메뉴 건너뛰기




Volumn 118, Issue 1, 2016, Pages 95-107

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology

Author keywords

fibroblast growth factor; heart diseases; myocardial infarction; regeneration; stem cells

Indexed keywords

ANGIOPOIETIN; AZACITIDINE; BETA1 INTEGRIN; CASPASE 3; COLLAGEN; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; NEU DIFFERENTIATION FACTOR; PLATELET DERIVED GROWTH FACTOR; PROCOLLAGEN C PROTEINASE; PROTEIN KINASE C; SCATTER FACTOR; SECRETED FRIZZLED RELATED PROTEIN 2; SOMATOMEDIN C; STAT3 PROTEIN; STEM CELL FACTOR; THROMBOPLASTIN; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; WNT3A PROTEIN;

EID: 84954496969     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.305373     Document Type: Review
Times cited : (221)

References (149)
  • 1
    • 78649386082 scopus 로고    scopus 로고
    • Genetic engineering of mesenchymal stem cells and its application in human disease therapy
    • Hodgkinson CP, Gomez JA, Mirotsou M, Dzau VJ. Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther. 2010;21:1513-1526. doi: 10.1089/hum.2010.165.
    • (2010) Hum Gene Ther , vol.21 , pp. 1513-1526
    • Hodgkinson, C.P.1    Gomez, J.A.2    Mirotsou, M.3    Dzau, V.J.4
  • 2
    • 77953434949 scopus 로고    scopus 로고
    • Emerging use of stem cells in regenerative medicine
    • Teo AK, Vallier L. Emerging use of stem cells in regenerative medicine. Biochem J. 2010;428:11-23. doi: 10.1042/BJ20100102.
    • (2010) Biochem J , vol.428 , pp. 11-23
    • Teo, A.K.1    Vallier, L.2
  • 3
    • 77649146795 scopus 로고    scopus 로고
    • Stem cell therapy for type 1 diabetes mellitus
    • Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010;6:139-148. doi: 10.1038/nrendo.2009.274.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 139-148
    • Aguayo-Mazzucato, C.1    Bonner-Weir, S.2
  • 4
    • 72949098042 scopus 로고    scopus 로고
    • Upper airway 2: Bronchiectasis, cystic fibrosis and sinusitis
    • Loebinger MR, Bilton D, Wilson R. Upper airway 2: Bronchiectasis, cystic fibrosis and sinusitis. Thorax. 2009;64:1096-1101. doi: 10.1136/thx.2008.112870.
    • (2009) Thorax , vol.64 , pp. 1096-1101
    • Loebinger, M.R.1    Bilton, D.2    Wilson, R.3
  • 5
    • 77949433853 scopus 로고    scopus 로고
    • Potential of mesenchymal stem cells for the therapy of autoimmune diseases
    • Pistoia V, Raffaghello L. Potential of mesenchymal stem cells for the therapy of autoimmune diseases. Expert Rev Clin Immunol. 2010;6:211-218.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 211-218
    • Pistoia, V.1    Raffaghello, L.2
  • 6
    • 77952888968 scopus 로고    scopus 로고
    • Clinical potential of adult vascular progenitor cells
    • Kumar AH, Caplice NM. Clinical potential of adult vascular progenitor cells. Arterioscler Thromb Vasc Biol. 2010;30:1080-1087. doi: 10.1161/ATVBAHA.109.198895.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1080-1087
    • Kumar, A.H.1    Caplice, N.M.2
  • 7
    • 14644414788 scopus 로고    scopus 로고
    • Unchain my heart: The scientific foundations of cardiac repair
    • Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest. 2005;115:572-583. doi: 10.1172/JCI24283.
    • (2005) J Clin Invest , vol.115 , pp. 572-583
    • Dimmeler, S.1    Zeiher, A.M.2    Schneider, M.D.3
  • 11
    • 77958012860 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    • Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010;107:913-922. doi: 10.1161/CIRCRESAHA.110.222703.
    • (2010) Circ Res , vol.107 , pp. 913-922
    • Hatzistergos, K.E.1    Quevedo, H.2    Oskouei, B.N.3
  • 12
    • 84901314372 scopus 로고    scopus 로고
    • Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction
    • Zhang Z, Liang D, Gao X, Zhao C, Qin X, Xu Y, Su T, Sun D, Li W, Wang H, Liu B, Cao F. Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction. Basic Res Cardiol. 2014;109:417. doi: 10.1007/s00395-014-0417-x.
    • (2014) Basic Res Cardiol , vol.109 , pp. 417
    • Zhang, Z.1    Liang, D.2    Gao, X.3    Zhao, C.4    Qin, X.5    Xu, Y.6    Su, T.7    Sun, D.8    Li, W.9    Wang, H.10    Liu, B.11    Cao, F.12
  • 14
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi M, Zhang Z, Ni A, Dzau VJ. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. 2008;103:1204-1219. doi: 10.1161/CIRCRESAHA.108.176826.
    • (2008) Circ Res , vol.103 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3    Dzau, V.J.4
  • 15
    • 1942517003 scopus 로고    scopus 로고
    • Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    • Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668-673. doi: 10.1038/nature02460.
    • (2004) Nature , vol.428 , pp. 668-673
    • Balsam, L.B.1    Wagers, A.J.2    Christensen, J.L.3    Kofidis, T.4    Weissman, I.L.5    Robbins, R.C.6
  • 18
    • 19944426939 scopus 로고    scopus 로고
    • Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    • Kajstura J, Rota M, Whang B, et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res. 2005;96:127-137. doi: 10.1161/01.RES.0000151843.79801.60.
    • (2005) Circ Res , vol.96 , pp. 127-137
    • Kajstura, J.1    Rota, M.2    Whang, B.3
  • 19
    • 33751038565 scopus 로고    scopus 로고
    • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    • Noiseux N, Gnecchi M, Lopez-Ilasaca M, Zhang L, Solomon SD, Deb A, Dzau VJ, Pratt RE. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther. 2006;14:840-850. doi: 10.1016/j.ymthe.2006.05.016.
    • (2006) Mol Ther , vol.14 , pp. 840-850
    • Noiseux, N.1    Gnecchi, M.2    Lopez-Ilasaca, M.3    Zhang, L.4    Solomon, S.D.5    Deb, A.6    Dzau, V.J.7    Pratt, R.E.8
  • 23
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    • Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 2006;20:661-669. doi: 10.1096/fj.05-5211com
    • (2006) FASEB J , vol.20 , pp. 661-669
    • Gnecchi, M.1    He, H.2    Noiseux, N.3    Liang, O.D.4    Zhang, L.5    Morello, F.6    Mu, H.7    Melo, L.G.8    Pratt, R.E.9    Ingwall, J.S.10    Dzau, V.J.11
  • 25
    • 33746836891 scopus 로고    scopus 로고
    • Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury
    • Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, Ikeda Y, Matsuzaki M, Hamano K. Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol. 2006;291:H886-H893. doi: 10.1152/ajpheart.00142.2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. H886-H893
    • Takahashi, M.1    Li, T.S.2    Suzuki, R.3    Kobayashi, T.4    Ito, H.5    Ikeda, Y.6    Matsuzaki, M.7    Hamano, K.8
  • 26
    • 33745356932 scopus 로고    scopus 로고
    • Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    • Uemura R, Xu M, Ahmad N, Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006;98:1414-1421. doi: 10.1161/01.RES.0000225952.61196.39.
    • (2006) Circ Res , vol.98 , pp. 1414-1421
    • Uemura, R.1    Xu, M.2    Ahmad, N.3    Ashraf, M.4
  • 27
    • 33846395496 scopus 로고    scopus 로고
    • In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function
    • Xu M, Uemura R, Dai Y, Wang Y, Pasha Z, Ashraf M. In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol. 2007;42:441-448. doi: 10.1016/j.yjmcc.2006.10.009.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 441-448
    • Xu, M.1    Uemura, R.2    Dai, Y.3    Wang, Y.4    Pasha, Z.5    Ashraf, M.6
  • 28
    • 33846845067 scopus 로고    scopus 로고
    • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
    • Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci USA. 2007;104:1643-1648. doi: 10.1073/pnas.0610024104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1643-1648
    • Mirotsou, M.1    Zhang, Z.2    Deb, A.3    Zhang, L.4    Gnecchi, M.5    Noiseux, N.6    Mu, H.7    Pachori, A.8    Dzau, V.9
  • 29
    • 59149102022 scopus 로고    scopus 로고
    • Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a
    • Zhang Z, Deb A, Zhang Z, Pachori A, He W, Guo J, Pratt R, Dzau VJ. Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol. 2009;46:370-377. doi: 10.1016/j.yjmcc.2008.11.016.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 370-377
    • Zhang, Z.1    Deb, A.2    Zhang, Z.3    Pachori, A.4    He, W.5    Guo, J.6    Pratt, R.7    Dzau, V.J.8
  • 30
    • 47249088331 scopus 로고    scopus 로고
    • Identifying autism loci and genes by tracing recent shared ancestry
    • Morrow EM, Yoo SY, Flavell SW, et al. Identifying autism loci and genes by tracing recent shared ancestry. Science. 2008;321:218-223. doi: 10.1126/science.1157657.
    • (2008) Science , vol.321 , pp. 218-223
    • Morrow, E.M.1    Yoo, S.Y.2    Flavell, S.W.3
  • 33
    • 66149154936 scopus 로고    scopus 로고
    • Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells
    • Zhang Y, Ingram DA, Murphy MP, Saadatzadeh MR, Mead LE, Prater DN, Rehman J. Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2009;296:H1675-H1682. doi: 10.1152/ajpheart.00665.2008.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , pp. H1675-H1682
    • Zhang, Y.1    Ingram, D.A.2    Murphy, M.P.3    Saadatzadeh, M.R.4    Mead, L.E.5    Prater, D.N.6    Rehman, J.7
  • 34
    • 63049108277 scopus 로고    scopus 로고
    • Human peripheral blood endothelial progenitor cells synthesize and express functionally active tissue factor
    • Di Stefano R, Barsotti MC, Armani C, Santoni T, Lorenzet R, Balbarini A, Celi A. Human peripheral blood endothelial progenitor cells synthesize and express functionally active tissue factor. Thromb Res. 2009;123:925-930. doi: 10.1016/j.thromres.2008.10.013.
    • (2009) Thromb Res , vol.123 , pp. 925-930
    • Di Stefano, R.1    Barsotti, M.C.2    Armani, C.3    Santoni, T.4    Lorenzet, R.5    Balbarini, A.6    Celi, A.7
  • 35
    • 15944376184 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    • Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005;105:2821-2827. doi: 10.1182/blood-2004-09-3696.
    • (2005) Blood , vol.105 , pp. 2821-2827
    • Glennie, S.1    Soeiro, I.2    Dyson, P.J.3    Lam, E.W.4    Dazzi, F.5
  • 37
    • 77649285139 scopus 로고    scopus 로고
    • Stem cell paracrine actions and tissue regeneration
    • Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010;5:121-143. doi: 10.2217/rme.09.74.
    • (2010) Regen Med , vol.5 , pp. 121-143
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 38
    • 33947593728 scopus 로고    scopus 로고
    • Mesenchymal stem cells stimulate antibody secretion in human B cells
    • Rasmusson I, Le Blanc K, Sundberg B, Ringdén O. Mesenchymal stem cells stimulate antibody secretion in human B cells. Scand J Immunol. 2007;65:336-343. doi: 10.1111/j.1365-3083.2007.01905.x.
    • (2007) Scand J Immunol , vol.65 , pp. 336-343
    • Rasmusson, I.1    Le Blanc, K.2    Sundberg, B.3    Ringdén, O.4
  • 40
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2
    • Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009;113:6576-6583. doi: 10.1182/blood-2009-02-203943.
    • (2009) Blood , vol.113 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4
  • 41
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: Role of indoleamine 2,3-dioxygenase and prostaglandin E2
    • Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood. 2008;111:1327-1333. doi: 10.1182/blood-2007-02-074997.
    • (2008) Blood , vol.111 , pp. 1327-1333
    • Spaggiari, G.M.1    Capobianco, A.2    Abdelrazik, H.3    Becchetti, F.4    Mingari, M.C.5    Moretta, L.6
  • 42
    • 34547402979 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    • Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA. 2007;104:11002-11007. doi: 10.1073/pnas.0704421104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11002-11007
    • Ortiz, L.A.1    Dutreil, M.2    Fattman, C.3    Pandey, A.C.4    Torres, G.5    Go, K.6    Phinney, D.G.7
  • 47
    • 78149335954 scopus 로고    scopus 로고
    • Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing
    • Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A, Nguyen AL, Kwon CW, Le AD. Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells. 2010;28:1856-1868. doi: 10.1002/stem.503.
    • (2010) Stem Cells , vol.28 , pp. 1856-1868
    • Zhang, Q.Z.1    Su, W.R.2    Shi, S.H.3    Wilder-Smith, P.4    Xiang, A.P.5    Wong, A.6    Nguyen, A.L.7    Kwon, C.W.8    Le, A.D.9
  • 48
    • 70449527554 scopus 로고    scopus 로고
    • Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages
    • Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages. Exp Hematol. 2009;37:1445-1453. doi: 10.1016/j.exphem.2009.09.004.
    • (2009) Exp Hematol , vol.37 , pp. 1445-1453
    • Kim, J.1    Hematti, P.2
  • 49
    • 84856723391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction
    • Dayan V, Yannarelli G, Billia F, Filomeno P, Wang XH, Davies JE, Keating A. Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction. Basic Res Cardiol. 2011;106:1299-1310. doi: 10.1007/s00395-011-0221-9.
    • (2011) Basic Res Cardiol , vol.106 , pp. 1299-1310
    • Dayan, V.1    Yannarelli, G.2    Billia, F.3    Filomeno, P.4    Wang, X.H.5    Davies, J.E.6    Keating, A.7
  • 51
    • 48849108401 scopus 로고    scopus 로고
    • Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction
    • Burchfield JS, Iwasaki M, Koyanagi M, Urbich C, Rosenthal N, Zeiher AM, Dimmeler S. Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res. 2008;103:203-211. doi: 10.1161/CIRCRESAHA.108.178475.
    • (2008) Circ Res , vol.103 , pp. 203-211
    • Burchfield, J.S.1    Iwasaki, M.2    Koyanagi, M.3    Urbich, C.4    Rosenthal, N.5    Zeiher, A.M.6    Dimmeler, S.7
  • 53
    • 0037073890 scopus 로고    scopus 로고
    • Heart regeneration in zebrafish
    • Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298:2188-2190. doi: 10.1126/science.1077857.
    • (2002) Science , vol.298 , pp. 2188-2190
    • Poss, K.D.1    Wilson, L.G.2    Keating, M.T.3
  • 54
    • 79956334658 scopus 로고    scopus 로고
    • Heart regeneration
    • Laflamme MA, Murry CE. Heart regeneration. Nature. 2011;473:326-335. doi: 10.1038/nature10147.
    • (2011) Nature , vol.473 , pp. 326-335
    • Laflamme, M.A.1    Murry, C.E.2
  • 56
    • 0031013253 scopus 로고    scopus 로고
    • Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts
    • Soonpaa MH, Field LJ. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol. 1997;272:H220-H226.
    • (1997) Am J Physiol , vol.272 , pp. H220-H226
    • Soonpaa, M.H.1    Field, L.J.2
  • 59
    • 34748864144 scopus 로고    scopus 로고
    • Different regulation of p27 and Akt during cardiomyocyte proliferation and hypertrophy
    • Hinrichsen R, Haunsø S, Busk PK. Different regulation of p27 and Akt during cardiomyocyte proliferation and hypertrophy. Growth Factors. 2007;25:132-140. doi: 10.1080/08977190701549835.
    • (2007) Growth Factors , vol.25 , pp. 132-140
    • Hinrichsen, R.1    Haunsø, S.2    Busk, P.K.3
  • 60
    • 0032562770 scopus 로고    scopus 로고
    • Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    • Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, Kelly RA. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998;273:10261-10269.
    • (1998) J Biol Chem , vol.273 , pp. 10261-10269
    • Zhao, Y.Y.1    Sawyer, D.R.2    Baliga, R.R.3    Opel, D.J.4    Han, X.5    Marchionni, M.A.6    Kelly, R.A.7
  • 61
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138:257-270. doi: 10.1016/j.cell.2009.04.060.
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kühn, B.4
  • 62
    • 84870014721 scopus 로고    scopus 로고
    • ERBB2 inhibition and heart failure
    • Cote GM, Sawyer DB, Chabner BA. ERBB2 inhibition and heart failure. N Engl J Med. 2012;367:2150-2153. doi: 10.1056/NEJMcibr1203156.
    • (2012) N Engl J Med , vol.367 , pp. 2150-2153
    • Cote, G.M.1    Sawyer, D.B.2    Chabner, B.A.3
  • 63
    • 84937232088 scopus 로고    scopus 로고
    • Conserved microRNA program as key to mammalian cardiac regeneration: Insights from zebrafish
    • Hodgkinson CP, Dzau VJ. Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish. Circ Res. 2015;116:1109-1111. doi: 10.1161/CIRCRESAHA.115.305852.
    • (2015) Circ Res , vol.116 , pp. 1109-1111
    • Hodgkinson, C.P.1    Dzau, V.J.2
  • 65
    • 84900331122 scopus 로고    scopus 로고
    • A proliferative burst during preadolescence establishes the final cardiomyocyte number
    • Naqvi N, Li M, Calvert JW, et al. A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell. 2014;157:795-807. doi: 10.1016/j.cell.2014.03.035.
    • (2014) Cell , vol.157 , pp. 795-807
    • Naqvi, N.1    Li, M.2    Calvert, J.W.3
  • 66
    • 84874530139 scopus 로고    scopus 로고
    • Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2
    • Przybyt E, Krenning G, Brinker MG, Harmsen MC. Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2. J Transl Med. 2013;11:39. doi: 10.1186/1479-5876-11-39.
    • (2013) J Transl Med , vol.11 , pp. 39
    • Przybyt, E.1    Krenning, G.2    Brinker, M.G.3    Harmsen, M.C.4
  • 67
    • 59649110883 scopus 로고    scopus 로고
    • Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling
    • Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009;16:233-244. doi: 10.1016/j. devcel.2008.12.007.
    • (2009) Dev Cell , vol.16 , pp. 233-244
    • Ieda, M.1    Tsuchihashi, T.2    Ivey, K.N.3    Ross, R.S.4    Hong, T.T.5    Shaw, R.M.6    Srivastava, D.7
  • 68
    • 82555164970 scopus 로고    scopus 로고
    • Periostin mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth in a xenograft lung adenocarcinoma model
    • Heo SC, Lee KO, Shin SH, Kwon YW, Kim YM, Lee CH, Kim YD, Lee MK, Yoon MS, Kim JH. Periostin mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth in a xenograft lung adenocarcinoma model. Biochim Biophys Acta. 2011;1813:2061-2070. doi: 10.1016/j.bbamcr.2011.08.004.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 2061-2070
    • Heo, S.C.1    Lee, K.O.2    Shin, S.H.3    Kwon, Y.W.4    Kim, Y.M.5    Lee, C.H.6    Kim, Y.D.7    Lee, M.K.8    Yoon, M.S.9    Kim, J.H.10
  • 69
    • 34547691243 scopus 로고    scopus 로고
    • Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
    • Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med. 2007;13:962-969. doi: 10.1038/nm1619.
    • (2007) Nat Med , vol.13 , pp. 962-969
    • Kühn, B.1    Del Monte, F.2    Hajjar, R.J.3    Chang, Y.S.4    Lebeche, D.5    Arab, S.6    Keating, M.T.7
  • 70
    • 59649112680 scopus 로고    scopus 로고
    • Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair
    • Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res. 2009;104:e1-e7. doi: 10.1161/CIRCRESAHA.108.188649.
    • (2009) Circ Res , vol.104 , pp. e1-e7
    • Lorts, A.1    Schwanekamp, J.A.2    Elrod, J.W.3    Sargent, M.A.4    Molkentin, J.D.5
  • 72
    • 84899910899 scopus 로고    scopus 로고
    • Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts
    • Zhao S, Wu H, Xia W, Chen X, Zhu S, Zhang S, Shao Y, Ma W, Yang D, Zhang J. Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts. J Cardiol. 2014;63:373-378. doi: 10.1016/j.jjcc.2013.09.013.
    • (2014) J Cardiol , vol.63 , pp. 373-378
    • Zhao, S.1    Wu, H.2    Xia, W.3    Chen, X.4    Zhu, S.5    Zhang, S.6    Shao, Y.7    Ma, W.8    Yang, D.9    Zhang, J.10
  • 73
    • 84881667960 scopus 로고    scopus 로고
    • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3KAKT-CDK7 pathway
    • Beigi F, Schmeckpeper J, Pow-Anpongkul P, Payne JA, Zhang L, Zhang Z, Huang J, Mirotsou M, Dzau VJ. C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3KAKT-CDK7 pathway. Circ Res. 2013;113:372-380. doi: 10.1161/CIRCRESAHA.113.301075.
    • (2013) Circ Res , vol.113 , pp. 372-380
    • Beigi, F.1    Schmeckpeper, J.2    Pow-Anpongkul, P.3    Payne, J.A.4    Zhang, L.5    Zhang, Z.6    Huang, J.7    Mirotsou, M.8    Dzau, V.J.9
  • 74
    • 85019293260 scopus 로고    scopus 로고
    • Abstract 15731: Hypoxia and Akt induced stem cell factor exerts cardioprotective effects via specific binding to the insulin-like growth factor-1 receptor
    • Bareja A, Hodgkinson C, Payne A, Pratt R, Dzau V. Abstract 15731: hypoxia and Akt induced stem cell factor exerts cardioprotective effects via specific binding to the insulin-like growth factor-1 receptor. Circulation. 2014;130:A15731.
    • (2014) Circulation , vol.130 , pp. A15731
    • Bareja, A.1    Hodgkinson, C.2    Payne, A.3    Pratt, R.4    Dzau, V.5
  • 75
    • 0028799490 scopus 로고
    • Insulinlike growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure
    • Duerr RL, Huang S, Miraliakbar HR, Clark R, Chien KR, Ross J Jr. Insulinlike growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 1995;95:619-627. doi: 10.1172/JCI117706.
    • (1995) J Clin Invest , vol.95 , pp. 619-627
    • Duerr, R.L.1    Huang, S.2    Miraliakbar, H.R.3    Clark, R.4    Chien, K.R.5    Ross, J.6
  • 76
    • 0037478581 scopus 로고    scopus 로고
    • Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    • Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA. 2003;100:8407-8411. doi: 10.1073/pnas.1432929100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8407-8411
    • Ortiz, L.A.1    Gambelli, F.2    McBride, C.3    Gaupp, D.4    Baddoo, M.5    Kaminski, N.6    Phinney, D.G.7
  • 77
    • 33644900780 scopus 로고    scopus 로고
    • Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    • Oyagi S, Hirose M, Kojima M, Okuyama M, Kawase M, Nakamura T, Ohgushi H, Yagi K. Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol. 2006;44:742-748. doi: 10.1016/j.jhep.2005.10.026.
    • (2006) J Hepatol , vol.44 , pp. 742-748
    • Oyagi, S.1    Hirose, M.2    Kojima, M.3    Okuyama, M.4    Kawase, M.5    Nakamura, T.6    Ohgushi, H.7    Yagi, K.8
  • 78
    • 33745697880 scopus 로고    scopus 로고
    • Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice
    • Ninichuk V, Gross O, Segerer S, Hoffmann R, Radomska E, Buchstaller A, Huss R, Akis N, Schlöndorff D, Anders HJ. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int. 2006;70:121-129. doi: 10.1038/sj.ki.5001521.
    • (2006) Kidney Int , vol.70 , pp. 121-129
    • Ninichuk, V.1    Gross, O.2    Segerer, S.3    Hoffmann, R.4    Radomska, E.5    Buchstaller, A.6    Huss, R.7    Akis, N.8    Schlöndorff, D.9    Anders, H.J.10
  • 79
    • 34247619261 scopus 로고    scopus 로고
    • Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells
    • Ohnishi S, Yasuda T, Kitamura S, Nagaya N. Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells. Stem Cells. 2007;25:1166-1177. doi: 10.1634/stemcells.2006-0347.
    • (2007) Stem Cells , vol.25 , pp. 1166-1177
    • Ohnishi, S.1    Yasuda, T.2    Kitamura, S.3    Nagaya, N.4
  • 80
    • 20644471364 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats
    • Xu X, Xu Z, Xu Y, Cui G. Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coron Artery Dis. 2005;16:245-255.
    • (2005) Coron Artery Dis , vol.16 , pp. 245-255
    • Xu, X.1    Xu, Z.2    Xu, Y.3    Cui, G.4
  • 81
    • 34547685923 scopus 로고    scopus 로고
    • Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
    • Ohnishi S, Sumiyoshi H, Kitamura S, Nagaya N. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett. 2007;581:3961-3966. doi: 10.1016/j. febslet.2007.07.028.
    • (2007) FEBS Lett , vol.581 , pp. 3961-3966
    • Ohnishi, S.1    Sumiyoshi, H.2    Kitamura, S.3    Nagaya, N.4
  • 82
    • 84877687210 scopus 로고    scopus 로고
    • Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
    • Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013;153:828-839. doi: 10.1016/j.cell.2013.04.015.
    • (2013) Cell , vol.153 , pp. 828-839
    • Loffredo, F.S.1    Steinhauser, M.L.2    Jay, S.M.3
  • 83
    • 78650489190 scopus 로고    scopus 로고
    • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    • He W, Zhang L, Ni A, Zhang Z, Mirotsou M, Mao L, Pratt RE, Dzau VJ. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci USA. 2010;107:21110-21115. doi: 10.1073/pnas.1004708107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21110-21115
    • He, W.1    Zhang, L.2    Ni, A.3    Zhang, Z.4    Mirotsou, M.5    Mao, L.6    Pratt, R.E.7    Dzau, V.J.8
  • 87
    • 84900028554 scopus 로고    scopus 로고
    • A new molecular target for blunting organ fibrosis. Focus on Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
    • Ostrom RS. A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention". Am J Physiol Cell Physiol. 2014;306:C527-C528. doi: 10.1152/ajpcell.00020.2014.
    • (2014) Am J Physiol Cell Physiol , vol.306 , pp. C527-C528
    • Ostrom, R.S.1
  • 88
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005;85:1093-1129. doi: 10.1152/physrev.00006.2004.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 90
    • 34548394568 scopus 로고    scopus 로고
    • Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation
    • Feygin J, Mansoor A, Eckman P, Swingen C, Zhang J. Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation. Am J Physiol Heart Circ Physiol. 2007;293:H1772-H1780. doi: 10.1152/ajpheart.00242.2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H1772-H1780
    • Feygin, J.1    Mansoor, A.2    Eckman, P.3    Swingen, C.4    Zhang, J.5
  • 91
    • 65649128494 scopus 로고    scopus 로고
    • Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction
    • Gnecchi M, He H, Melo LG, Noiseaux N, Morello F, de Boer RA, Zhang L, Pratt RE, Dzau VJ, Ingwall JS. Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells. 2009;27:971-979. doi: 10.1002/stem.12.
    • (2009) Stem Cells , vol.27 , pp. 971-979
    • Gnecchi, M.1    He, H.2    Melo, L.G.3    Noiseaux, N.4    Morello, F.5    De Boer, R.A.6    Zhang, L.7    Pratt, R.E.8    Dzau, V.J.9    Ingwall, J.S.10
  • 92
    • 0029769103 scopus 로고    scopus 로고
    • The effect of insulin-like growth factor-1 on adult rat cardiac contractility
    • Freestone NS, Ribaric S, Mason WT. The effect of insulin-like growth factor-1 on adult rat cardiac contractility. Mol Cell Biochem. 1996;163-164:223-229.
    • (1996) Mol Cell Biochem , vol.163-164 , pp. 223-229
    • Freestone, N.S.1    Ribaric, S.2    Mason, W.T.3
  • 94
    • 9344265225 scopus 로고    scopus 로고
    • Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis
    • Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura S. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. 2004;287:H2670-H2676. doi: 10.1152/ajpheart.01071.2003.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. H2670-H2676
    • Nagaya, N.1    Fujii, T.2    Iwase, T.3    Ohgushi, H.4    Itoh, T.5    Uematsu, M.6    Yamagishi, M.7    Mori, H.8    Kangawa, K.9    Kitamura, S.10
  • 95
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, Fuchs S, Epstein SE. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. 2004;109:1543-1549. doi: 10.1161/01.CIR.0000124062.31102.57.
    • (2004) Circulation , vol.109 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3    Shou, M.4    Lee, C.W.5    Barr, S.6    Fuchs, S.7    Epstein, S.E.8
  • 96
    • 0037418213 scopus 로고    scopus 로고
    • Peripheral blood endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors
    • Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107:1164-1169.
    • (2003) Circulation , vol.107 , pp. 1164-1169
    • Rehman, J.1    Li, J.2    Orschell, C.M.3    March, K.L.4
  • 97
    • 21744461723 scopus 로고    scopus 로고
    • Therapeutic potential of endothelial progenitor cells in cardiovascular diseases
    • Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG. Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension. 2005;46:7-18. doi: 10.1161/01.HYP.0000168923.92885.f7.
    • (2005) Hypertension , vol.46 , pp. 7-18
    • Dzau, V.J.1    Gnecchi, M.2    Pachori, A.S.3    Morello, F.4    Melo, L.G.5
  • 98
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S, Epstein SE. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res. 2004;94:678-685. doi: 10.1161/01.RES.0000118601.37875.AC.
    • (2004) Circ Res , vol.94 , pp. 678-685
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3    Lee, C.W.4    Barr, S.5    Fuchs, S.6    Epstein, S.E.7
  • 99
    • 34547670282 scopus 로고    scopus 로고
    • Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
    • Tse HF, Siu CW, Zhu SG, Songyan L, Zhang QY, Lai WH, Kwong YL, Nicholls J, Lau CP. Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium. Eur J Heart Fail. 2007;9:747-753. doi: 10.1016/j.ejheart.2007.03.008.
    • (2007) Eur J Heart Fail , vol.9 , pp. 747-753
    • Tse, H.F.1    Siu, C.W.2    Zhu, S.G.3    Songyan, L.4    Zhang, Q.Y.5    Lai, W.H.6    Kwong, Y.L.7    Nicholls, J.8    Lau, C.P.9
  • 100
    • 57349177854 scopus 로고    scopus 로고
    • VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function
    • Markel TA, Wang Y, Herrmann JL, Crisostomo PR, Wang M, Novotny NM, Herring CM, Tan J, Lahm T, Meldrum DR. VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function. Am J Physiol Heart Circ Physiol. 2008;295:H2308-H2314. doi: 10.1152/ajpheart.00565.2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , pp. H2308-H2314
    • Markel, T.A.1    Wang, Y.2    Herrmann, J.L.3    Crisostomo, P.R.4    Wang, M.5    Novotny, N.M.6    Herring, C.M.7    Tan, J.8    Lahm, T.9    Meldrum, D.R.10
  • 101
    • 66249097415 scopus 로고    scopus 로고
    • Novel cell-free strategy for therapeutic angiogenesis: In vitro generated conditioned medium can replace progenitor cell transplantation
    • Di Santo S, Yang Z, Wyler von Ballmoos M, Voelzmann J, Diehm N, Baumgartner I, Kalka C. Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation. PLoS One. 2009;4:e5643. doi: 10.1371/journal. pone.0005643.
    • (2009) PLoS One , vol.4 , pp. e5643
    • Di Santo, S.1    Yang, Z.2    Wyler Von Ballmoos, M.3    Voelzmann, J.4    Diehm, N.5    Baumgartner, I.6    Kalka, C.7
  • 102
    • 26844525184 scopus 로고    scopus 로고
    • Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
    • Urbich C, Aicher A, Heeschen C, Dernbach E, Hofmann WK, Zeiher AM, Dimmeler S. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol. 2005;39:733-742. doi: 10.1016/j. yjmcc.2005.07.003.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 733-742
    • Urbich, C.1    Aicher, A.2    Heeschen, C.3    Dernbach, E.4    Hofmann, W.K.5    Zeiher, A.M.6    Dimmeler, S.7
  • 103
    • 82255175382 scopus 로고    scopus 로고
    • Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial
    • Bolli R, Chugh AR, D'Amario D, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011;378:1847-1857. doi: 10.1016/S0140-6736(11)61590-0.
    • (2011) Lancet , vol.378 , pp. 1847-1857
    • Bolli, R.1    Chugh, A.R.2    D'Amario, D.3
  • 104
  • 105
    • 74949120679 scopus 로고    scopus 로고
    • Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction
    • Tang XL, Rokosh G, Sanganalmath SK, et al. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010;121:293-305. doi: 10.1161/CIRCULATIONAHA.109.871905.
    • (2010) Circulation , vol.121 , pp. 293-305
    • Tang, X.L.1    Rokosh, G.2    Sanganalmath, S.K.3
  • 106
    • 84900562998 scopus 로고    scopus 로고
    • C-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart
    • Hong KU, Guo Y, Li QH, Cao P, Al-Maqtari T, Vajravelu BN, Du J, Book MJ, Zhu X, Nong Y, Bhatnagar A, Bolli R. c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart. PLoS One. 2014;9:e96725. doi: 10.1371/journal.pone.0096725.
    • (2014) PLoS One , vol.9 , pp. e96725
    • Hong, K.U.1    Guo, Y.2    Li, Q.H.3    Cao, P.4    Al-Maqtari, T.5    Vajravelu, B.N.6    Du, J.7    Book, M.J.8    Zhu, X.9    Nong, Y.10    Bhatnagar, A.11    Bolli, R.12
  • 107
    • 24744449943 scopus 로고    scopus 로고
    • IGF-1, inflammation and stem cells: Interactions during muscle regeneration
    • Mourkioti F, Rosenthal N. IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol. 2005;26:535-542. doi: 10.1016/j.it.2005.08.002.
    • (2005) Trends Immunol , vol.26 , pp. 535-542
    • Mourkioti, F.1    Rosenthal, N.2
  • 112
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
    • Rani S, Ryan AE, Griffin MD, Ritter T. Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Mol Ther. 2015;23:812-823. doi: 10.1038/mt.2015.44.
    • (2015) Mol Ther , vol.23 , pp. 812-823
    • Rani, S.1    Ryan, A.E.2    Griffin, M.D.3    Ritter, T.4
  • 114
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • EL Andaloussi S, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347-357. doi: 10.1038/nrd3978.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 347-357
    • Andaloussi S, E.L.1    Mager, I.2    Breakefield, X.O.3    Wood, M.J.4
  • 115
    • 84883426378 scopus 로고    scopus 로고
    • Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles
    • Yu B, Gong M, Wang Y, Millard RW, Pasha Z, Yang Y, Ashraf M, Xu M. Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles. PLoS One. 2013;8:e73304. doi: 10.1371/journal.pone.0073304.
    • (2013) PLoS One , vol.8 , pp. e73304
    • Yu, B.1    Gong, M.2    Wang, Y.3    Millard, R.W.4    Pasha, Z.5    Yang, Y.6    Ashraf, M.7    Xu, M.8
  • 120
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • Bruno S, Grange C, Collino F, Deregibus MC, Cantaluppi V, Biancone L, Tetta C, Camussi G. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One. 2012;7:e33115. doi: 10.1371/journal.pone.0033115.
    • (2012) PLoS One , vol.7 , pp. e33115
    • Bruno, S.1    Grange, C.2    Collino, F.3    Deregibus, M.C.4    Cantaluppi, V.5    Biancone, L.6    Tetta, C.7    Camussi, G.8
  • 121
    • 84866162950 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats
    • Reis LA, Borges FT, Simões MJ, Borges AA, Sinigaglia-Coimbra R, Schor N. Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats. PLoS One. 2012;7:e44092. doi: 10.1371/journal. pone.0044092.
    • (2012) PLoS One , vol.7 , pp. e44092
    • Reis, L.A.1    Borges, F.T.2    Simões, M.J.3    Borges, A.A.4    Sinigaglia-Coimbra, R.5    Schor, N.6
  • 123
    • 84893786295 scopus 로고    scopus 로고
    • Exosomes derived from Rab27aoverexpressing tumor cells elicit efficient induction of antitumor immunity
    • Li W, Mu D, Tian F, Hu Y, Jiang T, Han Y, Chen J, Han G, Li X. Exosomes derived from Rab27aoverexpressing tumor cells elicit efficient induction of antitumor immunity. Mol Med Rep. 2013;8:1876-1882. doi: 10.3892/mmr.2013.1738.
    • (2013) Mol Med Rep , vol.8 , pp. 1876-1882
    • Li, W.1    Mu, D.2    Tian, F.3    Hu, Y.4    Jiang, T.5    Han, Y.6    Chen, J.7    Han, G.8    Li, X.9
  • 125
    • 84885389641 scopus 로고    scopus 로고
    • Ligandtargeted particulate nanomedicines undergoing clinical evaluation: Current status
    • van der Meel R, Vehmeijer LJ, Kok RJ, Storm G, van Gaal EV. Ligandtargeted particulate nanomedicines undergoing clinical evaluation: current status. Adv Drug Deliv Rev. 2013;65:1284-1298. doi: 10.1016/j. addr.2013.08.012.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1284-1298
    • Van Der Meel, R.1    Vehmeijer, L.J.2    Kok, R.J.3    Storm, G.4    Van Gaal, E.V.5
  • 126
    • 80053413863 scopus 로고    scopus 로고
    • An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response
    • Steenblock ER, Fadel T, Labowsky M, Pober JS, Fahmy TM. An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response. J Biol Chem. 2011;286:34883-34892. doi: 10.1074/jbc.M111.276329.
    • (2011) J Biol Chem , vol.286 , pp. 34883-34892
    • Steenblock, E.R.1    Fadel, T.2    Labowsky, M.3    Pober, J.S.4    Fahmy, T.M.5
  • 127
    • 84904070258 scopus 로고    scopus 로고
    • Fgf10: A paracrine-signaling molecule in development, disease, and regenerative medicine
    • Itoh N, Ohta H. Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine. Curr Mol Med. 2014;14:504-509.
    • (2014) Curr Mol Med , vol.14 , pp. 504-509
    • Itoh, N.1    Ohta, H.2
  • 128
    • 84865646610 scopus 로고    scopus 로고
    • Signaling mechanisms controlling cell fate and embryonic patterning
    • Perrimon N, Pitsouli C, Shilo BZ. Signaling mechanisms controlling cell fate and embryonic patterning. Cold Spring Harb Perspect Biol. 2012;4:a005975. doi: 10.1101/cshperspect.a005975.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , pp. a005975
    • Perrimon, N.1    Pitsouli, C.2    Shilo, B.Z.3
  • 129
    • 84881668804 scopus 로고    scopus 로고
    • Targeting inflammatory pathways in myocardial infarction
    • Christia P, Frangogiannis NG. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest. 2013;43:986-995. doi: 10.1111/eci.12118.
    • (2013) Eur J Clin Invest , vol.43 , pp. 986-995
    • Christia, P.1    Frangogiannis, N.G.2
  • 130
    • 77953812469 scopus 로고    scopus 로고
    • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium
    • Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, Mirotsou M, Pratt RE, Dzau VJ. Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res. 2010;106:1753-1762. doi: 10.1161/CIRCRESAHA.109.196030.
    • (2010) Circ Res , vol.106 , pp. 1753-1762
    • Huang, J.1    Zhang, Z.2    Guo, J.3    Ni, A.4    Deb, A.5    Zhang, L.6    Mirotsou, M.7    Pratt, R.E.8    Dzau, V.J.9
  • 132
    • 0036898764 scopus 로고    scopus 로고
    • A temporal and spatial summation model for T-cell activation: Signal integration and antigen decoding
    • Rachmilewitz J, Lanzavecchia A. A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding. Trends Immunol. 2002;23:592-595.
    • (2002) Trends Immunol , vol.23 , pp. 592-595
    • Rachmilewitz, J.1    Lanzavecchia, A.2
  • 133
    • 0034573213 scopus 로고    scopus 로고
    • Dendritic integration of excitatory synaptic input
    • Magee JC. Dendritic integration of excitatory synaptic input. Nat Rev Neurosci. 2000;1:181-190. doi: 10.1038/35044552.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 181-190
    • Magee, J.C.1
  • 134
    • 84877103013 scopus 로고    scopus 로고
    • Endocytosis of receptor tyrosine kinases
    • Goh LK, Sorkin A. Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 2013;5:a017459. doi: 10.1101/cshperspect.a017459.
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a017459
    • Goh, L.K.1    Sorkin, A.2
  • 135
    • 84863315972 scopus 로고    scopus 로고
    • Probing embryonic stem cell autocrine and paracrine signaling using microfluidics
    • Przybyla L, Voldman J. Probing embryonic stem cell autocrine and paracrine signaling using microfluidics. Annu Rev Anal Chem (Palo Alto Calif). 2012;5:293-315. doi: 10.1146/annurev-anchem-062011-143122.
    • (2012) Annu Rev Anal Chem (Palo Alto Calif) , vol.5 , pp. 293-315
    • Przybyla, L.1    Voldman, J.2
  • 136
    • 84895423383 scopus 로고    scopus 로고
    • HASF, a PKC-activator with novel features for cardiomyocyte protection
    • Miura T. HASF, a PKC-activator with novel features for cardiomyocyte protection. J Mol Cell Cardiol. 2014;69:1-3. doi: 10.1016/j. yjmcc.2014.01.011.
    • (2014) J Mol Cell Cardiol , vol.69 , pp. 1-3
    • Miura, T.1
  • 137
    • 80052818491 scopus 로고    scopus 로고
    • IIPKC and PKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure
    • Ferreira JC, Brum PC, Mochly-Rosen D. IIPKC and PKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. J Mol Cell Cardiol. 2011;51:479-484. doi: 10.1016/j. yjmcc.2010.10.020.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 479-484
    • Ferreira, J.C.1    Brum, P.C.2    Mochly-Rosen, D.3
  • 138
    • 84935008448 scopus 로고    scopus 로고
    • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways
    • Schmeckpeper J, Verma A, Yin L, Beigi F, Zhang L, Payne A, Zhang Z, Pratt RE, Dzau VJ, Mirotsou M. Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. J Mol Cell Cardiol. 2015;85:215-225. doi: 10.1016/j. yjmcc.2015.06.003.
    • (2015) J Mol Cell Cardiol , vol.85 , pp. 215-225
    • Schmeckpeper, J.1    Verma, A.2    Yin, L.3    Beigi, F.4    Zhang, L.5    Payne, A.6    Zhang, Z.7    Pratt, R.E.8    Dzau, V.J.9    Mirotsou, M.10
  • 139
    • 84936883573 scopus 로고    scopus 로고
    • Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins
    • Mizumoto S, Yamada S, Sugahara K. Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins. Curr Opin Struct Biol. 2015;34:35-42. doi: 10.1016/j. sbi.2015.06.004.
    • (2015) Curr Opin Struct Biol , vol.34 , pp. 35-42
    • Mizumoto, S.1    Yamada, S.2    Sugahara, K.3
  • 141
    • 22144475112 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: Short-and long-term effects
    • Dai W, Hale SL, Martin BJ, Kuang JQ, Dow JS, Wold LE, Kloner RA. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short-and long-term effects. Circulation. 2005;112:214-223. doi: 10.1161/CIRCULATIONAHA.104.527937.
    • (2005) Circulation , vol.112 , pp. 214-223
    • Dai, W.1    Hale, S.L.2    Martin, B.J.3    Kuang, J.Q.4    Dow, J.S.5    Wold, L.E.6    Kloner, R.A.7
  • 142
    • 79955545447 scopus 로고    scopus 로고
    • IL-6 and TGF-costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-JNK-and PI3K-mediated mechanisms
    • Herrmann JL, Weil BR, Abarbanell AM, Wang Y, Poynter JA, Manukyan MC, Meldrum DR. IL-6 and TGF-costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms. Shock. 2011;35:512-516. doi: 10.1097/SHK.0b013e31820b2fb9.
    • (2011) Shock , vol.35 , pp. 512-516
    • Herrmann, J.L.1    Weil, B.R.2    Abarbanell, A.M.3    Wang, Y.4    Poynter, J.A.5    Manukyan, M.C.6    Meldrum, D.R.7
  • 143
  • 144
    • 84924706315 scopus 로고    scopus 로고
    • Pre-activation of mesenchymal stem cells with TNF-, IL-1 and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury
    • Chen H, Min XH, Wang QY, Leung FW, Shi L, Zhou Y, Yu T, Wang CM, An G, Sha WH, Chen QK. Pre-activation of mesenchymal stem cells with TNF-, IL-1 and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury. Sci Rep. 2015;5:8718. doi: 10.1038/srep08718.
    • (2015) Sci Rep , vol.5 , pp. 8718
    • Chen, H.1    Min, X.H.2    Wang, Q.Y.3    Leung, F.W.4    Shi, L.5    Zhou, Y.6    Yu, T.7    Wang, C.M.8    An, G.9    Sha, W.H.10    Chen, Q.K.11
  • 145
    • 84892776788 scopus 로고    scopus 로고
    • Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells
    • Sullivan KE, Quinn KP, Tang KM, Georgakoudi I, Black LD III. Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells. Stem Cell Res Ther. 2014;5:14. doi: 10.1186/scrt403.
    • (2014) Stem Cell Res Ther , vol.5 , pp. 14
    • Sullivan, K.E.1    Quinn, K.P.2    Tang, K.M.3    Georgakoudi, I.4    Black, L.D.5
  • 146
    • 84864136249 scopus 로고    scopus 로고
    • Mesenchymal stem cells as a treatment for neonatal ischemic brain damage
    • van Velthoven CT, Kavelaars A, Heijnen CJ. Mesenchymal stem cells as a treatment for neonatal ischemic brain damage. Pediatr Res. 2012;71:474-481. doi: 10.1038/pr.2011.64.
    • (2012) Pediatr Res , vol.71 , pp. 474-481
    • Van Velthoven, C.T.1    Kavelaars, A.2    Heijnen, C.J.3
  • 147
    • 77954736319 scopus 로고    scopus 로고
    • Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function
    • van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J Neurosci. 2010;30:9603-9611. doi: 10.1523/JNEUROSCI.1835-10.2010.
    • (2010) J Neurosci , vol.30 , pp. 9603-9611
    • Van Velthoven, C.T.1    Kavelaars, A.2    Van Bel, F.3    Heijnen, C.J.4
  • 148
    • 84892913238 scopus 로고    scopus 로고
    • C-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy
    • Sanada F, Kim J, Czarna A, et al. c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res. 2014;114:41-55. doi: 10.1161/CIRCRESAHA.114.302500.
    • (2014) Circ Res , vol.114 , pp. 41-55
    • Sanada, F.1    Kim, J.2    Czarna, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.