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Volumn 13, Issue 3, 2009, Pages 332-337

Emerging therapies for metabolic diseases-the focus is on diabetes and obesity

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCOSE; LIRAGLUTIDE; MELANOCORTIN 4 RECEPTOR; METFORMIN PLUS SITAGLIPTIN; METFORMIN PLUS VILDAGLIPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; RIMONABANT; ROSIGLITAZONE; SITAGLIPTIN; VILDAGLIPTIN;

EID: 67649877924     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2009.04.622     Document Type: Review
Times cited : (17)

References (54)
  • 1
    • 38449096553 scopus 로고    scopus 로고
    • DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes
    • Deacon C.F., Carr R.D., and Holst J.J. DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes. Front Biosci 13 (2008) 1780
    • (2008) Front Biosci , vol.13 , pp. 1780
    • Deacon, C.F.1    Carr, R.D.2    Holst, J.J.3
  • 2
    • 58149265313 scopus 로고    scopus 로고
    • Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes
    • Ahrén B. Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes. Expert Opin Emerg Drugs 13 (2008) 593
    • (2008) Expert Opin Emerg Drugs , vol.13 , pp. 593
    • Ahrén, B.1
  • 4
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J., Kim S.W., Baron M.A., Camisasca R.P., Cressier F., Couturier A., and Dejager S. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 9 (2007) 175
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175
    • Rosenstock, J.1    Kim, S.W.2    Baron, M.A.3    Camisasca, R.P.4    Cressier, F.5    Couturier, A.6    Dejager, S.7
  • 5
    • 33845968872 scopus 로고    scopus 로고
    • Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea
    • Mari A., Nielsen L.L., Nanayakkara N., DeFronzo R.A., Ferrannini E., and Halseth A. Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. Horm Metab Res 38 (2006) 838
    • (2006) Horm Metab Res , vol.38 , pp. 838
    • Mari, A.1    Nielsen, L.L.2    Nanayakkara, N.3    DeFronzo, R.A.4    Ferrannini, E.5    Halseth, A.6
  • 6
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck M.A., Kleine N., Orskov C., Holst J.J., Willms B., and Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36 (1993) 741
    • (1993) Diabetologia , vol.36 , pp. 741
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 8
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials
    • Lago R.M., Singh P.P., and Nesto R.W. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 370 (2007) 1129
    • (2007) Lancet , vol.370 , pp. 1129
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 9
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
    • Lincoff A.M., Wolski K., Nicholls S.J., and Nissen S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 298 (2007) 1180
    • (2007) JAMA , vol.298 , pp. 1180
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 10
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., and Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356 (2007) 2457
    • (2007) N Engl J Med , vol.356 , pp. 2457
    • Nissen, S.E.1    Wolski, K.2
  • 12
    • 34249888775 scopus 로고    scopus 로고
    • Genome wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative. Genome wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331
    • (2007) Science , vol.316 , pp. 1331
    • Diabetes Genetics Initiative1
  • 13
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
    • Zeggini E., Scott L.J., Saxena R., Voight BF., and for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40 (2008) 638
    • (2008) Nat Genet , vol.40 , pp. 638
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, BF.4
  • 18
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • The eleven known common single nucleotide polymorphisms affecting diabetes risk were genotyped in over 18 000 subjects, and were related to the development of diabetes and pancreatic beta cell dysfunction over a 23.5 year median follow-up period. While genetic variants were highly significantly associated with risk of developing type 2 diabetes, the combined effects of all genes remained small relative to clinical determinants, particularly body mass index (obesity) and impaired insulin secretion. This is one of the first studies to put genetic and clinical factors into perspective.
    • Lyssenko V., Jonsson A., Almgren P., Pulizzi N., Isomaa B., Tuomi T., Berglund G., Altshuler D., Nilsson P., and Groop L. Clinical risk factors, DNA variants, and the development of type 2 diabetes. New Engl J Med 359 (2008) 2220. The eleven known common single nucleotide polymorphisms affecting diabetes risk were genotyped in over 18 000 subjects, and were related to the development of diabetes and pancreatic beta cell dysfunction over a 23.5 year median follow-up period. While genetic variants were highly significantly associated with risk of developing type 2 diabetes, the combined effects of all genes remained small relative to clinical determinants, particularly body mass index (obesity) and impaired insulin secretion. This is one of the first studies to put genetic and clinical factors into perspective.
    • (2008) New Engl J Med , vol.359 , pp. 2220
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3    Pulizzi, N.4    Isomaa, B.5    Tuomi, T.6    Berglund, G.7    Altshuler, D.8    Nilsson, P.9    Groop, L.10
  • 21
  • 22
    • 54249088172 scopus 로고    scopus 로고
    • Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
    • Orho-Melander M., Melander O., Guiducci C., Perez-Martinez P., Corella D., Roos C., Tewhey R., Rieder M.J., Hall J., Abecasis G., et al. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 57 (2008) 3112
    • (2008) Diabetes , vol.57 , pp. 3112
    • Orho-Melander, M.1    Melander, O.2    Guiducci, C.3    Perez-Martinez, P.4    Corella, D.5    Roos, C.6    Tewhey, R.7    Rieder, M.J.8    Hall, J.9    Abecasis, G.10
  • 27
    • 67649858097 scopus 로고    scopus 로고
    • BDNF/TrkB signaling is a downstream effector of the brainstem melanocortin system in food intake control
    • [Epub ahead of print], PMID: 19179431
    • Bariohay B., Roux J., Tardivel C., Trouslard J., Jean A., and Lebrun B. BDNF/TrkB signaling is a downstream effector of the brainstem melanocortin system in food intake control. Endocrinol January (2009) [Epub ahead of print], PMID: 19179431
    • (2009) Endocrinol , Issue.January
    • Bariohay, B.1    Roux, J.2    Tardivel, C.3    Trouslard, J.4    Jean, A.5    Lebrun, B.6
  • 28
    • 34547702501 scopus 로고    scopus 로고
    • Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    • This paper is the first to comprehensively assign functional consequences to a major genetic risk factor for type 2 diabetes. The TCF7L2 risk allele imparts dysfunction in pancreatic islet function that strongly implicates the Wnt signaling pathway and provides theoretical support a range of new drug targets that impact the incretin hormone system and Wnt signaling in pancreatic beta cells.
    • Lyssenko V., Lupi R., Marchetti P., Del Guerra S., Orho-Melander M., Almgren P., Sjögren M., Ling C., Eriksson K.F., Lethagen A.L., et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117 (2007) 2155. This paper is the first to comprehensively assign functional consequences to a major genetic risk factor for type 2 diabetes. The TCF7L2 risk allele imparts dysfunction in pancreatic islet function that strongly implicates the Wnt signaling pathway and provides theoretical support a range of new drug targets that impact the incretin hormone system and Wnt signaling in pancreatic beta cells.
    • (2007) J Clin Invest , vol.117 , pp. 2155
    • Lyssenko, V.1    Lupi, R.2    Marchetti, P.3    Del Guerra, S.4    Orho-Melander, M.5    Almgren, P.6    Sjögren, M.7    Ling, C.8    Eriksson, K.F.9    Lethagen, A.L.10
  • 29
    • 40749157994 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide-mediated up-regulation of β-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2
    • Kim S.-J., Nian C., Widenmaier S., and McIntosh C.H.S. Glucose-dependent insulinotropic polypeptide-mediated up-regulation of β-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol Cell Biol 28 (2008) 1644
    • (2008) Mol Cell Biol , vol.28 , pp. 1644
    • Kim, S.-J.1    Nian, C.2    Widenmaier, S.3    McIntosh, C.H.S.4
  • 30
    • 51849099001 scopus 로고    scopus 로고
    • Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119
    • This paper outlines the discovery and characterization of one of the first reported GPR119 agonists discovered from the starting point of an inverse agonist high-throughput screening hit. The paper demonstrates improved glucose metabolism in animals treated by oral gavage, establishing efficacy of the chemical class.
    • Semple G., Fioravanti B., Pereira G., Calderon I., Uy J., Choi K., Xiong Y., Ren A., Morgan M., Dave V., et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem 51 (2008) 5172. This paper outlines the discovery and characterization of one of the first reported GPR119 agonists discovered from the starting point of an inverse agonist high-throughput screening hit. The paper demonstrates improved glucose metabolism in animals treated by oral gavage, establishing efficacy of the chemical class.
    • (2008) J Med Chem , vol.51 , pp. 5172
    • Semple, G.1    Fioravanti, B.2    Pereira, G.3    Calderon, I.4    Uy, J.5    Choi, K.6    Xiong, Y.7    Ren, A.8    Morgan, M.9    Dave, V.10
  • 31
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry J.D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 (2002) 7
    • (2002) Diabetes , vol.51 , pp. 7
    • McGarry, J.D.1
  • 33
    • 33645074450 scopus 로고    scopus 로고
    • Etiology of insulin resistance
    • Petersen K.F., and Shulman G.I. Etiology of insulin resistance. Am J Med 119 (2006) S10
    • (2006) Am J Med , vol.119
    • Petersen, K.F.1    Shulman, G.I.2
  • 34
    • 52349105273 scopus 로고    scopus 로고
    • A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    • Vallerie S.N., Furuhashi M., Fucho R., and Hotamisligil G.S. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS 3 (2008) e3151
    • (2008) PLoS , vol.3
    • Vallerie, S.N.1    Furuhashi, M.2    Fucho, R.3    Hotamisligil, G.S.4
  • 35
    • 66849142449 scopus 로고    scopus 로고
    • Biochemical and physiological function of stearoyl-CoA desaturase
    • [Epub ahead of print] PMID: 19066317
    • Paton C.M., and Ntambi J.M. Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab December (2008) [Epub ahead of print] PMID: 19066317
    • (2008) Am J Physiol Endocrinol Metab , Issue.December
    • Paton, C.M.1    Ntambi, J.M.2
  • 36
    • 39149122218 scopus 로고    scopus 로고
    • Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor
    • This paper chronicles the optimization of highly potent and orally active DGAT1 inhibitors, and demonstrates their efficacy in rodent models of meal-stimulated plasma lipid excursions, body weight loss in diet-induced obesity, and liver steatosis.
    • Zhao G., Souers A.J., Voorbach M., Falls H.D., Droz B., Brodjian S., Lau Y.Y., Iyengar R.R., Gao J., Judd A.S., et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 51 (2008) 380. This paper chronicles the optimization of highly potent and orally active DGAT1 inhibitors, and demonstrates their efficacy in rodent models of meal-stimulated plasma lipid excursions, body weight loss in diet-induced obesity, and liver steatosis.
    • (2008) J Med Chem , vol.51 , pp. 380
    • Zhao, G.1    Souers, A.J.2    Voorbach, M.3    Falls, H.D.4    Droz, B.5    Brodjian, S.6    Lau, Y.Y.7    Iyengar, R.R.8    Gao, J.9    Judd, A.S.10
  • 37
  • 38
    • 67349275999 scopus 로고    scopus 로고
    • A novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • [Epub ahead of print] PMID: 19129749
    • Komoroski B., Vachharajani N., Feng Y., Li L., Kornhauser D., Pfister M., and Dapagliflozin. A novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther January (2009) [Epub ahead of print] PMID: 19129749
    • (2009) Clin Pharmacol Ther , Issue.January
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfister, M.6    Dapagliflozin7
  • 39
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • This paper describes the pharmacological profiling of dapagliflozin, the presently most advanced SGLT2 inhibitor in clinical trials for type 2 diabetes. The compound was shown to rapidly reduce glycemia and improve glucose utilization in diabetic rat models that normally are difficult to normalize with other anti-diabetic agents, serving as the basis for pharmacological modeling of compounds in this mechanistic class.
    • Han S., Hagan D.L., Taylor J.R., Xin L., Meng W., Biller S.A., Wetterau J.R., Washburn W.N., and Whaley J.M. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 57 (2008) 1723. This paper describes the pharmacological profiling of dapagliflozin, the presently most advanced SGLT2 inhibitor in clinical trials for type 2 diabetes. The compound was shown to rapidly reduce glycemia and improve glucose utilization in diabetic rat models that normally are difficult to normalize with other anti-diabetic agents, serving as the basis for pharmacological modeling of compounds in this mechanistic class.
    • (2008) Diabetes , vol.57 , pp. 1723
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3    Xin, L.4    Meng, W.5    Biller, S.A.6    Wetterau, J.R.7    Washburn, W.N.8    Whaley, J.M.9
  • 40
    • 34249899669 scopus 로고    scopus 로고
    • OBD-202 Study Group: a randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients
    • Rosenstock J., Hollander P., Gadde K.M., Sun X., Strauss R., and Leung A. OBD-202 Study Group: a randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients. Diabetes Care 30 (2007) 1480
    • (2007) Diabetes Care , vol.30 , pp. 1480
    • Rosenstock, J.1    Hollander, P.2    Gadde, K.M.3    Sun, X.4    Strauss, R.5    Leung, A.6
  • 41
    • 36248988473 scopus 로고    scopus 로고
    • Comparison of percent of United States adults weighing ≥300 pounds (136 kilograms) in three time periods and comparison of five atherosclerotic risk factors for those weighing ≥300 pounds to those <300 pounds
    • Mondolfi R.N., Jones T.M., Hyre A.D., Raggi P., and Muntner P. Comparison of percent of United States adults weighing ≥300 pounds (136 kilograms) in three time periods and comparison of five atherosclerotic risk factors for those weighing ≥300 pounds to those <300 pounds. Am J Cardiol 100 (2007) 1651
    • (2007) Am J Cardiol , vol.100 , pp. 1651
    • Mondolfi, R.N.1    Jones, T.M.2    Hyre, A.D.3    Raggi, P.4    Muntner, P.5
  • 43
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins-novel therapeutic targets to treat age-associated diseases
    • Lavu S, Boss O, Elliott PJ, Lambert PD: Sirtuins-novel therapeutic targets to treat age-associated diseases. Nature Rev Drug Disc 2008, 7:841.
    • (2008) Nature Rev Drug Disc , vol.7 , pp. 841
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 44
    • 67349169091 scopus 로고    scopus 로고
    • Clinical application of laparoscopic bariatric surgery: an evidence-based review
    • [Epub ahead of print] PMID: 19125308
    • Farrell T.M., Haggerty S.P., Overby D.W., Kohn G.P., Richardson W.S., and Fanelli R.D. Clinical application of laparoscopic bariatric surgery: an evidence-based review. Surg Endosc January (2009) [Epub ahead of print] PMID: 19125308
    • (2009) Surg Endosc , Issue.January
    • Farrell, T.M.1    Haggerty, S.P.2    Overby, D.W.3    Kohn, G.P.4    Richardson, W.S.5    Fanelli, R.D.6
  • 45
    • 34848851922 scopus 로고    scopus 로고
    • Angiogenesis modulates adipogenesis and obesity
    • Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest 117 (2007) 2362
    • (2007) J Clin Invest , vol.117 , pp. 2362
    • Cao, Y.1
  • 46
    • 33846646009 scopus 로고    scopus 로고
    • How do I fatten thee? Let me count the ways...
    • Coleman R.A. How do I fatten thee? Let me count the ways.... Cell Metab 5 (2007) 87
    • (2007) Cell Metab , vol.5 , pp. 87
    • Coleman, R.A.1
  • 47
  • 48
    • 64149083743 scopus 로고    scopus 로고
    • Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
    • [Epub ahead of print]
    • Yen C.L., Cheong M.L., Grueter C., Zhou P., Moriwaki J., Wong J.S., Hubbard B., Marmor S., and Farese Jr. R.V. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med March (2009) [Epub ahead of print]
    • (2009) Nat Med , Issue.March
    • Yen, C.L.1    Cheong, M.L.2    Grueter, C.3    Zhou, P.4    Moriwaki, J.5    Wong, J.S.6    Hubbard, B.7    Marmor, S.8    Farese Jr., R.V.9
  • 49
    • 57649233035 scopus 로고    scopus 로고
    • Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
    • Cheng D., Iqbal J., Devenny J., Chu C.H., Chen L., Dong J., Seethala R., Keim W.J., Azzara A.V., Lawrence R.M., et al. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J Biol Chem 283 (2008) 29802
    • (2008) J Biol Chem , vol.283 , pp. 29802
    • Cheng, D.1    Iqbal, J.2    Devenny, J.3    Chu, C.H.4    Chen, L.5    Dong, J.6    Seethala, R.7    Keim, W.J.8    Azzara, A.V.9    Lawrence, R.M.10
  • 51
    • 36448991861 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    • Miyazaki M., Flowers M.T., Sampath H., Chu K., Otzelberger C., Liu X., and Ntambi J.M. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 6 (2007) 484
    • (2007) Cell Metab , vol.6 , pp. 484
    • Miyazaki, M.1    Flowers, M.T.2    Sampath, H.3    Chu, K.4    Otzelberger, C.5    Liu, X.6    Ntambi, J.M.7
  • 52
    • 18044388542 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase as a new drug target for obesity treatment
    • Dobrzyn A., and Ntambi J.M. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev 6 (2005) 169
    • (2005) Obes Rev , vol.6 , pp. 169
    • Dobrzyn, A.1    Ntambi, J.M.2


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