Control of cell identity in pancreas development and regeneration

Gastroenterology

Volumn 144, Issue 6, 2013, Pages 1170-1179

  Stanger, Ben Z ^a   Hebrok, Matthias ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell Identity; Development; Pancreas; Regeneration

Indexed keywords

CYTOKERATIN 19; OSTEOGENIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR SOX9;

ACINAR CELL; ACUTE PANCREATITIS; BASEMENT MEMBRANE; CAMPOMELIC DYSPLASIA; CANCER GROWTH; CELL COUNT; CELL DIFFERENTIATION; CELL TRANSDIFFERENTIATION; DNA METHYLATION; EMBRYO DEVELOPMENT; ENDOCRINE CELL; ENDODERM; ENTEROENDOCRINE CELL; ENZYME ACTIVATION; EXOCRINE CELL; FETUS DEVELOPMENT; GENE EXPRESSION; HAPLOINSUFFICIENCY; HUMAN; MESENCHYME; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS DEVELOPMENT; PANCREAS DUCT LIGATION; PANCREAS INJURY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS REGENERATION; PANCREAS RESECTION; PANCREATITIS; PERITONEAL CAVITY; PHENOTYPE; PHYLOGENETIC TREE; PRIMORDIUM; PRIORITY JOURNAL; REGENERATIVE MEDICINE; RETROPERITONEUM; REVIEW; STEM CELL; TISSUE REGENERATION; TRANSIENT EXPRESSION;

EID: 84876800552     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.074     Document Type: Article

References (80)

1. I. Pavlov The work of the digestive glands 1902 Charles Griffin London, UK
2. K.L. Teff How neural mediation of anticipatory and compensatory insulin release helps us tolerate food Physiol Behav 103 2011 44 50
3. R.S. Heller The comparative anatomy of islets Adv Exp Med Biol 654 2010 21 37
4. O.D. Madsen Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell' C R Biol 330 2007 534 537
5. D. Hesselson, R.M. Anderson, D.Y. Stainier Suppression of Ptf1a activity induces acinar-to-endocrine conversion Curr Biol 21 2011 712 717
6. F. Atouf, P. Czernichow, R. Scharfmann Expression of neuronal traits in pancreatic beta cells Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer J Biol Chem 272 1997 1929 1934
7. S. Wang, N. Tulina, D.L. Carlin The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis Proc Natl Acad Sci U S A 104 2007 19873 19878
8. J.M. Wells, D.A. Melton Early mouse endoderm is patterned by soluble factors from adjacent germ layers Development 127 2000 1563 1572
9. E. Bayha, M.C. Jorgensen, P. Serup Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis PLoS One 4 2009 e5845
10. D. Stafford, R.J. White, M.D. Kinkel Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells Development 133 2006 949 956
11. J.M.W. Slack Developmental biology of the pancreas Development 121 1995 1569 1580
12. S.K. Kim, M. Hebrok, D.A. Melton Notochord to endoderm signaling is required for pancreas development Development 124 1997 4243 4252
13. M. Hebrok Hedgehog signaling in pancreas development Mech Dev 20 2003 45 57
14. M. Hebrok, S.K. Kim, D.A. Melton Notochord repression of endodermal Sonic hedgehog permits pancreas development Genes Dev 12 1998 1705 1713
15. E. Lammert, O. Cleaver, D. Melton Induction of pancreatic differentiation by signals from blood vessels Science V294 2001 564 567
16. L. Landsman, A. Nijagal, T.J. Whitchurch Pancreatic mesenchyme regulates epithelial organogenesis throughout development PLoS Biol 9 2011 e1001143
17. H. Yoshitomi, K.S. Zaret Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a Development 131 2004 807 817
18. M. Kumar, N. Jordan, D. Melton Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate Dev Biol 259 2003 109 122
19. E. Wandzioch, K.S. Zaret Dynamic signaling network for the specification of embryonic pancreas and liver progenitors Science 324 2009 1707 1710
20. A. Villasenor, D.C. Chong, M. Henkemeyer Epithelial dynamics of pancreatic branching morphogenesis Development 137 2010 4295 4305
21. Q. Zhou, A.C. Law, J. Rajagopal A multipotent progenitor domain guides pancreatic organogenesis Dev Cell 13 2007 103 114
22. T. Masui, Q. Long, T.M. Beres Early pancreatic development requires the vertebrate suppressor of hairless (RBPJ) in the PTF1 bHLH complex Genes Dev 21 2007 2629 2643
23. T. Masui, G.H. Swift, T. Deering Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells Gastroenterology 139 2010 270 280
24. J. Fujikura, K. Hosoda, H. Iwakura Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas Cell Metab 3 2006 59 65
25. F. Esni, B. Ghosh, A.V. Biankin Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas Development 131 2004 4213 4224
26. S. Cervantes, J. Lau, D.A. Cano Primary cilia regulate Gli/Hedgehog activation in pancreas Proc Natl Acad Sci U S A 107 2010 10109 10114
27. P.W. Heiser, J. Lau, M.M. Taketo Stabilization of beta-catenin impacts pancreas growth Development 133 2006 2023 2032
28. L.C. Murtaugh, A.C. Law, Y. Dor Beta-catenin is essential for pancreatic acinar but not islet development Development 132 2005 4663 4674
29. A. Strom, C. Bonal, R. Ashery-Padan Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas Development 134 2007 2719 2725
30. M.D. Keefe, H. Wang, O.J. De La Beta-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice Dis Model Mech 5 2012 503 514
31. J.P. Morris 4th, D.A. Cano, S. Sekine Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice J Clin Invest 120 2010 508 520
32. S. Puri, M. Hebrok Dynamics of embryonic pancreas development using real-time imaging Dev Biol 306 2007 82 93
33. J.L. Kopp, C.L. Dubois, A.E. Schaffer Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas Development 138 2011 653 665
34. M. Solar, C. Cardalda, I. Houbracken Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth Dev Cell 17 2009 849 860
35. O. Cabrera, D.M. Berman, N.S. Kenyon The unique cytoarchitecture of human pancreatic islets has implications for islet cell function Proc Natl Acad Sci U S A 103 2006 2334 2339
36. G.S. Sellick, K.T. Barker, I. Stolte-Dijkstra Mutations in PTF1A cause pancreatic and cerebellar agenesis Nat Genet 36 2004 1301 1305
37. D.A. Stoffers, N.T. Zinkin, V. Stanojevic Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence Nat Genet 15 1997 106 110
38. K. Piper, S.G. Ball, J.W. Keeling Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia Mech Dev 116 2002 223 226
39. J. Wang, G. Cortina, S.V. Wu Mutant neurogenin-3 in congenital malabsorptive diarrhea N Engl J Med 355 2006 270 280
40. J.N. Jensen, L.C. Rosenberg, J. Hecksher-Sorensen Mutant neurogenin-3 in congenital malabsorptive diarrhea N Engl J Med 356 2007 1781 1782
41. A.D. Goldberg, C.D. Allis, E. Bernstein Epigenetics: a landscape takes shape Cell 128 2007 635 638
42. U. Ahlgren, J. Jonsson, L. Jonsson Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes Genes Dev 12 1998 1763 1768
43. Y.P. Yang, F. Thorel, D.F. Boyer Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression Genes Dev 25 2011 1680 1685
44. J.B. Papizan, R.A. Singer, S.I. Tschen Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming Genes Dev 25 2011 2291 2305
45. S. Dhawan, S. Georgia, S.I. Tschen Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx Dev Cell 20 2011 419 429
46. P. Collombat, J. Hecksher-Sorensen, J. Krull Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression J Clin Invest 117 2007 961 970
47. Y.C. Chan, P.S. Leung Acute pancreatitis: animal models and recent advances in basic research Pancreas 34 2007 1 14
48. M.M. Lerch, M.P. Lutz, H. Weidenbach Dissociation and reassembly of adherens junctions during experimental acute pancreatitis Gastroenterology 113 1997 1355 1366
49. S. Puri, M. Hebrok Cellular plasticity within the pancreas-lessons learned from development Dev Cell 18 2010 342 356
50. J.N. Jensen, E. Cameron, M.V. Garay Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration Gastroenterology 128 2005 728 741
51. A. Criscimanna, J.A. Speicher, G. Houshmand Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice Gastroenterology 141 2010 1451 1462 1462.e1-6
52. J.T. Siveke, C. Lubeseder-Martellato, M. Lee Notch signaling is required for exocrine regeneration after acute pancreatitis Gastroenterology 134 2008 544 555
53. D. Kopinke, M. Brailsford, F.C. Pan Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas Dev Biol 362 2012 57 64
54. V. Fendrich, F. Esni, M.V. Garay Hedgehog signaling is required for effective regeneration of exocrine pancreas Gastroenterology 135 2008 621 631
55. J.P. Morris 4th, S.C. Wang, M. Hebrok KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma Nat Rev Cancer 10 2010 683 695
56. A.B. Lowenfels, P. Maisonneuve, E.P. DiMagno et al. Hereditary pancreatitis and the risk of pancreatic cancer International Hereditary Pancreatitis Study Group J Natl Cancer Inst 89 1997 442 446
57. C. Guerra, A.J. Schuhmacher, M. Canamero Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice Cancer Cell 11 2007 291 302
58. A.D. Rhim, E.T. Mirek, N.M. Aiello EMT and dissemination precede pancreatic tumor formation Cell 148 2012 349 361
59. G.L. Beatty, E.G. Chiorean, M.P. Fishman CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans Science 331 2011 1612 1616
60. C. Carriere, E.S. Seeley, T. Goetze The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia Proc Natl Acad Sci U S A 104 2007 4437 4442
61. O.J. De La, L.L. Emerson, J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci U S A 105 2008 18907 18912
62. J.L. Kopp, G. von Figura, E. Mayes Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma Cancer Cell 22 2012 737 750
63. B. Fan, Y. Malato, D.F. Calvisi Cholangiocarcinomas can originate from hepatocytes in mice J Clin Invest 122 2012 2911 2915
64. Y. Dor, J. Brown, O.I. Martinez Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation Nature 429 2004 41 46
65. D.A. Cano, I.C. Rulifson, P.W. Heiser Regulated beta-cell regeneration in the adult mouse pancreas Diabetes 57 2008 958 966
66. T. Nir, D.A. Melton, Y. Dor Recovery from diabetes in mice by beta cell regeneration J Clin Invest 117 2007 2553 2561
67. F. Thorel, V. Nepote, I. Avril Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss Nature 464 2010 1149 1154
68. C. Talchai, S. Xuan, H.V. Lin Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure Cell 150 2012 1223 1234
69. M.M. Rankin, J.A. Kushner Adaptive beta-cell proliferation is severely restricted with advanced age Diabetes 58 2009 1365 1372
70. Y. Saisho, A.E. Butler, E. Manesso Beta-cell mass and turnover in humans: effects of obesity and aging Diabetes Care 36 2013 111 117
71. S.I. Tschen, S. Dhawan, T. Gurlo Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice Diabetes 58 2009 1312 1320
72. X. Xu, J. D'Hoker, G. Stange Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas Cell 132 2008 197 207
73. C.N. Shen, J.M. Slack, D. Tosh Molecular basis of transdifferentiation of pancreas to liver Nat Cell Biol 2 2000 879 887
74. V. Yechoor, V. Liu, C. Espiritu Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes Dev Cell 16 2009 358 373
75. K. Takahashi, S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
76. Q. Zhou, J. Brown, A. Kanarek In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632
77. E. Akinci, A. Banga, L.V. Greder Reprogramming of pancreatic exocrine cells towards a beta (beta) cell character using Pdx1, Ngn3 and MafA Biochem J 442 2012 539 550
78. A.T. Cheung, B. Dayanandan, J.T. Lewis Glucose-dependent insulin release from genetically engineered K cells Science 290 2000 1959 1962
79. C. Talchai, S. Xuan, T. Kitamura Generation of functional insulin-producing cells in the gut by Foxo1 ablation Nat Genet 44 2012 406 412 S1
80. S. Puri, M. Hebrok Diabetic B cells: To be or not to be? Cell 150 2012 1103 1104