TCF7L2 promotes beta cell regeneration in human and mouse pancreas

Diabetologia

Volumn 55, Issue 12, 2012, Pages 3296-3307

  Shu, L ^a,b   Zien, K ^a   Gutjahr, G ^a   Oberholzer, J ^c   Pattou, F ^d   Kerr Conte, J ^d   Maedler, K ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIV LILLE   (France)

Author keywords

Beta cell regeneration; Diabetes; Islets; TCF7L2

Indexed keywords

EXENDIN 4; JANUS KINASE 2; STAT3 PROTEIN; STREPTOZOCIN; TRANSCRIPTION FACTOR 7 LIKE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CELL LEVEL; CELL PROLIFERATION; CELL REGENERATION; CELL RENEWAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DISEASE SEVERITY; EPITHELIUM CELL; EXOCRINE CELL; GENE; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INTRACELLULAR SIGNALING; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SUGAR INTAKE; TCF7L2 GENE;

AGING; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; PANCREAS; REGENERATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84868204727     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2693-z     Document Type: Article

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