Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia

Gastroenterology

Volumn 145, Issue 5, 2013, Pages

  Greer, Renee L ^a   Staley, Binnaz K ^a   Liou, Angela ^a   Hebrok, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acinar to Ductal Metaplasia; Kras; Pancreatitis; PanIN

Indexed keywords

CELL PROTEIN; CERULETIDE; INTEGRIN; PROTEIN NUMB; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEDIFFERENTIATION; CELL JUNCTION; CELL REGENERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; METAPLASIA; MOUSE; NONHUMAN; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS INJURY; PANCREATITIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 84886803482     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.07.027     Document Type: Article

References (48)

1. R.H. Hruban, M. Goggins, and J. Parsons Progression model for pancreatic cancer Clin Cancer Res 6 2000 2969 2972
2. G. Feldmann, and A. Maitra Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts J Mol Diagn 10 2008 111 122
3. C. Almoguera, D. Shibata, and K. Forrester Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes Cell 53 1988 549 554
4. S.R. Hingorani, E.F. Petricoin, and A. Maitra Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437 450
5. O.J. De La, L.L. Emerson, and J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci U S A 105 2008 18907 18912
6. C. Guerra, A.J. Schuhmacher, and M. Canamero Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice Cancer Cell 11 2007 291 302
7. N. Habbe, G. Shi, and R.A. Meguid Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice Proc Natl Acad Sci U S A 105 2008 18913 18918
8. J.P. Morris IV, D.A. Cano, and S. Sekine Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice J Clin Invest 120 2010 508 520
9. L. Zhu, G. Shi, C.M. Schmidt, and R.H. Hruban Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia Am J Pathol 171 2007 263 273
10. C. Carriere, A.L. Young, and J.R. Gunn Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras Biochem Biophys Res Commun 382 2009 561 565
11. V. Fendrich, F. Esni, and M.V. Garay Hedgehog signaling is required for effective regeneration of exocrine pancreas Gastroenterology 135 2008 621 631
12. O. Strobel, Y. Dor, and J. Alsina In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia Gastroenterology 133 2007 1999 2009
13. J.N. Jensen, E. Cameron, and M.V. Garay Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration Gastroenterology 128 2005 728 741
14. J.T. Siveke, C. Lubeseder-Martellato, and M. Lee Notch signaling is required for exocrine regeneration after acute pancreatitis Gastroenterology 134 2008 544 555
15. M.M. Lerch, M.P. Lutz, and H. Weidenbach Dissociation and reassembly of adherens junctions during experimental acute pancreatitis Gastroenterology 113 1997 1355 1366
16. L. Bombardelli, E.S. Carpenter, and A.P. Wu Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarity Gastroenterology 138 2010 2531 2540 2540 e1-4
17. T. Miyatsuka, H. Kaneto, and T. Shiraiwa Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation Genes Dev 20 2006 1435 1440
18. Y. Miyamoto, A. Maitra, and B. Ghosh Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis Cancer Cell 3 2003 565 576
19. P.H. Petersen, K. Zou, and J.K. Hwang Progenitor cell maintenance requires numb and numblike during mouse neurogenesis Nature 419 2002 929 934
20. P.H. Petersen, K. Zou, and S. Krauss Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis Nat Neurosci 7 2004 803 811
21. W. Zhong, J.N. Feder, and M.M. Jiang Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis Neuron 17 1996 43 53
22. M.A. McGill, and C.J. McGlade Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain J Biol Chem 278 2003 23196 23203
23. M.A. McGill, S.E. Dho, and G. Weinmaster Numb regulates post-endocytic trafficking and degradation of Notch1 J Biol Chem 284 2009 26427 26438
24. C. Kwon, P. Cheng, and I.N. King Notch post-translationally regulates beta-catenin protein in stem and progenitor cells Nat Cell Biol 13 2011 1244 1251
25. Z. Wang, S. Sandiford, and C. Wu Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling EMBO J 28 2009 2360 2373
26. L. Di Marcotullio, E. Ferretti, and A. Greco Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination Nat Cell Biol 8 2006 1415 1423
27. I.N. Colaluca, D. Tosoni, and P. Nuciforo NUMB controls p53 tumour suppressor activity Nature 451 2008 76 80
28. M.R. Rasin, V.R. Gazula, and J.J. Breunig Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors Nat Neurosci 10 2007 819 827
29. T. Nishimura, and K. Kaibuchi Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3 Dev Cell 13 2007 15 28
30. W. Zhong, M.M. Jiang, and M.D. Schonemann Mouse numb is an essential gene involved in cortical neurogenesis Proc Natl Acad Sci U S A 97 2000 6844 6849
31. T. Sugiyama, R.T. Rodriguez, and G.W. McLean Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS Proc Natl Acad Sci U S A 104 2007 175 180
32. Y. Kawaguchi, B. Cooper, and M. Gannon The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors Nat Genet 32 2002 128 134
33. P.W. Heiser, D.A. Cano, and L. Landsman Stabilization of beta-catenin induces pancreas tumor formation Gastroenterology 135 2008 1288 1300
34. D. Kopinke, M. Brailsford, and F.C. Pan Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas Dev Biol 362 2012 57 64
35. E.L. Jackson, N. Willis, and K. Mercer Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras Genes Dev 15 2001 3243 3248
36. H. Pei, L. Li, and B.L. Fridley FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt Cancer Cell 16 2009 259 266
37. D. Segara, A.V. Biankin, and J.G. Kench Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia Clin Cancer Res 11 2005 3587 3596
38. C.D. Logsdon, D.M. Simeone, and C. Binkley Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer Cancer Res 63 2003 2649 2657
39. L. Badea, V. Herlea, and S.O. Dima Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia Hepatogastroenterology 55 2008 2016 2027
40. J.P. I.V. Morris, S.C. Wang, and M. Hebrok KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma Nat Rev Cancer 10 2010 683 695
41. T. Imai, A. Tokunaga, and T. Yoshida The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA Mol Cell Biol 21 2001 3888 3900
42. S. Pece, M. Serresi, and E. Santolini Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis J Cell Biol 167 2004 215 221
43. B.J. Beres, R. George, and E.J. Lougher Numb regulates Notch1, but not Notch3, during myogenesis Mech Dev 128 2011 247 257
44. X. Yang, R. Klein, and X. Tian Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway Dev Biol 269 2004 81 94
45. P.K. Mazur, H. Einwachter, and M. Lee Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma Proc Natl Acad Sci U S A 107 2010 13438 13443
46. E.T. Sawey, J.A. Johnson, and H.C. Crawford Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway Proc Natl Acad Sci U S A 104 2007 19327 19332
47. S.A. Forbes, N. Bindal, and S. Bamford COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer Nucleic Acids Res 39 2010 D945 D950
48. J.N. Jensen, E. Cameron, and M.V. Garay Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration Gastroenterology 128 2005 728 741