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Volumn 19, Issue 11, 2011, Pages 1942-1949

New generation of plasmid backbones devoid of antibiotic resistance marker for gene therapy trials

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; DNA VACCINE; FIBROBLAST GROWTH FACTOR; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LACK ANTIGEN; LEISHMANIA VACCINE; PARASITE ANTIGEN; PLASMID DNA; PROTEIN E7; TRANSFER RNA; UNCLASSIFIED DRUG;

EID: 80555150705     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.182     Document Type: Review
Times cited : (90)

References (68)
  • 2
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Wolff, JA, Malone, RW, Williams, P, Chong, W, Acsadi, G, Jani, A et al. (1990). Direct gene transfer into mouse muscle in vivo. Science 247(4949 Pt 1): 1465-1468.
    • (1990) Science , vol.247 , Issue.4949 PART 1 , pp. 1465-1468
    • Wolff, J.A.1    Malone, R.W.2    Williams, P.3    Chong, W.4    Acsadi, G.5    Jani, A.6
  • 3
    • 2342653439 scopus 로고    scopus 로고
    • Plasmid copy number and plasmid stability
    • Friehs, K (2004). Plasmid copy number and plasmid stability. Adv Biochem Eng Biotechnol 86: 47-82.
    • (2004) Adv Biochem Eng Biotechnol , vol.86 , pp. 47-82
    • Friehs, K.1
  • 4
    • 0031659852 scopus 로고    scopus 로고
    • Timing, self-control and a sense of direction are the secrets of multicopy plasmid stability
    • DOI 10.1046/j.1365-2958.1998.01012.x
    • Summers, D (1998). Timing, self-control and a sense of direction are the secrets of multicopy plasmid stability. Mol Microbiol 29: 1137-1145. (Pubitemid 28408837)
    • (1998) Molecular Microbiology , vol.29 , Issue.5 , pp. 1137-1145
    • Summers, D.1
  • 8
    • 0003716535 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • US Food and Drug Administration. Guidance for human somatic cell therapy and gene therapy (1998).http://www.fda.gov/downloads/BiologicsBloodVaccines/ GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ ucm081670.pdf
    • (1998) Guidance for Human Somatic Cell Therapy and Gene Therapy
  • 9
    • 78751532880 scopus 로고    scopus 로고
    • Current challenges in the management of the infected patient
    • Nicolau, DP (2011). Current challenges in the management of the infected patient. Curr Opin Infect Dis 24 Suppl 1: S1-10.
    • (2011) Curr Opin Infect Dis , vol.24 , Issue.SUPPL. 1
    • Nicolau, D.P.1
  • 10
    • 26444491047 scopus 로고    scopus 로고
    • Resistance to antibiotics: Are we in the post-antibiotic era?
    • DOI 10.1016/j.arcmed.2005.06.009, PII S0188440905002730, Infectious Diseases: Revisiting Past Problems and Addressing Future Challenges
    • Alanis, AJ (2005). Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res 36: 697-705. (Pubitemid 41436239)
    • (2005) Archives of Medical Research , vol.36 , Issue.6 , pp. 697-705
    • Alanis, A.J.1
  • 11
    • 0038239644 scopus 로고    scopus 로고
    • Hypersensitivity reactions to beta-lactam antibiotics
    • Solensky, R (2003). Hypersensitivity reactions to beta-lactam antibiotics. Clin Rev Allergy Immunol 24: 201-220.
    • (2003) Clin Rev Allergy Immunol , vol.24 , pp. 201-220
    • Solensky, R.1
  • 13
    • 67650066209 scopus 로고    scopus 로고
    • Factors affecting plasmid production in Escherichia coli from a resource allocation standpoint
    • Cunningham, DS, Koepsel, RR, Ataai, MM and Domach, MM (2009). Factors affecting plasmid production in Escherichia coli from a resource allocation standpoint. Microb Cell Fact 8: 27.
    • (2009) Microb Cell Fact , vol.8 , pp. 27
    • Cunningham, D.S.1    Koepsel, R.R.2    Ataai, M.M.3    Domach, M.M.4
  • 14
    • 0031915282 scopus 로고    scopus 로고
    • Cationic lipid-mediated gene transfer: Analysis of cellular uptake and nuclear import of plasmid DNA
    • DOI 10.1023/A:1007425803756
    • Escriou, V, Ciolina, C, Helbling-Leclerc, A, Wils, P and Scherman, D (1998). Cationic lipid-mediated gene transfer: analysis of cellular uptake and nuclear import of plasmid DNA. Cell Biol Toxicol 14: 95-104. (Pubitemid 28123599)
    • (1998) Cell Biology and Toxicology , vol.14 , Issue.2 , pp. 95-104
    • Escriou, V.1    Ciolina, C.2    Helbling-Leclerc, A.3    Wils, P.4    Scherman, D.5
  • 15
    • 0035286970 scopus 로고    scopus 로고
    • Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer
    • DOI 10.1002/jgm.174
    • Escriou, V, Carrière, M, Bussone, F, Wils, P and Scherman, D (2001). Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer. J Gene Med 3: 179-187. (Pubitemid 33685445)
    • (2001) Journal of Gene Medicine , vol.3 , Issue.2 , pp. 179-187
    • Escriou, V.1    Carriere, M.2    Bussone, F.3    Wils, P.4    Scherman, D.5
  • 16
  • 18
    • 4243080427 scopus 로고    scopus 로고
    • Plasmid DNA electrotransfer for intracellular and secreted proteins expression: New methodological developments and applications
    • DOI 10.1002/jgm.508
    • Bloquel, C, Fabre, E, Bureau, MF and Scherman, D (2004). Plasmid DNA electrotransfer for intracellular and secreted proteins expression: new methodological developments and applications. J Gene Med 6 Suppl 1: S11-S23. (Pubitemid 40228013)
    • (2004) Journal of Gene Medicine , vol.6 , Issue.SUPPL. 1
    • Bloquel, C.1    Fabre, E.2    Bureau, M.F.3    Scherman, D.4
  • 19
    • 79955932603 scopus 로고    scopus 로고
    • Gene therapy for cancer: Bacteria-mediated anti-angiogenesis therapy
    • Gardlik, R, Behuliak, M, Palffy, R, Celec, P and Li, CJ (2011). Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy. Gene Ther 18: 425-431.
    • (2011) Gene Ther , vol.18 , pp. 425-431
    • Gardlik, R.1    Behuliak, M.2    Palffy, R.3    Celec, P.4    Li, C.J.5
  • 20
    • 29944435270 scopus 로고    scopus 로고
    • Bacteria in gene therapy: Bactofection versus alternative gene therapy
    • DOI 10.1038/sj.gt.3302635, PII 3302635
    • Pálffy, R, Gardlík, R, Hodosy, J, Behuliak, M, Resko, P, Radvánský, J et al. (2006). Bacteria in gene therapy: bactofection versus alternative gene therapy. Gene Ther 13: 101-105. (Pubitemid 43039902)
    • (2006) Gene Therapy , vol.13 , Issue.2 , pp. 101-105
    • Palffy, R.1    Gardlik, R.2    Hodosy, J.3    Behuliak, M.4    Resko, P.5    Radvansky, J.6    Celec, P.7
  • 21
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • DOI 10.1146/annurev.immunol.20.100301.064842
    • Krieg, AM (2002). CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20: 709-760. (Pubitemid 34293438)
    • (2002) Annual Review of Immunology , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 23
    • 39749143172 scopus 로고    scopus 로고
    • Development of an antibiotic-free plasmid selection system based on glycine auxotrophy for recombinant protein overproduction in Escherichia coli
    • Vidal, L, Pinsach, J, Striedner, G, Caminal, G and Ferrer, P (2008). Development of an antibiotic-free plasmid selection system based on glycine auxotrophy for recombinant protein overproduction in Escherichia coli. J Biotechnol 134: 127-136.
    • (2008) J Biotechnol , vol.134 , pp. 127-136
    • Vidal, L.1    Pinsach, J.2    Striedner, G.3    Caminal, G.4    Ferrer, P.5
  • 24
    • 77950275418 scopus 로고    scopus 로고
    • Novel antibiotic-free plasmid selection system based on complementation of host auxotrophy in the NAD de novo synthesis pathway
    • Dong, WR, Xiang, LX and Shao, JZ (2010). Novel antibiotic-free plasmid selection system based on complementation of host auxotrophy in the NAD de novo synthesis pathway. Appl Environ Microbiol 76: 2295-2303.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 2295-2303
    • Dong, W.R.1    Xiang, L.X.2    Shao, J.Z.3
  • 25
    • 2942511439 scopus 로고    scopus 로고
    • A host/plasmid system that is not dependent on antibiotics and antibiotic resistance genes for stable plasmid maintenance in Escherichia coli
    • DOI 10.1016/j.jbiotec.2004.03.010, PII S0168165604001658
    • Hägg, P, de Pohl, JW, Abdulkarim, F and Isaksson, LA (2004). A host/plasmid system that is not dependent on antibiotics and antibiotic resistance genes for stable plasmid maintenance in Escherichia coli. J Biotechnol 111: 17-30. (Pubitemid 38757817)
    • (2004) Journal of Biotechnology , vol.111 , Issue.1 , pp. 17-30
    • Hagg, P.1    De Pohl, J.W.2    Abdulkarim, F.3    Isaksson, L.A.4
  • 27
    • 15244339715 scopus 로고    scopus 로고
    • Improvement of pCOR plasmid copy number for pharmaceutical applications
    • DOI 10.1007/s00253-004-1729-9
    • Soubrier, F, Laborderie, B and Cameron, B (2005). Improvement of pCOR plasmid copy number for pharmaceutical applications. Appl Microbiol Biotechnol 66: 683-688. (Pubitemid 40385632)
    • (2005) Applied Microbiology and Biotechnology , vol.66 , Issue.6 , pp. 683-688
    • Soubrier, F.1    Laborderie, B.2    Cameron, B.3
  • 28
    • 77950896663 scopus 로고    scopus 로고
    • PFARs, plasmids free of antibiotic resistance markers, display high-level transgene expression in muscle, skin and tumour cells
    • Marie, C, Vandermeulen, G, Quiviger, M, Richard, M, Préat, V and Scherman, D (2010). pFARs, plasmids free of antibiotic resistance markers, display high-level transgene expression in muscle, skin and tumour cells. J Gene Med 12: 323-332.
    • (2010) J Gene Med , vol.12 , pp. 323-332
    • Marie, C.1    Vandermeulen, G.2    Quiviger, M.3    Richard, M.4    Préat, V.5    Scherman, D.6
  • 29
    • 79953171927 scopus 로고    scopus 로고
    • Prokaryotic toxin-antitoxin systems-the role in bacterial physiology and application in molecular biology
    • Bukowski, M, Rojowska, A and Wladyka, B (2011). Prokaryotic toxin-antitoxin systems-the role in bacterial physiology and application in molecular biology. Acta Biochim Pol 58: 1-9.
    • (2011) Acta Biochim Pol , vol.58 , pp. 1-9
    • Bukowski, M.1    Rojowska, A.2    Wladyka, B.3
  • 30
    • 0030946721 scopus 로고    scopus 로고
    • Combining the hok/sok, parDE, and pnd postsegregational killer loci to enhance plasmid stability
    • Pecota, DC, Kim, CS, Wu, K, Gerdes, K and Wood, TK (1997). Combining the hok/sok, parDE, and pnd postsegregational killer loci to enhance plasmid stability. Appl Environ Microbiol 63: 1917-1924. (Pubitemid 27194855)
    • (1997) Applied and Environmental Microbiology , vol.63 , Issue.5 , pp. 1917-1924
    • Pecota, D.C.1    Kim, C.S.2    Wu, K.3    Gerdes, K.4    Wood, T.K.5
  • 31
    • 0036196365 scopus 로고    scopus 로고
    • Molecular interactions of the CcdB poison with its bacterial target, the DNA gyrase
    • Van Melderen, L (2002). Molecular interactions of the CcdB poison with its bacterial target, the DNA gyrase. Int J Med Microbiol 291: 537-544. (Pubitemid 34206834)
    • (2001) International Journal of Medical Microbiology , vol.291 , Issue.6-7 , pp. 537-544
    • Van Melderen, L.1
  • 32
    • 18444380606 scopus 로고    scopus 로고
    • Separate-component-stabilization system for protein and DNA production without the use of antibiotics
    • Szpirer, CY and Milinkovitch, MC (2005). Separate-component-stabilization system for protein and DNA production without the use of antibiotics. BioTechniques 38: 775-781. (Pubitemid 40647046)
    • (2005) BioTechniques , vol.38 , Issue.5 , pp. 775-781
    • Szpirer, C.Y.1    Milinkovitch, M.C.2
  • 33
    • 77956468731 scopus 로고    scopus 로고
    • Antibiotic-free selection in E. coli: New considerations for optimal design and improved production
    • Peubez, I, Chaudet, N, Mignon, C, Hild, G, Husson, S, Courtois, V et al. (2010). Antibiotic-free selection in E. coli: new considerations for optimal design and improved production. Microb Cell Fact 9: 65.
    • (2010) Microb Cell Fact , vol.9 , pp. 65
    • Peubez, I.1    Chaudet, N.2    Mignon, C.3    Hild, G.4    Husson, S.5    Courtois, V.6
  • 35
    • 0035286339 scopus 로고    scopus 로고
    • Escherichia coli strains that allow antibiotic-free plasmid selection and maintenance by repressor titration
    • Cranenburgh, RM, Hanak, JA, Williams, SG and Sherratt, DJ (2001). Escherichia coli strains that allow antibiotic-free plasmid selection and maintenance by repressor titration. Nucleic Acids Res 29: E26.
    • (2001) Nucleic Acids Res , vol.29
    • Cranenburgh, R.M.1    Hanak, J.A.2    Williams, S.G.3    Sherratt, D.J.4
  • 36
    • 70350077805 scopus 로고    scopus 로고
    • Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system
    • Luke, J, Carnes, AE, Hodgson, CP and Williams, JA (2009). Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system. Vaccine 27: 6454-6459.
    • (2009) Vaccine , vol.27 , pp. 6454-6459
    • Luke, J.1    Carnes, A.E.2    Hodgson, C.P.3    Williams, J.A.4
  • 37
    • 79953777976 scopus 로고    scopus 로고
    • Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers
    • Luke, JM, Vincent, JM, Du, SX, Gerdemann, U, Leen, AM, Whalen, RG et al. (2011). Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers. Gene Ther 18: 334-343.
    • (2011) Gene Ther , vol.18 , pp. 334-343
    • Luke, J.M.1    Vincent, J.M.2    Du, S.X.3    Gerdemann, U.4    Leen, A.M.5    Whalen, R.G.6
  • 38
    • 77953923884 scopus 로고    scopus 로고
    • Marker-free plasmids for gene therapeutic applications-lack of antibiotic resistance gene substantially improves the manufacturing process
    • Mairhofer, J, Cserjan-Puschmann, M, Striedner, G, Nöbauer, K, Razzazi-Fazeli, E and Grabherr, R (2010). Marker-free plasmids for gene therapeutic applications-lack of antibiotic resistance gene substantially improves the manufacturing process. J Biotechnol 146: 130-137.
    • (2010) J Biotechnol , vol.146 , pp. 130-137
    • Mairhofer, J.1    Cserjan-Puschmann, M.2    Striedner, G.3    Nöbauer, K.4    Razzazi-Fazeli, E.5    Grabherr, R.6
  • 39
    • 33748877784 scopus 로고    scopus 로고
    • An array of Escherichia coli clones over-expressing essential proteins: A new strategy of identifying cellular targets of potent antibacterial compounds
    • DOI 10.1016/j.bbrc.2006.08.166, PII S0006291X06019826
    • Xu, HH, Real, L and Bailey, MW (2006). An array of Escherichia coli clones over-expressing essential proteins: a new strategy of identifying cellular targets of potent antibacterial compounds. Biochem Biophys Res Commun 349: 1250-1257. (Pubitemid 44419612)
    • (2006) Biochemical and Biophysical Research Communications , vol.349 , Issue.4 , pp. 1250-1257
    • Xu, H.H.1    Real, L.2    Bailey, M.W.3
  • 40
    • 50849136499 scopus 로고    scopus 로고
    • Plasmid selection in Escherichia coli using an endogenous essential gene marker
    • Goh, S and Good, L (2008). Plasmid selection in Escherichia coli using an endogenous essential gene marker. BMC Biotechnol 8: 61.
    • (2008) BMC Biotechnol , vol.8 , pp. 61
    • Goh, S.1    Good, L.2
  • 42
    • 60449098993 scopus 로고    scopus 로고
    • Progress and prospects: The design and production of plasmid vectors
    • Gill, DR, Pringle, IA and Hyde, SC (2009). Progress and prospects: the design and production of plasmid vectors. Gene Ther 16: 165-171.
    • (2009) Gene Ther , vol.16 , pp. 165-171
    • Gill, D.R.1    Pringle, I.A.2    Hyde, S.C.3
  • 43
    • 0031436820 scopus 로고    scopus 로고
    • A new DNA vehicle for nonviral gene delivery: Supercoiled minicircle
    • Darquet, AM, Cameron, B, Wils, P, Scherman, D and Crouzet, J (1997). A new DNA vehicle for nonviral gene delivery: supercoiled minicircle. Gene Ther 4: 1341-1349. (Pubitemid 28004593)
    • (1997) Gene Therapy , vol.4 , Issue.12 , pp. 1341-1349
    • Darquet, A.-M.1    Cameron, B.2    Wils, P.3    Scherman, D.4    Crouzet, J.5
  • 45
    • 0035933760 scopus 로고    scopus 로고
    • An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy
    • Bigger, BW, Tolmachov, O, Collombet, JM, Fragkos, M, Palaszewski, I and Coutelle, C (2001). An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy. J Biol Chem 276: 23018-23027.
    • (2001) J Biol Chem , vol.276 , pp. 23018-23027
    • Bigger, B.W.1    Tolmachov, O.2    Collombet, J.M.3    Fragkos, M.4    Palaszewski, I.5    Coutelle, C.6
  • 46
    • 13844292517 scopus 로고    scopus 로고
    • Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo
    • DOI 10.1089/hum.2005.16.126
    • Chen, ZY, He, CY and Kay, MA (2005). Improved production and purifcation of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Hum Gene Ther 16: 126-131. (Pubitemid 40250338)
    • (2005) Human Gene Therapy , vol.16 , Issue.1 , pp. 126-131
    • Chen, Z.-Y.1    He, C.-Y.2    Kay, M.A.3
  • 47
    • 78650028269 scopus 로고    scopus 로고
    • A robust system for production of minicircle DNA vectors
    • Kay, MA, He, CY and Chen, ZY (2010). A robust system for production of minicircle DNA vectors. Nat Biotechnol 28: 1287-1289.
    • (2010) Nat Biotechnol , vol.28 , pp. 1287-1289
    • Kay, M.A.1    He, C.Y.2    Chen, Z.Y.3
  • 48
    • 58149193835 scopus 로고    scopus 로고
    • Minicircle-DNA production by site specifc recombination and protein-DNA interaction chromatography
    • Mayrhofer, P, Blaesen, M, Schleef, M and Jechlinger, W (2008). Minicircle-DNA production by site specifc recombination and protein-DNA interaction chromatography. J Gene Med 10: 1253-1269.
    • (2008) J Gene Med , vol.10 , pp. 1253-1269
    • Mayrhofer, P.1    Blaesen, M.2    Schleef, M.3    Jechlinger, W.4
  • 49
    • 1142273140 scopus 로고    scopus 로고
    • Gene Therapy of Collagen-Induced Arthritis by Electrotransfer of Human Tumor Necrosis Factor-a Soluble Receptor I Variants
    • DOI 10.1089/104303404772679995
    • Bloquel, C, Bessis, N, Boissier, MC, Scherman, D and Bigey, P (2004). Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants. Hum Gene Ther 15: 189-201. (Pubitemid 38210533)
    • (2004) Human Gene Therapy , vol.15 , Issue.2 , pp. 189-201
    • Bloquel, C.1    Bessis, N.2    Boissier, M.-C.3    Scherman, D.4    Bigey, P.5
  • 50
    • 0037791929 scopus 로고    scopus 로고
    • Effcacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis
    • Saidenberg-Kermanac'h, N, Bessis, N, Deleuze, V, Bloquel, C, Bureau, M, Scherman, D et al. (2003). Effcacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis. J Gene Med 5: 164-171.
    • (2003) J Gene Med , vol.5 , pp. 164-171
    • Saidenberg-Kermanac'H, N.1    Bessis, N.2    Deleuze, V.3    Bloquel, C.4    Bureau, M.5    Scherman, D.6
  • 51
    • 0035114984 scopus 로고    scopus 로고
    • Partial prevention of cisplatin-induced neuropathy by electroporation-mediated nonviral gene transfer
    • DOI 10.1089/10430340150503993
    • Pradat, P F, Finiels, F, Kennel, P, Naimi, S, Orsini, C, Delaere, P et al. (2001). Partial prevention of cisplatin-induced neuropathy by electroporation-mediated nonviral gene transfer. Hum Gene Ther 12: 367-375. (Pubitemid 32186649)
    • (2001) Human Gene Therapy , vol.12 , Issue.4 , pp. 367-375
    • Pradat, P.-F.1    Finiels, F.2    Kennel, P.3    Naimi, S.4    Orsini, C.5    Delaere, P.6    Revah, F.7    Mallet, J.8
  • 52
    • 41549132636 scopus 로고    scopus 로고
    • Careful adjustment of Epo non-viral gene therapy for beta-thalassemic anaemia treatment
    • Fabre, EE, Bigey, P, Beuzard, Y, Scherman, D and Payen, E (2008). Careful adjustment of Epo non-viral gene therapy for beta-thalassemic anaemia treatment. Genet Vaccines Ther 6: 10.
    • (2008) Genet Vaccines Ther , vol.6 , pp. 10
    • Fabre, E.E.1    Bigey, P.2    Beuzard, Y.3    Scherman, D.4    Payen, E.5
  • 53
    • 33744476943 scopus 로고    scopus 로고
    • Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model
    • DOI 10.1007/s00109-005-0031-3
    • Witzenbichler, B, Mahfoudi, A, Soubrier, F, Le Roux, A, Branellec, D, Schultheiss, HP et al. (2006). Intramuscular gene transfer of fbroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model. J Mol Med 84: 491-502. (Pubitemid 43801328)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.6 , pp. 491-502
    • Witzenbichler, B.1    Mahfoudi, A.2    Soubrier, F.3    Le Roux, A.4    Branellec, D.5    Schultheiss, H.-P.6    Isner, J.M.7
  • 58
    • 0033826855 scopus 로고    scopus 로고
    • Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya
    • Hanke, T and McMichael, AJ (2000). Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat Med 6: 951-955.
    • (2000) Nat Med , vol.6 , pp. 951-955
    • Hanke, T.1    McMichael, A.J.2
  • 59
    • 0036135692 scopus 로고    scopus 로고
    • A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques
    • Wee, EG, Patel, S, McMichael, AJ and Hanke, T (2002). A DNA/MVA-based candidate human immunodefciency virus vaccine for Kenya induces multi-specifc T cell responses in rhesus macaques. J Gen Virol 83(Pt 1): 75-80. (Pubitemid 34030812)
    • (2002) Journal of General Virology , vol.83 , Issue.1 , pp. 75-80
    • Wee, E.G.-T.1    Patel, S.2    McMichael, A.J.3    Hanke, T.4
  • 60
    • 33644888264 scopus 로고    scopus 로고
    • An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specifc T cell response
    • Ohlschläger, P, Pes, M, Osen, W, Dürst, M, Schneider, A, Gissmann, L et al. (2006). An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specifc T cell response. Vaccine 24: 2880-2893.
    • (2006) Vaccine , vol.24 , pp. 2880-2893
    • Ohlschläger, P.1    Pes, M.2    Osen, W.3    Dürst, M.4    Schneider, A.5    Gissmann, L.6
  • 61
    • 70350567744 scopus 로고    scopus 로고
    • Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection
    • Ramos, I, Alonso, A, Peris, A, Marcen, JM, Abengozar, MA, Alcolea, PJ et al. (2009). Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection. Vaccine 27: 6695-6703.
    • (2009) Vaccine , vol.27 , pp. 6695-6703
    • Ramos, I.1    Alonso, A.2    Peris, A.3    Marcen, J.M.4    Abengozar, M.A.5    Alcolea, P.J.6
  • 62
    • 79960572516 scopus 로고    scopus 로고
    • Antitumoral and antimetastatic effect of antiangiogenic plasmids in B16 melanoma: Higher effciency of the recombinant disintegrin domain of ADAM 15
    • Daugimont, L, Vandermeulen, G, Defresne, F, Bouzin, C, Mir, LM, Bouquet, C et al. (2011). Antitumoral and antimetastatic effect of antiangiogenic plasmids in B16 melanoma: Higher effciency of the recombinant disintegrin domain of ADAM 15. Eur J Pharm Biopharm 78: 314-319.
    • (2011) Eur J Pharm Biopharm , vol.78 , pp. 314-319
    • Daugimont, L.1    Vandermeulen, G.2    Defresne, F.3    Bouzin, C.4    Mir, L.M.5    Bouquet, C.6
  • 63
    • 70349786604 scopus 로고    scopus 로고
    • Novel minicircle vector for gene therapy in murine myocardial infarction
    • Huang, M, Chen, Z, Hu, S, Jia, F, Li, Z, Hoyt, G et al. (2009). Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation 120(11 Suppl): S230-S237.
    • (2009) Circulation , vol.120 , Issue.11 SUPPL.
    • Huang, M.1    Chen, Z.2    Hu, S.3    Jia, F.4    Li, Z.5    Hoyt, G.6
  • 64
    • 67651102609 scopus 로고    scopus 로고
    • Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor
    • Stenler, S, Andersson, A, Simonson, OE, Lundin, KE, Chen, ZY, Kay, MA et al. (2009). Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor. J Cardiovasc Pharmacol 53: 18-23.
    • (2009) J Cardiovasc Pharmacol , vol.53 , pp. 18-23
    • Stenler, S.1    Andersson, A.2    Simonson, O.E.3    Lundin, K.E.4    Chen, Z.Y.5    Kay, M.A.6
  • 65
    • 0041315884 scopus 로고    scopus 로고
    • Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
    • DOI 10.1016/S1525-0016(03)00168-0
    • Chen, ZY, He, CY, Ehrhardt, A and Kay, MA (2003). Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther 8: 495-500. (Pubitemid 37161471)
    • (2003) Molecular Therapy , vol.8 , Issue.3 , pp. 495-500
    • Chen, Z.-Y.1    He, C.-Y.2    Ehrhardt, A.3    Kay, M.A.4
  • 66
    • 33748050464 scopus 로고    scopus 로고
    • Minicircle-IFNγ induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma
    • DOI 10.1158/1078-0432.CCR-06-0520
    • Wu, J, Xiao, X, Zhao, P, Xue, G, Zhu, Y, Zhu, X et al. (2006). Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma. Clin Cancer Res 12: 4702-4713. (Pubitemid 44297824)
    • (2006) Clinical Cancer Research , vol.12 , Issue.15 , pp. 4702-4713
    • Wu, J.1    Xiao, X.2    Zhao, P.3    Xue, G.4    Zhu, Y.5    Zhu, X.6    Zheng, L.7    Zeng, Y.8    Huang, W.9
  • 67
    • 37549056600 scopus 로고    scopus 로고
    • Efficient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy
    • DOI 10.1016/j.jconrel.2007.10.014, PII S0168365907005718
    • Chang, CW, Christensen, LV, Lee, M and Kim, SW (2008). Effcient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy. J Control Release 125: 155-163. (Pubitemid 50008037)
    • (2008) Journal of Controlled Release , vol.125 , Issue.2 , pp. 155-163
    • Chang, C.-W.1    Christensen, L.V.2    Lee, M.3    Kim, S.W.4
  • 68
    • 50649102345 scopus 로고    scopus 로고
    • Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene
    • Zhang, X, Epperly, MW, Kay, MA, Chen, ZY, Dixon, T, Franicola, D et al. (2008). Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene. Hum Gene Ther 19: 820-826.
    • (2008) Hum Gene Ther , vol.19 , pp. 820-826
    • Zhang, X.1    Epperly, M.W.2    Kay, M.A.3    Chen, Z.Y.4    Dixon, T.5    Franicola, D.6


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