Genetic adjuvants for DNA vaccines

Vaccine

Volumn 19, Issue 17-19, 2001, Pages 2647-2656

  Scheerlinck, Jean Pierre Y ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chemokine; Costimulatory molecules; Cytokine; DNA vaccination; Targeting

Indexed keywords

ADJUVANT; B7 ANTIGEN; CD86 ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN TCA 3; RANTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN BINDING; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TARGETING; GENE FUSION; GENE GUN; GENE THERAPY; HUMAN; IMMUNOMODULATION; IMMUNOSTIMULATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; VACCINATION; VACCINE PRODUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; CHEMOKINES; CYTOKINES; HUMANS; VACCINES, COMBINED; VACCINES, DNA;

EID: 0035925610     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00495-3     Document Type: Conference Paper

References (68)

1. Direct gene transfer into mouse muscle in vivo
2. Genetic immunization is a simple method for eliciting an immune response
3. DNA vaccination strategies against infectious diseases
4. Immunization of animals: From DNA to the dinner plate
5. Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants
6. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
7. DNA immunization: Induction of higher avidity antibody and effect of route on T cell cytotoxicity
8. Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses
9. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
10. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
11. Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells
12. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
13. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
14. Modulating the immune response to genetic immunization
15. The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine
16. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration
17. The effect of intradermal injection of GM-CSF and TNF-alpha on the accumulation of dendritic cells in ovine skin
18. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV
19. Protective immunity against heterologous challenge with encephalomyocarditis virus by VP1 DNA vaccination: Effect of coinjection with a granulocyte-macrophage colony stimulating factor gene
20. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
21. Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes
22. Polynucleotide vaccines in animals: Enhancing and modulating responses
23. IL-6 induces long-term protective immunity against a lethal challenge of influenza virus
24. A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine
25. Improving protective immunity induced by DNA-based immunization: Priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus
26. IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+T cell-mediated protective immunity against herpes simplex virus-2 challenge
27. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes
28. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
29. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
30. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
31. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
32. Immunomodulation by mucosal gene transfer using TGF-beta DNA
33. Potentiation of antigen-specific, Th1 immune responses by multiple DNA vaccination with an ovalbumin/interferon-gamma hybrid construct
34. The effect of interferon-gamma on genetic immunization
35. Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvants
36. Coimmunization with IFN-gamma or IL-2, but not IL-13 or IL-4 cDNA can enhance Th1-type DNA vaccine-induced immune responses in vivo
37. Induction of antibodies to a kappa V region by gene immunization
38. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine
39. Intranasal administration of human immunodeficiency virus type-1 (HIV-1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1
40. In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model
41. Immune modulation by IL-10 gene transfer via viral vector and plasmid DNA: Implication for gene therapy
42. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
43. Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12
44. Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype
45. Interleukin-12 (IL-12) enhancement of the cellular immune response against human immunodeficiency virus Type 1 env antigen in a DNA prime/vaccinia virus boost vaccine regimen is time and dose dependent: Suppressive effects of IL-12 boost are mediated by nitric oxide
46. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
47. Modulation of virus-induced delayed-type hypersensitivity by plasmid DNA encoding the cytokine interleukin-10
48. Vaccination with an ovalbumin/interleukin-4 fusion DNA efficiently induces Th2 cell-mediated immune responses in an ovalbumin-specific manner
49. Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice
50. Use of equine IL-6 plasmid as an adjuvant in DNA influenza vaccination of horses
51. Long-lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines
52. Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines
53. CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo
54. Modulation of the immune response to DNA vaccine by co-delivery of costimulatry molecules
55. Weiner DB. HIV-1 DNA vaccines and chemokines
56. Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1
57. HIV-1-specific cell-mediated immunity is enhanced by co-inoculation of TCA3 expression plasmid with DNA vaccine
58. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes
59. Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen
60. Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes
61. Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC
62. The immunotargeting approach to adjuvant-independent subunit vaccine design
63. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction
64. Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization
65. A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge
66. Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: Cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization
67. Targeting improves the efficacy of a DNA vaccine against Corynebacterium pseudotuberculosis in sheep
68. Site-directed immune responses in DNA vaccines encoding ligand-antigen fusions