Transcriptional regulation of osteoblasts

Cells Tissues Organs

Volumn 189, Issue 1-4, 2008, Pages 144-152

  Franceschi, Renny T ^a,d   Ge, Chunxi ^a   Xiao, Guozhi ^c   Roca, Hernan ^b   Jiang, Di ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

Bone; Development; Osteoblast; Transcription

Indexed keywords

BONE SIALOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR RUNX2;

BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINEAGE; CONFERENCE PAPER; GENE EXPRESSION; GROWTH RATE; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CHROMATIN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; OSTEOBLASTS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIALOGLYCOPROTEINS; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 57449091120     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151747     Document Type: Conference Paper

References (32)

1. Afzal, F., J. Pratap, K. Ito, Y. Ito, J.L. Stein, A.J. van Wijnen, G.S. Stein, J.B. Lian, A. Javed (2005) Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 204: 63-72.
2. Benson, M.D., J.L. Bargeon, G. Xiao, P.E. Thomas, A. Kim, Y. Cui, R.T. Franceschi (2000) Identification of a homeodomain binding element in the bone sialoprotein gene promoter that is required for its osteoblast-selective expression. J Biol Chem 275: 13907-13917.
3. Bialek, P., B. Kern, X. Yang, M. Schrock, D. Sosic, N. Hong, H. Wu, K. Yu, D.M. Ornitz, E.N. Olson, M.J. Justice, G. Karsenty (2004) A twist code determines the onset of osteoblast differentiation. Dev Cell 6: 423-435.
4. Ducy, P., R. Zhang, V. Geoffroy, A.L. Ridall, G. Karsenty (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
5. Engler, A.J., S. Sen, H.L. Sweeney, D.E. Discher (2006) Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
6. Franceschi, R., C. Ge, G. Xiao, H. Roca, D. Jiang (2007) Transcriptional regulation of osteoblasts. Ann NY Acad Sci 1116: 196-207.
7. Franceschi, R.T. (1992) The role of ascorbic acid in mesenchymal differentiation. Nutr Rev 50: 65-70.
8. Frendo, J.L., G. Xiao, S. Fuchs, R.T. Franceschi, G. Karsenty, P. Ducy (1998) Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J Biol Chem 273: 30509-30516.
9. Ge, C., G. Xiao, D. Jiang, R.T. Franceschi (2007) Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176: 709-718.
10. Gopalakrishnan, R., P.E. Thomas, M.D. Benson, D. Wang, R.T. Franceschi (2003) A homeodomain protein binding element in the bone sialoprotein promoter is critical for tissue-specific expression in bone. Connect Tissue Res 44(suppl 1): 154-160.
11. Hynes, R.O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
12. Imai, Y., M. Kurokawa, Y. Yamaguchi, K. Izutsu, E. Nitta, K. Mitani, M. Satake, T. Noda, Y. Ito, H. Hirai (2004) The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1. Mol Cell Biol 24: 1033-1043.
13. Ito, Y. (2004) Oncogenic potential of the RUNX gene family: 'overview'. Oncogene 23: 4198-4208.
14. Jeon, E.J., K.Y. Lee, N.S. Choi, M.H. Lee, H.N. Kim, Y.H. Jin, H.M. Ryoo, J.Y. Choi, M. Yoshida, N. Nishino, B.C. Oh, K.S. Lee, Y.H. Lee, S.C. Bae (2006) Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem 281: 16502-16511.
15. Jiang, D., R.T. Franceschi, H. Boules, G. Xiao (2004) Parathyroid hormone induction of the osteocalcin gene: requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple-signaling pathways. J Biol Chem 279: 5329-5337.
16. Kanno, T., T. Takahashi, T. Tsujisawa, W. Ariyoshi, T. Nishihara (2007) Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem 101: 1266-1277.
17. Kim, H.J., J.H. Kim, S.C. Bae, J.Y. Choi, H.M. Ryoo (2003) The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278: 319-326.
18. Komori, T., H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y.H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, T. Kishimoto (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
19. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, R.R. Behringer, B. de Crombrugghe (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
20. Otto, F., A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, I.R. Rosewell, G.W. Stamp, R.S. Beddington, S. Mundlos, B.R. Olsen, P. B. Selby, M.J. Owen (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771.
21. Roca, H., M. Phimphilai, R. Gopalakrishnan, G. Xiao, R.T. Franceschi (2005) Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chemi 280: 30845-30855.
22. Wang, F.S., C.J. Wang, S.M. Sheen-Chen, Y.R. Kuo, R.F. Chen, K.D. Yang (2002) Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. J Biol Chem 277: 10931-10937.
23. Xiao, G., Y. Cui, P. Ducy, G. Karsenty, R.T. Franceschi (1997) Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol 11: 1103-1113.
24. Xiao, G., D. Jiang, C. Ge, Z. Zhao, Y. Lai, H. Boules, M. Phimphilai, X. Yang, G. Karsenty, R.T. Franceschi (2005) Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem 280: 30689-30696.
25. Xiao, G., D. Jiang, R. Gopalakrishnan, R.T. Franceschi (2002) Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem 277: 36181-36187.
26. Xiao, G., D. Jiang, P. Thomas, M.D. Benson, K. Guan, G. Karsenty, R.T. Franceschi (2000) MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275: 4453-4459.
27. Xiao, G., D. Wang, M.D. Benson, G. Karsenty, R.T. Franceschi (1998) Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem 273: 32988-32994.
28. Yang, X., K. Matsuda, P. Bialek, S. Jacquot, H.C. Masuoka, T. Schinke, L. Li, S. Brancorsini, P. Sassone-Corsi, T.M. Townes, A. Hanauer, G. Karsenty (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry syndrome. Cell 117: 387-398.
29. You, J., G.C. Reilly, X. Zhen, C.E. Yellowley, Q. Chen, H.J. Donahue, C.R. Jacobs (2001) Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276: 13365-13371.
30. Zaidi, S.K., A.J. Sullivan, A.J. van Wijnen, J.L. Stein, G.S. Stein, J.B. Lian (2002) Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci USA 99: 8048-8053.
31. Zhou, G., Q. Zheng, F. Engin, E. Munivez, Y. Chen, E. Sebald, D. Krakow, B. Lee (2006) Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci USA 103: 19004-19009.
32. Ziros, P.G., A.P. Gil, T. Georgakopoulos, I. Habeos, D. Kletsas, E.K. Basdra, A.G. Papavassiliou (2002) The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 277: 23934-23941.