메뉴 건너뛰기




Volumn 22, Issue 5, 2015, Pages 325-330

Hypothalamic inflammation and gliosis in obesity

Author keywords

gliosis; hypothalamus; inflammation; obesity

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; GLUCOSE;

EID: 84955476784     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0000000000000182     Document Type: Review
Times cited : (115)

References (78)
  • 1
    • 84891919414 scopus 로고    scopus 로고
    • Long-Term drug treatment for obesity: A systematic and clinical review
    • Yanovski SZ, Yanovski JA. Long-Term drug treatment for obesity: a systematic and clinical review. JAMA 2014; 311:74-86.
    • (2014) JAMA , vol.311 , pp. 74-86
    • Yanovski, S.Z.1    Yanovski, J.A.2
  • 2
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature 2000; 404:661-671.
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1    Woods, S.C.2    Porte, D.3
  • 3
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • Morton GJ, Cummings DE, Baskin DG, et al. Central nervous system control of food intake and body weight. Nature 2006; 443:289-295.
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3
  • 4
    • 0342833463 scopus 로고
    • Influence of body weight and body fat on appetite of normal lean and obese rats
    • Cohn C, Joseph D. Influence of body weight and body fat on appetite of normal lean and obese rats. Yale J Biol Med 1962; 34:598-607.
    • (1962) Yale J Biol Med , vol.34 , pp. 598-607
    • Cohn, C.1    Joseph, D.2
  • 5
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334:292-295.
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 6
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza CT, Araujo EP, Bordin S, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005; 146:4192-4199.
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3
  • 7
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-Alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-Alpha in human obesity and insulin resistance. J Clin Invest 1995; 95:2409-2415.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3
  • 8
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121:2111-2117.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 9
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell 2015; 161:146-160.
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 10
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • Milanski M, Degasperi G, Coope A, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 2009; 29:359-370.
    • (2009) J Neurosci , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3
  • 11
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • Posey KA, Clegg DJ, Printz RL, et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 2009; 296:E1003-E1012.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E1003-E1012
    • Posey, K.A.1    Clegg, D.J.2    Printz, R.L.3
  • 12
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity
    • Kleinridders A, Schenten D, Könner AC, et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity. Cell Metab 2009; 10:249-259.
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Könner, A.C.3
  • 13
    • 77950216899 scopus 로고    scopus 로고
    • Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
    • Grayson BE, Levasseur PR, Williams SM, et al. Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 2010; 151:1622-1632.
    • (2010) Endocrinology , vol.151 , pp. 1622-1632
    • Grayson, B.E.1    Levasseur, P.R.2    Williams, S.M.3
  • 14
    • 84919674550 scopus 로고    scopus 로고
    • Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ER alpha
    • Morselli E, Fuente-Martin E, Finan B, et al. Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ER alpha. Cell Rep 2014; 9:633-645.
    • (2014) Cell Rep , vol.9 , pp. 633-645
    • Morselli, E.1    Fuente-Martin, E.2    Finan, B.3
  • 15
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • Valdearcos M, Robblee MM, Benjamin DI, et al. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep 2014; 9:2124-2138.
    • (2014) Cell Rep , vol.9 , pp. 2124-2138
    • Valdearcos, M.1    Robblee, M.M.2    Benjamin, D.I.3
  • 16
    • 84907546285 scopus 로고    scopus 로고
    • IKKepsilon is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity
    • Weissmann L, Quaresma PG, Santos AC, et al. IKKepsilon is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes 2014; 63:3334-3345.
    • (2014) Diabetes , vol.63 , pp. 3334-3345
    • Weissmann, L.1    Quaresma, P.G.2    Santos, A.C.3
  • 17
    • 84891824510 scopus 로고    scopus 로고
    • The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats
    • Maric T, Woodside B, Luheshi GN. The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats. Brain Behav Immun 2014; 36:35-45.
    • (2014) Brain Behav Immun , vol.36 , pp. 35-45
    • Maric, T.1    Woodside, B.2    Luheshi, G.N.3
  • 18
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • Thaler JP, Yi CX, Schur EA, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 2012; 122:153-162.
    • (2012) J Clin Invest , vol.122 , pp. 153-162
    • Thaler, J.P.1    Yi, C.X.2    Schur, E.A.3
  • 19
    • 84924045774 scopus 로고    scopus 로고
    • Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-Term
    • Ziko I, De Luca S, Dinan T, et al. Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-Term. Brain Behav Immun 2014; 41:32-43.
    • (2014) Brain Behav Immun , vol.41 , pp. 32-43
    • Ziko, I.1    De Luca, S.2    Dinan, T.3
  • 20
    • 84927539363 scopus 로고    scopus 로고
    • Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins
    • Wee YS, Weis JJ, Gahring LC, et al. Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins. PloS One 2015; 10:e0123218.
    • (2015) PloS One , vol.10 , pp. e0123218
    • Wee, Y.S.1    Weis, J.J.2    Gahring, L.C.3
  • 21
    • 84886684378 scopus 로고    scopus 로고
    • CNS inflammation and bone marrow neuropathy in type 1 diabetes
    • Hu P, Thinschmidt JS, Yan Y, et al. CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol 2013; 183:1608-1620.
    • (2013) Am J Pathol , vol.183 , pp. 1608-1620
    • Hu, P.1    Thinschmidt, J.S.2    Yan, Y.3
  • 22
    • 84929625899 scopus 로고    scopus 로고
    • Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice
    • Hu P, Thinschmidt JS, Caballero S, et al. Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. Am J Physiol Endocrinol Metab 2015; 308:E688-E698.
    • (2015) Am J Physiol Endocrinol Metab , vol.308 , pp. E688-E698
    • Hu, P.1    Thinschmidt, J.S.2    Caballero, S.3
  • 23
    • 84917743669 scopus 로고    scopus 로고
    • Obesity induces neuroinflammation mediated by altered expression of the renin-Angiotensin system in mouse forebrain nuclei
    • de Kloet AD, Pioquinto DJ, Nguyen D, et al. Obesity induces neuroinflammation mediated by altered expression of the renin-Angiotensin system in mouse forebrain nuclei. Physiol Behav 2014; 136:31-38.
    • (2014) Physiol Behav , vol.136 , pp. 31-38
    • De Kloet, A.D.1    Pioquinto, D.J.2    Nguyen, D.3
  • 24
    • 84920644057 scopus 로고    scopus 로고
    • Morphological changes in glial fibrillary acidic protein immunopositive astrocytes in the hippocampus of dietary-induced obese mice
    • Cano V, Valladolid-Acebes I, Hernandez-Nuno F, et al. Morphological changes in glial fibrillary acidic protein immunopositive astrocytes in the hippocampus of dietary-induced obese mice. Neuroreport 2014; 25:819-822.
    • (2014) Neuroreport , vol.25 , pp. 819-822
    • Cano, V.1    Valladolid-Acebes, I.2    Hernandez-Nuno, F.3
  • 25
    • 84914173605 scopus 로고    scopus 로고
    • The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice
    • Baquedano E, Ruiz-Lopez AM, Sustarsic EG, et al. The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice. Endocrinology 2014; 155:4856-4867.
    • (2014) Endocrinology , vol.155 , pp. 4856-4867
    • Baquedano, E.1    Ruiz-Lopez, A.M.2    Sustarsic, E.G.3
  • 26
    • 84935052674 scopus 로고    scopus 로고
    • Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
    • Naznin F, Toshinai K, Waise TM, et al. Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J Endocrinol 2015; 226:81-92.
    • (2015) J Endocrinol , vol.226 , pp. 81-92
    • Naznin, F.1    Toshinai, K.2    Waise, T.M.3
  • 27
    • 77249153620 scopus 로고    scopus 로고
    • Cognitive impairment following high fat diet consumption is associated with brain inflammation
    • Pistell PJ, Morrison CD,Gupta S, et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol 2010; 219 (1-2):25-32.
    • (2010) J Neuroimmunol , vol.219 , Issue.1-2 , pp. 25-32
    • Pistell, P.J.1    Morrison Cdgupta, S.2
  • 28
    • 84861846116 scopus 로고    scopus 로고
    • Resveratrol attenuates obesity-Associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
    • Jeon BT, Jeong EA, Shin HJ, et al. Resveratrol attenuates obesity-Associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes 2012; 61:1444-1454.
    • (2012) Diabetes , vol.61 , pp. 1444-1454
    • Jeon, B.T.1    Jeong, E.A.2    Shin, H.J.3
  • 29
    • 79960117277 scopus 로고    scopus 로고
    • Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-( and NF-(B
    • Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-( and NF-(B. Nat Med 2011; 17:883-887.
    • (2011) Nat Med , vol.17 , pp. 883-887
    • Purkayastha, S.1    Zhang, G.2    Cai, D.3
  • 30
    • 84861918690 scopus 로고    scopus 로고
    • Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
    • Milanski M, Arruda AP, Coope A, et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 2012; 61:1455-1462.
    • (2012) Diabetes , vol.61 , pp. 1455-1462
    • Milanski, M.1    Arruda, A.P.2    Coope, A.3
  • 31
    • 79953889813 scopus 로고    scopus 로고
    • Inflammation of the hypothalamus leads to defective pancreatic islet function
    • Calegari VC, Torsoni AS, Vanzela EC, et al. Inflammation of the hypothalamus leads to defective pancreatic islet function. J Biol Chem 2011; 286:12870-12880.
    • (2011) J Biol Chem , vol.286 , pp. 12870-12880
    • Calegari, V.C.1    Torsoni, A.S.2    Vanzela, E.C.3
  • 32
    • 84908344159 scopus 로고    scopus 로고
    • Obesity-And aging-induced excess of central transforming growth factor-beta potentiates diabetic development via an RNA stress response
    • Yan J, Zhang H, Yin Y, et al. Obesity-And aging-induced excess of central transforming growth factor-beta potentiates diabetic development via an RNA stress response. Nat Med 2014; 20:1001-1008.
    • (2014) Nat Med , vol.20 , pp. 1001-1008
    • Yan, J.1    Zhang, H.2    Yin, Y.3
  • 33
    • 84893434815 scopus 로고    scopus 로고
    • Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
    • Balland E, Dam J, Langlet F, et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 2014; 19:293-301.
    • (2014) Cell Metab , vol.19 , pp. 293-301
    • Balland, E.1    Dam, J.2    Langlet, F.3
  • 34
    • 84865578156 scopus 로고    scopus 로고
    • Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice
    • Borg ML, Omran SF, Weir J, et al. Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice. J Physiol 2012; 590 (Pt 17):4377-4389.
    • (2012) J Physiol , vol.590 , pp. 4377-4389
    • Borg, M.L.1    Omran, S.F.2    Weir, J.3
  • 35
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • Milanski M, Degasperi G, Coope A, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 2009; 29:359-370.
    • (2009) J Neurosci , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3
  • 36
    • 84928281004 scopus 로고    scopus 로고
    • Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice
    • Cheng L, Yu Y, Szabo A, et al. Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice. J Nutr Biochem 2015; 26:541-548.
    • (2015) J Nutr Biochem , vol.26 , pp. 541-548
    • Cheng, L.1    Yu, Y.2    Szabo, A.3
  • 37
    • 84930661681 scopus 로고    scopus 로고
    • Arachidonic acid impairs hypothalamic leptin signaling and hepatic energy homeostasis in mice
    • Cheng L, Yu Y, Zhang Q, et al. Arachidonic acid impairs hypothalamic leptin signaling and hepatic energy homeostasis in mice. Mol Cell Endocrinol 2015; 412:12-18.
    • (2015) Mol Cell Endocrinol , vol.412 , pp. 12-18
    • Cheng, L.1    Yu, Y.2    Zhang, Q.3
  • 38
    • 84925400753 scopus 로고    scopus 로고
    • Saturated fatty acids modulate autophagys proteins in the hypothalamus
    • Portovedo M, Ignacio-Souza LM, Bombassaro B, et al. Saturated fatty acids modulate autophagys proteins in the hypothalamus. PloS One 2015; 10:e0119850.
    • (2015) PloS One , vol.10 , pp. e0119850
    • Portovedo, M.1    Ignacio-Souza, L.M.2    Bombassaro, B.3
  • 39
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan L, Ergin AS, Lu A, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009; 9:35-51.
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3
  • 40
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008; 135:61-73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3
  • 41
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity
    • Kleinridders A, Schenten D, Konner AC, et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity. Cell Metab 2009; 10:249-259.
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Konner, A.C.3
  • 42
    • 64549104642 scopus 로고    scopus 로고
    • High-fat diet induces apoptosis of hypothalamic neurons
    • Moraes JC, Coope A, Morari J, et al. High-fat diet induces apoptosis of hypothalamic neurons. PloS One 2009; 4:e5045.
    • (2009) PloS One , vol.4 , pp. e5045
    • Moraes, J.C.1    Coope, A.2    Morari, J.3
  • 43
    • 84922780528 scopus 로고    scopus 로고
    • Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats
    • Li JM, Ge CX, Xu MX, et al. Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Mol Nutr Food Res 2015; 59:189-202.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 189-202
    • Li, J.M.1    Ge, C.X.2    Xu, M.X.3
  • 44
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol 2004; 172:2731-2738.
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 45
    • 84927712360 scopus 로고    scopus 로고
    • You are what you eat, or are you? the challenges of translating high-fat-fed rodents to human obesity and diabetes
    • Lai M, Chandrasekera PC, Barnard ND. You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes. Nutr Diabetes 2014; 4:e135.
    • (2014) Nutr Diabetes , vol.4 , pp. e135
    • Lai, M.1    Chandrasekera, P.C.2    Barnard, N.D.3
  • 46
    • 84908638565 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity
    • Morari J, Anhe GF, Nascimento LF, et al. Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity. Diabetes 2014; 63:3770-3784.
    • (2014) Diabetes , vol.63 , pp. 3770-3784
    • Morari, J.1    Anhe, G.F.2    Nascimento, L.F.3
  • 47
    • 84888867859 scopus 로고    scopus 로고
    • Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system
    • Buckman LB, Hasty AH, Flaherty DK, et al. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun 2014; 35:33-42.
    • (2014) Brain Behav Immun , vol.35 , pp. 33-42
    • Buckman, L.B.1    Hasty, A.H.2    Flaherty, D.K.3
  • 48
    • 84874782370 scopus 로고    scopus 로고
    • Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
    • Kierdorf K, Katzmarski N, Haas CA, Prinz M. Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias. PloS One 2013; 8:e58544.
    • (2013) PloS One , vol.8 , pp. e58544
    • Kierdorf, K.1    Katzmarski, N.2    Haas, C.A.3    Prinz, M.4
  • 49
    • 84877824392 scopus 로고    scopus 로고
    • Perivascular, but not parenchymal, cerebral engraftment of donor cells after nonmyeloablative bone marrow transplantation
    • Yang Y, Jorstad NL, Shiao C, et al. Perivascular, but not parenchymal, cerebral engraftment of donor cells after nonmyeloablative bone marrow transplantation. Exp Mol Pathol 2013; 95:7-17.
    • (2013) Exp Mol Pathol , vol.95 , pp. 7-17
    • Yang, Y.1    Jorstad, N.L.2    Shiao, C.3
  • 50
    • 84874156024 scopus 로고    scopus 로고
    • Regional astrogliosis in the mouse hypothalamus in response to obesity
    • Buckman LB, Thompson MM, Moreno HN, Ellacott KL. Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol 2013; 521:1322-1333.
    • (2013) J Comp Neurol , vol.521 , pp. 1322-1333
    • Buckman, L.B.1    Thompson, M.M.2    Moreno, H.N.3    Ellacott, K.L.4
  • 51
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • Burda JE, Sofroniew MV. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 2014; 81:229-248.
    • (2014) Neuron , vol.81 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 52
    • 84905014938 scopus 로고    scopus 로고
    • Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: A combined immunohistochemical and magnetic resonance imaging study
    • Berkseth KE, Guyenet SJ, Melhorn SJ, et al. Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology 2014; 155:2858-2867.
    • (2014) Endocrinology , vol.155 , pp. 2858-2867
    • Berkseth, K.E.1    Guyenet, S.J.2    Melhorn, S.J.3
  • 53
    • 84888134187 scopus 로고    scopus 로고
    • Hormones and diet, but not body weight, control hypothalamic microglial activity
    • Gao Y, Ottaway N, Schriever SC, et al. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 2014; 62:17-25.
    • (2014) Glia , vol.62 , pp. 17-25
    • Gao, Y.1    Ottaway, N.2    Schriever, S.C.3
  • 54
    • 77957053600 scopus 로고    scopus 로고
    • Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    • Horvath TL, Sarman B, Garcia-Caceres C, et al. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A 2010; 107:14875-14880.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14875-14880
    • Horvath, T.L.1    Sarman, B.2    Garcia-Caceres, C.3
  • 55
    • 84868629649 scopus 로고    scopus 로고
    • Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
    • Fuente-Martin E, Garcia-Caceres C, Granado M, et al. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. J Clin Invest 2012; 122:3900-3913.
    • (2012) J Clin Invest , vol.122 , pp. 3900-3913
    • Fuente-Martin, E.1    Garcia-Caceres, C.2    Granado, M.3
  • 56
    • 84926433834 scopus 로고    scopus 로고
    • Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior
    • Reis WL, Yi CX, Gao Y, et al. Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior. Endocrinology 2015; 156:1303-1315.
    • (2015) Endocrinology , vol.156 , pp. 1303-1315
    • Reis, W.L.1    Yi, C.X.2    Gao, Y.3
  • 57
    • 84855426656 scopus 로고    scopus 로고
    • Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
    • McNay DE, Briancon N, Kokoeva MV, et al. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest 2012; 122:142-152.
    • (2012) J Clin Invest , vol.122 , pp. 142-152
    • McNay, D.E.1    Briancon, N.2    Kokoeva, M.V.3
  • 58
    • 84903382613 scopus 로고    scopus 로고
    • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    • Kim JG, Suyama S, Koch M, et al. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci 2014; 17:908-910.
    • (2014) Nat Neurosci , vol.17 , pp. 908-910
    • Kim, J.G.1    Suyama, S.2    Koch, M.3
  • 59
    • 84931028718 scopus 로고    scopus 로고
    • Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors
    • Yang L, Qi Y, Yang Y. Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. Cell Rep 2015; 11:798-807.
    • (2015) Cell Rep , vol.11 , pp. 798-807
    • Yang, L.1    Qi, Y.2    Yang, Y.3
  • 60
    • 84862776637 scopus 로고    scopus 로고
    • Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
    • Lee DA, Bedont JL, Pak T, et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci 2012; 15:700-702.
    • (2012) Nat Neurosci , vol.15 , pp. 700-702
    • Lee, D.A.1    Bedont, J.L.2    Pak, T.3
  • 61
    • 84856275099 scopus 로고    scopus 로고
    • Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity
    • Chang Y, She ZG, Sakimura K, et al. Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. PloS One 2012; 7:e30637.
    • (2012) PloS One , vol.7 , pp. e30637
    • Chang, Y.1    She, Z.G.2    Sakimura, K.3
  • 62
    • 84877669409 scopus 로고    scopus 로고
    • Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food
    • Guyenet SJ, Matsen ME, Morton GJ, et al. Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food. Mol Metab 2013; 2:116-122.
    • (2013) Mol Metab , vol.2 , pp. 116-122
    • Guyenet, S.J.1    Matsen, M.E.2    Morton, G.J.3
  • 63
    • 84940107968 scopus 로고    scopus 로고
    • Central inhibition of IKKbeta/NF-kappaB signaling attenuates high-fat diet-induced obesity and glucose intolerance
    • Benzler J, Ganjam GK, Pretz D, et al. Central inhibition of IKKbeta/NF-kappaB signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes 2015; 64:2015-2027.
    • (2015) Diabetes , vol.64 , pp. 2015-2027
    • Benzler, J.1    Ganjam, G.K.2    Pretz, D.3
  • 64
    • 84886888337 scopus 로고    scopus 로고
    • GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet
    • Ito Y, Banno R, Shibata M, et al. GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet. J Neurosci 2013; 33:17166-17173.
    • (2013) J Neurosci , vol.33 , pp. 17166-17173
    • Ito, Y.1    Banno, R.2    Shibata, M.3
  • 65
    • 79952316899 scopus 로고    scopus 로고
    • Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion
    • Arruda AP, Milanski M, Coope A, et al. Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology 2011; 152:1314-1326.
    • (2011) Endocrinology , vol.152 , pp. 1314-1326
    • Arruda, A.P.1    Milanski, M.2    Coope, A.3
  • 66
    • 84920722615 scopus 로고    scopus 로고
    • Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice
    • Buckman LB, ThompsonMM, Lippert RN, et al. Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab 2015; 4:58-63.
    • (2015) Mol Metab , vol.4 , pp. 58-63
    • Buckman, L.B.1    ThompsonMM2    Lippert, R.N.3
  • 67
    • 84894082286 scopus 로고    scopus 로고
    • High-fat diet induces leptin resistance in leptin-Deficient mice
    • Koch CE, Lowe C, Pretz D, et al. High-fat diet induces leptin resistance in leptin-Deficient mice. J Neuroendocrinol 2014; 26:58-67.
    • (2014) J Neuroendocrinol , vol.26 , pp. 58-67
    • Koch, C.E.1    Lowe, C.2    Pretz, D.3
  • 68
    • 84977872415 scopus 로고    scopus 로고
    • Neonatal overfeeding attenuates acute central pro-inflammatory effects of short-Term high fat diet
    • Cai G, Dinan T, Barwood JM, et al. Neonatal overfeeding attenuates acute central pro-inflammatory effects of short-Term high fat diet. Front Neurosci 2014; 8:446.
    • (2014) Front Neurosci , vol.8 , pp. 446
    • Cai, G.1    Dinan, T.2    Barwood, J.M.3
  • 69
    • 84865000323 scopus 로고    scopus 로고
    • Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet
    • Wang X, Ge A, Cheng M, et al. Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet. Exp Diabetes Res 2012; 2012:847246.
    • (2012) Exp Diabetes Res , vol.2012 , pp. 847246
    • Wang, X.1    Ge, A.2    Cheng, M.3
  • 70
    • 84905018799 scopus 로고    scopus 로고
    • The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats
    • Garcia-Caceres C, Fuente-Martin E, Diaz F, et al. The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats. Endocrinology 2014; 155:2868-2880.
    • (2014) Endocrinology , vol.155 , pp. 2868-2880
    • Garcia-Caceres, C.1    Fuente-Martin, E.2    Diaz, F.3
  • 71
    • 84865191020 scopus 로고    scopus 로고
    • Neuron-specific deletion of peroxisome proliferator-Activated receptor delta (PPARdelta) in mice leads to increased susceptibility to diet-induced obesity
    • Kocalis HE, Turney MK, Printz RL, et al. Neuron-specific deletion of peroxisome proliferator-Activated receptor delta (PPARdelta) in mice leads to increased susceptibility to diet-induced obesity. PloS One 2012; 7:e42981.
    • (2012) PloS One , vol.7 , pp. e42981
    • Kocalis, H.E.1    Turney, M.K.2    Printz, R.L.3
  • 72
    • 84929000367 scopus 로고    scopus 로고
    • A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice
    • Lemus MB, Bayliss JA, Lockie SH, et al. A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice. Endocrinology 2015; 156:1701-1713.
    • (2015) Endocrinology , vol.156 , pp. 1701-1713
    • Lemus, M.B.1    Bayliss, J.A.2    Lockie, S.H.3
  • 73
    • 79151485914 scopus 로고    scopus 로고
    • Obesity-mediated inflammation may damage the brain circuit that regulates food intake
    • Cazettes F, Cohen JI, Yau PL, et al. Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Res 2011; 1373:101-109.
    • (2011) Brain Res , vol.1373 , pp. 101-109
    • Cazettes, F.1    Cohen, J.I.2    Yau, P.L.3
  • 74
    • 84927566096 scopus 로고    scopus 로고
    • Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects
    • Puig J, Blasco G, Daunis IEJ, et al. Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects. J Clin Endocrinol Metab 2015; 100:E276-E281.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E276-E281
    • Puig, J.1    Blasco, G.2    Daunis, I.E.J.3
  • 75
    • 79954490068 scopus 로고    scopus 로고
    • Sex-Dependent influences of obesity on cerebral white matter investigated by diffusion-Tensor imaging
    • Mueller K, Anwander A, Moller HE, et al. Sex-Dependent influences of obesity on cerebral white matter investigated by diffusion-Tensor imaging. PloS One 2011; 6:e18544.
    • (2011) PloS One , vol.6 , pp. e18544
    • Mueller, K.1    Anwander, A.2    Moller, H.E.3
  • 76
    • 79952006211 scopus 로고    scopus 로고
    • Obesity is associated with reduced white matter integrity in otherwise healthy adults
    • Stanek KM, Grieve SM, Brickman AM, et al. Obesity is associated with reduced white matter integrity in otherwise healthy adults. Obesity (Silver Spring) 2011; 19:500-504.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 500-504
    • Stanek, K.M.1    Grieve, S.M.2    Brickman, A.M.3
  • 77
    • 84884931456 scopus 로고    scopus 로고
    • Association of obesity-mediated insulin resistance and hypothalamic volumes: Possible sex differences
    • Ha J, Cohen JI, Tirsi A, Convit A. Association of obesity-mediated insulin resistance and hypothalamic volumes: possible sex differences. Dis Markers 2013; 35:249-259.
    • (2013) Dis Markers , vol.35 , pp. 249-259
    • Ha, J.1    Cohen, J.I.2    Tirsi, A.3    Convit, A.4
  • 78
    • 84899001763 scopus 로고    scopus 로고
    • Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women
    • Kilpatrick LA, Coveleskie K, Connolly L, et al. Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women. Gastroenterology 2014; 146:1212-1221.
    • (2014) Gastroenterology , vol.146 , pp. 1212-1221
    • Kilpatrick, L.A.1    Coveleskie, K.2    Connolly, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.