Silencing Mist1 gene expression is essential for recovery from acute pancreatitis

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Karki, Anju ^a   Humphrey, Sean E ^a   Steele, Rebecca E ^a   Hess, David A ^a   Taparowsky, Elizabeth J ^a   Konieczny, Stephen F ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACINAR CELL; ACINAR DUCTAL METAPLASIA; ACUTE PANCREATITIS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICALLY ENGINEERED MOUSE STRAIN; METAPLASIA; MIST1 GENE; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; TRANSGENE; ACUTE DISEASE; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREATITIS; PATHOLOGY; STROMA CELL;

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; MIST1 PROTEIN, MOUSE;

ACINAR CELLS; ACUTE DISEASE; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENE SILENCING; MICE; MODELS, BIOLOGICAL; PANCREATITIS; STROMAL CELLS; TRANSCRIPTION, GENETIC;

EID: 84957068734     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0145724     Document Type: Article

References (80)

1. Stanger BZ, Hebrok M. Control of cell identity in pancreas development and regeneration. Gastroenterology. 2013;144(6):1170-9. Epub 2013/04/30. doi: 10.1053/j.gastro.2013.01.074 PMID: 23622126.
2. Puri S, Hebrok M. Cellular plasticity within the pancreas-lessons learned from development. Dev Cell. 2010;18(3):342-56. Epub 2010/03/17. doi: 10.1016/j.devcel.2010.02.005 PMID: 20230744.
3. MacDonald RJ, Swift GH, Real FX. Transcriptional control of acinar development and homeostasis. Progress in molecular biology and translational science. 2010;97:1-40. Epub 2010/11/16. doi: 10. 1016/B978-0-12-385233-5.00001-5 PMID: 21074728.
4. Gittes GK. Developmental biology of the pancreas: a comprehensive review. Developmental Biology. 2009;326(1):4-35. Epub 2008/11/18. doi: 10.1016/j.ydbio.2008.10.024 PMID: 19013144.
5. Pin CL, Ryan JF, Mehmood R. Acinar cell reprogramming: a clinically important target in pancreatic disease. Epigenomics. 2015;7(2):267-81. doi: 10.2217/epi.14.83 PMID: 25942535.
6. Chevet E, Hetz C, Samali A. Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis. Cancer discovery. 2015;5(6):586-97. doi: 10.1158/2159-8290. CD-14-1490 PMID: 25977222.
7. Glimcher LH. XBP1: the last two decades. Ann Rheum Dis. 2010;69 Suppl 1:i67-71. PMID: 19995749. doi: 10.1136/ard.2009.119388
8. Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res. 2005;569(1-2):29-63. PMID: 15603751.
9. Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annual review of biochemistry. 2005;74:739-89. PMID: 15952902.
10. Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, et al. Advances in acute and chronic pancreatitis: from development to inflammation and repair. Gastroenterology. 2013;144(1):e1-4. Epub 2012/11/20. doi: 10.1053/j.gastro.2012.11.018 PMID: 23159450.
11. Grady T, Mah'Moud M, Otani T, Rhee S, Lerch MM, Gorelick FS. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. The American journal of physiology. 1998;275(5 Pt 1):G1010-7. Epub 1998/11/14. PMID: 9815031.
12. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. The New England journal of medicine. 1993;328(20):1433-7. PMID: 8479461.
13. Malka D, Hammel P, Maire F, Rufat P, Madeira I, Pessione F, et al. Risk of pancreatic adenocarcinoma in chronic pancreatitis. Gut. 2002;51(6):849-52. PMID: 12427788.
14. Pinho AV, Chantrill L, Rooman I. Chronic pancreatitis: a path to pancreatic cancer. Cancer Lett. 2014;345(2):203-9. Epub 2013/08/29. doi: 10.1016/j.canlet.2013.08.015 PMID: 23981573.
15. Carriere C, Young AL, Gunn JR, Longnecker DS, Korc M. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochemical and biophysical research communications. 2009. PMID: 19292977.
16. Carriere C, Young AL, Gunn JR, Longnecker DS, Korc M. Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage. PLoS One. 2011;6(11):e27725. Epub 2011/12/06. doi: 10.1371/journal.pone.0027725 PMID: 22140463; PubMed Central PMCID: PMC3225359.
17. Collins MA, Yan W, Sebolt-Leopold JS, Pasca di Magliano M. MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. Gastroenterology. 2014;146(3):822-34 e7. Epub 2013/12/10. doi: 10.1053/j.gastro.2013.11.052 PMID: 24315826.
18. Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernandez-Porras I, Canamero M, et al. Pancreatitisinduced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell. 2011;19(6):728-39. Epub 2011/06/15. S1535-6108 (11) 00189-9 [pii] doi: 10.1016/j.ccr. 2011.05.011 PMID: 21665147.
19. Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, Perez-Gallego L, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 2007;11(3):291-302. Epub 2007/03/14. doi: 10.1016/j.ccr.2007.01.012 PMID: 17349585.
20. Molero X, Vaquero EC, Flandez M, Gonzalez AM, Ortiz MA, Cibrian-Uhalte E, et al. Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1alpha in acinar cell homeostasis. Gut. 2012;61(8):1187-96. Epub 2011/09/29. doi: 10.1136/gutjnl-2011-300360 PMID: 21948943.
21. Pinho AV, Rooman I, Reichert M, De Medts N, Bouwens L, Rustgi AK, et al. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut. 2011;60(7):958-66. Epub 2011/01/05. doi: 10. 1136/gut.2010.225920 PMID: 21193456.
22. Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology. 2008;134(2):544-55. PMID: 18242220. doi: 10.1053/j.gastro.2007.11.003
23. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JPt, et al. Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2012;22(6):737-50. Epub 2012/12/04. doi: 10.1016/j.ccr.2012.10.025 PMID: 23201164.
24. Prevot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut. 2012;61(12):1723-32. doi: 10.1136/gutjnl-2011-300266 PMID: 22271799; PubMed Central PMCID: PMC3898034.
25. Prevot PP, Augereau C, Simion A, Van den Steen G, Dauguet N, Lemaigre FP, et al. Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6. Gastroenterology. 2013;145(3):668-78 e3. Epub 2013/05/21. doi: 10.1053/j.gastro.2013.05.016 PMID: 23684747.
26. Shi G, Zhu L, Sun Y, Bettencourt R, Damsz B, Hruban RH, et al. Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology. 2009;136(4):1368-78. doi: 10.1053/j.gastro.2008.12.066 PMID: 19249398; PubMed Central PMCID: PMC2845927.
27. Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol. 2007;171(1):263-73. doi: 10.2353/ajpath. 2007.061176 PMID: 17591971; PubMed Central PMCID: PMC1941579.
28. Huang H, Daniluk J, Liu Y, Chu J, Li Z, Ji B, et al. Oncogenic K-Ras requires activation for enhanced activity. Oncogene. 2013. Epub 2013/01/22. doi: 10.1038/onc.2012.619 PMID: 23334325.
29. Collins MA, Bednar F, Zhang Y, Brisset JC, Galban S, Galban CJ, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. The Journal of Clinical Investigation. 2012;122(2):639-53. Epub 2012/01/11. doi: 10.1172/JCI59227 PMID: 22232209; PubMed Central PMCID: PMC3266788.
30. Ardito CM, Gruner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, et al. EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis. Cancer Cell. 2012;22(3):304-17. Epub 2012/09/15. doi: 10.1016/j.ccr.2012.07.024 PMID: 22975374; PubMed Central PMCID: PMC3443395.
31. Mills JC, Taghert PH. Scaling factors: transcription factors regulating subcellular domains. BioEssays: news and reviews in molecular, cellular and developmental Biology. 2012;34(1):10-6. Epub 2011/10/27. doi: 10.1002/bies.201100089 PMID: 22028036; PubMed Central PMCID: PMC3692000.
32. Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, et al. The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell-formation and acinar differentiation during pancreatic organogenesis. Development. 2014. doi: 10.1242/dev. 109405 PMID: 25063451.
33. Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, et al. Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology. 2012;143(2):469-80. doi: 10. 1053/j.gastro.2012.04.011 PMID: 22510200; PubMed Central PMCID: PMC3664941.
34. Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, et al. LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev. 2011;25(16):1674-9. Epub 2011/08/20. doi: 10.1101/gad.16860911 PMID: 21852532; PubMed Central PMCID: PMC3165932.
35. Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, et al. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology. 2010;139(1):270-80. Epub 2010/04/20. doi: 10.1053/j.gastro.2010.04.003 PMID: 20398665; PubMed Central PMCID: PMC2902682.
36. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, et al. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012;122(10):3516-28. Epub 2012/09/26. doi: 10.1172/JCI63352 PMID: 23006325; PubMed Central PMCID: PMC3461916.
37. Martinelli P, Madriles F, Canamero M, Pau EC, Pozo ND, Guerra C, et al. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice. Gut. 2015. Epub 2015/01/18. doi: 10. 1136/gutjnl-2014-308042 PMID: 25596178.
38. Flandez M, Cendrowski J, Canamero M, Salas A, del Pozo N, Schoonjans K, et al. Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas (G12V)-driven pancreatic tumourigenesis. Gut. 2014;63(4):647-55. Epub 2013/04/20. doi: 10.1136/gutjnl-2012-304381 PMID: 23598351.
39. Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF. Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. Oncogene. 2013;32(15):1950-8. doi: 10. 1038/onc.2012.210 PMID: 22665051; PubMed Central PMCID: PMC3435479.
40. Krah NM, De La OJ, Swift GH, Hoang CQ, Willet SG, Chen Pan F, et al. The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. eLife. 2015;4. Epub 2015/07/08. doi: 10.7554/eLife.07125 PMID: 26151762; PubMed Central PMCID: PMC4536747.
41. Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ. PTF1 is an organ-specific and Notchindependent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol. 2006;26(1):117-30. PMID: 16354684.
42. Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev. 2007;21(20):2629-43. PMID: 17938243.
43. Rodolosse A, Chalaux E, Adell T, Hagege H, Skoudy A, Real FX. PTF1alpha/p48 transcription factor couples proliferation and differentiation in the exocrine pancreas [corrected]. Gastroenterology. 2004;127(3):937-49. Epub 2004/09/14. PMID: 15362048.
44. Garside VC, Kowalik AS, Johnson CL, DiRenzo D, Konieczny SF, Pin CL. MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2. Exp Cell Res. 2010;316(17):2859-70. doi: 10.1016/j.yexcr.2010.06.014 PMID: 20599950; PubMed Central PMCID: PMC3342848.
45. Hess DA, Humphrey SE, Ishibashi J, Damsz B, Lee AH, Glimcher LH, et al. Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology. 2011;141(4):1463-72. doi: 10.1053/j.gastro.2011.06.045 PMID: 21704586; PubMed Central PMCID: PMC3186847.
46. Jia D, Sun Y, Konieczny SF. Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1. Gastroenterology. 2008;135(5):1687-97. doi: 10.1053/j.gastro.2008.07.026 PMID: 18762186; PubMed Central PMCID: PMC2853247.
47. Luo X, Shin DM, Wang X, Konieczny SF, Muallem S. Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem. 2005;280(13):12668-75. doi: 10.1074/jbc. M411973200 PMID: 15665001.
48. Pin CL, Rukstalis JM, Johnson C, Konieczny SF. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol. 2001;155(4):519-30. doi: 10.1083/jcb.200105060 PMID: 11696558; PubMed Central PMCID: PMC2198859.
49. Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL, Konieczny SF. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci. 2003;116(Pt 16):3315-25. doi: 10.1242/jcs.00631 PMID: 12829745.
50. Zhu L, Tran T, Rukstalis JM, Sun P, Damsz B, Konieczny SF. Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol. 2004;24(7):2673-81. PMID: 15024058; PubMed Central PMCID: PMC371125.
51. Aure MH, Konieczny SF, Ovitt CE. Salivary gland homeostasis is maintained through acinar cell self-duplication. Dev Cell. 2015;33(2):231-7. Epub 2015/04/07. doi: 10.1016/j.devcel.2015.02.013 PMID: 25843887; PubMed Central PMCID: PMC4406828.
52. Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, et al. XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology. 2010;139(6):2038-49. doi: 10.1053/j.gastro.2010.08.050 PMID: 20816838; PubMed Central PMCID: PMC2997137.
53. Pin CL, Bonvissuto AC, Konieczny SF. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec. 2000;259(2):157-67. PMID: 10820318.
54. Bredemeyer AJ, Geahlen JH, Weis VG, Huh WJ, Zinselmeyer BH, Srivatsan S, et al. The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol. 2009;325(1):211-24. Epub 2008/11/18. doi: 10.1016/j.ydbio.2008.10.025 PMID: 19013146; PubMed Central PMCID: PMC2634829.
55. Capoccia BJ, Lennerz JK, Bredemeyer AJ, Klco JM, Frater JL, Mills JC. Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells. Physiol Genomics. 2011;43(3):174-86. Epub 2010/11/26. physiolgenomics.00084.2010 [pii] doi: 10.1152/physiolgenomics.00084.2010 PMID: 21098683; PubMed Central PMCID: PMC3055710.
56. Tian X, Jin RU, Bredemeyer AJ, Oates EJ, Blazewska KM, McKenna CE, et al. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Mol Cell Biol. 2010;30(5):1269-84. Epub 2009/12/30. MCB.01328-09 [pii] doi: 10.1128/MCB.01328-09 PMID: 20038531; PubMed Central PMCID: PMC2820885.
57. Zhao Y, Johansson C, Tran T, Bettencourt R, Itahana Y, Desprez PY, et al. Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Mol Endocrinol. 2006;20(9):2187-98. doi: 10.1210/me.2005-0214 PMID: 16645041.
58. Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A. 2008;105(48):18913-8. doi: 10.1073/pnas.0810097105 PMID: 19028870; PubMed Central PMCID: PMC2596215.
59. Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, et al. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol. 2010;177(3):1514-33. Epub 2010/08/17. S0002-9440 (10) 60203-9 [pii] doi: 10. 2353/ajpath.2010.100328 PMID: 20709804; PubMed Central PMCID: PMC2928982.
60. Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, et al. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology. 2010;139(6):2028-37 e9. doi: 10.1053/j.gastro. 2010.09.005 PMID: 20854822; PubMed Central PMCID: PMC2997152.
61. Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, et al. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 2008;134(2):511-22. doi: 10.1053/j.gastro.2007.11.058 PMID: 18242217; PubMed Central PMCID: PMC2857727.
62. Pin CL, Lemercier C, Konieczny SF. Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3. Cytogenetics and cell genetics. 1999;86(3-4):219-22. 15342. PMID: 10575209.
63. de Boer E, Rodriguez P, Bonte E, Krijgsveld J, Katsantoni E, Heck A, et al. Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A. 2003;100(13):7480-5. PMID: 12802011.
64. Luo X, Shin DM, Wang X, Konieczny SF, Muallem S. Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem. 2005;280(13):12668-75. Epub 2005/01/25. doi: 10.1074/jbc. M411973200 PMID: 15665001.
65. Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL, Konieczny SF. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci. 2003;116(Pt 16):3315-25. Epub 2003/06/28. doi: 10.1242/jcs.00631 PMID: 12829745.
66. Morris JPt, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010;10(10):683-95. Epub 2010/09/04. nrc2899 [pii] doi: 10.1038/nrc2899 PMID: 20814421.
67. Greer RL, Staley BK, Liou A, Hebrok M. Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. Gastroenterology. 2013;145(5):1088-97 e8. Epub 2013/07/31. doi: 10.1053/j.gastro.2013.07.027 PMID: 23891977; PubMed Central PMCID: PMC3805717.
68. von Figura G, Morris JPt, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut. 2014;63(4):656-64. Epub 2013/05/07. doi: 10.1136/gutjnl-2012-304287 PMID: 23645620; PubMed Central PMCID: PMC3883808.
69. Jensen JN, Cameron E, Garay MV, Starkey TW, Gianani R, Jensen J. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology. 2005;128(3):728-41. Epub 2005/03/15. PMID: 15765408.
70. Kowalik AS, Johnson CL, Chadi SA, Weston JY, Fazio EN, Pin CL. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2007;292(4):G1123-32. PMID: 17170023.
71. Lerch MM, Gorelick FS. Models of acute and chronic pancreatitis. Gastroenterology. 2013;144(6):1180-93. Epub 2013/04/30. doi: 10.1053/j.gastro.2012.12.043 PMID: 23622127.
72. Johnson CL, Mehmood R, Laing SW, Stepniak CV, Kharitonenkov A, Pin CL. Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1. American journal of physiology Endocrinology and metabolism. 2014;306(8):E916-28. doi: 10.1152/ajpendo.00559. 2013 PMID: 24549397.
73. Mehmood R, Varga G, Mohanty SQ, Laing SW, Lu Y, Johnson CL, et al. Epigenetic reprogramming in Mist1 (-/-) mice predicts the molecular response to cerulein-induced pancreatitis. PLoS One. 2014;9(1):e84182. doi: 10.1371/journal.pone.0084182 PMID: 24465395; PubMed Central PMCID: PMC3897368.
74. Johnson CL, Kowalik AS, Rajakumar N, Pin CL. Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract. Mech Dev. 2004;121(3):261-72. PMID: 15003629.
75. Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF, Mills JC. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development. 2007;134(1):211-22. doi: 10.1242/dev. 02700 PMID: 17164426.
76. Kim S, Lahmy R, Riha C, Yang C, Jakubison BL, van Niekerk J, et al. The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential. Pancreas. 2015;44(5):718-27. Epub 2015/04/22. doi: 10.1097/MPA. 0000000000000328 PMID: 25894862; PubMed Central PMCID: PMC4464938.
77. De La OJ, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A. 2008;105(48):18907-12. Epub 2008/11/26. doi: 10.1073/pnas.0810111105 PMID: 19028876; PubMed Central PMCID: PMC2585942.
78. Houbracken I, de Waele E, Lardon J, Ling Z, Heimberg H, Rooman I, et al. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology. 2011;141(2):731-41 e4. Epub 2011/06/28. S0016-5085 (11) 00605-6 [pii] doi: 10.1053/j.gastro.2011.04.050 PMID: 21703267.
79. di Magliano MP, Logsdon CD. Roles for KRAS in Pancreatic Tumor Development and Progression. Gastroenterology. 2013;144(6):1220-9. Epub 2013/04/30. doi: 10.1053/j.gastro.2013.01.071 PMID: 23622131.
80. Alahari S, Mehmood R, Johnson CL, Pin CL. The absence of MIST1 leads to increased ethanol sensitivity and decreased activity of the unfolded protein response in mouse pancreatic acinar cells. PLoS One. 2011;6(12):e28863. Epub 2012/01/05. doi: 10.1371/journal.pone.0028863 PMID: 22216129; PubMed Central PMCID: PMC3247225.