Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

IUBMB Life

Volumn 64, Issue 3, 2012, Pages 226-230

  Wang, Chunxia ^a   Guo, Feifan ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

ATF4; energy homeostasis; glucose metabolism; insulin secretion and sensitivity; lipid metabolism

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4;

CARBOHYDRATE METABOLISM; ENERGY BALANCE; GLUCOSE METABOLISM; HOMEOSTASIS; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID METABOLISM; MAMMAL; NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CARBOHYDRATE METABOLISM; HOMEOSTASIS; HUMANS; LIPID METABOLISM;

EID: 84863164415     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.605     Document Type: Review

References (44)

1. Vallejo, M., Ron, D., Miller, C. P., and, Habener, J. F., (1993) C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci USA 90, 4679-4683. (Pubitemid 23148969)
2. Karpinski, B. A., Morle, G. D., Huggenvik, J., Uhler, M. D., and, Leiden, J. M., (1992) Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci USA 89, 4820-4824.
3. Mielnicki, L. M., and, Pruitt, S. C., (1991) Isolation and nucleotide sequence of a murine cDNA homologous to human activating transcription factor 4. Nucleic Acids Res 19, 6332.
4. Lin, Y. S., and, Green, M. R., (1988) Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters. Proc Natl Acad Sci USA 85, 3396-3400.
5. Mamady, H., and, Storey, K. B., (2008) Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels. Arch Biochem Biophys 477, 77-85.
6. Ameri, K., and, Harris, A. L., (2008) Activating transcription factor 4. Int J Biochem Cell Biol 40, 14-21. (Pubitemid 350064577)
7. Hai, T., and, Hartman, M. G., (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273, 1-11. (Pubitemid 32718721)
8. Lassot, I., Estrabaud, E., Emiliani, S., Benkirane, M., Benarous, R., and, Margottin-Goguet, F., (2005) p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem 280, 41537-41545. (Pubitemid 41832215)
9. Danciu, T. E., Li, Y., Koh, A., Xiao, G., McCauley, L. K., and, Franceschi, R. T., (2011) The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem, doi: 10.1002/jcb.23329.
10. Hiwatashi, Y., Kanno, K., Takasaki, C., Goryo, K., Sato, T., Torii, S., Sogawa, K., and, Yasumoto, K. I., (2011) PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation. Exp Cell Res, 317, 2789-2799.
11. De Angelis, R., Iezzi, S., Bruno, T., Corbi, N., Di Padova, M., Floridi, A., Fanciulli, M., and, Passananti, C., (2003) Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett 547, 15-19. (Pubitemid 36829371)
12. Hogan, M. R., Cockram, G. P., and, Lu, R., (2006) Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element. FEBS Lett 580, 58-62. (Pubitemid 43005312)
13. Su, N., and, Kilberg, M. S., (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem 283, 35106-35117.
14. Siu, F., Bain, P. J., LeBlanc-Chaffin, R., Chen, H., and, Kilberg, M. S., (2002) ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem 277, 24120-24127. (Pubitemid 34951925)
15. Masuoka, H. C., and, Townes, T. M., (2002) Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 99, 736-745. (Pubitemid 34525531)
16. Tanaka, T., Tsujimura, T., Takeda, K., Sugihara, A., Maekawa, A., Terada, N., Yoshida, N., and, Akira, S., (1998) Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells 3, 801-810. (Pubitemid 29098936)
17. Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes, T. M., Hanauer, A., and, Karsenty, G., (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117, 387-398. (Pubitemid 38534544)
18. Brightwell, J. J., Gallagher, M., and, Colombo, P. J., (2004) Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol Learn Mem 81, 19-26. (Pubitemid 37518336)
19. Mohamed, H. A., Yao, W., Fioravante, D., Smolen, P. D., and, Byrne, J. H., (2005) cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: implications for feedback loops modulating long term memory. J Biol Chem 280, 27035-27043. (Pubitemid 41040740)
20. Ye, J., and, Koumenis, C., (2009) ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis. Curr Mol Med 9, 411-416.
21. Igarashi, T., Izumi, H., Uchiumi, T., Nishio, K., Arao, T., Tanabe, M., Uramoto, H., Sugio, K., Yasumoto, K., Sasaguri, Y., Wang, K. Y., Otsuji, Y., and, Kohno, K., (2007) Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene 26, 4749-4760. (Pubitemid 47093179)
22. Whitney, M. L., Jefferson, L. S., and, Kimball, S. R., (2009) ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun 379, 451-455.
23. Milani, M., Rzymski, T., Mellor, H. R., Pike, L., Bottini, A., Generali, D., and, Harris, A. L., (2009) The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res 69, 4415-4423.
24. Kilberg, M. S., Shan, J., and, Su, N., (2009) ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab 20, 436-443.
25. Fels, D. R., and, Koumenis, C., (2006) The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth. Cancer Biol Ther 5, 723-728. (Pubitemid 44794028)
26. Rzymski, T., Milani, M., Singleton, D. C., and, Harris, A. L., (2009) Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell Cycle 8, 3838-3847.
27. Seo, J., Fortuno, E. S. 3rd, Suh, J. M., Stenesen, D., Tang, W., Parks, E. J., Adams, C. M., Townes, T., and, Graff, J. M., (2009) Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 58, 2565-2573.
28. Sarbassov, D. D., Ali, S. M., and, Sabatini, D. M., (2005) Growing roles for the mTOR pathway. Curr Opin Cell Biol 17, 596-603. (Pubitemid 41540408)
29. Tsukiyama-Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A. C., Katsume, A., Elchebly, M., Spiegelman, B. M., Harper, M. E., Tremblay, M. L., and, Sonenberg, N., (2001) Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 7, 1128-1132. (Pubitemid 33010021)
30. Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., and, Thomas, G., (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205. (Pubitemid 39243474)
31. Wang, C., Huang, Z., Du, Y., Cheng, Y., Chen, S., and, Guo, F., (2010) ATF4 regulates lipid metabolism and thermogenesis. Cell Res 20, 174-184.
32. Karamitri, A., Shore, A. M., Docherty, K., Speakman, J. R., and, Lomax, M. A., (2009) Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes. J Biol Chem 284, 20738-20752.
33. Werstuck, G. H., Lentz, S. R., Dayal, S., Hossain, G. S., Sood, S. K., Shi, Y. Y., Zhou, J., Maeda, N., Krisans, S. K., Malinow, M. R., and, Austin, R. C., (2001) Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 107, 1263-1273. (Pubitemid 32494543)
34. Kim, A. J., Shi, Y., Austin, R. C., and, Werstuck, G. H., (2005) Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci 118, 89-99. (Pubitemid 40277107)
35. Li, H., Meng, Q., Xiao, F., Chen, S., Du, Y., Yu, J., Wang, C., and, Guo, F., (2011) ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis. Biochem J 438, 283-289.
36. Murphy, K. G., and, Bloom, S. R., (2006) Gut hormones and the regulation of energy homeostasis. Nature 444, 854-859. (Pubitemid 46024992)
37. Rosen, E. D., and, Spiegelman, B. M., (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853. (Pubitemid 46024991)
38. Broberger, C., and, Hokfelt, T., (2001) Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol Behav 74, 669-682. (Pubitemid 34081212)
39. Macht, M., (2008) How emotions affect eating: a five-way model. Appetite 50, 1-11.
40. Yoshizawa, T., Hinoi, E., Jung, D. Y., Kajimura, D., Ferron, M., Seo, J., Graff, J. M., Kim, J. K., and, Karsenty, G., (2009) The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 119, 2807-2817.
41. Liew, C. W., Bochenski, J., Kawamori, D., Hu, J., Leech, C. A., Wanic, K., Malecki, M., Warram, J. H., Qi, L., Krolewski, A. S., and, Kulkarni, R. N., (2010) The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest 120, 2876-2888.
42. Yamaguchi, S., Ishihara, H., Yamada, T., Tamura, A., Usui, M., Tominaga, R., Munakata, Y., Satake, C., Katagiri, H., Tashiro, F., Aburatani, H., Tsukiyama-Kohara, K., Miyazaki, J., Sonenberg, N., and, Oka, Y., (2008) ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab 7, 269-276. (Pubitemid 351285529)
43. Scheuner, D., and, Kaufman, R. J., (2008) The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 29, 317-333. (Pubitemid 351679702)
44. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Gorgun, C., Glimcher, L. H., and, Hotamisligil, G. S., (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461. (Pubitemid 39372439)