Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques

Vaccine

Volumn 26, Issue 3, 2008, Pages 440-448

  Hirao, Lauren A ^a   Wu, Ling ^a   Khan, Amir S ^b   Satishchandran, Abhishek ^a   Draghia Akli, Ruxandra ^b   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VGX Pharmaceuticals Inc   (United States)

Author keywords

Electroporation; HIV; Intradermal; Macaque; Vaccine

Indexed keywords

DNA VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG POTENCY; ELECTROPORATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GENE EXPRESSION; GENE TARGETING; IMMUNIZATION; MALE; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SWINE; TH1 CELL;

AIDS VACCINES; ANIMALS; ELECTROPORATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; INJECTIONS, INTRADERMAL; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE II; MACACA MULATTA; MALE; PLASMIDS; SWINE; TH1 CELLS; VACCINES, DNA;

EID: 37549037877     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.10.041     Document Type: Article

References (44)

1. Hokey D.A., and Weiner D.B. DNA vaccines for HIV: challenges and opportunities. Springer Semin Immunopathol 28 3 (2006) 267-279
2. Kodihalli S., Goto H., Kobasa D.L., Krauss S., Kawaoka Y., and Webster R.G. DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice. J Virol 73 3 (1999) 2094-2098
3. Casimiro D.R., Chen L., Fu T.M., Evans R.K., Caulfield M.J., Davies M.E., et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol 77 11 (2003) 6305-6313
4. Andre S., Seed B., Eberle J., Schraut W., Bultmann A., and Haas J. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J Virol 72 2 (1998) 1497-1503
5. Deml L., Bojak A., Steck S., Graf M., Wild J., Schirmbeck R., et al. Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein. J Virol 75 22 (2001) 10991-11001
6. Schneider R., Campbell M., Nasioulas G., Felber B.K., and Pavlakis G.N. Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation. J Virol 71 7 (1997) 4892-4903
7. Muthumani K., Zhang D., Dayes N.S., Hwang D.S., Calarota S.A., Choo A.Y., et al. Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo. Virology 314 1 (2003) 134-146
8. Yang J.S., Kim J.J., Hwang D., Choo A.Y., Dang K., Maguire H., et al. Induction of potent Th1-type immune responses from a novel DNA vaccine for West Nile virus New York isolate (WNV-NY1999). J Infect Dis 184 7 (2001) 809-816
9. Gao F., Weaver E.A., Lu Z., Li Y., Liao H.X., Ma B., et al. Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. J Virol 79 2 (2005) 1154-1163
10. Yan J., Yoon H., Kumar S., Ramanathan M.P., Corbitt N., Kutzler M., et al. Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine. Mol Ther 15 2 (2007) 411-421
11. Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., and Murphy K.M. Development of TH1 CD4 + T cells through IL-12 produced by Listeria-induced macrophages. Science 260 5107 (1993) 547-549
12. Amara R.R., Ibegbu C., Villinger F., Montefiori D.C., Sharma S., Nigam P., et al. Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. Virology 343 2 (2005) 246-255
13. Egan M.A., Chong S.Y., Megati S., Montefiori D.C., Rose N.F., Boyer J.D., et al. Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus. AIDS Res Hum Retroviruses 21 7 (2005) 629-643
14. Boyer J.D., Robinson T.M., Kutzler M.A., Parkinson R., Calarota S.A., Sidhu M.K., et al. SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques. J Med Primatol 34 5-6 (2005) 262-270
15. Boyer J.D., Cohen A.D., Ugen K.E., Edgeworth R.L., Bennett M., Shah A., et al. Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids. Aids 14 11 (2000) 1515-1522
16. Chong S.Y., Egan M.A., Kutzler M., Megati S., Masood A., Roopchard V., et al. Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine (2007)
17. Pertmer T.M., Eisenbraun M.D., McCabe D., Prayaga S.K., Fuller D.H., and Haynes J.R. Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 13 15 (1995) 1427-1430
18. Fuller D.H., Murphey-Corb M., Clements J., Barnett S., and Haynes J.R. Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination. J Med Primatol 25 3 (1996) 236-241
19. Brave A., Ljungberg K., Boberg A., Rollman E., Isaguliants M., Lundgren B., et al. Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. Mol Ther 12 6 (2005) 1197-1205
20. Widera G., Austin M., Rabussay D., Goldbeck C., Barnett S.W., Chen M., et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 164 9 (2000) 4635-4640
21. Prud'homme G.J., Draghia-Akli R., and Wang Q. Plasmid-based gene therapy of diabetes mellitus. Gene Ther 14 7 (2007) 553-564
22. Ugen K.E., Kutzler M.A., Marrero B., Westover J., Coppola D., Weiner D.B., et al. Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation. Cancer Gene Ther 13 10 (2006) 969-974
23. Otten G., Schaefer M., Doe B., Liu H., Srivastava I., zur Megede J., et al. Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 22 19 (2004) 2489-2493
24. Otten G.R., Schaefer M., Doe B., Liu H., Megede J.Z., Donnelly J., et al. Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation. Vaccine 24 21 (2006) 4503-4509
25. Porgador A., Irvine K.R., Iwasaki A., Barber B.H., Restifo N.P., and Germain R.N. Predominant role for directly transfected dendritic cells in antigen presentation to CD8 + T cells after gene gun immunization. J Exp Med 188 6 (1998) 1075-1082
26. Condon C., Watkins S.C., Celluzzi C.M., Thompson K., and Falo Jr. L.D. DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 2 10 (1996) 1122-1128
27. Danko I., Williams P., Herweijer H., Zhang G., Latendresse J.S., Bock I., et al. High expression of naked plasmid DNA in muscles of young rodents. Hum Mol Genet 6 9 (1997) 1435-1443
28. Raz E., Carson D.A., Parker S.E., Parr T.B., Abai A.M., Aichinger G., et al. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci U S A 91 20 (1994) 9519-9523
29. Drabick J.J., Glasspool-Malone J., King A., and Malone R.W. Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Mol Ther 3 2 (2001) 249-255
30. Frederickson R.M., Carter B.J., and Pilaro A.M. Nonclinical toxicology in support of licensure of gene therapies. Arlington, VA, USA, March 13-14, 2003. Mol Ther 8 1 (2003) 8-10
31. Tjelle T.E., Salte R., Mathiesen I., and Kjeken R. A novel electroporation device for gene delivery in large animals and humans. Vaccine 24 21 (2006) 4667-4670
32. Heller L.C., Jaroszeski M.J., Coppola D., McCray A.N., Hickey J., and Heller R. Optimization of cutaneous electrically mediated plasmid DNA delivery using novel electrode. Gene Ther 14 3 (2007) 275-280
33. Feltquate D.M., Heaney S., Webster R.G., and Robinson H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 158 5 (1997) 2278-2284
34. Schirmbeck R., and Reimann J. Modulation of gene-gun-mediated Th2 immunity to hepatitis B surface antigen by bacterial CpG motifs or IL-12. Intervirology 44 2-3 (2001) 115-123
35. Prud'homme G.J., Glinka Y., Khan A.S., and Draghia-Akli R. Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. Curr Gene Ther 6 2 (2006) 243-273
36. Medi B.M., Hoselton S., Marepalli R.B., and Singh J. Skin targeted DNA vaccine delivery using electroporation in rabbits. I: efficacy. Int J Pharm 294 1-2 (2005) 53-63
37. Medi B.M., and Singh J. Skin targeted DNA vaccine delivery using electroporation in rabbits II. Safety. Int J Pharm 308 1-2 (2006) 61-68
38. Hooper J.W., Golden J.W., Ferro A.M., and King A.D. Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge. Vaccine 25 10 (2007) 1814-1823
39. Hebel H., Attra H., Khan A., and Draghia-Akli R. Successful parallel development and integration of a plasmid-based biologic, container/closure system and electrokinetic delivery device. Vaccine 24 21 (2006) 4607-4614
40. Cui Z., Dierling A., and Foldvari M. Non-invasive immunization on the skin using DNA vaccine. Curr Drug Deliv 3 1 (2006) 29-35
41. Dujardin N., Staes E., Kalia Y., Clarys P., Guy R., and Preat V. In vivo assessment of skin electroporation using square wave pulses. J Control Release 79 1-3 (2002) 219-227
42. Hirao L.A, Wu L, Khan A.S, Hokey D.A, Yan J, Dai A, et al., Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques. Vaccine, submitted.
43. Strid J., Hourihane J., Kimber I., Callard R., and Strobel S. Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. Eur J Immunol 34 8 (2004) 2100-2109
44. Luckay A., Sidhu M.K., Kjeken R., Megati S., Chong S.Y., Roopchand V., et al. Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J Virol 81 10 (2007) 5257-5269