Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy

Toxicologic Pathology

Volumn 36, Issue 7, 2008, Pages 932-943

  Sharma, Alok K ^a,b   Jordan, William H ^c   Reams, Rachel Y ^b   Greg Hall, D ^c   Snyder, Paul W ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b Department of Molecular and Anatomical Imaging   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Animal model; Astrogliosis; Fischer 344 rat; Histopathology; Lesions; Mesial temporal lobe epilepsy (MTLE); Microgliosis; Mossy fiber sprouting; Neurodegeneration; Neurogenesis

Indexed keywords

DOUBLECORTIN; EOSIN; HEMATOXYLIN; KAINIC ACID; KI 67 ANTIGEN; AMINO ACID RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; BRAIN REGION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EPILEPTIC STATE; HISTOPATHOLOGY; MALE; MICROGLIA; MORPHOLOGY; MOSSY FIBER; NERVE CELL; NERVE CELL DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SURVIVAL RATE; TEMPORAL LOBE EPILEPSY; ANIMAL; ANIMAL BEHAVIOR; ASTROCYTE; CHEMICALLY INDUCED DISORDER; DENTATE GYRUS; DISEASE MODEL; DRUG EFFECT; FISCHER 344 RAT; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVE DEGENERATION; PATHOLOGY; THALAMUS;

ANIMALIA; RATTUS;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; DENTATE GYRUS; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID AGONISTS; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; MICROGLIA; MOSSY FIBERS, HIPPOCAMPAL; NERVE DEGENERATION; RATS; RATS, INBRED F344; SEIZURES; STATUS EPILEPTICUS; THALAMUS;

EID: 68149179808     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308326093     Document Type: Article

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