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Volumn 6, Issue 5, 2015, Pages

Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GENIPOSIDE; GLUCOSE; JANUS KINASE 2; N BENZYL 1,2,3,4,8,9 HEXAHYDRO 6 (4 HYDROXYBENZYL) 8 (1 NAPHTHYLMETHYL) 4,7 DIOXO 2H PYRAZINO[1,2 A]PYRIMIDINE 1(6H) CARBOXAMIDE; PROTEIN KINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; IRIDOID; MESSENGER RNA; TCF7L2 PROTEIN, MOUSE;

EID: 84957309153     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.107     Document Type: Article
Times cited : (51)

References (51)
  • 1
    • 0024351557 scopus 로고
    • Type II diabetes, glucose "non-sense," and islet desensitization
    • Robertson RP. Type II diabetes, glucose "non-sense", and islet desensitization. Diabetes 1989;38:1501-1505.
    • (1989) Diabetes , vol.38 , pp. 1501-1505
    • Robertson, R.P.1
  • 2
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812.
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 3
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 4
    • 24944591025 scopus 로고    scopus 로고
    • New sources of pancreatic beta-cells
    • Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol 2005;23:857-861.
    • (2005) Nat Biotechnol , vol.23 , pp. 857-861
    • Bonner-Weir, S.1    Weir, G.C.2
  • 5
    • 55649098154 scopus 로고    scopus 로고
    • Wnt signaling: Relevance to beta-cell biology and diabetes
    • Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab 2008;19:349-355.
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 349-355
    • Welters, H.J.1    Kulkarni, R.N.2
  • 6
    • 55049106032 scopus 로고    scopus 로고
    • The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
    • Jin T, Liu L. The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 2008;22:2383-2392.
    • (2008) Mol Endocrinol , vol.22 , pp. 2383-2392
    • Jin, T.1    Liu, L.2
  • 8
    • 74949116364 scopus 로고    scopus 로고
    • Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats
    • Figeac F, Uzan B, Faro M, Chelali N, Portha B, Movassat J. Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats. Am J Physiol Endocrinol Metab 2010;298:E245-E256.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E245-E256
    • Figeac, F.1    Uzan, B.2    Faro, M.3    Chelali, N.4    Portha, B.5    Movassat, J.6
  • 9
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    • Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 2009;18:2388-2399.
    • (2009) Hum Mol Genet , vol.18 , pp. 2388-2399
    • Shu, L.1    Matveyenko, A.V.2    Kerr-Conte, J.3    Cho, J.H.4    McIntosh, C.H.5    Maedler, K.6
  • 11
    • 40949141938 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
    • Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 2008;57:645-653.
    • (2008) Diabetes , vol.57 , pp. 645-653
    • Shu, L.1    Sauter, N.S.2    Schulthess, F.T.3    Matveyenko, A.V.4    Oberholzer, J.5    Maedler, K.6
  • 14
    • 84894538334 scopus 로고    scopus 로고
    • TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass
    • Takamoto I, Kubota N, Nakaya K, Kumagai K, Hashimoto S, Kubota T et al. TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass. Diabetologia 2014;57:542-553.
    • (2014) Diabetologia , vol.57 , pp. 542-553
    • Takamoto, I.1    Kubota, N.2    Nakaya, K.3    Kumagai, K.4    Hashimoto, S.5    Kubota, T.6
  • 15
    • 12544254474 scopus 로고    scopus 로고
    • TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    • Yi F, Brubaker PL, Jin T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 2005;280:1457-1464.
    • (2005) J Biol Chem , vol.280 , pp. 1457-1464
    • Yi, F.1    Brubaker, P.L.2    Jin, T.3
  • 17
    • 0005377589 scopus 로고    scopus 로고
    • Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen
    • Pham TQ, Cormier F, Farnworth E, Tong VH, Van Calsteren MR. Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J Agric Food Chem 2000;48:1455-1461.
    • (2000) J Agric Food Chem , vol.48 , pp. 1455-1461
    • Pham, T.Q.1    Cormier, F.2    Farnworth, E.3    Tong, V.H.4    Van Calsteren, M.R.5
  • 18
    • 0020399085 scopus 로고
    • Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats
    • Kimura Y, Okuda H, Arichi S. Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats. Chem Pharm Bull (Tokyo) 1982;30:4444-4447.
    • (1982) Chem Pharm Bull (Tokyo) , vol.30 , pp. 4444-4447
    • Kimura, Y.1    Okuda, H.2    Arichi, S.3
  • 19
    • 65349141758 scopus 로고    scopus 로고
    • Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
    • Wu SY, Wang GF, Liu ZQ, Rao JJ, Lu L, Xu W et al. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin 2009;30:202-208.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 202-208
    • Wu, S.Y.1    Wang, G.F.2    Liu, Z.Q.3    Rao, J.J.4    Lu, L.5    Xu, W.6
  • 20
    • 84863133805 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
    • Guo LX, Xia ZN, Gao X, Yin F, Liu JH. Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells. Acta Pharmacol Sin 2012;33:237-241.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 237-241
    • Guo, L.X.1    Xia, Z.N.2    Gao, X.3    Yin, F.4    Liu, J.H.5
  • 21
    • 84866053595 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced beta-cell apoptosis
    • Liu J, Yin F, Xiao H, Guo L, Gao X. Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced beta-cell apoptosis. Toxicol In Vitro 2012;26:1093-1097.
    • (2012) Toxicol in Vitro , vol.26 , pp. 1093-1097
    • Liu, J.1    Yin, F.2    Xiao, H.3    Guo, L.4    Gao, X.5
  • 23
    • 0036738398 scopus 로고    scopus 로고
    • Glucoseinduced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA et al. Glucoseinduced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002;110:851-860.
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3    Oberholzer, J.4    Joller-Jemelka, H.I.5    Spinas, G.A.6
  • 25
    • 34249724553 scopus 로고    scopus 로고
    • Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes
    • Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K et al. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007;56:1551-1558.
    • (2007) Diabetes , vol.56 , pp. 1551-1558
    • Xu, G.1    Kaneto, H.2    Laybutt, D.R.3    Duvivier-Kali, V.F.4    Trivedi, N.5    Suzuma, K.6
  • 27
    • 84863129902 scopus 로고    scopus 로고
    • FTY720 normalizes hyperglycemia by stimulating beta-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57 (KIP2)
    • Zhao Z, Choi J, Zhao C, Ma ZA. FTY720 normalizes hyperglycemia by stimulating beta-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57 (KIP2). J Biol Chem 2012;287:5562-5573.
    • (2012) J Biol Chem , vol.287 , pp. 5562-5573
    • Zhao, Z.1    Choi, J.2    Zhao, C.3    Ma, Z.A.4
  • 28
    • 84863271896 scopus 로고    scopus 로고
    • β-Cell-protective effect of 2-aminobicyclo-(2, 2, 1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice
    • Han SJ, Choi SE, Yi SA, Lee SJ, Kim HJ, Kim DJ et al. β-Cell-protective effect of 2-aminobicyclo-(2, 2, 1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice. J Endocrinol 2012;212:307-315.
    • (2012) J Endocrinol , vol.212 , pp. 307-315
    • Han, S.J.1    Choi, S.E.2    Yi, S.A.3    Lee, S.J.4    Kim, H.J.5    Kim, D.J.6
  • 29
    • 84865130936 scopus 로고    scopus 로고
    • Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice
    • Do GM, Jung UJ, Park HJ, Kwon EY, Jeon SM, McGregor RA et al. Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Mol Nutr Food Res 2012;56:1282-1291.
    • (2012) Mol Nutr Food Res , vol.56 , pp. 1282-1291
    • Do, G.M.1    Jung, U.J.2    Park, H.J.3    Kwon, E.Y.4    Jeon, S.M.5    McGregor, R.A.6
  • 30
    • 33644828800 scopus 로고    scopus 로고
    • Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas
    • Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ et al. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med 2006;12:310-316.
    • (2006) Nat Med , vol.12 , pp. 310-316
    • Hao, E.1    Tyrberg, B.2    Itkin-Ansari, P.3    Lakey, J.R.4    Geron, I.5    Monosov, E.Z.6
  • 31
    • 62749172470 scopus 로고    scopus 로고
    • Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation
    • Uzan B, Figeac F, Portha B, Movassat J. Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation. PLoS One 2009;4:e4734.
    • (2009) PLoS One , vol.4 , pp. e4734
    • Uzan, B.1    Figeac, F.2    Portha, B.3    Movassat, J.4
  • 32
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000;97:1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 33
    • 77952472242 scopus 로고    scopus 로고
    • Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass
    • Lee JH, Jo J, Hardikar AA, Periwal V, Rane SG. Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass. PLoS One 2010;5:e8653.
    • (2010) PLoS One , vol.5 , pp. e8653
    • Lee, J.H.1    Jo, J.2    Hardikar, A.A.3    Periwal, V.4    Rane, S.G.5
  • 35
    • 33749590993 scopus 로고    scopus 로고
    • Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway
    • Baeyens L, Bonne S, German MS, Ravassard P, Heimberg H, Bouwens L. Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ 2006;13:1892-1899.
    • (2006) Cell Death Differ , vol.13 , pp. 1892-1899
    • Baeyens, L.1    Bonne, S.2    German, M.S.3    Ravassard, P.4    Heimberg, H.5    Bouwens, L.6
  • 38
    • 79251634527 scopus 로고    scopus 로고
    • Beta cell regeneration in human pancreas
    • Gianani R. Beta cell regeneration in human pancreas. Semin Immunopathol 2011;33:23-27.
    • (2011) Semin Immunopathol , vol.33 , pp. 23-27
    • Gianani, R.1
  • 39
  • 40
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 42
    • 43749120731 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
    • Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 2008;283:8723-8735.
    • (2008) J Biol Chem , vol.283 , pp. 8723-8735
    • Liu, Z.1    Habener, J.F.2
  • 43
    • 67649877924 scopus 로고    scopus 로고
    • Emerging therapies for metabolic diseases-the focus is on diabetes and obesity
    • Hughes TE. Emerging therapies for metabolic diseases-the focus is on diabetes and obesity. Curr Opin Chem Biol 2009;13:332-337.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 332-337
    • Hughes, T.E.1
  • 45
    • 84871596296 scopus 로고    scopus 로고
    • Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand
    • Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P et al. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 2012;151:1595-1607.
    • (2012) Cell , vol.151 , pp. 1595-1607
    • Boj, S.F.1    Van Es, J.H.2    Huch, M.3    Li, V.S.4    Jose, A.5    Hatzis, P.6
  • 46
    • 84873345249 scopus 로고    scopus 로고
    • TCF7L2 and diabetes: A tale of two tissues, and of two species
    • McCarthy MI, Rorsman P, Gloyn AL. TCF7L2 and diabetes: a tale of two tissues, and of two species. Cell Metab 2013;17:157-159.
    • (2013) Cell Metab , vol.17 , pp. 157-159
    • McCarthy, M.I.1    Rorsman, P.2    Gloyn, A.L.3
  • 47
    • 21244441973 scopus 로고    scopus 로고
    • Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass
    • Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. J Clin Endocrinol Metab 2005;90:3401-3409.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3401-3409
    • Suarez-Pinzon, W.L.1    Lakey, J.R.2    Brand, S.J.3    Rabinovitch, A.4
  • 48
    • 78651322595 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells
    • Shin JA, Hong OK, Lee HJ, Jeon SY, Kim JW, Lee SH et al. Transforming growth factor-beta induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells. J Cell Biochem 2011;112:179-188.
    • (2011) J Cell Biochem , vol.112 , pp. 179-188
    • Shin, J.A.1    Hong, O.K.2    Lee, H.J.3    Jeon, S.Y.4    Kim, J.W.5    Lee, S.H.6
  • 49
    • 0030912531 scopus 로고    scopus 로고
    • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
    • Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997;99:2100-2109.
    • (1997) J Clin Invest , vol.99 , pp. 2100-2109
    • Rafaeloff, R.1    Pittenger, G.L.2    Barlow, S.W.3    Qin, X.F.4    Yan, B.5    Rosenberg, L.6
  • 50
    • 77957252252 scopus 로고    scopus 로고
    • Blockade of JAK2 activity suppressed accumulation of beta-catenin in leukemic cells
    • Liu YC, Lai WC, Chuang KA, Shen YJ, Hu WS, Ho CH et al. Blockade of JAK2 activity suppressed accumulation of beta-catenin in leukemic cells. J Cell Biochem 2010;111:402-411.
    • (2010) J Cell Biochem , vol.111 , pp. 402-411
    • Liu, Y.C.1    Lai, W.C.2    Chuang, K.A.3    Shen, Y.J.4    Hu, W.S.5    Ho, C.H.6
  • 51
    • 53249127054 scopus 로고    scopus 로고
    • Beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
    • Yan S, Zhou C, Zhang W, Zhang G, Zhao X, Yang S et al. beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett 2008;271:85-97.
    • (2008) Cancer Lett , vol.271 , pp. 85-97
    • Yan, S.1    Zhou, C.2    Zhang, W.3    Zhang, G.4    Zhao, X.5    Yang, S.6


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