XBP1: The last two decades

Annals of the Rheumatic Diseases

Volumn 69, Issue SUPPL. 1, 2010, Pages

  Glimcher, L H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; X BOX BINDING PROTEIN 1; CASPASE RECRUITMENT DOMAIN PROTEIN 15; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE;

CROHN DISEASE; ENDOPLASMIC RETICULUM STRESS; ENTERITIS; GENETIC RISK; HUMAN; IMMUNE SYSTEM; INFLAMMATION; INTESTINE EPITHELIUM; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; CELL FUNCTION; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; INFLAMMATORY DISEASE; INNATE IMMUNITY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK FACTOR; SEQUENCE ANALYSIS; UNFOLDED PROTEIN RESPONSE; X BOX BINDING PROTEIN 1 GENE;

ANIMALS; CROHN DISEASE; DNA-BINDING PROTEINS; ENTERITIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; MICE; MUTATION; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 75749144215     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.119388     Document Type: Review

References (44)

1. Liou HC, Polla BS, Aragnol D, et al. A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control. Proc Natl Acad Sci USA 1988;85:2738-42.
2. Liou H-C, Boothby MR, Glimcher LH. Distinct cloned class II MHC DNA-binding proteins recognize the X box transcription element. Science 1988;242:69-71.
3. Ono SJ, Liou H-C, Davidon R, et al. Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos. Proc Natl Acad Sci U S A 1991;88:4309-12.
4. Reimold AM, Grusby MJ, Kosaras B, et al. Chondrodysplasia and neurologic abnormalities in ATF-2-deficient mice. Nature 1996;379:262-5.
5. Hai TW, Liu F, Coukos WJ, Green MR. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev 1989;3:2083-90.
6. Erratum in: Genes Dev 1990;4:682.
7. Kara CJ, Liou H-C, Ivashkiv LB, Glimcher LH. A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain. Mol Cell Biol 1990;10:1347-57.
8. Ivashkiv LB, Liou H-C, Kara CJ, et al. mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-0-tetradecanoylphorbol-13-acetate, response element. Mol Cell Biol 1990;10:1609-21.
9. Liou HC, Boothby MR, Finn PW, et al. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science 1990;247:1581-4.
10. Clauss IM, Chu M, Zhao JL, Glimcher LH. The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core. Nucleic Acids Res 1996;24:1855- 64.
11. Clauss IM, Gravallese EM, Darling JM, et al. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn 1993;197:146-56.
12. Reimold AM, Etkin A, Clauss I, et al. An essential role in liver development for transcription factor XBP-1. Genes Dev 2000;14:152-7.
13. Shen X, Ellis RE, Lee K, et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 2001;107:893-903.
14. Yoshida H, Matsui T, Yamamoto A, et al. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-91.
15. Calfon M, Zeng H, Urano F, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002;415:92-6.
16. Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires transcription factor XBP-1. Nature 2001;412:300-7.
17. Reimold AM, Ponath PD, Yue-Shing L, et al. Transcription factor B cell lineagespecific activator protein regulates the gene for human X-box binding protein 1. J Exp Med 1996;183:393-401.
18. Iwakoshi NN, Lee AH, Vallabhajosyula P, et al. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 2003;4:321-9.
19. Lee AH, Chu G, Iwakoshi NN, Glimcher LH. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 2005;24:4368-80.
20. Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A 2003;100:9946-51.
21. Todd DJ, McHeyzer-Williams L, Kowal C, et al. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med 2009; in press.
22. Iwakoshi NN, Pypaert M, Glimcher LH. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med 2007;204:2267-75.
23. Patil C, Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol 2001;13:349-55.
24. Kozutsumi Y, Segal M, Normington K, et al. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 1988;332:462-4.
25. Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 1993;73:197-206.
26. Cox JS, Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 1996;87:391-404.
27. Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, et al. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 2003;19:607-20.
28. Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 2004;21:81-93.
29. Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003;23:7448-59.
30. Costa-Alvear D, Zhou Y, Blais A, et al. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell 2007;27:53-66.
31. Kaser A, Lee A-H, Franke A, et al. Transcription factor XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008;134:743-56.
32. ReyaT, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50.
33. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29.
34. Urano F, Wang X, Bertolotti A, et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000;287:664-66.
35. Yang Q, Kim YS, Lin Y, et al. Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK. EMBO Rep 2006;7:622-7.
36. Waetzig GH, Seegert D, Rosenstiel P, et al. p38 Mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol 2002;168:5342-51.
37. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
38. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
39. Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell b-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005;102:18129-34.
40. Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005;307:731-4.
41. Strober W. Immunology: unraveling gut inflammation. Science 2006;313:1052-4.
42. Todd DJ, Lee AH, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008;9:663-74.
43. Hetz C, Glimcher LH. XBP-1 and the UPRosome: mastering secretory cell function. Curr Immunol Rev 2009; in press.
44. Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008;320:1492-6.