Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

Molecular Metabolism

Volumn 4, Issue 1, 2015, Pages 58-63

  Buckman, Laura B ^a,b   Thompson, Misty M ^a,c   Lippert, Rachel N ^a,d   Blackwell, Timothy S ^a   Yull, Fiona E ^a   Ellacott, Kate L J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Astrocyte; CNS; Food intake; GFAP; Glia; HFD; High fat diet; Hypothalamus; MBH; NF B; Nuclear factor kappaB

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN S100B; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CALORIC INTAKE; CELL ACTIVATION; CELL NUCLEUS; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HOMEOSTASIS; HYPERPHAGIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPID DIET; MEDIOBASAL HYPOTHALAMUS; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSGENE;

MUS; MUS MUSCULUS; RODENTIA;

EID: 84920722615     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.10.001     Document Type: Article

References (34)

1. Williams K.W., Elmquist J.K. From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nature Neuroscience 2012, 15(10):1350-1355.
2. Zeltser L.M., Seeley R.J., Tschop M.H. Synaptic plasticity in neuronal circuits regulating energy balance. Nature Neuroscience 2012, 15(10):1336-1342.
3. Chowen J.A., Argente J., Horvath T.L. Uncovering novel roles of nonneuronal cells in body weight homeostasis and obesity. Endocrinology 2013, 154(9):3001-3007.
4. Le Foll C., Dunn-Meynell A.A., Miziorko H.M., Levin B.E. Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids. Diabetes 2014, 63(4):1259-1269.
5. Thaler J.P., Yi C.X., Schur E.A., Guyenet S.J., Hwang B.H., Dietrich M.O., et al. Obesity is associated with hypothalamic injury in rodents and humans. Journal of Clinical Investigation 2012, 122(1):153-162.
6. Yi C.X., Habegger K.M., Chowen J.A., Stern J., Tschop M.H. Arole for astrocytes in the central control of metabolism. Neuroendocrinology 2011, 93(3):143-149.
7. De Souza C.T., Araujo E.P., Bordin S., Ashimine R., Zollner R.L., Boschero A.C., et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146(10):4192-4199.
8. Nerurkar P.V., Johns L.M., Buesa L.M., Kipyakwai G., Volper E., Sato R., et al. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. Journal of Neuroinflammation 2011, 8:64.
9. Buckman L.B., Thompson M.M., Moreno H.N., Ellacott K.L. Regional astrogliosis in the mouse hypothalamus in response to obesity. Journal of Comparative Neurology 2013, 521(6):1322-1333.
10. Horvath T.L., Sarman B., Garcia-Caceres C., Enriori P.J., Sotonyi P., Shanabrough M., et al. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(33):14875-14880.
11. Hsuchou H., He Y., Kastin A.J., Tu H., Markadakis E.N., Rogers R.C., et al. Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 2009, 132(Pt 4):889-902.
12. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathologica 2010, 119(1):7-35.
13. Czeh M., Gressens P., Kaindl A.M. The yin and yang of microglia. Developmental Neuroscience 2011, 33(3-4):199-209.
14. Lian H., Shim D.J., Gaddam S.S., Rodriguez-Rivera J., Bitner B.R., Pautler R.G., et al. IkappaBalpha deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery. Molecular Neurodegeneration 2012, 7:47.
15. Brambilla R., Bracchi-Ricard V., Hu W.H., Frydel B., Bramwell A., Karmally S., et al. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. The Journal of Experimental Medicine 2005, 202(1):145-156.
16. Connelly L., Barham W., Onishko H.M., Chen L., Sherrill T.P., Zabuawala T., et al. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Research: BCR 2011, 13(4):R83.
17. Cheng D.S., Han W., Chen S.M., Sherrill T.P., Chont M., Park G.Y., et al. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. The Journal of Immunology 2007, 178(10):6504-6513.
18. Chen S.M., Cheng D.S., Williams B.J., Sherrill T.P., Han W., Chont M., et al. The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clinical and Experimental Immunology 2008, 153(3):420-428.
19. Connelly L., Barham W., Onishko H.M., Sherrill T., Chodosh L.A., Blackwell T.S., et al. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene 2011, 30(12):1402-1412.
20. Connelly L., Barham W., Pigg R., Saint-Jean L., Sherrill T., Cheng D.S., et al. Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. Journal of Cellular Physiology 2010, 222(1):73-81.
21. Connelly L., Robinson-Benion C., Chont M., Saint-Jean L., Li H., Polosukhin V.V., et al. Atransgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. The Journal of Biological Chemistry 2007, 282(13):10028-10035.
22. Paxinos G., Franklin K.B.J., Franklin K.B.J. The mouse brain in stereotaxic coordinates 2001, Academic Press, San Diego. 2nd ed.
23. Xie Z., Morgan T.E., Rozovsky I., Finch C.E. Aging and glial responses to lipopolysaccharide invitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Experimental Neurology 2003, 182(1):135-141.
24. Lam A.G., Koppal T., Akama K.T., Guo L., Craft J.M., Samy B., et al. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiology of Aging 2001, 22(5):765-772.
25. Morga E., Mouad-Amazzal L., Felten P., Heurtaux T., Moro M., Michelucci A., et al. Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways. Glia 2009, 57(16):1741-1753.
26. Berthoud H.R. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterology & Motility 2008, 20(Suppl.1):64-72.
27. Gard A.L., White F.P., Dutton G.R. Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver. Journal of Neuroimmunology 1985, 8(4-6):359-375.
28. Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998, 43(1):128-133.
29. Jessen K.R., Mirsky R. Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Nature 1980, 286(5774):736-737.
30. Benani A., Hryhorczuk C., Gouaze A., Fioramonti X., Brenachot X., Guissard C., et al. Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice. The Journal of Neuroscience 2012, 32(35):11970-11979.
31. Tasker J.G., Oliet S.H., Bains J.S., Brown C.H., Stern J.E. Glial regulation of neuronal function: from synapse to systems physiology. Journal of Neuroendocrinology 2012, 24(4):566-576.
32. Gupta S., Knight A.G., Keller J.N., Bruce-Keller A.J. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. Journal of Neurochemistry 2012, 120(6):1060-1071.
33. Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135(1):61-73.
34. Xanthos D.N., Sandkuhler J. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nature Reviews Neuroscience 2014, 15(1):43-53.