(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model

Neuropharmacology

Volumn 85, Issue , 2014, Pages 104-112

  Bogdanović, Renée Marie ^a   Syvänen, Stina ^b   Michler, Christina ^a   Russmann, Vera ^a   Eriksson, Jonas ^c   Windhorst, Albert D ^d   Lammertsma, Adriaan A ^d   De Lange, Elisabeth C ^e   Voskuyl, Rob A ^e,f   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

Author keywords

Drug refractoriness; Neuroinflammation; Pharmacoresistance; Positron emission tomography; Translocator protein 18 kDa

Indexed keywords

CARRIER PROTEIN; FLUORODEOXYGLUCOSE F 18; MOLECULAR MARKER; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; PHENOBARBITAL; TRANSLOCATOR PROTEIN 18; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; BZRP PROTEIN, RAT; CARBON; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CELL ACTIVATION; CELL LOSS; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG RESPONSE; ELECTROENCEPHALOGRAM; FEMALE; GENERAL PATHOLOGICAL PARAMETERS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOLECULAR IMAGING; MORNING DOSAGE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OCCIPITAL CORTEX; PARIETAL CORTEX; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; PRIORITY JOURNAL; PUTAMEN; RAT; SEIZURE FREQUENCY; TEMPORAL LOBE EPILEPSY; VIDEORECORDING; ANIMAL; BLOOD; BRAIN; CHRONIC DISEASE; DIAGNOSTIC USE; DISEASE MODEL; DRUG EFFECTS; DRUG RESISTANCE; ELECTRODE IMPLANT; EPILEPSY, TEMPORAL LOBE; IMMUNOMODULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SCINTISCANNING; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS;

ANIMALS; ANTICONVULSANTS; BRAIN; CARBON RADIOISOTOPES; CARRIER PROTEINS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; ELECTRODES, IMPLANTED; EPILEPSY, TEMPORAL LOBE; FEMALE; ISOQUINOLINES; MICROGLIA; NEUROIMMUNOMODULATION; PHENOBARBITAL; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STATUS EPILEPTICUS;

EID: 84902245477     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.05.002     Document Type: Article

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