β-cell-protective effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice

Journal of Endocrinology

Volumn 212, Issue 3, 2012, Pages 307-315

  Han, Seung Jin ^a,b   Choi, Sung E ^a   Yi, Sang A ^a   Lee, Soo Jin ^a   Kim, Hae Jin ^a   Kim, Dae Jung ^a   Lee, Hyun Chul ^b   Lee, Kwan Woo ^a   Kang, Yup ^a  

^a Ajou University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; CASPASE 3; ENZYME ACTIVATOR; GLUCOSE; GLUTAMATE DEHYDROGENASE; PALMITIC ACID; PLACEBO; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DEATH; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLYCEMIC CONTROL; IMMUNOHISTOLOGY; IN VIVO STUDY; INSULIN RELEASE; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINO ACIDS, CYCLIC; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIABETES MELLITUS; DRUG SYNERGISM; ENZYME ACTIVATION; GENE EXPRESSION; GLUCOSE; GLUTAMATE DEHYDROGENASE; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; MICE; PANCREATIC NEOPLASMS; RATS;

EID: 84863271896     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0340     Document Type: Article

References (31)

1. Anno T, Uehara S, Katagiri H, Ohta Y, Ueda K, Mizuguchi H, Moriyama Y, Oka Y & Tanizawa Y 2004 Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation. American Journal of Physiology. Endocrinology and Metabolism 286 E280-E285. (doi:10.1152/ajpendo.00380.2003).
2. Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N & Leibowitz G 2009 Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS ONE 4 e4954. (doi:10.1371/journal.pone.0004954).
3. Carobbio S, Ishihara H, Fernandez-Pascual S, Bartley C, Martin-Del-Rio R & Maechler P 2004 Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets. Diabetologia 47 266-276. (doi:10.1007/s00125-003-1306-2).
4. Carobbio S, Frigerio F, Rubi B, Vetterli L, Bloksgaard M, Gjinovci A, Pournourmohammadi S, Herrera PL, Reith W, Mandrup S et al. 2009 Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. Journal of Biological Chemistry 284 921-929. (doi:10.1074/jbc.M806295200).
5. Choi SE, Lee YJ, Hwang GS, Chung JH, Lee SJ, Lee JH, Han SJ, Kim HJ, Lee KW, Kim Y et al. 2011 Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death. Archives of Biochemistry and Biophysics 505 231-241. (doi:10.1016/j.abb. 2010.10.011).
6. Christensen HN & Cullen AM 1969 Behavior in the rat of a transportspecific, bicyclic amino acid. Hypoglycemic action. Journal of Biological Chemistry 244 1521-1526.
7. Christensen HN, Hellman B, Lernmark A, Sehlin J, Tager HS & Taljedal IB 1971 In vitro stimulation of insulin release by non-metabolizable, transportspecific amino acids. Biochimica et Biophysica Acta 241 341-348. (doi:10. 1016/0005-2736(71)90034-4).
8. Eizirik DL, Korbutt GS & Hellerstrom C 1992 Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. Journal of Clinical Investigation 90 1263-1268. (doi:10.1172/ JCI115989).
9. El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L & Prentki M 2003 Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 144 4154-4163. (doi:10.1210/en.2003-0410).
10. El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E et al. 2010 Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells. Endocrinology 151 3061-3073. (doi:10.1210/en.2009-1238).
11. Fajans SS, Quibrera R, Pek S, Floyd JC Jr, Christensen HN & Conn JW 1971 Stimulation of insulin release in the dog by a nonmetabollizable amino acid. Comparison with leucine and arginine. Journal of Clinical Endocrinology and Metabolism 33 35-41. (doi:10.1210/jcem-33-1-35).
12. Frigerio F, Casimir M, Carobbio S & Maechler P 2008 Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis. Biochimica et Biophysica Acta 1777 965-972. (doi:10.1016/j.bbabio. 2008.04.031).
13. Gao ZY, Li G, Najafi H, Wolf BA & Matschinsky FM 1999 Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes 48 1535-1542. (doi:10.2337/diabetes.48.8.1535).
14. Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG et al. 2008 Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 57 424-431. (doi:10.2337/ db07-1285).
15. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G et al. 2006 SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 941-954. (doi:10.1016/ j.cell.2006.06.057).
16. Hudson RC & Daniel RM 1993 L-glutamate dehydrogenases: distribution, properties and mechanism. Comparative Biochemistry and Physiology, Part B 106 767-792. (doi:10.1016/0305-0491(93)90031-Y).
17. Jacqueminet S, Briaud I, Rouault C, Reach G & Poitout V 2000 Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism 49 532-536. (doi:10.1016/S0026- 0495(00)80021-9).
18. Kelly A, Li C, Gao Z, Stanley CA & Matschinsky FM 2002 Glutaminolysis and insulin secretion: from bedside to bench and back. Diabetes 51 (Suppl 3) S421-S426. (doi:10.2337/diabetes.51.2007.S421).
19. Liu YJ, Cheng H, Drought H, MacDonald MJ, Sharp GW& Straub SG 2003 Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH. American Journal of Physiology. Endocrinology and Metabolism 285 E380-E389. (doi:10.1152/ajpendo.00008. 2003).
20. Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV & Wheeler MB 2010 Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes 59 448-459. (doi:10.2337/db09-0129).
21. MacDonald MJ, Longacre MJ, Langberg EC, Tibell A, Kendrick MA, Fukao T & Ostenson CG 2009 Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes. Diabetologia 52 1087-1091. (doi:10.1007/s00125-009-1319-6).
22. Maechler P & Wollheim CB 2001 Mitochondrial function in normal and diabetic beta-cells. Nature 414 807-812. (doi:10.1038/414807a).
23. Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E & Melloul D 1999 Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 48 1230-1236. (doi:10.2337/diabetes.48.6.1230).
24. Martinez SC, Tanabe K, Cras-Meneur C, Abumrad NA, Bernal-Mizrachi E & Permutt MA 2008 Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 57 846-859. (doi:10.2337/db07-0595).
25. PantenU,Zielmann S, Langer J, ZunklerBJ&Lenzen S 1984 Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue. Biochemical Journal 219 189-196.
26. Poitout V & Robertson RP 2008 Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocrine Reviews 29 351-366. (doi:10.1210/er.2007-0023).
27. Sener A & Malaisse WJ 1980 L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 288 187-189. (doi:10.1038/288187a0).
28. Sener A, Malaisse-Lagae F & Malaisse WJ 1981 Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. PNAS 78 5460-5464. (doi:10.1073/pnas.78.9.5460).
29. Stanley CA, Lieu YK, Hsu BY, Burlina AB, Greenberg CR, Hopwood NJ, Perlman K, Rich BH, Zammarchi E & Poncz M 1998 Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. New England Journal of Medicine 338 1352-1357. (doi:10.1056/NEJM199805073381904).
30. Stanley CA, Fang J, Kutyna K, Hsu BY, Ming JE, Glaser B & Poncz M 2000 Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. Diabetes 49 667-673. (doi:10.2337/diabetes.49.4.667).
31. Tanizawa Y, Nakai K, Sasaki T, Anno T, Ohta Y, Inoue H, Matsuo K, Koga M, Furukawa S & Oka Y 2002 Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase. Diabetes 51 712-717. (doi:10.2337/diabetes.51.3.712).