메뉴 건너뛰기




Volumn 64, Issue 1, 2016, Pages 33-46

The Role of Cathelicidin LL-37 in Cancer Development

Author keywords

Cancer; Carcinogenesis; Cathelicidin; Immune system; LL 37

Indexed keywords

CASPASE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 32; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEIN P42; PROTEIN P44; SOMATOMEDIN C RECEPTOR; TELOMERASE; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN;

EID: 84954362778     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-015-0359-5     Document Type: Review
Times cited : (94)

References (108)
  • 1
    • 0034332193 scopus 로고    scopus 로고
    • The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations
    • Agerberth B, Charo J, Werr J et al (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086–3093
    • (2000) Blood , vol.96 , pp. 3086-3093
    • Agerberth, B.1    Charo, J.2    Werr, J.3
  • 2
    • 84928403174 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori on gastric epithelial cells
    • Alzahrani S, Lina TT, Gonzalez J et al (2014) Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol 20:12767–12780
    • (2014) World J Gastroenterol , vol.20 , pp. 12767-12780
    • Alzahrani, S.1    Lina, T.T.2    Gonzalez, J.3
  • 3
    • 12844286042 scopus 로고    scopus 로고
    • Marked reduction of LL-37/hCAP-18, an antimicrobial peptide, in patients with acute myeloid leukemia
    • An LL, Ma XT, Yang YH et al (2005) Marked reduction of LL-37/hCAP-18, an antimicrobial peptide, in patients with acute myeloid leukemia. Int J Hematol 81:45–47
    • (2005) Int J Hematol , vol.81 , pp. 45-47
    • An, L.L.1    Ma, X.T.2    Yang, Y.H.3
  • 4
    • 53049089942 scopus 로고    scopus 로고
    • Cancer is a preventable disease that requires major lifestyle changes
    • Anand P, Kunnumakkara AB, Sundaram C et al (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116
    • (2008) Pharm Res , vol.25 , pp. 2097-2116
    • Anand, P.1    Kunnumakkara, A.B.2    Sundaram, C.3
  • 5
    • 8844285950 scopus 로고    scopus 로고
    • Identification and quantification of innate immune system mediators in human breast milk
    • Armogida SA, Yannaras NM, Melton AL et al (2004) Identification and quantification of innate immune system mediators in human breast milk. Allergy Asthma Proc 25:297–304
    • (2004) Allergy Asthma Proc , vol.25 , pp. 297-304
    • Armogida, S.A.1    Yannaras, N.M.2    Melton, A.L.3
  • 6
    • 0042237031 scopus 로고    scopus 로고
    • Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
    • Arnoult D, Gaume B, Karbowski M et al (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 22:4385–4399
    • (2003) EMBO J , vol.22 , pp. 4385-4399
    • Arnoult, D.1    Gaume, B.2    Karbowski, M.3
  • 7
    • 0032482980 scopus 로고    scopus 로고
    • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
    • Bals R, Wang X, Zasloff M et al (1998) The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 95:9541–9546
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9541-9546
    • Bals, R.1    Wang, X.2    Zasloff, M.3
  • 8
    • 80054841451 scopus 로고    scopus 로고
    • Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37
    • Barlow PG, Svoboda P, Mackellar A et al (2011) Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One 6:e25333
    • (2011) PLoS One , vol.6 , pp. e25333
    • Barlow, P.G.1    Svoboda, P.2    Mackellar, A.3
  • 9
    • 0035895622 scopus 로고    scopus 로고
    • Pathways governing G1/S transition and their response to DNA damage
    • Bartek J, Lukas J (2001) Pathways governing G1/S transition and their response to DNA damage. FEBS Lett 490:117–122
    • (2001) FEBS Lett , vol.490 , pp. 117-122
    • Bartek, J.1    Lukas, J.2
  • 10
    • 33748801511 scopus 로고    scopus 로고
    • Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes
    • Bucki R, Janmey PA (2006) Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes. Antimicrobial Agents Chemother 50:2932–2940
    • (2006) Antimicrobial Agents Chemother , vol.50 , pp. 2932-2940
    • Bucki, R.1    Janmey, P.A.2
  • 11
    • 2142825687 scopus 로고    scopus 로고
    • Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin
    • Bucki R, Pastore JJ, Randhawa P et al (2004) Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrobial Agents Chemother 48:1526–1533
    • (2004) Antimicrobial Agents Chemother , vol.48 , pp. 1526-1533
    • Bucki, R.1    Pastore, J.J.2    Randhawa, P.3
  • 12
    • 34147139491 scopus 로고    scopus 로고
    • Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum
    • Bucki R, Byfield FJ, Janmey PA (2007) Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum. Eur Respir J 29:624–632
    • (2007) Eur Respir J , vol.29 , pp. 624-632
    • Bucki, R.1    Byfield, F.J.2    Janmey, P.A.3
  • 13
    • 47249162101 scopus 로고    scopus 로고
    • Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13
    • Bucki R, Namiot DB, Namiot Z et al (2008) Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13. J Antimicrob Chemother 62:329–335
    • (2008) J Antimicrob Chemother , vol.62 , pp. 329-335
    • Bucki, R.1    Namiot, D.B.2    Namiot, Z.3
  • 14
    • 76649101759 scopus 로고    scopus 로고
    • Cathelicidin LL-37: a multitask antimicrobial peptide
    • Bucki R, Leszczynska K, Namiot A et al (2010) Cathelicidin LL-37: a multitask antimicrobial peptide. Arch Immunol Ther Exp 58:15–25
    • (2010) Arch Immunol Ther Exp , vol.58 , pp. 15-25
    • Bucki, R.1    Leszczynska, K.2    Namiot, A.3
  • 15
    • 83755183848 scopus 로고    scopus 로고
    • Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa
    • Byfield FJ, Kowalski M, Cruz K et al (2011) Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa. J Immunol 187:6402–6409
    • (2011) J Immunol , vol.187 , pp. 6402-6409
    • Byfield, F.J.1    Kowalski, M.2    Cruz, K.3
  • 16
    • 84887444286 scopus 로고    scopus 로고
    • Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation
    • Castells M, Milhas D, Gandy C et al (2013) Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation. Cell Death Dis 4:e887
    • (2013) Cell Death Dis , vol.4 , pp. e887
    • Castells, M.1    Milhas, D.2    Gandy, C.3
  • 17
    • 79960563303 scopus 로고    scopus 로고
    • Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells
    • Chen PM, Yen ML, Liu KJ et al (2011) Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. J Biomed Sci 18:49
    • (2011) J Biomed Sci , vol.18 , pp. 49
    • Chen, P.M.1    Yen, M.L.2    Liu, K.J.3
  • 18
    • 84919701468 scopus 로고    scopus 로고
    • Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts
    • Cheng M, Ho S, Yoo JH et al (2014) Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts. Clin Exp Gastroenterol 8:13–29
    • (2014) Clin Exp Gastroenterol , vol.8 , pp. 13-29
    • Cheng, M.1    Ho, S.2    Yoo, J.H.3
  • 19
    • 84904860097 scopus 로고    scopus 로고
    • Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation
    • Choi KY, Napper S, Mookherjee N (2014) Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation. Immunology 143:68–80
    • (2014) Immunology , vol.143 , pp. 68-80
    • Choi, K.Y.1    Napper, S.2    Mookherjee, N.3
  • 20
    • 64049103406 scopus 로고    scopus 로고
    • Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer
    • Chuang CM, Monie A, Wu A et al (2009) Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer. Hum Gene Ther 20:303–313
    • (2009) Hum Gene Ther , vol.20 , pp. 303-313
    • Chuang, C.M.1    Monie, A.2    Wu, A.3
  • 22
    • 38749148077 scopus 로고    scopus 로고
    • Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion
    • Coffelt SB, Waterman RS, Florez L et al (2008) Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. Int J Cancer 122:1030–1039
    • (2008) Int J Cancer , vol.122 , pp. 1030-1039
    • Coffelt, S.B.1    Waterman, R.S.2    Florez, L.3
  • 23
    • 62649126972 scopus 로고    scopus 로고
    • The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells
    • Coffelt SB, Marini FC, Watson K et al (2009) The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. Proc Natl Acad Sci USA 106:3806–3811
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3806-3811
    • Coffelt, S.B.1    Marini, F.C.2    Watson, K.3
  • 24
    • 84887911347 scopus 로고    scopus 로고
    • Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2
    • Cohen S, Bruchim I, Graiver D et al (2013) Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2. J Mol Med 91:357–368
    • (2013) J Mol Med , vol.91 , pp. 357-368
    • Cohen, S.1    Bruchim, I.2    Graiver, D.3
  • 25
    • 84883431889 scopus 로고    scopus 로고
    • The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus
    • Currie SM, Findlay EG, McHugh BJ et al (2013) The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS One 8:e73659
    • (2013) PLoS One , vol.8 , pp. e73659
    • Currie, S.M.1    Findlay, E.G.2    McHugh, B.J.3
  • 26
    • 33750299010 scopus 로고    scopus 로고
    • IL-32, a novel cytokine with a possible role in disease
    • Dinarello CA, Kim SH (2006) IL-32, a novel cytokine with a possible role in disease. Ann Rheum Dis 65(Suppl 3):iii61–iii64
    • (2006) Ann Rheum Dis , vol.65 , pp. iii61-iii64
    • Dinarello, C.A.1    Kim, S.H.2
  • 27
    • 84900847833 scopus 로고    scopus 로고
    • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy
    • Donato AL, Huang Q, Liu X et al (2014) Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. J Invest Dermatol 134:1686–1692
    • (2014) J Invest Dermatol , vol.134 , pp. 1686-1692
    • Donato, A.L.1    Huang, Q.2    Liu, X.3
  • 28
    • 84907993181 scopus 로고    scopus 로고
    • Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides
    • Dosler S, Karaaslan E (2014) Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides. Peptides 62:32–37
    • (2014) Peptides , vol.62 , pp. 32-37
    • Dosler, S.1    Karaaslan, E.2
  • 30
    • 33646072818 scopus 로고    scopus 로고
    • The P2X7 receptor: a key player in IL-1 processing and release
    • Ferrari D, Pizzirani C, Adinolfi E et al (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176:3877–3883
    • (2006) J Immunol , vol.176 , pp. 3877-3883
    • Ferrari, D.1    Pizzirani, C.2    Adinolfi, E.3
  • 32
    • 0030956070 scopus 로고    scopus 로고
    • The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
    • Frohm M, Agerberth B, Ahangari G et al (1997) The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272:15258–15263
    • (1997) J Biol Chem , vol.272 , pp. 15258-15263
    • Frohm, M.1    Agerberth, B.2    Ahangari, G.3
  • 33
    • 45449097463 scopus 로고    scopus 로고
    • No death without life: vital functions of apoptotic effectors
    • Galluzzi L, Joza N, Tasdemir E et al (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ 15:1113–1123
    • (2008) Cell Death Differ , vol.15 , pp. 1113-1123
    • Galluzzi, L.1    Joza, N.2    Tasdemir, E.3
  • 34
    • 84911892431 scopus 로고    scopus 로고
    • Association between interleukin-8 -251A/T polymorphism and risk of lung cancer: a meta-analysis
    • Gao P, Zhao H, You J et al (2014) Association between interleukin-8 -251A/T polymorphism and risk of lung cancer: a meta-analysis. Cancer Invest 32:518–525
    • (2014) Cancer Invest , vol.32 , pp. 518-525
    • Gao, P.1    Zhao, H.2    You, J.3
  • 35
    • 84855968882 scopus 로고    scopus 로고
    • Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor
    • Girnita A, Zheng H, Grönberg A et al (2012) Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor. Oncogene 31:352–365
    • (2012) Oncogene , vol.31 , pp. 352-365
    • Girnita, A.1    Zheng, H.2    Grönberg, A.3
  • 36
    • 10744224946 scopus 로고    scopus 로고
    • Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori
    • Hase K, Murakami M, Iimura M et al (2003) Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 125:1613–1625
    • (2003) Gastroenterology , vol.125 , pp. 1613-1625
    • Hase, K.1    Murakami, M.2    Iimura, M.3
  • 37
    • 14844311295 scopus 로고    scopus 로고
    • Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells
    • Heilborn JD, Nilsson MF, Jimenez CI et al (2005) Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells. Int J Cancer 114:713–719
    • (2005) Int J Cancer , vol.114 , pp. 713-719
    • Heilborn, J.D.1    Nilsson, M.F.2    Jimenez, C.I.3
  • 38
    • 79952396539 scopus 로고    scopus 로고
    • LL-37 as a therapeutic target for late stage prostate cancer
    • Hensel JA, Chanda D, Kumar S et al (2011) LL-37 as a therapeutic target for late stage prostate cancer. Prostate 71:659–670
    • (2011) Prostate , vol.71 , pp. 659-670
    • Hensel, J.A.1    Chanda, D.2    Kumar, S.3
  • 39
    • 79960127640 scopus 로고    scopus 로고
    • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
    • Huang Q, Li F, Liu X et al (2011) Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med 17:860–866
    • (2011) Nat Med , vol.17 , pp. 860-866
    • Huang, Q.1    Li, F.2    Liu, X.3
  • 40
    • 77949315485 scopus 로고    scopus 로고
    • LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells
    • Hurtado P, Peh CA (2010) LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. J Immunol 184:1425–1435
    • (2010) J Immunol , vol.184 , pp. 1425-1435
    • Hurtado, P.1    Peh, C.A.2
  • 41
    • 84874686549 scopus 로고    scopus 로고
    • IL-32 expression is an independent prognostic marker for gastric cancer
    • Ishigami S, Arigami T, Uchikado Y et al (2013) IL-32 expression is an independent prognostic marker for gastric cancer. Med Oncol 30:472
    • (2013) Med Oncol , vol.30 , pp. 472
    • Ishigami, S.1    Arigami, T.2    Uchikado, Y.3
  • 42
    • 84878418009 scopus 로고    scopus 로고
    • Human cathelicidin peptide LL37 binds telomeric G-quadruplex
    • Jana J, Kar RK, Ghosh A et al (2013) Human cathelicidin peptide LL37 binds telomeric G-quadruplex. Mol BioSyst 9:1833–1836
    • (2013) Mol BioSyst , vol.9 , pp. 1833-1836
    • Jana, J.1    Kar, R.K.2    Ghosh, A.3
  • 43
    • 33644765841 scopus 로고    scopus 로고
    • IL-32, a proinflammatory cytokine in rheumatoid arthritis
    • Joosten LA, Netea MG, Kim SH et al (2006) IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci USA 103:3298–3303
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3298-3303
    • Joosten, L.A.1    Netea, M.G.2    Kim, S.H.3
  • 44
    • 0034453098 scopus 로고    scopus 로고
    • The effects of insulin-like growth factors on tumorigenesis and neoplastic growth
    • Khandwala HM, McCutcheon IE, Flyvbjerg A et al (2000) The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 21:215–244
    • (2000) Endocr Rev , vol.21 , pp. 215-244
    • Khandwala, H.M.1    McCutcheon, I.E.2    Flyvbjerg, A.3
  • 45
    • 78249268522 scopus 로고    scopus 로고
    • The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma
    • Kim JE, Kim HJ, Choi JM et al (2010) The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma. Br J Dermatol 163:959–967
    • (2010) Br J Dermatol , vol.163 , pp. 959-967
    • Kim, J.E.1    Kim, H.J.2    Choi, J.M.3
  • 46
    • 84969317482 scopus 로고    scopus 로고
    • Helicobacter pylori and molecular markers as prognostic indicators for gastric cancer in Korea
    • Kim HJ, Hwang SW, Kim N et al (2014) Helicobacter pylori and molecular markers as prognostic indicators for gastric cancer in Korea. J Cancer Prev 19:56–67
    • (2014) J Cancer Prev , vol.19 , pp. 56-67
    • Kim, H.J.1    Hwang, S.W.2    Kim, N.3
  • 47
    • 0038142308 scopus 로고    scopus 로고
    • An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
    • Koczulla R, von Degenfeld G, Kupatt C et al (2003) An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 111:1665–1672
    • (2003) J Clin Invest , vol.111 , pp. 1665-1672
    • Koczulla, R.1    von Degenfeld, G.2    Kupatt, C.3
  • 48
    • 84921269090 scopus 로고    scopus 로고
    • Polymorphism of the IL-8 gene and the risk of ovarian cancer
    • Koensgen D, Bruennert D, Ungureanu S et al (2015) Polymorphism of the IL-8 gene and the risk of ovarian cancer. Cytokine 71:334–338
    • (2015) Cytokine , vol.71 , pp. 334-338
    • Koensgen, D.1    Bruennert, D.2    Ungureanu, S.3
  • 49
    • 84890710196 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target
    • Korhonen R, Moilanen E (2014) Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target. Basic Clin Pharmacol Toxicol 114:24–36
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 24-36
    • Korhonen, R.1    Moilanen, E.2
  • 50
    • 84922098178 scopus 로고    scopus 로고
    • Efficient apoptosis and necrosis induction by proteasome inhibitor: bortezomib in the DLD-1 human colon cancer cell line
    • Krętowski R, Stypułkowska A, Cechowska-Pasko M (2015) Efficient apoptosis and necrosis induction by proteasome inhibitor: bortezomib in the DLD-1 human colon cancer cell line. Mol Cell Biochem 398:165–173
    • (2015) Mol Cell Biochem , vol.398 , pp. 165-173
    • Krętowski, R.1    Stypułkowska, A.2    Cechowska-Pasko, M.3
  • 52
    • 84881044619 scopus 로고    scopus 로고
    • Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells
    • Kuroda K, Fukuda T, Okumura K et al (2013) Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells. Anticancer Drugs 24:826–834
    • (2013) Anticancer Drugs , vol.24 , pp. 826-834
    • Kuroda, K.1    Fukuda, T.2    Okumura, K.3
  • 53
    • 79251627826 scopus 로고    scopus 로고
    • Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene
    • Lee S, Kim JH, Kim H et al (2011) Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene. Immunology 132:410–420
    • (2011) Immunology , vol.132 , pp. 410-420
    • Lee, S.1    Kim, J.H.2    Kim, H.3
  • 54
    • 84873571921 scopus 로고    scopus 로고
    • Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections
    • Leszczynska K, Namiot D, Byfield FJ et al (2013) Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections. J Antimicrob Chemother 68:610–618
    • (2013) J Antimicrob Chemother , vol.68 , pp. 610-618
    • Leszczynska, K.1    Namiot, D.2    Byfield, F.J.3
  • 55
    • 44649101436 scopus 로고    scopus 로고
    • p53: the Janus of autophagy?
    • Levine B, Abrams J (2008) p53: the Janus of autophagy? Nat Cell Biol 10:637–639
    • (2008) Nat Cell Biol , vol.10 , pp. 637-639
    • Levine, B.1    Abrams, J.2
  • 56
    • 33646597266 scopus 로고    scopus 로고
    • Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
    • Li X, Li Y, Han H et al (2006) Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J Am Chem Soc 128:5776–5785
    • (2006) J Am Chem Soc , vol.128 , pp. 5776-5785
    • Li, X.1    Li, Y.2    Han, H.3
  • 57
    • 85040711538 scopus 로고    scopus 로고
    • Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
    • Lim R, Lappas M, Riley C et al (2013) Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer. J Ovarian Res 6:5
    • (2013) J Ovarian Res , vol.6 , pp. 5
    • Lim, R.1    Lappas, M.2    Riley, C.3
  • 58
    • 22144453571 scopus 로고    scopus 로고
    • Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection
    • López-García B, Lee PH, Yamasaki K et al (2005) Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection. J Invest Dermatol 125:108–115
    • (2005) J Invest Dermatol , vol.125 , pp. 108-115
    • López-García, B.1    Lee, P.H.2    Yamasaki, K.3
  • 59
    • 84859219044 scopus 로고    scopus 로고
    • Inflammation and ovarian cancer
    • Macciò A, Madeddu C (2012) Inflammation and ovarian cancer. Cytokine 58:133–147
    • (2012) Cytokine , vol.58 , pp. 133-147
    • Macciò, A.1    Madeddu, C.2
  • 60
    • 66349099109 scopus 로고    scopus 로고
    • The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity
    • Mader JS, Mookherjee N, Hancock RE et al (2009) The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Mol Cancer Res 7:689–702
    • (2009) Mol Cancer Res , vol.7 , pp. 689-702
    • Mader, J.S.1    Mookherjee, N.2    Hancock, R.E.3
  • 61
    • 85015818790 scopus 로고    scopus 로고
    • Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers
    • Mai CW, Kang YB, Pichika MR (2013) Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers. Onco Targets Ther 6:1573–1587
    • (2013) Onco Targets Ther , vol.6 , pp. 1573-1587
    • Mai, C.W.1    Kang, Y.B.2    Pichika, M.R.3
  • 62
    • 34147101680 scopus 로고    scopus 로고
    • C-reactive protein concentrations and subsequent ovarian cancer risk
    • McSorley MA, Alberg AJ, Allen DS et al (2007) C-reactive protein concentrations and subsequent ovarian cancer risk. Obstet Gynecol 109:933–941
    • (2007) Obstet Gynecol , vol.109 , pp. 933-941
    • McSorley, M.A.1    Alberg, A.J.2    Allen, D.S.3
  • 63
    • 84877816234 scopus 로고    scopus 로고
    • Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis
    • Mishra J, Drummond J, Quazi SH et al (2013) Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis. Crit Rev Oncol Hematol 86:232–250
    • (2013) Crit Rev Oncol Hematol , vol.86 , pp. 232-250
    • Mishra, J.1    Drummond, J.2    Quazi, S.H.3
  • 64
    • 79954880573 scopus 로고    scopus 로고
    • Involvement of P2X(7) purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts
    • Montreekachon P, Chotjumlong P, Bolscher JG et al (2011) Involvement of P2X(7) purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts. J Periodontal Res 46:327–337
    • (2011) J Periodontal Res , vol.46 , pp. 327-337
    • Montreekachon, P.1    Chotjumlong, P.2    Bolscher, J.G.3
  • 65
    • 30044433704 scopus 로고    scopus 로고
    • Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37
    • Mookherjee N, Brown KL, Bowdish DM et al (2006) Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol 176:2455–2464
    • (2006) J Immunol , vol.176 , pp. 2455-2464
    • Mookherjee, N.1    Brown, K.L.2    Bowdish, D.M.3
  • 66
    • 84905653969 scopus 로고    scopus 로고
    • Toll-like Receptors in ovarian cancer as targets for immunotherapies
    • Muccioli M, Benencia F (2014) Toll-like Receptors in ovarian cancer as targets for immunotherapies. Front Immunol 5:341
    • (2014) Front Immunol , vol.5 , pp. 341
    • Muccioli, M.1    Benencia, F.2
  • 67
    • 76349122184 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer
    • Neidle S (2010) Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS J 277:1118–1125
    • (2010) FEBS J , vol.277 , pp. 1118-1125
    • Neidle, S.1
  • 68
    • 33748369134 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-gamma-dependent mechanism
    • Netea MG, Azam T, Lewis EC et al (2006) Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-gamma-dependent mechanism. PLoS Med 3:e277
    • (2006) PLoS Med , vol.3 , pp. e277
    • Netea, M.G.1    Azam, T.2    Lewis, E.C.3
  • 69
    • 84933508997 scopus 로고    scopus 로고
    • Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells
    • Niemirowicz K, Prokop I, Wilczewska AZ et al (2015) Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells. Int J Nanomedicine 10:3843–3853
    • (2015) Int J Nanomedicine , vol.10 , pp. 3843-3853
    • Niemirowicz, K.1    Prokop, I.2    Wilczewska, A.Z.3
  • 71
    • 43749102276 scopus 로고    scopus 로고
    • Immune surveillance: a balance between protumor and antitumor immunity
    • Ostrand-Rosenberg S (2008) Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev 18:11–18
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 11-18
    • Ostrand-Rosenberg, S.1
  • 72
    • 84868197448 scopus 로고    scopus 로고
    • Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
    • Ouyang L, Shi Z, Zhao S et al (2012) Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 45:487–498
    • (2012) Cell Prolif , vol.45 , pp. 487-498
    • Ouyang, L.1    Shi, Z.2    Zhao, S.3
  • 73
    • 51949104801 scopus 로고    scopus 로고
    • Human host defense peptide LL-37 prevents bacterial biofilm formation
    • Overhage J, Campisano A, Bains M et al (2008) Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun 76:4176–4182
    • (2008) Infect Immun , vol.76 , pp. 4176-4182
    • Overhage, J.1    Campisano, A.2    Bains, M.3
  • 74
    • 84898439107 scopus 로고    scopus 로고
    • Elevated interleukin-32 expression is associated with Helicobacter pylori-related gastritis
    • Peng LS, Zhuang Y, Li WH et al (2014) Elevated interleukin-32 expression is associated with Helicobacter pylori-related gastritis. PLoS One 9:e88270
    • (2014) PLoS One , vol.9 , pp. e88270
    • Peng, L.S.1    Zhuang, Y.2    Li, W.H.3
  • 75
    • 84937500843 scopus 로고    scopus 로고
    • The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis
    • Prevete N, Liotti F, Visciano C et al (2015) The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis. Oncogene 34:3826–3838
    • (2015) Oncogene , vol.34 , pp. 3826-3838
    • Prevete, N.1    Liotti, F.2    Visciano, C.3
  • 76
    • 84871188238 scopus 로고    scopus 로고
    • Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer
    • Ren SX, Cheng AS, To KF et al (2012) Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 72:6512–6523
    • (2012) Cancer Res , vol.72 , pp. 6512-6523
    • Ren, S.X.1    Cheng, A.S.2    To, K.F.3
  • 77
    • 84877887193 scopus 로고    scopus 로고
    • FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells
    • Ren SX, Shen J, Cheng AS et al (2013) FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS One 8:e63641
    • (2013) PLoS One , vol.8 , pp. e63641
    • Ren, S.X.1    Shen, J.2    Cheng, A.S.3
  • 78
    • 18344394135 scopus 로고    scopus 로고
    • Proteasome inhibition in the treatment of cancer
    • Richardson PG, Mitsiades C, Hideshima T et al (2005) Proteasome inhibition in the treatment of cancer. Cell Cycle 4:290–296
    • (2005) Cell Cycle , vol.4 , pp. 290-296
    • Richardson, P.G.1    Mitsiades, C.2    Hideshima, T.3
  • 79
    • 84872433200 scopus 로고    scopus 로고
    • Effect of antimicrobial peptides derived from human cathelicidin LL-37 on Entamoeba histolytica trophozoites
    • Rico-Mata R, De Leon-Rodriguez LM, Avila EE (2013) Effect of antimicrobial peptides derived from human cathelicidin LL-37 on Entamoeba histolytica trophozoites. Exp Parasitol 133:300–306
    • (2013) Exp Parasitol , vol.133 , pp. 300-306
    • Rico-Mata, R.1    De Leon-Rodriguez, L.M.2    Avila, E.E.3
  • 80
    • 84859378520 scopus 로고    scopus 로고
    • Minireview: human ovarian cancer: biology, current management, and paths to personalizing therapy
    • Romero I, Bast RC (2012) Minireview: human ovarian cancer: biology, current management, and paths to personalizing therapy. Endocrinology 153:1593–1602
    • (2012) Endocrinology , vol.153 , pp. 1593-1602
    • Romero, I.1    Bast, R.C.2
  • 81
    • 84867605419 scopus 로고    scopus 로고
    • Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation
    • Sakitani K, Hirata Y, Hayakawa Y et al (2012) Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation. Infect Immun 80:3795–3803
    • (2012) Infect Immun , vol.80 , pp. 3795-3803
    • Sakitani, K.1    Hirata, Y.2    Hayakawa, Y.3
  • 82
    • 0036785559 scopus 로고    scopus 로고
    • The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses
    • Scott MG, Davidson DJ, Gold MR et al (2002) The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 169:3883–3891
    • (2002) J Immunol , vol.169 , pp. 3883-3891
    • Scott, M.G.1    Davidson, D.J.2    Gold, M.R.3
  • 83
    • 27144468929 scopus 로고    scopus 로고
    • Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure
    • Shaykhiev R, Beisswenger C, Kändler K et al (2005) Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol Lung Cell Mol Physiol 289:L842–L848
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289 , pp. L842-L848
    • Shaykhiev, R.1    Beisswenger, C.2    Kändler, K.3
  • 84
    • 34547887644 scopus 로고    scopus 로고
    • Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease
    • Shioya M, Nishida A, Yagi Y et al (2007) Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol 149:480–486
    • (2007) Clin Exp Immunol , vol.149 , pp. 480-486
    • Shioya, M.1    Nishida, A.2    Yagi, Y.3
  • 85
    • 9644255763 scopus 로고    scopus 로고
    • Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases
    • Sieprawska-Lupa M, Mydel P, Krawczyk K et al (2004) Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother 48:4673–4679
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4673-4679
    • Sieprawska-Lupa, M.1    Mydel, P.2    Krawczyk, K.3
  • 86
    • 84907170649 scopus 로고    scopus 로고
    • Tuberculosis and risk of cancer: a Danish nationwide cohort study
    • Simonsen DF, Farkas DK, Søgaard M et al (2014) Tuberculosis and risk of cancer: a Danish nationwide cohort study. Int J Tuberc Lung Dis 18:1211–1219
    • (2014) Int J Tuberc Lung Dis , vol.18 , pp. 1211-1219
    • Simonsen, D.F.1    Farkas, D.K.2    Søgaard, M.3
  • 87
    • 0035877995 scopus 로고    scopus 로고
    • Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3
    • Sørensen OE, Follin P, Johnsen AH et al (2001) Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97:3951–3959
    • (2001) Blood , vol.97 , pp. 3951-3959
    • Sørensen, O.E.1    Follin, P.2    Johnsen, A.H.3
  • 88
    • 70349878484 scopus 로고    scopus 로고
    • Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype
    • Sorrentino C, Di Carlo E (2009) Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am J Respir Crit Care Med 180:769–779
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 769-779
    • Sorrentino, C.1    Di Carlo, E.2
  • 89
    • 84907067520 scopus 로고    scopus 로고
    • Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer
    • Steg AD, Burke MR, Amm HM et al (2014) Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer. Oncotarget 5:7065–7080
    • (2014) Oncotarget , vol.5 , pp. 7065-7080
    • Steg, A.D.1    Burke, M.R.2    Amm, H.M.3
  • 90
    • 84919383679 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling promotes the migration of human melanoma cells
    • Takazawa Y, Kiniwa Y, Ogawa E et al (2014) Toll-like receptor 4 signaling promotes the migration of human melanoma cells. Tohoku J Exp Med 234:57–65
    • (2014) Tohoku J Exp Med , vol.234 , pp. 57-65
    • Takazawa, Y.1    Kiniwa, Y.2    Ogawa, E.3
  • 91
    • 0346996865 scopus 로고    scopus 로고
    • The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor
    • Tjabringa GS, Aarbiou J, Ninaber DK et al (2003) The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171:6690–6696
    • (2003) J Immunol , vol.171 , pp. 6690-6696
    • Tjabringa, G.S.1    Aarbiou, J.2    Ninaber, D.K.3
  • 92
    • 84908062896 scopus 로고    scopus 로고
    • Role of mesenchymal cells in the natural history of ovarian cancer: a review
    • Touboul C, Vidal F, Pasquier J et al (2014) Role of mesenchymal cells in the natural history of ovarian cancer: a review. J Transl Med 12:271
    • (2014) J Transl Med , vol.12 , pp. 271
    • Touboul, C.1    Vidal, F.2    Pasquier, J.3
  • 93
    • 0034098916 scopus 로고    scopus 로고
    • Bactericidal activity of mammalian cathelicidin-derived peptides
    • Travis SM, Anderson NN, Forsyth WR et al (2000) Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun 68:2748–2755
    • (2000) Infect Immun , vol.68 , pp. 2748-2755
    • Travis, S.M.1    Anderson, N.N.2    Forsyth, W.R.3
  • 94
    • 36749039163 scopus 로고    scopus 로고
    • The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer
    • Van Cutsem E, Geboes K (2007) The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer. Best Pract Res Clin Gastroenterol 21:1089–1108
    • (2007) Best Pract Res Clin Gastroenterol , vol.21 , pp. 1089-1108
    • Van Cutsem, E.1    Geboes, K.2
  • 95
    • 84871027267 scopus 로고    scopus 로고
    • A comprehensive summary of LL-37, the factotum human cathelicidin peptide
    • Vandamme D, Landuyt B, Luyten W et al (2012) A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol 280:22–35
    • (2012) Cell Immunol , vol.280 , pp. 22-35
    • Vandamme, D.1    Landuyt, B.2    Luyten, W.3
  • 96
    • 37549027589 scopus 로고    scopus 로고
    • The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells
    • von Haussen Koczulla R, Shaykhiev RJ et al (2008) The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells. Lung Cancer 59:12–23
    • (2008) Lung Cancer , vol.59 , pp. 12-23
    • von Haussen, K.R.1    Shaykhiev, R.J.2
  • 98
    • 67549084970 scopus 로고    scopus 로고
    • Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer
    • Weber G, Chamorro CI, Granath F et al (2009) Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer. Breast Cancer Res 11:R6
    • (2009) Breast Cancer Res , vol.11 , pp. R6
    • Weber, G.1    Chamorro, C.I.2    Granath, F.3
  • 99
    • 77952420148 scopus 로고    scopus 로고
    • Proteasome inhibition: a new therapeutic strategy to cancer treatment
    • Wu WK, Cho CH, Lee CW et al (2010a) Proteasome inhibition: a new therapeutic strategy to cancer treatment. Cancer Lett 293:15–22
    • (2010) Cancer Lett , vol.293 , pp. 15-22
    • Wu, W.K.1    Cho, C.H.2    Lee, C.W.3
  • 100
    • 75749117540 scopus 로고    scopus 로고
    • The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells
    • Wu WK, Sung JJ, To KF et al (2010b) The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. J Cell Physiol 223:178–186
    • (2010) J Cell Physiol , vol.223 , pp. 178-186
    • Wu, W.K.1    Sung, J.J.2    To, K.F.3
  • 101
    • 77956363683 scopus 로고    scopus 로고
    • Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications
    • Wu WK, Wang G, Coffelt SB et al (2010c) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. J Int Cancer 127:1741–1747
    • (2010) J Int Cancer , vol.127 , pp. 1741-1747
    • Wu, W.K.1    Wang, G.2    Coffelt, S.B.3
  • 102
    • 84857366779 scopus 로고    scopus 로고
    • The autophagic paradox in cancer therapy
    • Wu WK, Coffelt SB, Cho CH et al (2012) The autophagic paradox in cancer therapy. Oncogene 31:939–953
    • (2012) Oncogene , vol.31 , pp. 939-953
    • Wu, W.K.1    Coffelt, S.B.2    Cho, C.H.3
  • 103
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    • Yang De, Chen Q, Schmidt AP et al (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192:1069–1074
    • (2000) J Exp Med , vol.192 , pp. 1069-1074
    • Yang, D.1    Chen, Q.2    Schmidt, A.P.3
  • 104
    • 84938493066 scopus 로고    scopus 로고
    • A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
    • Yerlikaya A, Okur E, Baykal AT et al (2015) A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line. J Proteomics 113:315–325
    • (2015) J Proteomics , vol.113 , pp. 315-325
    • Yerlikaya, A.1    Okur, E.2    Baykal, A.T.3
  • 105
    • 84869872590 scopus 로고    scopus 로고
    • Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer
    • Yousif NG, Al-Amran FG, Hadi N et al (2013) Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer. Cytokine 61:223–227
    • (2013) Cytokine , vol.61 , pp. 223-227
    • Yousif, N.G.1    Al-Amran, F.G.2    Hadi, N.3
  • 106
    • 0036379140 scopus 로고    scopus 로고
    • Cathelicidins, essential gene-encoded mammalian antibiotics
    • Zaiou M, Gallo RL (2002) Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med 80:549–561
    • (2002) J Mol Med , vol.80 , pp. 549-561
    • Zaiou, M.1    Gallo, R.L.2
  • 107
    • 33947209622 scopus 로고    scopus 로고
    • DNA mismatch repair initiates 6-thioguanine—induced autophagy through p53 activation in human tumor cells
    • Zeng X, Yan T, Schupp JE et al (2007) DNA mismatch repair initiates 6-thioguanine—induced autophagy through p53 activation in human tumor cells. Clin Cancer Res 13:1315–1321
    • (2007) Clin Cancer Res , vol.13 , pp. 1315-1321
    • Zeng, X.1    Yan, T.2    Schupp, J.E.3
  • 108
    • 84888202837 scopus 로고    scopus 로고
    • Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kappaB induced matrix metalloproteinases 2 and 9 expression
    • Zeng Q, Li S, Zhou Y et al (2014) Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kappaB induced matrix metalloproteinases 2 and 9 expression. Cytokine 65:24–32
    • (2014) Cytokine , vol.65 , pp. 24-32
    • Zeng, Q.1    Li, S.2    Zhou, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.