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Volumn 5, Issue 1, 2010, Pages

Cdk4 regulates recruitment of quiescent β-cells and ductal epithelial progenitors to reconstitute β-cell mass

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; TRANSCRIPTION FACTOR PDX 1;

EID: 77952472242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008653     Document Type: Article
Times cited : (29)

References (59)
  • 1
    • 0021251188 scopus 로고
    • The life story of the pancreatic B cell
    • Hellerstrom C (1984) The life story of the pancreatic B cell. Diabetologia 26: 393-400.
    • (1984) Diabetologia , vol.26 , pp. 393-400
    • Hellerstrom, C.1
  • 2
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 3
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Muoio DM, Newgard CB (2008) Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9: 193-205.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 4
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • Weir GC, Bonner-Weir S (2004) Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53 Suppl 3: S16-21.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Weir, G.C.1    Bonner-Weir, S.2
  • 5
    • 0026329445 scopus 로고
    • Functional maturation and proliferation of fetal pancreatic beta-cells
    • Hellerstrom C, Swenne I (1991) Functional maturation and proliferation of fetal pancreatic beta-cells. Diabetes 40 Suppl 2: 89-93.
    • (1991) Diabetes , vol.40 , Issue.SUPPL. 2 , pp. 89-93
    • Hellerstrom, C.1    Swenne, I.2
  • 6
    • 0021225459 scopus 로고
    • Effect of genetic background on the capacity for islet cell replication in mice
    • Swenne I, Andersson A (1984) Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27: 464-467.
    • (1984) Diabetologia , vol.27 , pp. 464-467
    • Swenne, I.1    Andersson, A.2
  • 8
    • 0020696373 scopus 로고
    • Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat
    • Swenne I (1983) Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat. Diabetes 32: 14-19.
    • (1983) Diabetes , vol.32 , pp. 14-19
    • Swenne, I.1
  • 10
    • 33748935803 scopus 로고    scopus 로고
    • Intrinsic regulators of pancreatic beta-cell proliferation
    • Heit JJ, Karnik SK, Kim SK (2006) Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 22: 311-338.
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 311-338
    • Heit, J.J.1    Karnik, S.K.2    Kim, S.K.3
  • 11
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir S, Sharma A (2002) Pancreatic stem cells. J Pathol 197: 519-526.
    • (2002) J Pathol , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 12
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720.
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 13
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, et al. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50: 521-533.
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3    Daniel, P.B.4    Moritz, W.5
  • 14
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, et al. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292: 1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5
  • 15
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus A, Holz GG, Theise ND, Hussain MA (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111: 843-850.
    • (2003) J Clin Invest , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 16
    • 0037820427 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells initiate pancreatic regeneration
    • Hess D, Li L, Martin M, Sakano S, Hill D, et al. (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21: 763-770.
    • (2003) Nat Biotechnol , vol.21 , pp. 763-770
    • Hess, D.1    Li, L.2    Martin, M.3    Sakano, S.4    Hill, D.5
  • 17
    • 0036266272 scopus 로고    scopus 로고
    • beta-cell neogenesis during prolonged hyperglycemia in rats
    • Lipsett M, Finegood DT (2002) beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51: 1834-1841.
    • (2002) Diabetes , vol.51 , pp. 1834-1841
    • Lipsett, M.1    Finegood, D.T.2
  • 18
    • 11144315998 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
    • Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, et al. (2004) Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306: 2261-2264.
    • (2004) Science , vol.306 , pp. 2261-2264
    • Gershengorn, M.C.1    Hardikar, A.A.2    Wei, C.3    Geras-Raaka, E.4    Marcus-Samuels, B.5
  • 19
    • 0034748027 scopus 로고    scopus 로고
    • Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes
    • Guz Y, Nasir I, Teitelman G (2001) Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142: 4956-4968.
    • (2001) Endocrinology , vol.142 , pp. 4956-4968
    • Guz, Y.1    Nasir, I.2    Teitelman, G.3
  • 20
    • 0242582180 scopus 로고    scopus 로고
    • Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    • Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL (2003) Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302: 1223-1227.
    • (2003) Science , vol.302 , pp. 1223-1227
    • Kodama, S.1    Kuhtreiber, W.2    Fujimura, S.3    Dale, E.A.4    Faustman, D.L.5
  • 21
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S, Halkin A, Cohen H, Ber I, Einav Y, et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
    • (2000) Nat Med , vol.6 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3    Ber, I.4    Einav, Y.5
  • 22
    • 20344394437 scopus 로고    scopus 로고
    • Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
    • Sapir T, Shternhall K, Meivar-Levy I, Blumenfeld T, Cohen H, et al. (2005) Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci U S A 102: 7964-7969.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7964-7969
    • Sapir, T.1    Shternhall, K.2    Meivar-Levy, I.3    Blumenfeld, T.4    Cohen, H.5
  • 23
    • 0033672199 scopus 로고    scopus 로고
    • Molecular basis of transdifferentiation of pancreas to liver
    • Shen CN, Slack JM, Tosh D (2000) Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2: 879-887.
    • (2000) Nat Cell Biol , vol.2 , pp. 879-887
    • Shen, C.N.1    Slack, J.M.2    Tosh, D.3
  • 24
    • 33645226291 scopus 로고    scopus 로고
    • Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration
    • Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, et al. (2006) Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 311: 1774-1775.
    • (2006) Science , vol.311 , pp. 1774-1775
    • Chong, A.S.1    Shen, J.2    Tao, J.3    Yin, D.4    Kuznetsov, A.5
  • 25
    • 34147190365 scopus 로고    scopus 로고
    • Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration
    • Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, et al. (2007) Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest 117: 971-977.
    • (2007) J Clin Invest , vol.117 , pp. 971-977
    • Desai, B.M.1    Oliver-Krasinski, J.2    De Leon, D.D.3    Farzad, C.4    Hong, N.5
  • 26
    • 33645221626 scopus 로고    scopus 로고
    • Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    • Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, et al. (2006) Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 311: 1775-1778.
    • (2006) Science , vol.311 , pp. 1775-1778
    • Nishio, J.1    Gaglia, J.L.2    Turvey, S.E.3    Campbell, C.4    Benoist, C.5
  • 27
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455: 627-632.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 28
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 29
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S, Bhushan A (2004) Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114: 963-968.
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 30
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12: 817-826.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 31
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu X, D'Hoker J, Stange G, Bonne S, De Leu N, et al. (2008) Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132: 197-207.
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1    D'Hoker, J.2    Stange, G.3    Bonne, S.4    De Leu, N.5
  • 32
    • 27544470656 scopus 로고    scopus 로고
    • Mammalian cyclin-dependent kinases
    • Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem Sci 30: 630-641.
    • (2005) Trends Biochem Sci , vol.30 , pp. 630-641
    • Malumbres, M.1    Barbacid, M.2
  • 33
    • 0242280107 scopus 로고    scopus 로고
    • Cell cycle control of pancreatic beta cell proliferation
    • Rane SG, Reddy EP (2000) Cell cycle control of pancreatic beta cell proliferation. Front Biosci 5: D1-19.
    • (2000) Front Biosci , vol.5
    • Rane, S.G.1    Reddy, E.P.2
  • 34
    • 0347383875 scopus 로고    scopus 로고
    • Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice
    • Mettus RV, Rane SG (2003) Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice. Oncogene 22: 8413-8421.
    • (2003) Oncogene , vol.22 , pp. 8413-8421
    • Mettus, R.V.1    Rane, S.G.2
  • 35
    • 0036134935 scopus 로고    scopus 로고
    • Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence
    • Rane SG, Cosenza SC, Mettus RV, Reddy EP (2002) Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol Cell Biol 22: 644-656.
    • (2002) Mol Cell Biol , vol.22 , pp. 644-656
    • Rane, S.G.1    Cosenza, S.C.2    Mettus, R.V.3    Reddy, E.P.4
  • 36
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, et al. (1999) Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 22: 44-52.
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5
  • 38
    • 33845513370 scopus 로고    scopus 로고
    • p27 Regulates the transition of beta-cells from quiescence to proliferation
    • Georgia S, Bhushan A (2006) p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes 55: 2950-2956.
    • (2006) Diabetes , vol.55 , pp. 2950-2956
    • Georgia, S.1    Bhushan, A.2
  • 39
    • 33749187810 scopus 로고    scopus 로고
    • p16INK4a induces an age-dependent decline in islet regenerative potential
    • Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, et al. (2006) p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443: 453-457.
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1    Ramsey, M.R.2    Ligon, K.L.3    Torrice, C.4    Koh, A.5
  • 41
    • 33845530379 scopus 로고    scopus 로고
    • Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life
    • Rachdi L, Balcazar N, Elghazi L, Barker DJ, Krits I, et al. (2006) Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life. Diabetes 55: 3520-3528.
    • (2006) Diabetes , vol.55 , pp. 3520-3528
    • Rachdi, L.1    Balcazar, N.2    Elghazi, L.3    Barker, D.J.4    Krits, I.5
  • 42
    • 20044380925 scopus 로고    scopus 로고
    • Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
    • Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, et al. (2005) Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11: 175-182.
    • (2005) Nat Med , vol.11 , pp. 175-182
    • Uchida, T.1    Nakamura, T.2    Hashimoto, N.3    Matsuda, T.4    Kotani, K.5
  • 43
    • 14644422601 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia
    • Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, et al. (2005) Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes 54: 712-719.
    • (2005) Diabetes , vol.54 , pp. 712-719
    • Zhang, X.1    Gaspard, J.P.2    Mizukami, Y.3    Li, J.4    Graeme-Cook, F.5
  • 44
    • 40449140769 scopus 로고    scopus 로고
    • Cyclindependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model
    • Marzo N, Ortega S, Stratmann T, Garcia A, Rios M, et al. (2008) Cyclindependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model. J Immunol 180: 1189-1198.
    • (2008) J Immunol , vol.180 , pp. 1189-1198
    • Marzo, N.1    Ortega, S.2    Stratmann, T.3    Garcia, A.4    Rios, M.5
  • 45
    • 11444252141 scopus 로고    scopus 로고
    • The pancreatic ductal epithelium serves as a potential pool of progenitor cells
    • Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, et al. (2004) The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes 5 Suppl 2: 16-22.
    • (2004) Pediatr Diabetes , vol.5 , Issue.SUPPL. 2 , pp. 16-22
    • Bonner-Weir, S.1    Toschi, E.2    Inada, A.3    Reitz, P.4    Fonseca, S.Y.5
  • 46
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, et al. (2008) Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A 105: 19915-19919.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19915-19919
    • Inada, A.1    Nienaber, C.2    Katsuta, H.3    Fujitani, Y.4    Levine, J.5
  • 47
    • 0033009460 scopus 로고    scopus 로고
    • The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
    • Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, et al. (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48: 507-513.
    • (1999) Diabetes , vol.48 , pp. 507-513
    • Sharma, A.1    Zangen, D.H.2    Reitz, P.3    Taneja, M.4    Lissauer, M.E.5
  • 48
    • 0030747894 scopus 로고    scopus 로고
    • Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
    • Waguri M, Yamamoto K, Miyagawa JI, Tochino Y, Yamamori K, et al. (1997) Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 46: 1281-1290.
    • (1997) Diabetes , vol.46 , pp. 1281-1290
    • Waguri, M.1    Yamamoto, K.2    Miyagawa, J.I.3    Tochino, Y.4    Yamamori, K.5
  • 49
    • 33845536254 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    • Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, et al. (2006) Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 55: 3289-3298.
    • (2006) Diabetes , vol.55 , pp. 3289-3298
    • Peshavaria, M.1    Larmie, B.L.2    Lausier, J.3    Satish, B.4    Habibovic, A.5
  • 50
    • 0033859232 scopus 로고    scopus 로고
    • beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia
    • Liu YQ, Nevin PW, Leahy JL (2000) beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia. Am J Physiol Endocrinol Metab 279: E68-73.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Liu, Y.Q.1    Nevin, P.W.2    Leahy, J.L.3
  • 51
    • 0036301577 scopus 로고    scopus 로고
    • Pancreatic organogenesis-developmental mechanisms and implications for therapy
    • Edlund H (2002) Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 3: 524-532.
    • (2002) Nat Rev Genet , vol.3 , pp. 524-532
    • Edlund, H.1
  • 52
    • 0029868156 scopus 로고    scopus 로고
    • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    • Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, et al. (1996) PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122: 983-995.
    • (1996) Development , vol.122 , pp. 983-995
    • Offield, M.F.1    Jetton, T.L.2    Labosky, P.A.3    Ray, M.4    Stein, R.W.5
  • 53
    • 0032849353 scopus 로고    scopus 로고
    • Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity
    • Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, et al. (1999) Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol 19: 7011-7019.
    • (1999) Mol Cell Biol , vol.19 , pp. 7011-7019
    • Tsutsui, T.1    Hesabi, B.2    Moons, D.S.3    Pandolfi, P.P.4    Hansel, K.S.5
  • 54
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, et al. (2009) The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138: 449-462.
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3    Sosa-Pineda, B.4    Dussaud, S.5
  • 55
    • 68049088922 scopus 로고    scopus 로고
    • Alpha cells beget beta cells
    • Liu Z, Habener JF (2009) Alpha cells beget beta cells. Cell 138: 424-426.
    • (2009) Cell , vol.138 , pp. 424-426
    • Liu, Z.1    Habener, J.F.2
  • 56
    • 70349292206 scopus 로고    scopus 로고
    • Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling
    • Hesselson D, Anderson RM, Beinat M, Stainier DY (2009) Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling. Proc Natl Acad Sci U S A 106: 14896-14901.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14896-14901
    • Hesselson, D.1    Anderson, R.M.2    Beinat, M.3    Stainier, D.Y.4
  • 57
    • 33847210675 scopus 로고    scopus 로고
    • Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    • Stanger BZ, Tanaka AJ, Melton DA (2007) Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445: 886-891.
    • (2007) Nature , vol.445 , pp. 886-891
    • Stanger, B.Z.1    Tanaka, A.J.2    Melton, D.A.3
  • 58
    • 35848945091 scopus 로고    scopus 로고
    • MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3
    • Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA (2007) MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Dev Biol 311: 603-612.
    • (2007) Dev Biol , vol.311 , pp. 603-612
    • Joglekar, M.V.1    Parekh, V.S.2    Mehta, S.3    Bhonde, R.R.4    Hardikar, A.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.