An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 2, 2016, Pages E117-E126

  De Gassart, Aude ^a   Bujisic, Bojan ^a   Zaffalon, Léa ^a   Decosterd, Laurent A ^b   Di Micco, Antonia ^a   Frera, Gianluca ^a   Tallant, Rémy ^a   Martinon, Fabio ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

ER stress; HIV protease inhibitors; Nelfinavir; PPP1R15B; Translation initiation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; APOLIPOPROTEIN B; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; EDEM PROTEIN; ERDJ4 PROTEIN; GADD34 PROTEIN; HERP PROTEIN; HISTONE H2AX; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; INITIATION FACTOR 2ALPHA; NELFINAVIR; OXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PKR LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN; SESN 2 PROTEIN; TRIB 3 PROTEIN; TUNICAMYCIN; UNCLASSIFIED DRUG; ERN2 PROTEIN, MOUSE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INITIATION FACTOR 2; MEMBRANE PROTEIN; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CELLULAR STRESS RESPONSE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; INTEGRATED STRESS RESPONSE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN TARGETING; TRANSLATION INITIATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; HELA CELLS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; LIVER; MEMBRANE PROTEINS; MICE; NELFINAVIR; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; UNFOLDED PROTEIN RESPONSE;

EID: 84954532316     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514076113     Document Type: Article

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