Deficiency of neuronal p38α MAPK attenuates amyloid pathology in Alzheimer disease mouse and cell models through facilitating lysosomal degradation of BACE1

Journal of Biological Chemistry

Volumn 291, Issue 5, 2016, Pages 2067-2079

  Schnöder, Laura ^a   Hao, Wenlin ^a   Qin, Yiren ^a   Liu, Shirong ^b   Tomic, Inge ^a   Liu, Xu ^a   Fassbender, Klaus ^a   Liu, Yang ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BRAIN; CELLS; ENZYMES; GENE EXPRESSION; GLYCOPROTEINS; MAMMALS; NEURODEGENERATIVE DISEASES; NEURONS; PROTEINS;

ALZHEIMER AMYLOID; ALZHEIMER DISEASE; BIOCHEMICAL METHODS; DOMINANT NEGATIVE; LYSOSOMAL DEGRADATION; NEUROINFLAMMATION; SH SY5Y CELLS; TRANSGENIC MICE;

CYTOLOGY;

AMYLOID PROTEIN; BETA SECRETASE; BETA SECRETASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; AMYLOID; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE P38; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BACE1 GENE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; GENE; HIPPOCAMPUS; LYSOSOME; MAPK14 GENE; MOUSE; NEOCORTEX; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; UPREGULATION; ANIMAL; BRAIN; DISEASE MODEL; GENE VECTOR; HUMAN; INFLAMMATION; METABOLISM; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BIOLOGICAL TRANSPORT; BRAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GENETIC VECTORS; HUMANS; INFLAMMATION; LYSOSOMES; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84957035183     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.695916     Document Type: Article

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