensek, U.3
  • 55
    • 12344320234 scopus 로고    scopus 로고
    • TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines
    • Tudor D, Dubuquoy C, Gaboriau V, et al. TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines. Vaccine. 2005;23(10):1258-1264.
    • (2005) Vaccine , vol.23 , Issue.10 , pp. 1258-1264
    • Tudor, D.1    Dubuquoy, C.2    Gaboriau, V.3
  • 56
    • 4444325043 scopus 로고    scopus 로고
    • TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine
    • Babiuk S, Mookherjee N, Pontarollo R, et al. TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. Immunology. 2004;113(1):114-120.
    • (2004) Immunology , vol.113 , Issue.1 , pp. 114-120
    • Babiuk, S.1    Mookherjee, N.2    Pontarollo, R.3
  • 57
    • 80555150705 scopus 로고    scopus 로고
    • New Generation of Plasmid Backbones Devoid of Antibiotic Resistance Marker for Gene Therapy Trials
    • Vandermeulen G, Marie C, Scherman D, et al. New Generation of Plasmid Backbones Devoid of Antibiotic Resistance Marker for Gene Therapy Trials. Mol Ther. 2011;19(11):1942-1949.
    • (2011) Mol Ther , vol.19 , Issue.11 , pp. 1942-1949
    • Vandermeulen, G.1    Marie, C.2    Scherman, D.3
  • 58
    • 84906794766 scopus 로고    scopus 로고
    • Recent Developments in Preclinical DNA Vaccination
    • Okuda K, Wada Y, Shimada M. Recent Developments in Preclinical DNA Vaccination. Vaccines. 2014;2(1):89.
    • (2014) Vaccines , vol.2 , Issue.1 , pp. 89
    • Okuda, K.1    Wada, Y.2    Shimada, M.3
  • 59
    • 84930061743 scopus 로고    scopus 로고
    • Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: Vaccineplatforms for the battle against infectious diseases
    • Grunwald T, Ulbert S. Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccineplatforms for the battle against infectious diseases. Clin Exp Vaccine Res. 2015;4(1):1-10.
    • (2015) Clin Exp Vaccine Res , vol.4 , Issue.1 , pp. 1-10
    • Grunwald, T.1    Ulbert, S.2
  • 60
    • 36048955664 scopus 로고    scopus 로고
    • Immunotherapy of cancer by IL-12-based cytokine combinations
    • Weiss JM, Subleski JJ, Wigginton JM, et al. Immunotherapy of cancer by IL-12-based cytokine combinations. Expert Opin Biol Ther. 2007;7(11):1705-1721.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.11 , pp. 1705-1721
    • Weiss, J.M.1    Subleski, J.J.2    Wigginton, J.M.3
  • 61
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • Dinarello CA. Proinflammatory cytokines. Chest. 2000;118 (2):503-508.
    • (2000) Chest , vol.118 , Issue.2 , pp. 503-508
    • Dinarello, C.A.1
  • 62
    • 84890346971 scopus 로고    scopus 로고
    • Synthetic DNA vaccines: Improved vaccine potency by electroporation and co-delivered genetic adjuvants
    • Flingai S, Czerwonko M, Goodman J, et al. Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants. Front Immunol. 2013;4:354.
    • (2013) Front Immunol , vol.4 , pp. 354
    • Flingai, S.1    Czerwonko, M.2    Goodman, J.3
  • 63
    • 0035925610 scopus 로고    scopus 로고
    • Genetic adjuvants for DNA vaccines
    • Scheerlinck JY. Genetic adjuvants for DNA vaccines. Vaccine. 2001;19(17-19):2647-2656.
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2647-2656
    • Scheerlinck, J.Y.1
  • 64
    • 84940724757 scopus 로고    scopus 로고
    • Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer
    • Sersa G, Teissie J, Cemazar M, et al. Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer. Cancer Immunol Immunother. 2015;64 (10):1315-1327.
    • (2015) Cancer Immunol Immunother , vol.64 , Issue.10 , pp. 1315-1327
    • Sersa, G.1    Teissie, J.2    Cemazar, M.3
  • 65
    • 84930574522 scopus 로고    scopus 로고
    • The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation
    • Vandermeulen G, Vanvarenberg K, De Beuckelaer A, et al. The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation. Vaccine. 2015;33(28):3179-3185.
    • (2015) Vaccine , vol.33 , Issue.28 , pp. 3179-3185
    • Vandermeulen, G.1    Vanvarenberg, K.2    De Beuckelaer, A.3
  • 66
    • 77958028255 scopus 로고    scopus 로고
    • Gene electrotransfer to skin; Review of existing literature and clinical perspectives
    • Gothelf A, Gehl J. Gene electrotransfer to skin; review of existing literature and clinical perspectives. Curr Gene Ther. 2010;10(4):287-299.
    • (2010) Curr Gene Ther , vol.10 , Issue.4 , pp. 287-299
    • Gothelf, A.1    Gehl, J.2
  • 67
    • 80053109231 scopus 로고    scopus 로고
    • Efficacy of transgene expression in porcine skin as a function of electrode choice
    • Gothelf A, Mahmood F, Dagnaes-Hansen F, et al. Efficacy of transgene expression in porcine skin as a function of electrode choice. Bioelectrochemistry. 2011;82(2):95-102.
    • (2011) Bioelectrochemistry , vol.82 , Issue.2 , pp. 95-102
    • Gothelf, A.1    Mahmood, F.2    Dagnaes-Hansen, F.3
  • 68
    • 0035702872 scopus 로고    scopus 로고
    • Skin-targeted gene transfer using in vivo electroporation
    • Maruyama H, Ataka K, Higuchi N, et al. Skin-targeted gene transfer using in vivo electroporation. Gene Ther. 2001;8(23):1808-1812.
    • (2001) Gene Ther , vol.8 , Issue.23 , pp. 1808-1812
    • Maruyama, H.1    Ataka, K.2    Higuchi, N.3
  • 69
    • 77955303947 scopus 로고    scopus 로고
    • Hollow Microneedle Arrays for Intradermal Drug Delivery and DNA Electroporation
    • Daugimont L, Baron N, Vandermeulen G, et al. Hollow Microneedle Arrays for Intradermal Drug Delivery and DNA Electroporation. J Membrane Biol. 2010;236(1):117-125.
    • (2010) J Membrane Biol , vol.236 , Issue.1 , pp. 117-125
    • Daugimont, L.1    Baron, N.2    Vandermeulen, G.3
  • 70
    • 38149081350 scopus 로고    scopus 로고
    • Electrochemotherapy in treatment of tumours
    • Sersa G, Miklavcic D, Cemazar M, et al. Electrochemotherapy in treatment of tumours. Ejso-Eur J Surg Onc. 2008;34(2):232-240.
    • (2008) Ejso-Eur J Surg Onc , vol.34 , Issue.2 , pp. 232-240
    • Sersa, G.1    Miklavcic, D.2    Cemazar, M.3
  • 71
    • 77949744402 scopus 로고    scopus 로고
    • Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array
    • Heller R, Cruz Y, Heller LC, et al. Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array. Human Gene Therapy. 2010;21(3):357-362.
    • (2010) Human Gene Therapy , vol.21 , Issue.3 , pp. 357-362
    • Heller, R.1    Cruz, Y.2    Heller, L.C.3
  • 72
    • 79957445683 scopus 로고    scopus 로고
    • Electro-gene transfer to skin using a noninvasive multielectrode array
    • Guo SQ, Donate A, Basu G, et al. Electro-gene transfer to skin using a noninvasive multielectrode array. J Control Release. 2011;151(3):256-262.
    • (2011) J Control Release , vol.151 , Issue.3 , pp. 256-262
    • Guo, S.Q.1    Donate, A.2    Basu, G.3
  • 73
    • 0034990926 scopus 로고    scopus 로고
    • Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization
    • Drabick JJ, Glasspool-Malone J, Somiari S, et al. Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Mol Ther. 2001;3(2):249-255.
    • (2001) Mol Ther , vol.3 , Issue.2 , pp. 249-255
    • Drabick, J.J.1    Glasspool-Malone, J.2    Somiari, S.3
  • 74
    • 79955745986 scopus 로고    scopus 로고
    • Evaluation of a Novel Non-Penetrating Electrode for Use in DNA Vaccination
    • Donate A, Coppola D, Cruz Y, et al. Evaluation of a Novel Non-Penetrating Electrode for Use in DNA Vaccination. Plos One. 2011;6:4.
    • (2011) Plos One , vol.6 , pp. 4
    • Donate, A.1    Coppola, D.2    Cruz, Y.3
  • 75
    • 23944458367 scopus 로고    scopus 로고
    • DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse
    • Pavselj N, Preat V. DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse. J Control Release. 2005;106(3):407-415.
    • (2005) J Control Release , vol.106 , Issue.3 , pp. 407-415
    • Pavselj, N.1    Preat, V.2
  • 76
    • 69949121286 scopus 로고    scopus 로고
    • Optimization of Skin Electroporation in Mice to Increase Tolerability of DNA Vaccine Delivery to Patients
    • Roos AK, Eriksson F, Walters DC, et al. Optimization of Skin Electroporation in Mice to Increase Tolerability of DNA Vaccine Delivery to Patients. Mol Ther. 2009;17 (9):1637-1642.
    • (2009) Mol Ther , vol.17 , Issue.9 , pp. 1637-1642
    • Roos, A.K.1    Eriksson, F.2    Walters, D.C.3
  • 77
    • 57049129996 scopus 로고    scopus 로고
    • Efficiency of High- and Low-Voltage Pulse Combinations for Gene Electrotransfer in Muscle, Liver, Tumor, and Skin
    • Andre FM, Gehl J, Sersa G, et al. Efficiency of High- and Low-Voltage Pulse Combinations for Gene Electrotransfer in Muscle, Liver, Tumor, and Skin. Human Gene Therapy. 2008;19(11):1261-1271.
    • (2008) Human Gene Therapy , vol.19 , Issue.11 , pp. 1261-1271
    • Andre, F.M.1    Gehl, J.2    Sersa, G.3
  • 78
    • 0037459059 scopus 로고    scopus 로고
    • Enhancement of therapeutic drug and DNA delivery into cells by electroporation
    • Rabussay D, Dev NB, Fewell J, et al. Enhancement of therapeutic drug and DNA delivery into cells by electroporation. J Phys D Appl Phys. 2003;36(4):348-363.
    • (2003) J Phys D Appl Phys , vol.36 , Issue.4 , pp. 348-363
    • Rabussay, D.1    Dev, N.B.2    Fewell, J.3
  • 79
    • 84969382412 scopus 로고    scopus 로고
    • Toward the development of electroporation for delivery of DNA vaccines to humans
    • Rabussay D, Widera G, Zhang L, et al. Toward the development of electroporation for delivery of DNA vaccines to humans. Mol Ther. 2004;9:S209-S09.
    • (2004) Mol Ther , vol.9 , pp. S209-S219
    • Rabussay, D.1    Widera, G.2    Zhang, L.3
  • 80
    • 84945250789 scopus 로고    scopus 로고
    • Coupling treatment planning with navigation system: A new technological approach in treatment of head and neck tumors by electrochemotherapy
    • Groselj A, Kos B, Cemazar M, et al. Coupling treatment planning with navigation system: a new technological approach in treatment of head and neck tumors by electrochemotherapy. Biomed Eng Online. 2015;14(Suppl 3):S2.
    • (2015) Biomed Eng Online , vol.14 , pp. S2
    • Groselj, A.1    Kos, B.2    Cemazar, M.3
  • 81
    • 84902603341 scopus 로고    scopus 로고
    • Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells
    • Calvet CY, Famin D, Andre FM, et al. Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells. Oncoimmunology. 2014;3:e28131.
    • (2014) Oncoimmunology , vol.3
    • Calvet, C.Y.1    Famin, D.2    Andre, F.M.3
  • 82
    • 84863726990 scopus 로고    scopus 로고
    • A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo electroporation in chronic hepatitis B patients under lamivudine chemotherapy
    • Yang FQ, Yu YY, Wang GQ, et al. A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo electroporation in chronic hepatitis B patients under lamivudine chemotherapy. J Viral Hepat. 2012;19(8):581-593.
    • (2012) J Viral Hepat , vol.19 , Issue.8 , pp. 581-593
    • Yang, F.Q.1    Yu, Y.Y.2    Wang, G.Q.3
  • 83
    • 61849131130 scopus 로고    scopus 로고
    • Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation
    • Kim CY, Kang ES, Kim SB, et al. Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation. Exp Mol Med. 2008;40(6):669-676.
    • (2008) Exp Mol Med , vol.40 , Issue.6 , pp. 669-676
    • Kim, C.Y.1    Kang, E.S.2    Kim, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.