Use of the β-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 2, 2001, Pages 712-717

  Langlois, Xavier ^a   Te Riele, Paula ^a   Wintmolders, Cindy ^a   Leysen, Josée E ^a   Jurzak, Mirek ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROKININ 3 RECEPTOR ANTAGONIST; OSANETANT; RADIOLIGAND; SENKTIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BETA IMAGER; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEVICE; DOSE RESPONSE; DRUG BINDING SITE; DRUG PENETRATION; DRUG POTENCY; ENANTIOMER; GERBIL; MALE; MENTAL DISEASE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RECEPTOR OCCUPANCY;

ANIMALS; AUTORADIOGRAPHY; BETA RAYS; BRAIN; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GERBILLINAE; MALE; PEPTIDE FRAGMENTS; PIPERIDINES; RECEPTORS, NEUROKININ-3; SUBSTANCE P;

EID: 0034763146     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. 3 receptor stimulation in gerbil mesencephalic cell cultures
2. Optical imaging of the spatial distribution of β-particles emerging from surfaces
3. Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokin3 receptors
4. 3H]senktide
5. 3 receptor
6. Recent advances in neurokinin-3 receptor antagonists
7. 3 receptor stimulation
8. The distribution of the neurokinin B receptor in the human and rat hypothalamus
9. Distribution of NK3 receptors in the monkey brain: A beta imager autoradiographic study
10. Detailed distribution of neurokinin 3 receptors in the rat, guinea pig and gerbil brain: A comparative autoradiographic study
11. The mammalian tachykinin receptors
12. 3 receptor stimulation: An in vivo microdialysis approach in guinea-pig
13. Tachykinin NK3 receptor involvement in anxiety
14. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist
15. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist
16. Receptor occupancy by ritanserin and risperidone measured using ex vivo autoradiography
17. Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding
18. Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography
19. Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex