-
3
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012;491:399-405.
-
(2012)
Nature
, vol.491
, pp. 399-405
-
-
Biankin, A.V.1
Waddell, N.2
Kassahn, K.S.3
-
4
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
5
-
-
0032748508
-
Duct changes and K-ras mutations in the disease-free pancreas: Analysis of type, age relation and spatial distribution
-
Luttges J, Reinecke-Luthge A, Mollmann B, et al. Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 1999;435:461-8.
-
(1999)
Virchows Arch
, vol.435
, pp. 461-468
-
-
Luttges, J.1
Reinecke-Luthge, A.2
Mollmann, B.3
-
6
-
-
33645824724
-
Both p16 (Ink4a) and the p19 (Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy N, Aguirre AJ, Chu GC, et al. Both p16 (Ink4a) and the p19 (Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci USA 2006;103:5947-52.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
-
7
-
-
57749116315
-
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
-
De La OJ, Emerson LL, Goodman JL, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci USA 2008;105:18907-12.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18907-18912
-
-
De La, O.J.1
Emerson, L.L.2
Goodman, J.L.3
-
8
-
-
0041883654
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
-
Guerra C, Mijimolle N, Dhawahir A, et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 2003;4:111-20.
-
(2003)
Cancer Cell
, vol.4
, pp. 111-120
-
-
Guerra, C.1
Mijimolle, N.2
Dhawahir, A.3
-
9
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
10
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra C, Schuhmacher AJ, Canamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007;11:291-302.
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
Schuhmacher, A.J.2
Canamero, M.3
-
11
-
-
34547667454
-
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
-
Zhu L, Shi G, Schmidt CM, et al. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 2007;171:263-73.
-
(2007)
Am J Pathol
, vol.171
, pp. 263-273
-
-
Zhu, L.1
Shi, G.2
Schmidt, C.M.3
-
12
-
-
76649105065
-
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
-
Morris JPt, Cano DA, Sekine S, et al. Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest 2010;120:508-20.
-
(2010)
J Clin Invest
, vol.120
, pp. 508-520
-
-
Morris, J.P.T.1
Cano, D.A.2
Sekine, S.3
-
13
-
-
0029056792
-
Pancreatitis is a risk factor for pancreatic cancer
-
Bansal P, Sonnenberg A. Pancreatitis is a risk factor for pancreatic cancer. Gastroenterology 1995;109:247-51.
-
(1995)
Gastroenterology
, vol.109
, pp. 247-251
-
-
Bansal, P.1
Sonnenberg, A.2
-
14
-
-
33748056792
-
Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
-
Brune K, Abe T, Canto M, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 2006;30:1067-76.
-
(2006)
Am J Surg Pathol
, vol.30
, pp. 1067-1076
-
-
Brune, K.1
Abe, T.2
Canto, M.3
-
15
-
-
84857055748
-
Pancreatic ductal adenocarcinoma and acinar cells: A matter of differentiation and development?
-
Rooman I, Real FX. Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development? Gut 2012;61:449-58.
-
(2012)
Gut
, vol.61
, pp. 449-458
-
-
Rooman, I.1
Real, F.X.2
-
17
-
-
84884285309
-
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice
-
Martinelli P, Canamero M, Del Pozo N, et al. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut 2013;62:1481-8.
-
(2013)
Gut
, vol.62
, pp. 1481-1488
-
-
Martinelli, P.1
Canamero, M.2
Del Pozo, N.3
-
18
-
-
84867152330
-
GATA4 and GATA6 control mouse pancreas organogenesis
-
Carrasco M, Delgado I, Soria B, et al. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest 2012;122:3504-15.
-
(2012)
J Clin Invest
, vol.122
, pp. 3504-3515
-
-
Carrasco, M.1
Delgado, I.2
Soria, B.3
-
19
-
-
84867174750
-
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis
-
Xuan S, Borok MJ, Decker KJ, et al. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest 2012;122:3516-28.
-
(2012)
J Clin Invest
, vol.122
, pp. 3516-3528
-
-
Xuan, S.1
Borok, M.J.2
Decker, K.J.3
-
20
-
-
84876835924
-
Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma
-
Snyder EL, Watanabe H, Magendantz M, et al. Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Mol Cell 2013;50:185-99.
-
(2013)
Mol Cell
, vol.50
, pp. 185-199
-
-
Snyder, E.L.1
Watanabe, H.2
Magendantz, M.3
-
21
-
-
0036730427
-
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
-
Kawaguchi Y, Cooper B, Gannon M, et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-34.
-
(2002)
Nat Genet
, vol.32
, pp. 128-134
-
-
Kawaguchi, Y.1
Cooper, B.2
Gannon, M.3
-
22
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina M, Kurkowski MU, Ludes K, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011;19:456-69.
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
Kurkowski, M.U.2
Ludes, K.3
-
23
-
-
84861990162
-
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
-
Perez-Mancera PA, Rust AG, van der Weyden L, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 2012;486:266-70.
-
(2012)
Nature
, vol.486
, pp. 266-270
-
-
Perez-Mancera, P.A.1
Rust, A.G.2
Van Der Weyden, L.3
-
24
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
Guerra C, Collado M, Navas C, et al. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011;19:728-39.
-
(2011)
Cancer Cell
, vol.19
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
-
25
-
-
33745177351
-
Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases
-
Andrianifahanana M, Moniaux N, Batra SK. Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases. Biochim Biophys Acta 2006;1765:189-222.
-
(2006)
Biochim Biophys Acta
, vol.1765
, pp. 189-222
-
-
Andrianifahanana, M.1
Moniaux, N.2
Batra, S.K.3
-
27
-
-
77951812394
-
A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans
-
Menheniott TR, Peterson AJ, O'Connor L, et al. A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. Gastroenterology 2010;138:1823-35.
-
(2010)
Gastroenterology
, vol.138
, pp. 1823-1835
-
-
Menheniott, T.R.1
Peterson, A.J.2
O'Connor, L.3
-
28
-
-
4043059169
-
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
-
el Marjou F, Janssen KP, Chang BH, et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 2004;39:186-93.
-
(2004)
Genesis
, vol.39
, pp. 186-193
-
-
El Marjou, F.1
Janssen, K.P.2
Chang, B.H.3
-
29
-
-
0030744362
-
Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer
-
Rechreche H, Mallo GV, Montalto G, et al. Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer. Eur J Biochem 1997;248:225-30.
-
(1997)
Eur J Biochem
, vol.248
, pp. 225-230
-
-
Rechreche, H.1
Mallo, G.V.2
Montalto, G.3
-
30
-
-
0345017786
-
Transcription factors in liver development, differentiation, and regeneration
-
Costa RH, Kalinichenko VV, Holterman AX, et al. Transcription factors in liver development, differentiation, and regeneration. Hepatology 2003;38:1331-47.
-
(2003)
Hepatology
, vol.38
, pp. 1331-1347
-
-
Costa, R.H.1
Kalinichenko, V.V.2
Holterman, A.X.3
-
31
-
-
0035095067
-
Expression and localization of epithelial aquaporins in the adult human lung
-
Kreda SM, Gynn MC, Fenstermacher DA, et al. Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol 2001;24:224-34.
-
(2001)
Am J Respir Cell Mol Biol
, vol.24
, pp. 224-234
-
-
Kreda, S.M.1
Gynn, M.C.2
Fenstermacher, D.A.3
-
32
-
-
77953903417
-
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells
-
Masui T, Swift GH, Deering T, et al. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology 2010;139:270-80.
-
(2010)
Gastroenterology
, vol.139
, pp. 270-280
-
-
Masui, T.1
Swift, G.H.2
Deering, T.3
-
33
-
-
79954513296
-
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis
-
Pinho AV, Rooman I, Reichert M, et al. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut 2011;60:958-66.
-
(2011)
Gut
, vol.60
, pp. 958-966
-
-
Pinho, A.V.1
Rooman, I.2
Reichert, M.3
-
34
-
-
84866007085
-
EGF receptor is required for KRAS-induced pancreatic tumorigenesis
-
Ardito CM, Gruner BM, Takeuchi KK, et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 2012;22:304-17.
-
(2012)
Cancer Cell
, vol.22
, pp. 304-317
-
-
Ardito, C.M.1
Gruner, B.M.2
Takeuchi, K.K.3
-
35
-
-
84866035571
-
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma
-
Navas C, Hernandez-Porras I, Schuhmacher AJ, et al. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell 2012;22:318-30.
-
(2012)
Cancer Cell
, vol.22
, pp. 318-330
-
-
Navas, C.1
Hernandez-Porras, I.2
Schuhmacher, A.J.3
-
36
-
-
10744223624
-
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
-
Miyamoto Y, Maitra A, Ghosh B, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003;3:565-76.
-
(2003)
Cancer Cell
, vol.3
, pp. 565-576
-
-
Miyamoto, Y.1
Maitra, A.2
Ghosh, B.3
-
37
-
-
79953756460
-
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
-
Collisson EA, Sadanandam A, Olson P, et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2012;17:500-3.
-
(2012)
Nat Med
, vol.17
, pp. 500-503
-
-
Collisson, E.A.1
Sadanandam, A.2
Olson, P.3
-
38
-
-
60849121964
-
Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia
-
Badea L, Herlea V, Dima SO, et al. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology 2008;55:2016-27.
-
(2008)
Hepatogastroenterology
, vol.55
, pp. 2016-2027
-
-
Badea, L.1
Herlea, V.2
Dima, S.O.3
-
39
-
-
78650811554
-
A migration signature and plasma biomarker panel for pancreatic adenocarcinoma
-
Balasenthil S, Chen N, Lott ST, et al. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila) 2011;4:137-49.
-
(2011)
Cancer Prev Res (Phila)
, vol.4
, pp. 137-149
-
-
Balasenthil, S.1
Chen, N.2
Lott, S.T.3
-
40
-
-
84863278019
-
Integrative survival-based molecular profiling of human pancreatic cancer
-
Donahue TR, Tran LM, Hill R, et al. Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res 2012;18:1352-63.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1352-1363
-
-
Donahue, T.R.1
Tran, L.M.2
Hill, R.3
-
41
-
-
69249228672
-
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
-
Pei H, Li L, Fridley BL, et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009;16:259-66.
-
(2009)
Cancer Cell
, vol.16
, pp. 259-266
-
-
Pei, H.1
Li, L.2
Fridley, B.L.3
-
42
-
-
84964314145
-
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
-
Schonhuber N, Seidler B, Schuck K, et al. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med 2014;20:1340-7.
-
(2014)
Nat Med
, vol.20
, pp. 1340-1347
-
-
Schonhuber, N.1
Seidler, B.2
Schuck, K.3
-
43
-
-
84908295791
-
Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice
-
Hermann PC, Sancho P, Canamero M, et al. Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice. Gastroenterology 2014;147:1119-33 e4.
-
(2014)
Gastroenterology
, vol.147
, pp. 1119e4-1133e4
-
-
Hermann, P.C.1
Sancho, P.2
Canamero, M.3
-
44
-
-
84895503987
-
Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRasG12V-driven pancreatic tumourigenesis
-
Flandez M, Cendrowski J, Canamero M, et al. Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRasG12V-driven pancreatic tumourigenesis. Gut 2014;63:647-55.
-
(2014)
Gut
, vol.63
, pp. 647-655
-
-
Flandez, M.1
Cendrowski, J.2
Canamero, M.3
-
45
-
-
62949182142
-
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia
-
Shi G, Zhu L, Sun Y, et al. Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology 2009;136:1368-78.
-
(2009)
Gastroenterology
, vol.136
, pp. 1368-1378
-
-
Shi, G.1
Zhu, L.2
Sun, Y.3
-
46
-
-
84895442729
-
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
-
von Figura G, Morris JP, Wright CVE, et al. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut 2014;63:656-64.
-
(2014)
Gut
, vol.63
, pp. 656-664
-
-
Von Figura, G.1
Morris, J.P.2
Wright, C.V.E.3
-
47
-
-
0029027780
-
Developmental biology of the pancreas
-
Slack JM. Developmental biology of the pancreas. Development 1995;121:1569-80.
-
(1995)
Development
, vol.121
, pp. 1569-1580
-
-
Slack, J.M.1
-
48
-
-
16444378654
-
Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
-
Prasad NB, Biankin AV, Fukushima N, et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res 2005;65:1619-26.
-
(2005)
Cancer Res
, vol.65
, pp. 1619-1626
-
-
Prasad, N.B.1
Biankin, A.V.2
Fukushima, N.3
-
49
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-6.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
50
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013;369:1691-703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
-
52
-
-
54349103007
-
Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma
-
Fu B, Luo M, Lakkur S, et al. Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma. Cancer Biol Ther 2008;7:1593-601.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1593-1601
-
-
Fu, B.1
Luo, M.2
Lakkur, S.3
-
53
-
-
44949129758
-
Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer
-
Kwei KA, Bashyam MD, Kao J, et al. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genet 2008;4:e1000081.
-
(2008)
PLoS Genet
, vol.4
, pp. e1000081
-
-
Kwei, K.A.1
Bashyam, M.D.2
Kao, J.3
-
54
-
-
79960470568
-
GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1
-
Zhong Y, Wang Z, Fu B, et al. GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1. PLoS ONE 2011;6:e22129.
-
(2011)
PLoS ONE
, vol.6
, pp. e22129
-
-
Zhong, Y.1
Wang, Z.2
Fu, B.3
-
55
-
-
84903787162
-
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
-
Whissell G, Montagni E, Martinelli P, et al. The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. Nat Cell Biol 2014;16:695-707.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 695-707
-
-
Whissell, G.1
Montagni, E.2
Martinelli, P.3
|