Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Wang, Xiaoke ^a,b   Ge, Aiguo ^b   Cheng, Mengjie ^b   Guo, Fangfang ^b   Zhao, Min ^b   Zhou, Xiaoqi ^b   Liu, Liegang ^b   Yang, Nianhong ^b  

^a NANTONG UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; IMMUNE SYSTEM; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID DIET; MALE; METABOLISM; NONHUMAN; NUTRITIONAL HEALTH; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WEIGHT CHANGE; WEIGHT GAIN; ANIMAL; DISEASE MODEL; GENETIC PREDISPOSITION; PATHOLOGY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HYPOTHALAMUS; INFLAMMATION; INSULIN; MALE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 84865000323     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/847246     Document Type: Article

References (39)

1. Yach D., Stuckler D., Brownell K. D., Epidemiologic and economic consequences of the global epidemics of obesity and diabetes Nature Medicine 2006 12 1 62 66 (Pubitemid 43050076)
2. Wang Y., Rimm E. B., Stampfer M. J., Willett W. C., Hu F. B., Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men American Journal of Clinical Nutrition 2005 81 3 555 563
3. rnlv J., Ingelsson E., Sundstrm J., Lind L., Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men Circulation 2010 121 2 230 236
4. Bray G. A., Popkin B. M., Dietary fat intake does affect obesity American Journal of Clinical Nutrition 1998 68 6 1157 1173 (Pubitemid 28550944)
5. Levin B. E., Keesey R. E., Defense of differfing body weight set points in diet-induced obese and resistant rats American Journal of Physiology 1998 274 2 R412 R419
6. Bouchard C., Tremblay A., Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins Journal of Nutrition 1997 127 5, supplement 943S 947S (Pubitemid 27209475)
7. Levin B. E., Triscari J., Hogan S., Sullivan A. C., Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin American Journal of Physiology 1987 252 3 R471 R478
8. Bastard J. P., Maachi M., Lagathu C., Kim M. J., Caron M., Vidal H., Capeau J., Feve B., Recent advances in the relationship between obesity, inflammation, and insulin resistance European Cytokine Network 2006 17 1 4 12
9. De Souza C. T., Araujo E. P., Bordin S., Ashimine R., Zollner R. L., Boschero A. C., Saad M. J. A., Velloso L. A., Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus Endocrinology 2005 146 10 4192 4199 (Pubitemid 41324012)
10. Carvalheira J. B. C., Ribeiro E. B., Arajo E. P., Guimares R. B., Telles M. M., Torsoni M., Gontijo J. A. R., Velloso L. A., Saad M. J. A., Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats Diabetologia 2003 46 12 1629 1640 (Pubitemid 38005325)
11. Howard J. K., Cave B. J., Oksanen L. J., Tzameli I., Bjorbk C., Flier J. S., Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 Nature Medicine 2004 10 7 734 738 (Pubitemid 38937639)
12. Akira S., Uematsu S., Takeuchi O., Pathogen recognition and innate immunity Cell 2006 124 4 783 801 (Pubitemid 43261452)
13. Akira S., Takeda K., Toll-like receptor signalling Nature Reviews Immunology 2004 4 7 499 511 (Pubitemid 38931765)
14. Hayden M. S., Ghosh S., Shared principles in NF- B signaling Cell 2008 132 3 344 362
15. Milanski M., Degasperi G., Coope A., Morari J., Denis R., Cintra D. E., Tsukumo D. M. L., Anhe G., Amaral M. E., Takahashi H. K., Curi R., Oliveira H. C., Carvalheira J. B. C., Bordin S., Saad M. J., Velloso L. A., Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity Journal of Neuroscience 2009 29 2 359 370
16. Tsukumo D. M. L., Carvalho-Filho M. A., Carvalheira J. B. C., Prada P. O., Hirabara S. M., Schenka A. A., Arajo E. P., Vassallo J., Curi R., Velloso L. A., Saad M. J. A., Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance Diabetes 2007 56 8 1986 1998 (Pubitemid 47195825)
17. Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D., Hypothalamic IKK /NF- B and ER stress link overnutrition to energy imbalance and obesity Cell 2008 135 1 61 73
18. Posey K. A., Clegg D. J., Printz R. L., Byun J., Morton G. J., Vivekanandan-Giri A., Pennathur S., Baskin D. G., Heinecke J. W., Woods S. C., Schwartz M. W., Niswender K. D., Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet American Journal of Physiology 2009 296 5 E1003 E1012
19. Wang C., Yang N., Wu S., Liu L., Sun X., Nie S., Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet Hormone and Metabolic Research 2007 39 4 262 267 (Pubitemid 46715883)
20. Allen Y. S., Adrian T. E., Allen J. M., Neuropeptide Y distribution in the rat brain Science 1983 221 4613 872 879 (Pubitemid 13034294)
21. Beck B., Intracerebroventricular injection of proinsulin C-peptide does not influence food consumption in male long-evans rats Hormone and Metabolic Research 2006 38 5 314 316 (Pubitemid 43864952)
22. Larionov A., Krause A., Miller W. R., A standard curve based method for relative real time PCR data processing BMC Bioinformatics 2005 6, article 62
23. Perusse L., Bouchard C., Gene-diet interactions in obesity American Journal of Clinical Nutrition 2000 72 5, supplement 1285S 1290S
24. Levin B. E., Triscari J., Sullivan A. C., Metabolic features of diet-induced obesity without hyperphagia in young rats American Journal of Physiology 1986 251 3 R433 R440
25. Levin B. E., Hogan S., Sullivan A. C., Initiation and perpetuation of obesity and obesity resistance in rats American Journal of Physiology 1989 256 3 R766 R771
26. Ricci M. R., Levin B. E., Ontogeny of diet-induced obesity in selectively bred sprague-dawley rats American Journal of Physiology 2003 285 3 R610 R618
27. Sondergaard L., Homology between the mammalian liver and Drosophila fat body Trends in Genetics 1993 9 6 193 (Pubitemid 23165337)
28. Medzhitov R., Toll-like receptors and innate immunity Nature Reviews Immunology 2001 1 2 135 145 (Pubitemid 33741967)
29. Fessler M. B., Rudel L. L., Brown J. M., Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome Current Opinion in Lipidology 2009 20 5 379 385
30. Kendall A., Levitsky D. A., Strupp B. J., Lissner L., Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans American Journal of Clinical Nutrition 1991 53 5 1124 1129
31. Wang H., Storlien L. H., Huang X. F., Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression American Journal of Physiology 2002 282 6 E1352 E1359
32. Hill J. O., Dorton J., Sykes M. N., Digirolamo M., Reversal of dietary obesity is influenced by its duration and severity International Journal of Obesity 1989 13 5 711 722 (Pubitemid 20004819)
33. Enriori P. J., Evans A. E., Sinnayah P., Jobst E. E., Tonelli-Lemos L., Billes S. K., Glavas M. M., Grayson B. E., Perello M., Nillni E. A., Grove K. L., Cowley M. A., Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons Cell Metabolism 2007 5 3 181 194
34. Huang X. F., Xin X., McLennan P., Storlien L., Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression Diabetes, Obesity and Metabolism 2004 6 1 35 44 (Pubitemid 38159727)
35. Lee I. S., Shin G., Choue R., Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet Endocrine Journal 2010 57 1 39 50
36. Kleinridders A., Schenten D., Knner A. C., Belgardt B. F., Mauer J., Okamura T., Wunderlich F. T., Medzhitov R., Brning J. C., MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity Cell Metabolism 2009 10 4 249 259
37. Hotamisligil G. S., Inflammation and metabolic disorders Nature 2006 444 7121 860 867 (Pubitemid 46024993)
38. Hotamisligil G. S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 2010 140 6 900 917
39. Arruda A. P., Milanski M., Coope A., Torsoni A. S., Ropelle E., Carvalho D. P., Carvalheira J. B., Velloso L. A., Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion Endocrinology 2011 152 4 1314 1326