An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

EMBO Molecular Medicine

Volumn 7, Issue 2, 2015, Pages 175-189

  Kizuka, Yasuhiko ^a   Kitazume, Shinobu ^a   Fujinawa, Reiko ^a   Saito, Takashi ^b   Iwata, Nobuhisa ^b,c   Saido, Takaomi C ^b   Nakano, Miyako ^d   Yamaguchi, Yoshiki ^a   Hashimoto, Yasuhiro ^e   Staufenbiel, Matthias ^f   Hatsuta, Hiroyuki ^g   Murayama, Shigeo ^g   Manya, Hiroshi ^g   Endo, Tamao ^g   Taniguchi, Naoyuki ^a  

^a RIKEN   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^f NOVARTIS PHARMA AG   (Switzerland)

^g Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Alzheimer's disease (AD); Amyloid (A ); BACE1; Bisecting GlcNAc; GnT III (Mgat3)

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AXONIN 1; BETA SECRETASE 1; N ACETYLGLUCOSAMINE; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; COGNITION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENDOSOME; FEMALE; GLYCOSYLATION; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN TARGETING; ANIMAL; C57BL MOUSE; DEFICIENCY; ENZYMOLOGY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PROTEIN TRANSPORT;

ACETYLGLUCOSAMINE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; FEMALE; GLYCOSYLATION; HUMANS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN TRANSPORT;

EID: 84922016893     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404438     Document Type: Article

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