Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

Gut

Volumn 60, Issue 7, 2011, Pages 958-966

  Pinho, Andreia V ^a,b   Rooman, Ilse ^b,c   Reichert, Maximilian ^d   De Medts, Nele ^c   Bouwens, Luc ^c   Rustgi, Anil K ^d   Real, Francisco X ^a,b,e  

^a Centro Nacional de Investigations Oncológicas   (Spain)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c DIABETES RESEARCH CENTER   (Belgium)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CERULETIDE; HEPATOCYTE NUCLEAR FACTOR 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; RAS PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CPA 1; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR PTF 1A; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL ADHESION; CELL CULTURE; CELL DEDIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC PANCREATITIS; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PANCREAS DUCT LIGATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION;

ANIMALS; CAERULEIN; CELL AGING; CELL DEDIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; MICE; MICE, INBRED C57BL; PANCREAS, EXOCRINE; PANCREATITIS, CHRONIC; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 79954513296     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.225920     Document Type: Article

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