Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1493-1502

  Engels, Marc C ^a,b   Rajarajan, Kuppusamy ^a   Feistritzer, Rebecca ^a   Sharma, Arun ^c   Nielsen, Ulrik B ^d   Schalij, Martin J ^b   De Vries, Antoine A F ^b   Pijnappels, Daniël A ^b   Wu, Sean M ^a,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c STANFORD UNIVERSITY   (United States)

^d Silver Creek Pharmaceuticals   (United States)

^e HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

Akt; Cardiac differentiation; Cardiac progenitor cell; Cardiomyocyte; Development; Embryonic stem cell; In vitro screening; Insulin; Insulin like growth factor; Mesoderm

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; SOMATOMEDIN B; SOMATOMEDIN C; BRACHYURY PROTEIN; FETOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; T BOX TRANSCRIPTION FACTOR; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CARDIAC PROGENITOR CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; IN VITRO STUDY; MESODERM; MOUSE; NONHUMAN; REGENERATIVE MEDICINE; SCREENING; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL EXPANSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; GENE EXPRESSION REGULATION; HEART MUSCLE; METABOLISM; PHOSPHORYLATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL PROLIFERATION; EMBRYONIC STEM CELLS; FETAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MESODERM; MICE; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STEM CELLS; T-BOX DOMAIN PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84901414986     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1660     Document Type: Article

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