Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis

European Journal of Surgical Oncology

Volumn 39, Issue 1, 2013, Pages 4-16

  Mali, B ^a   Jarm, T ^a   Snoj, M ^b   Sersa, G ^b   Miklavcic, D ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE OF ONCOLOGY   (Slovenia)

Author keywords

Bleomycin; Chemotherapy; Cisplatin; Electroporation; Skin neoplasms; Treatment effectiveness

Indexed keywords

BLEOMYCIN; CISPLATIN;

CLINICAL EFFECTIVENESS; DATA EXTRACTION; ELECTROCHEMOTHERAPY; ELECTROPORATION; HUMAN; MELANOMA; META ANALYSIS; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; SARCOMA; SKIN CANCER; SKIN TUMOR; SUBCUTANEOUS TISSUE TUMOR; SYSTEMATIC REVIEW; TREATMENT RESPONSE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; BLEOMYCIN; CARCINOMA; CISPLATIN; CLINICAL TRIALS, PHASE I AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; ELECTROCHEMOTHERAPY; HUMANS; INFUSIONS, INTRALESIONAL; INFUSIONS, INTRAVENOUS; MELANOMA; OBSERVER VARIATION; SARCOMA; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 84870909757     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2012.08.016     Document Type: Review

References (92)

1. L.M. Mir, S. Orlowski, J. Belehradek Jr., and C. Paoletti Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses Eur J Cancer 27 1991 68 72.
2. G. Sersa, M. Cemazar, and D. Miklavcic Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice Cancer Res 55 1995 3450 3455.
3. G. Sersa, T. Jarm, and T. Kotnik Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma Br J Cancer 98 2008 388 398.
4. T. Jarm, M. Cemazar, D. Miklavcic, and G. Sersa Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases Expert Rev Anticancer Ther 10 2010 729 746.
5. G. Sersa, D. Miklavcic, M. Cemazar, J. Belehradek Jr., T. Jarm, and L.M. Mir Electrochemotherapy with CDDP on LPB sarcoma: comparison of the anti-tumor effectiveness in immunocompetent and immunodeficient mice Bioelectrochem Bioenerg 43 1997 279 283.
6. A.I. Daud, R.C. DeConti, and S. Andrews Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma J Clin Oncol 26 2008 5896 5903.
7. M. Cemazar, T. Jarm, and G. Sersa Cancer electrogene therapy with Interleukin-12 Curr Gene Ther 10 2010 300 311.
8. L.M. Mir, M. Belehradek, and C. Domenge Electrochemotherapy, a novel antitumor treatment - 1st clinical-trial (in French: L'electrochimiotherapie, un nouveau traitement antitumoral: premier essai clinique) C R Acad Sci III 313 1991 613 618.
9. M. Belehradek, C. Domenge, B. Luboinski, S. Orlowski, J. Belehradek, and L.M. Mir Electrochemotherapy, a new antitumor treatment - 1st clinical phase-I-II trial Cancer 72 1993 3694 3700.
10. G. Sersa, D. Miklavcic, M. Cemazar, Z. Rudolf, G. Pucihar, and M. Snoj Electrochemotherapy in treatment of tumours Eur J Surg Oncol 34 2008 232 240.
11. M. Marty, G. Sersa, and J.R. Garbay Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study Eur J Cancer Suppl 4 2006 3 13.
12. G. Sersa The state-of-the-art of electrochemotherapy before the ESOPE study; advantages and clinical uses Eur J Cancer Suppl 4 2006 52 59.
13. F.J. Landstrom, C.O.S. Nilsson, S. Crafoord, J.A. Reizenstein, G.B.M. Adamsson, and L.A. Lofgren Electroporation therapy of skin cancer in the head and neck area Dermatol Surg 36 2010 1245 1250.
14. E. Kis, J. Olah, and H. Ocsai Electrochemotherapy of cutaneous metastases of melanoma - a case series study and systematic review of the evidence Dermatol Surg 37 2011 1 9.
15. L.W. Matthiessen, R.L. Chalmers, and D.C.G. Sainsbury Management of cutaneous metastases using electrochemotherapy Acta Oncol 50 2011 621 629.
16. T. Hampton Electric pulses help with chemotherapy, may open new paths for other agents JAMA 305 2011 549 551.
17. G. Sersa, T. Cufer, S.M. Paulin, M. Cemazar, and M. Snoj Electrochemotherapy of chest wall breast cancer recurrence Cancer Treat Rev 38 2012 379 386.
18. L.M. Mir, J. Gehl, and G. Sersa Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator™ by means of invasive or non-invasive electrodes Eur J Cancer Suppl 4 2006 14 25.
19. M.G. Moller, S. Salwa, D.M. Soden, and G.C. O'Sullivan Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma Expert Rev Anticancer Ther 9 2009 1611 1630.
20. A. Testori, M.B. Faries, and J.F. Thompson Local and intralesional therapy of in-transit melanoma metastases J Surg Oncol 104 2011 391 396.
21. D. Miklavcic, S. Corovic, G. Pucihar, and N. Pavselj Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy Eur J Cancer Suppl 4 2006 45 51.
22. G.L. Colombo, S. Di Matteo, and L.M. Mir Cost-effectiveness analysis of electrochemotherapy with the Cliniporator™ vs other methods for the control and treatment of cutaneous and subcutaneous tumors Ther Clin Risk Manag 4 2008 541 548.
23. P. Quaglino, C. Mortera, and S. Osella-Abate Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases Ann Surg Oncol 15 2008 2215 2222.
24. L.G. Campana, S. Mocellin, and M. Basso Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients Ann Surg Oncol 16 2009 191 199.
25. L.G. Campana, S. Pasquali, and M. Basso Electrochemotherapy: clinical outcome and predictive factors from a single institution experience on 50 melanoma patients Ann Surg Oncol 17 2010 S106 S107.
26. A. Testori, G. Tosti, and C. Martinoli Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach Dermatol Ther 23 2010 651 661.
27. M. Snoj, M. Cemazar, T. Srnovrsnik, S.M. Paulin-Kosir, and G. Sersa Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy Tumor 95 2009 398 402.
28. M. Snoj, Z. Rudolf, M. Cemazar, B. Jancar, and G. Sersa Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy Anticancer Drugs 16 2005 345 348.
29. D.M. Soden, J.O. Larkin, and C.G. Collins Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours Cancer Lett 232 2006 300 310.
30. D. Miklavcic, M. Snoj, and A. Zupanic Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy BioMed Eng OnLine 9 2010 10.
31. F. Mahmood, and J. Gehl Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation Bioelectrochemistry 81 2011 10 16.
32. B. Agerholm-Larsen, H.K. Iversen, and P. Ibsen Preclinical validation of electrochemotherapy as an effective treatment for brain tumors Cancer Res 71 2011 3753 3762.
33. I. Edhemovic, E.M. Gadzijev, and E. Brecelj Electrochemotherapy: a new technological approach in treatment of metastases in the liver Technol Cancer Res Treat 10 2011 475 485.
34. C. Domenge, S. Orlowski, and B. Luboinski Antitumor electrochemotherapy - new advances in the clinical protocol Cancer 77 1996 956 963.
35. D. Miklavcic, K. Beravs, D. Semrov, M. Cemazar, F. Demsar, and G. Sersa The importance of electric field distribution for effective in vivo electroporation of tissues Biophys J 74 1998 2152 2158.
36. D. Miklavcic, D. Semrov, H. Mekid, and L.M. Mir A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy Biochim Biophys Acta 1523 2000 73 83.
37. M. Rebersek, T. Cufer, M. Cemazar, S. Kranjc, and G. Sersa Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer Anticancer Drugs 15 2004 593 597.
38. J.P.T. Higgins, and S. Green Cochrane handbook for systematic reviews of interventions 2008 Wiley-Blackwell West Sussex, UK.
39. World Health Organization WHO handbook for reporting results of cancer treatment 1979 World Health Organization Geneva, Switzerland.
40. P. Therasse, S.G. Arbuck, and E.A. Eisenhauer New guidelines to evaluate the response to treatment in solid tumors J Natl Cancer Inst 92 2000 205 216.
41. M. Borenstein, L.V. Hedges, J.P.T. Higgins, and H.R. Rothstein Introduction to meta-analysis 2009 Wiley West Sussex, UK.
42. A. Auperin, C. Le Pechoux, and E. Rolland Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer J Clin Oncol 28 2010 2181 2190.
43. K.L. Cooper, S. Harnan, and Y. Meng Positron emission tomography (PET) for assessment of axillary lymph node status in early breast cancer: a systematic review and meta-analysis Eur J Surg Oncol 37 2011 187 198.
44. P.J. Lovrics, S.D. Cornacchi, R. Vora, C.H. Goldsmith, and K. Kahnamoui Systematic review of radioguided surgery for non-palpable breast cancer Eur J Surg Oncol 37 2011 388 397.
45. G.A. Gooiker, W. van Gijn, P.N. Post, C.J.H. van de Velde, R. Tollenaar, and M. Wouters A systematic review and meta-analysis of the volume-outcome relationship in the surgical treatment of breast cancer. Are breast cancer patients better of with a high volume provider? Eur J Surg Oncol 36 2010 S27 S35.
46. J.P. Allegretti, and W.R. Panje Electroporation therapy for head and neck cancer including carotid artery involvement Laryngoscope 111 2001 52 56.
47. D.C. Bloom, and P.M. Goldfarb The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck Eur J Surg Oncol 31 2005 1029 1035.
48. M. Burian, M. Formanek, and H. Regele Electroporation therapy in head and neck cancer Acta Otolaryngol 123 2003 264 268.
49. C.M. Byrne, J.F. Thompson, and H. Johnston Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy) Melanoma Res 15 2005 45 51.
50. P. Curatolo, M. Mancini, A. Ruggiero, R. Clerico, P. Di Marco, and S. Calvieri Successful treatment of penile Kaposi's sarcoma with electrochemotherapy Dermatol Surg 34 2008 839 843.
51. P. Curatolo, M. Mancini, and R. Clerico Remission of extensive merkel cell carcinoma after electrochemotherapy Arch Dermatol 145 2009 494 495.
52. P. Curatolo, P. Quaglino, and F. Marenco Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: a two-center prospective phase II trial Ann Surg Oncol 19 2012 192 198.
53. F. Fantini, G. Gualdi, A. Cimitan, and A. Giannetti Metastatic basal cell carcinoma with squamous differentiation: report of a case with response of cutaneous metastases to electrochemotherapy Arch Dermatol 144 2008 1186 1188.
54. J.R. Garbay, V. Billard, C. Bernat, L.M. Mir, N. Morsli, and C. Robert Successful repetitive treatments by electrochemotherapy of multiple unresectable Kaposi sarcoma nodules Eur J Cancer Suppl 4 2006 29 31.
55. M. Gargiulo, M. Moio, G. Monda, S. Parascandolo, and G. Cubicciotti Electrochemotherapy: actual considerations and clinical experience in head and neck cancers Ann Surg 251 2010 773.
56. C. Gaudy, M.A. Richard, G. Folchetti, J.J. Bonerandi, and J.J. Grob Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma J Cutan Med Surg 10 2006 115 121.
57. J. Gehl, and P.F. Geertsen Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy Eur J Cancer Suppl 4 2006 35 37.
58. G. Gualdi, P. Monari, F. Fantini, A.M. Cesinaro, and A. Cimitan Electrochemotherapy-induced virus disappearance in HHV-8-positive skin nodules of Kaposi sarcoma: first histological and immunohistochemical demonstration of efficacy J Eur Acad Dermatol Venereol 24 2010 239 240.
59. R. Heller, M.J. Jaroszeski, and L.F. Glass Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy Cancer 77 1996 964 971.
60. R. Heller, M.J. Jaroszeski, and D.S. Reintgen Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin Cancer 83 1998 148 157.
61. K.C. Kaehler, F. Egberts, and A. Hauschild Electrochemotherapy in symptomatic melanoma skin metastases: intraindividual comparison with conventional surgery Dermatol Surg 36 2010 1200 1202.
62. Y. Kubota, L.M. Mir, T. Nakada, I. Sasagawa, H. Suzuki, and N. Aoyama Successful treatment of metastatic skin lesions with electrochemotherapy J Urol 160 1998 1426.
63. Y. Kubota, Y. Tomita, M. Tsukigi, H. Kurachi, T. Motoyama, and L.M. Mir A case of perineal malignant melanoma successfully treated with electrochemotherapy Melanoma Res 15 2005 133 134.
64. F.J. Landstrom, C.O.S. Nilsson, J.A. Reizenstein, K. Nordqvist, G.-B. Adamsson, and A.L. Lofgren Electroporation therapy for T1 and T2 oral tongue cancer Acta Otolaryngol 131 2011 660 664.
65. J.O. Larkin, C.G. Collins, and S. Aarons Electrochemotherapy - aspects of preclinical development and early clinical experience Ann Surg 245 2007 469 479.
66. F. Marenco, T. Nardo, P. Savoia, and M.G. Bernengo Effectiveness of electrochemotherapy in treatment of a recurrent squamous cell carcinoma of the scalp Eur J Dermatol 21 2011 618 619.
67. U. Marone, C. Caraco, and A.M. Anniciello Metastatic eccrine porocarcinoma: report of a case and review of the literature World J Surg Oncol 9 2011 32.
68. L.M. Mir, L.F. Glass, and G. Sersa Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy Br J Cancer 77 1998 2336 2342.
69. M.P. Rols, J.M. Bachaud, P. Giraud, C. Chevreau, H. Roche, and J. Teissie Electrochemotherapy of cutaneous metastases in malignant melanoma Melanoma Res 10 2000 468 474.
70. Z. Rudolf, B. Stabuc, M. Cemazar, D. Miklavcic, L. Vodovnik, and G. Sersa Electrochemotherapy with bleomycin. The first clinical experience in malignant melanoma patients Radiol Oncol 29 1995 229 235.
71. G. Sersa, B. Stabuc, M. Cemazar, B. Jancar, D. Miklavcic, and Z. Rudolf Electrochemotherapy with cisplatin: potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients Eur J Cancer 34 1998 1213 1218.
72. G. Sersa, B. Stabuc, M. Cemazar, D. Miklavcic, and Z. Rudolf Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients Clin Cancer Res 6 2000 863 867.
73. G. Sersa, M. Cemazar, and Z. Rudolf Electrochemotherapy: advantages and drawbacks in treatment of cancer patients Cancer Ther 1 2003 133 142.
74. T. Shimizu, T. Nikaido, and H. Gomyo Electrochemotherapy for digital chondrosarcoma J Orthop Sci 8 2003 248 251.
75. M. Snoj, Z. Rudolf, S.M. Paulin-Kosir, M. Cemazar, R. Snoj, and G. Sersa Long lasting complete response in melanoma treated by electrochemotherapy Eur J Cancer Suppl 4 2006 26 28.
76. M. Snoj, M. Cemazar, B. Slekovec Kolar, and G. Sersa Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy Croat Med J 48 2007 391 395.
77. B.M. Tijink, R. De Bree, G.A.M.S. Van Dongen, and C.R. Leemans How we do it: chemo-electroporation in the head and neck for otherwise untreatable patients Clin Otolaryngol 31 2006 447 451.
78. M.C. Whelan, J.O. Larkin, and C.G. Collins Effective treatment of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications of electrochemotherapy Eur J Cancer Suppl 4 2006 32 34.
79. M. Sadadcharam, D.M. Soden, and G.C. O'Sullivan Electrochemotherapy: an emerging cancer treatment Int J Hyperthermia 24 2008 263 273.
80. W.E. Evans, G.C. Yee, W.R. Crom, C.B. Pratt, and A.A. Green Clinical pharmacology of bleomycin and cisplatin Drug Intell Clin Pharm 16 1982 448 458.
81. L.M. Mir, O. Tounekti, and S. Orlowski Bleomycin: revival of an old drug Gen Pharmacol 27 1996 745 748.
82. L.M. Mir Bases and rationale of the electrochemotherapy Eur J Cancer Suppl 4 2006 38 44.
83. S. Orlowski, J. Belehradek Jr., C. Paoletti, and L.M. Mir Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs Biochem Pharmacol 37 1988 4727 4733.
84. D.S. Alberts, H.S. Chen, and R. Liu Bleomycin pharmacokinetics in man. I. Intravenous administration Cancer Chemother Pharmacol 1 1978 177 181.
85. S.W. Hall, J.E. Strong, A. Broughton, M.L. Frazier, and R.S. Benjamin Bleomycin clinical pharmacology by radioimmunoassay Cancer Chemother Pharmacol 9 1982 22 25.
86. D. Front, O. Israel, and G. Iosilevsky Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men J Nucl Med 31 1990 1784 1790.
87. L. Schnipper Clinical implications of tumor-cell heterogeneity N Engl J Med 314 1986 1423 1431.
88. J.R. Mourant, T.M. Johnson, G. Los, and I.J. Bigio Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements Phys Med Biol 44 1999 1397 1417.
89. R. Reif, M. Wang, S. Joshi, O. A'Amar, and I.J. Bigio Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue J Biomed Opt 12 2007 034036.
90. G. Sersa, M. Cemazar, D. Miklavcic, and L.M. Mir Electrochemotherapy: variable anti-tumor effect on different tumor models Bioelectrochem Bioenerg 35 1994 23 27.
91. M. Cemazar, D. Miklavcic, and G. Sersa Intrinsic sensitivity of tumor cells to bleomycin as an indicator of tumor response to electrochemotherapy Jpn J Cancer Res 89 1998 328 333.
92. S. Rodriguez-Cuevas, S. Barroso-Bravo, J. Almanza-Estrada, L. Cristobal-Martinez, and E. Gonzalez-Rodriguez Electrochemotherapy in primary and metastatic skin tumors: phase II trial using intralesional bleomycin Arch Med Res 32 2001 273 276