Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization

Molecular Therapy

Volumn 3, Issue 2, 2001, Pages 249-255

  Drabick, Joseph J ^a   Glasspool Malone, Jill ^b   Somiari, Stella ^d   King, Alan ^c   Malone, Robert W ^b  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b Institute for Molecular and Immunologic Strategic Therapies   (United States)

^c CytoPulse Sciences   (United States)

^d NONE

Author keywords

Dendritic cell; Electropermeabilization; Electroporation; Gene therapy; Nucleic acid vaccination; Skin

Indexed keywords

ALLERGEN; DNA VACCINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN SUBCLASS; TUMOR ANTIGEN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CODING; CONTROLLED STUDY; DENDRITIC CELL; DERMIS; DRUG TOLERABILITY; ELECTROPORATION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IN VIVO STUDY; LYMPH NODE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENICITY; PLASMID; SKIN FIBROBLAST; SKIN TEST; SWINE; TH1 CELL; TH2 CELL; TRANSGENE;

ANIMALIA; HEPATITIS B VIRUS; MURINAE; SUIDAE; SUS SCROFA;

EID: 0034990926     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0257     Document Type: Article

References (50)

1. Electropermeabilization of skeletal muscle enhances gene transfer in vivo
2. High-efficiency gene transfer into skeletal muscle mediated by electric pulses
3. Continuous erythropoietin delivery by muscle-targeted gene transfer using in vivo
4. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
5. Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation
6. Direct gene transfer into mouse muscle in vivo
7. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
8. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment
9. A direct in vivo approach for skin gene therapy
10. Biological features of genetic immunization
11. Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device
12. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
13. RNA viruses: Emerging vectors for vaccination and gene therapy
14. Replication-deficient recombinant adenoviruses expressing the human immunodeficiency virus
15. Enhanced immune response to the melanoma antigen gp100 using recombinant adenovirus-transduced dendritic cells
16. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
17. DNA-mediated immunization to the hepatitis B surface antigen. Activation and entrainment of the immune response
18. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state
19. Targeting the skin for genetic immunization
20. DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus
21. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
22. Expression of naked DNA in human, pig, and mouse skin
23. Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan equine encephalitis virus
24. DNA-based immunization by in vivo transfection of dendritic cells
25. Fundamentals of electroporative delivery of drugs and genes
26. Determination of optimal parameters for in vivo gene transfer by electroporation, using a rapid in vivo test for cell permeabilization
27. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin
28. In vivo gene delivery
29. In situ hybridization for the detection of HIV RNA in cells and tissues
30. Mucosal immune responses associated with polynucleotide vaccination
31. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma
32. Intranasal administration of human immunodeficiency virus type-1 (HIV-1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1
33. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA
34. Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: An approach to gene therapy of skin aging and other diseases
35. Mechanisms of a phosphorothioate oligonucleotide delivery by skin electroporation
36. DNA-mediated gene transfer into epidermal cells using electroporation
37. Acute electrical burns
38. Maturation and trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell-based vaccines
39. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
40. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
41. Natural adjuvants: Endogenous activators of dendritic cells
42. Gene therapy of viral hepatitis and hepatocellular carcinoma
43. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
44. Efficient vaccination by intradermal or intramuscular inoculation of plasmid DNA expressing hepatitis B surface antigen under desmin promoter/enhancer control
45. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates
46. Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses
47. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
48. Immunization with a DNA expression vector encoding the varicella zoster virus glycoprotein E (gE) gene via intramuscular and subcutaneous routes
49. A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity