MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice

Gastroenterology

Volumn 146, Issue 3, 2014, Pages

  Collins, Meredith A ^a   Yan, Wei ^b,c   Sebolt Leopold, Judith S ^b   Pasca Di Magliano, Marina ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Acinar Differentiation; Mouse Models; Pancreatic Cancer; Signal Transduction

Indexed keywords

CERULETIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MIST1; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS ADENOMA; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

ACINAR DIFFERENTIATION; MOUSE MODELS; PANCREATIC CANCER; SIGNAL TRANSDUCTION;

ACINAR CELLS; ANIMALS; CARCINOMA IN SITU; CELL DEDIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMALE; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PANCREATIC NEOPLASMS; PANCREATITIS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84894364786     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.11.052     Document Type: Article

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