Electrochemotherapy in treatment of tumours

European Journal of Surgical Oncology

Volumn 34, Issue 2, 2008, Pages 232-240

  Sersa, G ^a   Miklavcic, D ^b   Cemazar, M ^a   Rudolf, Z ^a   Pucihar, G ^b   Snoj, M ^a  

^a INSTITUTE OF ONCOLOGY   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Bleomycin; Cisplatin; Cutaneous tumours; Electrochemotherapy; Electroporation

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; MITOMYCIN C; PACLITAXEL; VINBLASTINE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST ADENOCARCINOMA; CANCER CHEMOTHERAPY; CELL MEMBRANE TRANSPORT; COLON CANCER; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; ELECTRIC FIELD; ELECTROCHEMOTHERAPY; ELECTRODE; ELECTROPORATION; GENE THERAPY; HEAD AND NECK TUMOR; HUMAN; INJECTION SITE; KAPOSI SARCOMA; KIDNEY CARCINOMA; LEIOMYOSARCOMA; MEDICAL TECHNOLOGY; MELANOMA; MOUSE; MUSCLE CONTRACTION; NEOPLASM; NONHUMAN; PAIN; PRIORITY JOURNAL; SALIVARY GLAND CARCINOMA; SKIN TUMOR; SUBCUTANEOUS TISSUE TUMOR; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA IN SITU;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CATS; DISEASE MODELS, ANIMAL; DOGS; ELECTROCHEMOTHERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MELANOMA; PROSPECTIVE STUDIES; RABBITS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RATS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 38149081350     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejso.2007.05.016     Document Type: Article

References (50)

1. Miklavcic D., Corovic S., Pucihar G., and Pavselj N. Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur J Cancer Suppl 4 (2006) 45-51
2. Miklavcic D., Semrov D., Mekid H., and Mir L.M. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 1523 (2000) 73-83
3. Pucihar G., Kotnik T., Valic B., and Miklavcic D. Numerical determination of transmembrane voltage induced on irregularly shaped cells. Ann Biomed Eng 34 (2006) 642-652
4. Mir L.M. Bases and rationale of the electrochemotherapy. Eur J Cancer Suppl 4 (2006) 38-44
5. Mir L.M., Belehradek M., Domenge C., et al. Electrochemotherapy, a new antitumor treatment: first clinical trial. C R Acad Sci III 313 (1991) 613-618
6. Sersa G. The state-of-the-art of electrochemotherapy before the ESOPE study: advantages and clinical uses. Eur J Cancer Suppl 4 (2006) 52-59
7. Byrne C.M., and Thompson J.F. Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert Rev. Anticancer Ther 6 (2006) 671-678
8. Pron G., Mahrour N., Orlowski S., et al. Internalisation of the bleomycin molecules responsible for bleomycin toxicity: a receptor-mediated endocytosis mechanism. Biochem Pharmacol 57 (1999) 45-56
9. Orlowski S., Belehradek Jr. J., Paoletti C., and Mir L.M. Transient electropermeabilization of cells in culture: increase in cytotoxicity of anticancer drugs. Biochem Pharmacol 37 (1988) 4727-4733
10. Sersa G., Cemazar M., and Miklavcic D. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res 55 (1995) 3450-3455
11. Sersa G., Cemazar M., Miklavcic D., and Rudolf Z. Electrochemotherapy of tumours. Radiol Oncol 40 (2006) 163-174
12. Mir L.M., Devauchelle P., Quintin-Colonna F., et al. First clinical trial of cat soft-tissue sarcomas treatment by electrochemotherapy. Br J Cancer 76 (1997) 1617-1622
13. Tozon N., Sersa G., and Cemazar M. Electrochemotherapy: potentiation of local antitumour effectiveness of cisplatin in dogs and cats. Anticancer Res 21 (2001) 2483-2486
14. Rols M.P., Tamzali Y., and Teissie J. Electrochemotherapy of horses: a preliminary clinical report. Bioelectrochem 55 (2002) 101-105
15. Spugnini E.P., and Porrello A. Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses. J Exp Clin Cancer Res 22 (2003) 571-580
16. Belehradek Jr. J., Orlowski S., Ramirez L.H., Pron G., Poddevin B., and Mir L.M. Electropermeabilization of cells and tissues assessed by the quantitative and qualitative electroloading of bleomycin. Biochim Biophys Acta 1190 (1994) 155-163
17. Cemazar M., Milacic R., Miklavcic D., Dolzan V., and Sersa G. Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness, sequence dependence and platinum content. Anticancer Drugs 9 (1998) 525-530
18. Sersa G., Cemazar M., Parkins C.S., and Chaplin D.J. Tumour blood flow changes induced by application of electric pulses. Eur J Cancer 35 (1999) 672-677
19. Sersa G., Cemazar M., Miklavcic D., and Chaplin D.J. Tumor blood flow modifying effect of electrochemotherapy with bleomycin. Anticancer Res 19 5B (1999) 4017-4022
20. Gehl J., Skovsgaard T., and Mir L.M. Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery. Biochim Biophys Acta 1569 (2002) 51-58
21. Sersa G., Krzic M., Sentjurc M., et al. Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin. Br J Cancer 87 (2002) 1047-1054
22. Sersa G., Miklavcic D., Cemazar M., Belehradek Jr. J., Jarm T., and Mir L.M. Electrochemotherapy with CDDP on LPB sarcoma: comparison of the anti-tumor effectiveness in immunocompetent and immunodeficient mice. Bioelectroch Bioener 43 (1997) 279-283
23. Sersa G., Cemazar M., Menart V., Gaberc-Porekar V., and Miklavcic D. Antitumor effectiveness of electrochemtherapy is inceased by TNF-α on SA-1 tumors in mice. Cancer Lett 116 (1997) 85-92
24. Heller L., Pottinger C., Jaroszeski M.J., Gilbert R., and Heller R. In vivo electroporation of plasmids encoding GM-CSF or interleukin-2 into existing B16 melanomas combined with electrochemotherapy induces long-term antitumour immunity. Melanoma Res 10 (2000) 577-583
25. Mir L.M., Glass L.F., Sersa G., et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 77 (1998) 2336-2342
26. Heller R., Jaroszeski M., Perrott R., Messina J., and Gilbert R. Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy. Melanoma Res 7 (1997) 10-18
27. Sersa G., Stabuc B., Cemazar M., Miklavcic D., and Rudolf Z. Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients. Clin Cancer Res 6 (2000) 863-867
28. Bloom D.C., and Goldfarb P.M. The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. Eur J Surg Oncol 31 (2005) 1029-1035
29. Byrne C.M., Thompson J.F., Johnston H., et al. Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Res 15 (2005) 45-51
30. Marty M., Sersa G., Garbay J.R., et al. Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 4 (2006) 3-13
31. WHO. WHO handbook for reporting results of cancer treatment. Vol 48. Geneva: WHO Offset Publications; 1997, p. 22-27.
32. Dev S.B. Killing cancer cells with a combination of pulsed electric fields and chemotherapeutic agents. Cancer Watch 3 (1994) 12-14
33. Mir L.M., Gehl J., Sersa G., et al. Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator™ by means of invasive or non-invasive electrodes. Eur J Cancer Suppl 4 (2006) 14-25
34. Domenge C., Orlowski S., Luboinski B., De Baere T., Belehradek Jr. J., and Mir L.M. Antitumor electrochemotherapy: new advances in the clinical protocol. Cancer 77 (1996) 956-963
35. Puc M., Corovic S., Flisar K., Petkovsek M., Nastran J., and Miklavcic D. Techniques of signal generation required for electropermeabilization: survey of electropermeabilization devices. Bioelectrochemistry 64 (2004) 113-124
36. Pavselj N., Bregar Z., Cukjati D., Batiuskaite D., Mir L.M., and Miklavcic D. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans Biomed Eng 52 (2005) 1373-1381
37. Snoj M., Cemazar M., Slekovec Kolar B., and Sersa G. Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy: case report. Croat Med J 48 (2007) 345-349
38. Snoj M., Rudolf Z., Paulin-Kosir S., Cemazar M., Snoj R., and Sersa G. Long lasting complete response in melanoma treated by electrochemotherapy. Eur J Cancer Suppl 4 11 (2006) 26-28
39. Snoj M., Rudolf Z., Cemazar M., Jancar B., and Sersa G. Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. AntiCancer Drugs 16 (2005) 345-348
40. Shimizu T., Nikaido T., Gomyo H., et al. Electrochemotherapy of digital chondrosarcoma. J Orthop Sci 8 (2003) 248-251
41. Glass L.F., Fenske N.A., Jaroszeski M., et al. Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol 34 (1996) 82-86
42. Sersa G., Kranjc S., and Cemazar M. Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors. Int J Radiat Oncol Biol Phys 46 (2000) 1037-1041
43. Kranjc S., Cemazar M., Grosel A., Sentjurc M., and Sersa G. Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice. BMC Cancer 5 (2005) 115
44. Soden D.M., Larkin J.O., Collins C.G., et al. Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours. Cancer Lett 232 (2006) 300-310
45. Andre F., and Mir L.M. DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther 11 Suppl 1 (2004) 33-42
46. Cemazar M., Golzio M., Sersa G., Rols M.P., and Teissie J. Electrically-assisted nucleic acids delivery to tissues in vivo: where do we stand?. Curr Pharm Des 12 (2006) 3817-3825
47. Heller L.C., and Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 17 (2006) 890-897
48. Edd J.F., Horowitz L., Davalos R.V., Mir L.M., and Rubinsky B. In vivo results of a new focal tissue ablation technique: irreversible electroporation. IEEE Trans Biomed Eng 53 (2006) 1409-1415
49. Nuccitelli R., Pliquet U., Chen X., et al. Nanosecond pulsed electric fields cause melanomas to self-destruct. Biochem Biophys Res Commun 343 (2006) 351-360
50. Cemazar M., Parkins C.S., Holder A.L., Kranjc S., Chaplin D.J., and Sersa G. Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in mice. Anticancer Res 21 (2001) 1151-1156