TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing

EMBO Journal

Volumn 35, Issue 3, 2016, Pages 335-355

  Marina, Ryan J ^a   Sturgill, David ^a   Bailly, Marc A ^a,b   Thenoz, Morgan ^a   Varma, Garima ^a,c   Prigge, Maria F ^a   Nanan, Kyster K ^a   Shukla, Sanjeev ^a,d   Haque, Nazmul ^a,e   Oberdoerffer, Shalini ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL   (India)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

alternative splicing; CTCF; DNA methylation; TET1; TET2

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; CD45 ANTIGEN; DNA METHYLTRANSFERASE 1; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR CTCF; CCCTC-BINDING FACTOR; DNA BINDING PROTEIN; MIXED FUNCTION OXIDASE; ONCOPROTEIN; REPRESSOR PROTEIN; TET1 PROTEIN, HUMAN; TET2 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ARTICLE; B LYMPHOCYTE; CATALYST; CD4+ T LYMPHOCYTE; CELL POPULATION; DNA BINDING; DNA HYBRIDIZATION; DNA METHYLATION; ENZYME MECHANISM; EXON; GENE CONTROL; GENE INTERACTION; GENE TRANSLOCATION; GENETIC ASSOCIATION; HUMAN; IN VITRO STUDY; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; RNA SPLICING; T LYMPHOCYTE ACTIVATION; TEN ELEVEN TRANSLOCATION; CELL LINE; METABOLISM; OXIDATION REDUCTION REACTION;

5-METHYLCYTOSINE; ALTERNATIVE SPLICING; CELL LINE; DNA-BINDING PROTEINS; HUMANS; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS;

EID: 84957427015     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201593235     Document Type: Article

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