Small-molecule targeting of translation initiation for cancer therapy

Oncotarget

Volumn 4, Issue 10, 2013, Pages 1606-1617

  Aktas, Bertal H ^a,b   Qiao, Yuan ^b   Ozdelen, Esra ^b   Schubert, Roland ^b   Sevinc, Sema ^b   Harbinski, Fred ^b   Grubissich, Luciano ^b   Singer, Samuel ^a   Halperin, Jose A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer; eIF2; Ternary complex; Translation; UTR

Indexed keywords

CALCIUM ION; COTRIMOXAZOLE; CYCLIN D1; GUANOSINE TRIPHOSPHATE; ICOSAPENTAENOIC ACID; INITIATION FACTOR 2ALPHA; SCATTER FACTOR RECEPTOR; TERNARY COMPLEX FACTOR; TRANSFER RNA; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM STRESS RESPONSE GENE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; TRANSLATION INITIATION; TUMOR GENE; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; CLOTRIMAZOLE; CYCLIN D1; DISEASE MODELS, ANIMAL; EICOSAPENTAENOIC ACID; EUKARYOTIC INITIATION FACTOR-2; FEMALE; HUMANS; MICE; MICE, INBRED DBA; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RANDOM ALLOCATION; THIAZOLIDINEDIONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886743598     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1186     Document Type: Article

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