Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

FASEB Journal

Volumn 26, Issue 4, 2012, Pages 1616-1628

  Engel, Tobias ^a   Gomez Villafuertes, Rosa ^b,c   Tanaka, Katsuhiro ^a,d   Mesuret, Guillaume ^a   Sanz Rodriguez, Amaya ^a   Garcia Huerta, Paula ^b,c   Miras Portugal, M Teresa ^b,c   Henshall, David C ^a   Diaz Hernandez, Miguel ^b,c  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^d MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Anticonvulsant; ATP; Pharmacoresistance; Temporal lobe epilepsy

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; 4 AMINOBUTYRIC ACID; A 438079; ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; ANTICONVULSIVE AGENT; BENZODIAZEPINE; BETA ACTIN; BRILLIANT BLUE G; ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 1BETA; IONOTROPIC RECEPTOR; KAINIC ACID; LORAZEPAM; NEUROTRANSMITTER; PURINERGIC P2X RECEPTOR; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X5 RECEPTOR; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN REGION; CELL POPULATION; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG TARGETING; ELECTROGRAPHY; EMBRYO; EPILEPTIC STATE; GENETIC TRANSCRIPTION; HIPPOCAMPUS; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; TRANSGENIC MOUSE; TREATMENT RESPONSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTICONVULSANTS; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; INTERLEUKIN-1BETA; KAINIC ACID; LORAZEPAM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PURINERGIC P2X RECEPTOR AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; SEIZURES; STATUS EPILEPTICUS;

MUS;

EID: 84860905529     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-196089     Document Type: Article

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