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Volumn 18, Issue 3, 2010, Pages 342-356

Cellular Plasticity within the Pancreas— Lessons Learned from Development

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CYTOLOGY; EMBRYONIC STEM CELL; GROWTH, DEVELOPMENT AND AGING; HUMAN; MORPHOGENESIS; MOUSE; PANCREAS; PANCREAS ISLET BETA CELL; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION;

EID: 77949878205     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2010.02.005     Document Type: Review
Times cited : (145)

References (142)
  • 1
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren, U., Jonsson, J., Edlund, H., The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122 (1996), 1409–1416.
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 2
    • 0031260579 scopus 로고    scopus 로고
    • Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    • Apelqvist, A., Ahlgren, U., Edlund, H., Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7 (1997), 801–804.
    • (1997) Curr. Biol. , vol.7 , pp. 801-804
    • Apelqvist, A.1    Ahlgren, U.2    Edlund, H.3
  • 6
    • 52749088737 scopus 로고    scopus 로고
    • HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro
    • Bar, Y., Russ, H.A., Knoller, S., Ouziel-Yahalom, L., Efrat, S., HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes 57 (2008), 2413–2420.
    • (2008) Diabetes , vol.57 , pp. 2413-2420
    • Bar, Y.1    Russ, H.A.2    Knoller, S.3    Ouziel-Yahalom, L.4    Efrat, S.5
  • 8
    • 33645236232 scopus 로고    scopus 로고
    • PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L
    • Beres, T.M., Masui, T., Swift, G.H., Shi, L., Henke, R.M., MacDonald, R.J., PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol. Cell. Biol. 26 (2006), 117–130.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 117-130
    • Beres, T.M.1    Masui, T.2    Swift, G.H.3    Shi, L.4    Henke, R.M.5    MacDonald, R.J.6
  • 9
    • 0035694459 scopus 로고    scopus 로고
    • Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    • Bhushan, A., Itoh, N., Kato, S., Thiery, J.P., Czernichow, P., Bellusci, S., Scharfmann, R., Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128 (2001), 5109–5117.
    • (2001) Development , vol.128 , pp. 5109-5117
    • Bhushan, A.1    Itoh, N.2    Kato, S.3    Thiery, J.P.4    Czernichow, P.5    Bellusci, S.6    Scharfmann, R.7
  • 11
    • 62949210744 scopus 로고    scopus 로고
    • Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells
    • Borowiak, M., Maehr, R., Chen, S., Chen, A.E., Tang, W., Fox, J.L., Schreiber, S.L., Melton, D.A., Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 (2009), 348–358.
    • (2009) Cell Stem Cell , vol.4 , pp. 348-358
    • Borowiak, M.1    Maehr, R.2    Chen, S.3    Chen, A.E.4    Tang, W.5    Fox, J.L.6    Schreiber, S.L.7    Melton, D.A.8
  • 12
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort, R., Martinez-Barbera, J.P., Beddington, R.S., Zaret, K.S., Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131 (2004), 797–806.
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 13
    • 33845540482 scopus 로고    scopus 로고
    • Pancreatic islet production of vascular endothelial growth factor—a is essential for islet vascularization, revascularization, and function
    • Brissova, M., Shostak, A., Shiota, M., Wiebe, P.O., Poffenberger, G., Kantz, J., Chen, Z., Carr, C., Jerome, W.G., Chen, J., et al. Pancreatic islet production of vascular endothelial growth factor—a is essential for islet vascularization, revascularization, and function. Diabetes 55 (2006), 2974–2985.
    • (2006) Diabetes , vol.55 , pp. 2974-2985
    • Brissova, M.1    Shostak, A.2    Shiota, M.3    Wiebe, P.O.4    Poffenberger, G.5    Kantz, J.6    Chen, Z.7    Carr, C.8    Jerome, W.G.9    Chen, J.10
  • 15
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    • Carriere, C., Young, A.L., Gunn, J.R., Longnecker, D.S., Korc, M., Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem. Biophys. Res. Commun. 82 (2009), 561–565.
    • (2009) Biochem. Biophys. Res. Commun. , vol.82 , pp. 561-565
    • Carriere, C.1    Young, A.L.2    Gunn, J.R.3    Longnecker, D.S.4    Korc, M.5
  • 16
    • 65249093055 scopus 로고    scopus 로고
    • Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    • Chen, H., Gu, X., Su, I.H., Bottino, R., Contreras, J.L., Tarakhovsky, A., Kim, S.K., Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev. 23 (2009), 975–985.
    • (2009) Genes Dev. , vol.23 , pp. 975-985
    • Chen, H.1    Gu, X.2    Su, I.H.3    Bottino, R.4    Contreras, J.L.5    Tarakhovsky, A.6    Kim, S.K.7
  • 17
    • 55549098894 scopus 로고    scopus 로고
    • Bmp2 signaling regulates the hepatic versus pancreatic fate decision
    • Chung, W.S., Shin, C.H., Stainier, D.Y., Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Dev. Cell 15 (2008), 738–748.
    • (2008) Dev. Cell , vol.15 , pp. 738-748
    • Chung, W.S.1    Shin, C.H.2    Stainier, D.Y.3
  • 24
    • 0035072545 scopus 로고    scopus 로고
    • A bipotential precursor population for pancreas and liver within the embryonic endoderm
    • Deutsch, G., Jung, J., Zheng, M., Lóra, J., Zaret, K.S., A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128 (2001), 871–881.
    • (2001) Development , vol.128 , pp. 871-881
    • Deutsch, G.1    Jung, J.2    Zheng, M.3    Lóra, J.4    Zaret, K.S.5
  • 25
    • 65249121864 scopus 로고    scopus 로고
    • Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
    • Dhawan, S., Tschen, S.I., Bhushan, A., Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 23 (2009), 906–911.
    • (2009) Genes Dev. , vol.23 , pp. 906-911
    • Dhawan, S.1    Tschen, S.I.2    Bhushan, A.3
  • 26
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O.I., Melton, D.A., Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 (2004), 41–46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 29
    • 55549101898 scopus 로고    scopus 로고
    • Origin of pancreatic endocrine cells from biliary duct epithelium
    • Eberhard, D., Tosh, D., Slack, J.M., Origin of pancreatic endocrine cells from biliary duct epithelium. Cell. Mol. Life Sci. 65 (2008), 3467–3480.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3467-3480
    • Eberhard, D.1    Tosh, D.2    Slack, J.M.3
  • 30
    • 16844375322 scopus 로고    scopus 로고
    • Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme
    • Edsbagge, J., Johansson, J.K., Esni, F., Luo, Y., Radice, G.L., Semb, H., Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development 132 (2005), 1085–1092.
    • (2005) Development , vol.132 , pp. 1085-1092
    • Edsbagge, J.1    Johansson, J.K.2    Esni, F.3    Luo, Y.4    Radice, G.L.5    Semb, H.6
  • 34
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    • Gao, R., Ustinov, J., Pulkkinen, M.A., Lundin, K., Korsgren, O., Otonkoski, T., Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52 (2003), 2007–2015.
    • (2003) Diabetes , vol.52 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.A.3    Lundin, K.4    Korsgren, O.5    Otonkoski, T.6
  • 35
    • 58049204234 scopus 로고    scopus 로고
    • Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    • Gao, N., LeLay, J., Vatamaniuk, M.Z., Rieck, S., Friedman, J.R., Kaestner, K.H., Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 22 (2008), 3435–3448.
    • (2008) Genes Dev. , vol.22 , pp. 3435-3448
    • Gao, N.1    LeLay, J.2    Vatamaniuk, M.Z.3    Rieck, S.4    Friedman, J.R.5    Kaestner, K.H.6
  • 36
    • 0033954474 scopus 로고    scopus 로고
    • Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
    • Garcia-Ocaña, A., Takane, K.K., Syed, M.A., Philbrick, W.M., Vasavada, R.C., Stewart, A.F., Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J. Biol. Chem. 275 (2000), 1226–1232.
    • (2000) J. Biol. Chem. , vol.275 , pp. 1226-1232
    • Garcia-Ocaña, A.1    Takane, K.K.2    Syed, M.A.3    Philbrick, W.M.4    Vasavada, R.C.5    Stewart, A.F.6
  • 38
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia, S., Bhushan, A., Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J. Clin. Invest. 114 (2004), 963–968.
    • (2004) J. Clin. Invest. , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 39
    • 33845513370 scopus 로고    scopus 로고
    • p27 Regulates the transition of beta-cells from quiescence to proliferation
    • Georgia, S., Bhushan, A., p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes 55 (2006), 2950–2956.
    • (2006) Diabetes , vol.55 , pp. 2950-2956
    • Georgia, S.1    Bhushan, A.2
  • 40
    • 58549093915 scopus 로고    scopus 로고
    • Developmental biology of the pancreas: a comprehensive review
    • Gittes, G.K., Developmental biology of the pancreas: a comprehensive review. Dev. Biol. 326 (2009), 4–35.
    • (2009) Dev. Biol. , vol.326 , pp. 4-35
    • Gittes, G.K.1
  • 41
    • 0030041280 scopus 로고    scopus 로고
    • Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors
    • Gittes, G.K., Galante, P.E., Hanahan, D., Rutter, W.J., Debase, H.T., Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development 122 (1996), 439–447.
    • (1996) Development , vol.122 , pp. 439-447
    • Gittes, G.K.1    Galante, P.E.2    Hanahan, D.3    Rutter, W.J.4    Debase, H.T.5
  • 42
    • 0034652287 scopus 로고    scopus 로고
    • neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl, G., Dierich, A., LeMeur, M., Guillemot, F., neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97 (2000), 1607–1611.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 44
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu, G., Dubauskaite, J., Melton, D.A., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129 (2002), 2447–2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 47
    • 0042665560 scopus 로고    scopus 로고
    • Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
    • Hald, J., Hjorth, J.P., German, M.S., Madsen, O.D., Serup, P., Jensen, J., Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260 (2003), 426–437.
    • (2003) Dev. Biol. , vol.260 , pp. 426-437
    • Hald, J.1    Hjorth, J.P.2    German, M.S.3    Madsen, O.D.4    Serup, P.5    Jensen, J.6
  • 48
    • 0141593480 scopus 로고    scopus 로고
    • Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    • Hart, A., Papadopoulou, S., Edlund, H., Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev. Dyn. 228 (2003), 185–193.
    • (2003) Dev. Dyn. , vol.228 , pp. 185-193
    • Hart, A.1    Papadopoulou, S.2    Edlund, H.3
  • 49
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok, M., Kim, S.K., Melton, D.A., Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12 (1998), 1705–1713.
    • (1998) Genes Dev. , vol.12 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 51
  • 52
    • 0036842027 scopus 로고    scopus 로고
    • Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation
    • Heller, R.S., Dichmann, D.S., Jensen, J., Miller, C., Wong, G., Madsen, O.D., Serup, P., Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev. Dyn. 225 (2002), 260–270.
    • (2002) Dev. Dyn. , vol.225 , pp. 260-270
    • Heller, R.S.1    Dichmann, D.S.2    Jensen, J.3    Miller, C.4    Wong, G.5    Madsen, O.D.6    Serup, P.7
  • 53
    • 0037191099 scopus 로고    scopus 로고
    • Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
    • Heremans, Y., Van De Casteele, M., Veld, P., Gradwohl, G., Serup, P., Madsen, O., Pipeleers, D., Heimberg, H., Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J. Cell Biol. 159 (2002), 303–312.
    • (2002) J. Cell Biol. , vol.159 , pp. 303-312
    • Heremans, Y.1    Van De Casteele, M.2    Veld, P.3    Gradwohl, G.4    Serup, P.5    Madsen, O.6    Pipeleers, D.7    Heimberg, H.8
  • 55
    • 30544438811 scopus 로고    scopus 로고
    • An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
    • Jacquemin, P., Yoshitomi, H., Kashima, Y., Rousseau, G.G., Lemaigre, F.P., Zaret, K.S., An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev. Biol. 290 (2006), 189–199.
    • (2006) Dev. Biol. , vol.290 , pp. 189-199
    • Jacquemin, P.1    Yoshitomi, H.2    Kashima, Y.3    Rousseau, G.G.4    Lemaigre, F.P.5    Zaret, K.S.6
  • 58
    • 15744400264 scopus 로고    scopus 로고
    • Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    • Jensen, J.N., Cameron, E., Garay, M.V., Starkey, T.W., Gianani, R., Jensen, J., Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 128 (2005), 728–741.
    • (2005) Gastroenterology , vol.128 , pp. 728-741
    • Jensen, J.N.1    Cameron, E.2    Garay, M.V.3    Starkey, T.W.4    Gianani, R.5    Jensen, J.6
  • 59
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson, K.A., Dursun, U., Jordan, N., Gu, G., Beermann, F., Gradwohl, G., Grapin-Botton, A., Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev. Cell 12 (2007), 457–465.
    • (2007) Dev. Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3    Gu, G.4    Beermann, F.5    Gradwohl, G.6    Grapin-Botton, A.7
  • 60
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson, J., Carlsson, L., Edlund, T., Edlund, H., Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371 (1994), 606–609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 61
    • 15944417831 scopus 로고    scopus 로고
    • PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    • Kaneto, H., Nakatani, Y., Miyatsuka, T., Matsuoka, T.A., Matsuhisa, M., Hori, M., Yamasaki, Y., PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 54 (2005), 1009–1022.
    • (2005) Diabetes , vol.54 , pp. 1009-1022
    • Kaneto, H.1    Nakatani, Y.2    Miyatsuka, T.3    Matsuoka, T.A.4    Matsuhisa, M.5    Hori, M.6    Yamasaki, Y.7
  • 62
    • 38449099624 scopus 로고    scopus 로고
    • Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    • Karnik, S.K., Chen, H., McLean, G.W., Heit, J.J., Gu, X., Zhang, A.Y., Fontaine, M., Yen, M.H., Kim, S.K., Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318 (2007), 806–809.
    • (2007) Science , vol.318 , pp. 806-809
    • Karnik, S.K.1    Chen, H.2    McLean, G.W.3    Heit, J.J.4    Gu, X.5    Zhang, A.Y.6    Fontaine, M.7    Yen, M.H.8    Kim, S.K.9
  • 63
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R.J., Wright, C.V., The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32 (2002), 128–134.
    • (2002) Nat. Genet. , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.6
  • 64
    • 0032573227 scopus 로고    scopus 로고
    • Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
    • Kim, S.K., Melton, D.A., Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA 95 (1998), 13036–13041.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13036-13041
    • Kim, S.K.1    Melton, D.A.2
  • 66
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L., NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med. 9 (2003), 596–603.
    • (2003) Nat. Med. , vol.9 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3    Younan, P.4    Imaeda, H.5    Maeda, M.6    Chan, L.7
  • 67
    • 0032417268 scopus 로고    scopus 로고
    • The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
    • Krapp, A., Knöfler, M., Ledermann, B., Bürki, K., Berney, C., Zoerkler, N., Hagenbüchle, O., Wellauer, P.K., The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12 (1998), 3752–3763.
    • (1998) Genes Dev. , vol.12 , pp. 3752-3763
    • Krapp, A.1    Knöfler, M.2    Ledermann, B.3    Bürki, K.4    Berney, C.5    Zoerkler, N.6    Hagenbüchle, O.7    Wellauer, P.K.8
  • 70
    • 0037706944 scopus 로고    scopus 로고
    • Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
    • Kumar, M., Jordan, N., Melton, D., Grapin-Botton, A., Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev. Biol. 259 (2003), 109–122.
    • (2003) Dev. Biol. , vol.259 , pp. 109-122
    • Kumar, M.1    Jordan, N.2    Melton, D.3    Grapin-Botton, A.4
  • 72
    • 0034212390 scopus 로고    scopus 로고
    • Notch gene expression during pancreatic organogenesis
    • Lammert, E., Brown, J., Melton, D.A., Notch gene expression during pancreatic organogenesis. Mech. Dev. 94 (2000), 199–203.
    • (2000) Mech. Dev. , vol.94 , pp. 199-203
    • Lammert, E.1    Brown, J.2    Melton, D.A.3
  • 73
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert, E., Cleaver, O., Melton, D., Induction of pancreatic differentiation by signals from blood vessels. Science 294 (2001), 564–567.
    • (2001) Science , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 78
    • 0041970072 scopus 로고    scopus 로고
    • Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
    • Matsuoka, T.A., Zhao, L., Artner, I., Jarrett, H.W., Friedman, D., Means, A., Stein, R., Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol. Cell. Biol. 23 (2003), 6049–6062.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6049-6062
    • Matsuoka, T.A.1    Zhao, L.2    Artner, I.3    Jarrett, H.W.4    Friedman, D.5    Means, A.6    Stein, R.7
  • 79
    • 24944441782 scopus 로고    scopus 로고
    • Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    • Means, A.L., Meszoely, I.M., Suzuki, K., Miyamoto, Y., Rustgi, A.K., Coffey, R.J. Jr., Wright, C.V., Stoffers, D.A., Leach, S.D., Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development 132 (2005), 3767–3776.
    • (2005) Development , vol.132 , pp. 3767-3776
    • Means, A.L.1    Meszoely, I.M.2    Suzuki, K.3    Miyamoto, Y.4    Rustgi, A.K.5    Coffey, R.J.6    Wright, C.V.7    Stoffers, D.A.8    Leach, S.D.9
  • 81
    • 0031916664 scopus 로고    scopus 로고
    • Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development
    • Miralles, F., Czernichow, P., Scharfmann, R., Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125 (1998), 1017–1024.
    • (1998) Development , vol.125 , pp. 1017-1024
    • Miralles, F.1    Czernichow, P.2    Scharfmann, R.3
  • 85
    • 16244406880 scopus 로고    scopus 로고
    • Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
    • Molotkov, A., Molotkova, N., Duester, G., Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev. Dyn. 232 (2005), 950–957.
    • (2005) Dev. Dyn. , vol.232 , pp. 950-957
    • Molotkov, A.1    Molotkova, N.2    Duester, G.3
  • 86
    • 76649105065 scopus 로고    scopus 로고
    • Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • Morris, J.P., Cano, D.A., Sekine, S., Wang, S.C., Hebrok, M., Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J. Clin. Invest. 120 (2010), 508–520.
    • (2010) J. Clin. Invest. , vol.120 , pp. 508-520
    • Morris, J.P.1    Cano, D.A.2    Sekine, S.3    Wang, S.C.4    Hebrok, M.5
  • 87
    • 74049139927 scopus 로고    scopus 로고
    • Preparing for the first breath: genetic and cellular mechanisms in the development of the vertebrate respiratory system
    • Morrisey, E.E., Hogan, B.L.M., Preparing for the first breath: genetic and cellular mechanisms in the development of the vertebrate respiratory system. Dev. Cell 18 (2010), 8–23.
    • (2010) Dev. Cell , vol.18 , pp. 8-23
    • Morrisey, E.E.1    Hogan, B.L.M.2
  • 88
    • 45849093670 scopus 로고    scopus 로고
    • The what, where, when and how of Wnt/beta-catenin signaling in pancreas development
    • Murtaugh, L.C., The what, where, when and how of Wnt/beta-catenin signaling in pancreas development. Organogenesis 4 (2008), 81–86.
    • (2008) Organogenesis , vol.4 , pp. 81-86
    • Murtaugh, L.C.1
  • 89
  • 92
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by beta cell regeneration
    • Nir, T., Melton, D.A., Dor, Y., Recovery from diabetes in mice by beta cell regeneration. J. Clin. Invest. 117 (2007), 2553–2561.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 94
    • 0344063697 scopus 로고    scopus 로고
    • FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
    • Norgaard, G.A., Jensen, J.N., Jensen, J., FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev. Biol. 264 (2003), 323–338.
    • (2003) Dev. Biol. , vol.264 , pp. 323-338
    • Norgaard, G.A.1    Jensen, J.N.2    Jensen, J.3
  • 95
    • 70449625611 scopus 로고    scopus 로고
    • New strategies to generate induced pluripotent stem cells
    • O'Malley, J., Woltjen, K., Kaji, K., New strategies to generate induced pluripotent stem cells. Curr. Opin. Biotechnol. 20 (2009), 516–521.
    • (2009) Curr. Opin. Biotechnol. , vol.20 , pp. 516-521
    • O'Malley, J.1    Woltjen, K.2    Kaji, K.3
  • 97
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson, H., Karlsson, K., Edlund, T., IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12 (1993), 4251–4259.
    • (1993) EMBO J. , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 100
    • 0026573783 scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
    • Parsons, J.A., Brelje, T.C., Sorenson, R.L., Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130 (1992), 1459–1466.
    • (1992) Endocrinology , vol.130 , pp. 1459-1466
    • Parsons, J.A.1    Brelje, T.C.2    Sorenson, R.L.3
  • 102
    • 0033602021 scopus 로고    scopus 로고
    • Analysis of pancreatic development using a cell lineage label
    • Percival, A.C., Slack, J.M., Analysis of pancreatic development using a cell lineage label. Exp. Cell Res. 247 (1999), 123–132.
    • (1999) Exp. Cell Res. , vol.247 , pp. 123-132
    • Percival, A.C.1    Slack, J.M.2
  • 103
    • 34249322654 scopus 로고    scopus 로고
    • Dynamics of embryonic pancreas development using real-time imaging
    • Puri, S., Hebrok, M., Dynamics of embryonic pancreas development using real-time imaging. Dev. Biol. 306 (2007), 82–93.
    • (2007) Dev. Biol. , vol.306 , pp. 82-93
    • Puri, S.1    Hebrok, M.2
  • 104
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
    • Ramiya, V.K., Maraist, M., Arfors, K.E., Schatz, D.A., Peck, A.B., Cornelius, J.G., Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat. Med. 6 (2000), 278–282.
    • (2000) Nat. Med. , vol.6 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3    Schatz, D.A.4    Peck, A.B.5    Cornelius, J.G.6
  • 105
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane, S.G., Dubus, P., Mettus, R.V., Galbreath, E.J., Boden, G., Reddy, E.P., Barbacid, M., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat. Genet. 22 (1999), 44–52.
    • (1999) Nat. Genet. , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 106
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • Rankin, M.M., Kushner, J.A., Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58 (2009), 1365–1372.
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 107
    • 0024354234 scopus 로고
    • Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment
    • Rao, M.S., Dwivedi, R.S., Yeldandi, A.V., Subbarao, V., Tan, X.D., Usman, M.I., Thangada, S., Nemali, M.R., Kumar, S., Scarpelli, D.G., et al. Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment. Am. J. Pathol. 134 (1989), 1069–1086.
    • (1989) Am. J. Pathol. , vol.134 , pp. 1069-1086
    • Rao, M.S.1    Dwivedi, R.S.2    Yeldandi, A.V.3    Subbarao, V.4    Tan, X.D.5    Usman, M.I.6    Thangada, S.7    Nemali, M.R.8    Kumar, S.9    Scarpelli, D.G.10
  • 108
    • 0035423751 scopus 로고    scopus 로고
    • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
    • Rossi, J.M., Dunn, N.R., Hogan, B.L., Zaret, K.S., Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 15 (2001), 1998–2009.
    • (2001) Genes Dev. , vol.15 , pp. 1998-2009
    • Rossi, J.M.1    Dunn, N.R.2    Hogan, B.L.3    Zaret, K.S.4
  • 113
    • 58149511982 scopus 로고    scopus 로고
    • Four-dimensional realistic modeling of pancreatic organogenesis
    • Setty, Y., Cohen, I.R., Dor, Y., Harel, D., Four-dimensional realistic modeling of pancreatic organogenesis. Proc. Natl. Acad. Sci. USA 105 (2008), 20374–20379.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20374-20379
    • Setty, Y.1    Cohen, I.R.2    Dor, Y.3    Harel, D.4
  • 115
    • 53649102798 scopus 로고    scopus 로고
    • A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    • Seymour, P.A., Freude, K.K., Dubois, C.L., Shih, H.P., Patel, N.A., Sander, M., A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev. Biol. 323 (2008), 19–30.
    • (2008) Dev. Biol. , vol.323 , pp. 19-30
    • Seymour, P.A.1    Freude, K.K.2    Dubois, C.L.3    Shih, H.P.4    Patel, N.A.5    Sander, M.6
  • 120
    • 0031253820 scopus 로고    scopus 로고
    • Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
    • Stoffers, D.A., Ferrer, J., Clarke, W.L., Habener, J.F., Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat. Genet. 17 (1997), 138–139.
    • (1997) Nat. Genet. , vol.17 , pp. 138-139
    • Stoffers, D.A.1    Ferrer, J.2    Clarke, W.L.3    Habener, J.F.4
  • 122
    • 0031843386 scopus 로고    scopus 로고
    • Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    • Sussel, L., Kalamaras, J., Hartigan-O'Connor, D.J., Meneses, J.J., Pedersen, R.A., Rubenstein, J.L., German, M.S., Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125 (1998), 2213–2221.
    • (1998) Development , vol.125 , pp. 2213-2221
    • Sussel, L.1    Kalamaras, J.2    Hartigan-O'Connor, D.J.3    Meneses, J.J.4    Pedersen, R.A.5    Rubenstein, J.L.6    German, M.S.7
  • 123
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006), 663–676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 124
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007), 861–872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 126
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta, M., Rankin, M.M., Long, S.Y., Stein, G.M., Kushner, J.A., Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev. Cell 12 (2007), 817–826.
    • (2007) Dev. Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 127
    • 14844333138 scopus 로고    scopus 로고
    • Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues
    • Tremblay, K.D., Zaret, K.S., Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev. Biol. 280 (2005), 87–99.
    • (2005) Dev. Biol. , vol.280 , pp. 87-99
    • Tremblay, K.D.1    Zaret, K.S.2
  • 128
    • 66649084335 scopus 로고    scopus 로고
    • Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice
    • Tschen, S.I., Dhawan, S., Gurlo, T., Bhushan, A., Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 58 (2009), 1312–1320.
    • (2009) Diabetes , vol.58 , pp. 1312-1320
    • Tschen, S.I.1    Dhawan, S.2    Gurlo, T.3    Bhushan, A.4
  • 129
    • 0034686028 scopus 로고    scopus 로고
    • Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia
    • Vasavada, R.C., Garcia-Ocaña, A., Zawalich, W.S., Sorenson, R.L., Dann, P., Syed, M., Ogren, L., Talamantes, F., Stewart, A.F., Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J. Biol. Chem. 275 (2000), 15399–15406.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15399-15406
    • Vasavada, R.C.1    Garcia-Ocaña, A.2    Zawalich, W.S.3    Sorenson, R.L.4    Dann, P.5    Syed, M.6    Ogren, L.7    Talamantes, F.8    Stewart, A.F.9
  • 130
    • 67649995217 scopus 로고    scopus 로고
    • Dynamic signaling network for the specification of embryonic pancreas and liver progenitors
    • Wandzioch, E., Zaret, K.S., Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science 324 (2009), 1707–1710.
    • (2009) Science , vol.324 , pp. 1707-1710
    • Wandzioch, E.1    Zaret, K.S.2
  • 131
    • 33846316025 scopus 로고    scopus 로고
    • Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver
    • Wang, A.Y., Ehrhardt, A., Xu, H., Kay, M.A., Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol. Ther. 15 (2007), 255–263.
    • (2007) Mol. Ther. , vol.15 , pp. 255-263
    • Wang, A.Y.1    Ehrhardt, A.2    Xu, H.3    Kay, M.A.4
  • 134
    • 70350330155 scopus 로고    scopus 로고
    • Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes
    • Weir, G.C., Marselli, L., Marchetti, P., Katsuta, H., Jung, M.H., Bonner-Weir, S., Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes. Metab. 11:Suppl 4 (2009), 82–90.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 82-90
    • Weir, G.C.1    Marselli, L.2    Marchetti, P.3    Katsuta, H.4    Jung, M.H.5    Bonner-Weir, S.6
  • 135
    • 0034093614 scopus 로고    scopus 로고
    • Early mouse endoderm is patterned by soluble factors from adjacent germ layers
    • Wells, J.M., Melton, D.A., Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 127 (2000), 1563–1572.
    • (2000) Development , vol.127 , pp. 1563-1572
    • Wells, J.M.1    Melton, D.A.2
  • 136
    • 62349089109 scopus 로고    scopus 로고
    • Pancreatic cancer: translating lessons from mouse models and hereditary syndromes
    • Wescott, M.P., Rustgi, A.K., Pancreatic cancer: translating lessons from mouse models and hereditary syndromes. Cancer Prev. Res. 1 (2008), 503–506.
    • (2008) Cancer Prev. Res. , vol.1 , pp. 503-506
    • Wescott, M.P.1    Rustgi, A.K.2
  • 137
    • 0037213587 scopus 로고    scopus 로고
    • Gene expression cascades in pancreatic development
    • Wilson, M.E., Scheel, D., German, M.S., Gene expression cascades in pancreatic development. Mech. Dev. 120 (2003), 65–80.
    • (2003) Mech. Dev. , vol.120 , pp. 65-80
    • Wilson, M.E.1    Scheel, D.2    German, M.S.3
  • 139
    • 61749094740 scopus 로고    scopus 로고
    • Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    • Yechoor, V., Liu, V., Espiritu, C., Paul, A., Oka, K., Kojima, H., Chan, L., Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 16 (2009), 358–373.
    • (2009) Dev. Cell , vol.16 , pp. 358-373
    • Yechoor, V.1    Liu, V.2    Espiritu, C.3    Paul, A.4    Oka, K.5    Kojima, H.6    Chan, L.7
  • 140
    • 1342263524 scopus 로고    scopus 로고
    • Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    • Yoshitomi, H., Zaret, K.S., Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131 (2004), 807–817.
    • (2004) Development , vol.131 , pp. 807-817
    • Yoshitomi, H.1    Zaret, K.S.2
  • 142
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., Melton, D.A., In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455 (2008), 627–632.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5


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