P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy

Neuropharmacology

Volumn 105, Issue , 2016, Pages 175-185

  Amhaoul, Halima ^a   Ali, Idrish ^a   Mola, Marco ^a   Van Eetveldt, Annemie ^a   Szewczyk, Krystyna ^a   Missault, Stephan ^a   Bielen, Kenny ^a   Kumar Singh, Samir ^a   Rech, Jason ^b   Lord, Brian ^b   Ceusters, Marc ^c   Bhattacharya, Anindya ^b   Dedeurwaerdere, Stefanie ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antagonist; Epilepsy; Microglia; P2X7 receptor; Seizure

Indexed keywords

ANTICONVULSIVE AGENT; CELL MARKER; JNJ 42253432; PURINERGIC P2 RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; INTERLEUKIN 1BETA; INTERLEUKIN-1BETA (163-171); ISOQUINOLINE DERIVATIVE; JNJ-42253432; PEPTIDE FRAGMENT; PIPERAZINE DERIVATIVE; PURINERGIC P2X RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SPONTANEOUS RECURRENT SEIZURE; TEMPORAL LOBE EPILEPSY; ANIMAL; BRAIN; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENCEPHALITIS; EPILEPSY, TEMPORAL LOBE; GLIOSIS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SEIZURES; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENCEPHALITIS; EPILEPSY, TEMPORAL LOBE; GLIOSIS; INTERLEUKIN-1BETA; ISOQUINOLINES; MICROGLIA; PEPTIDE FRAGMENTS; PIPERAZINES; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X7; SEIZURES; STATUS EPILEPTICUS;

EID: 84955470621     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.01.018     Document Type: Article

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