A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334

European Journal of Pharmacology

Volumn 765, Issue , 2015, Pages 551-559

  Lord, Brian ^a   Ameriks, Michael K ^a   Wang, Qi ^a   Fourgeaud, Lawrence ^a   Vliegen, Maarten ^a   Verluyten, Willy ^a   Haspeslagh, Pieter ^a   Carruthers, Nicholas I ^a   Lovenberg, Timothy W ^a   Bonaventure, Pascal ^a   Letavic, Michael A ^a   Bhattacharya, Anindya ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Autoradiography; Depression; JNJ 54140515; JNJ 54232334; P2X7; Radioligand binding; Receptor occupancy

Indexed keywords

2 CYANO 1 [ PHENYLETHYL] 3 QUINOLIN 5 YLGUANIDIN; 7 [2 CHLORO 3 [TRIFLUOROMETHYL]BENZYL] 6 METHYL 3 PYRAZIN 2 YL 6,7 DIHYDRO [1,2,4] TRIAZOLO [4,3 A] PYRAZIN 8 (5H) ONE; 7 [2 CHLORO 3 [TRIFLUOROMETHYL]BENZYL] 6 METHYL 3 PYRIMIDIN 2 YL 6,7 DIHYDRO [1,2,4] TRIAZOLO [4,3 A] PYRAZIN 8 (5H) ONE; LIGAND GATED ION CHANNEL; N [1 [[(CYANOAMINO) (5 QUINOLINYLAMINO)METYLENE]AMINO] 2,2 DIMETHYLPROPYL] 3,4 DIMETHOXYBENZENEACETAMIDE; PURINERGIC P2X7 RECEPTOR; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG; 2-CYANO-1-((1S)-1-PHENYLETHYL)-3-QUINOLIN-5-YLGUANIDINE; 7-(2-CHLORO-3-(TRIFLUOROMETHYL)BENZYL)-6-METHYL-3-PYRIMIDIN-2-YL-6,7-DIHYDRO(1,2,4)TRIAZOLO(4,3-A)PYRAZIN-8(5H)-ONE; ADENOSINE TRIPHOSPHATE; GUANIDINE DERIVATIVE; ION CHANNEL; PROTEIN BINDING; PURINERGIC P2X RECEPTOR ANTAGONIST; PYRAZINE DERIVATIVE; QUINOLINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN CORTEX; CALCIUM TRANSPORT; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR OCCUPANCY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PROCEDURES; RADIOASSAY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINES; HIPPOCAMPUS; ION CHANNELS; MALE; MICE; MICE, KNOCKOUT; PROTEIN BINDING; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRAZINES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X7; TRIAZOLES; TRITIUM;

EID: 84952867693     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.09.026     Document Type: Article

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