Toll-Like receptor 4 signaling promotes the migration of human melanoma cells

Tohoku Journal of Experimental Medicine

Volumn 234, Issue 1, 2014, Pages 57-65

  Takazawa, Yuko ^a   Kiniwa, Yukiko ^a   Ogawa, Eisaku ^a   Uchiyama, Aya ^a   Ashida, Atsuko ^a   Uhara, Hisashi ^a   Goto, Yasufumi ^a   Okuyama, Ryuhei ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Innate immunity; Melanoma; Migration; Proliferation; Toll like receptor 4

Indexed keywords

LIGAND; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; MYD88 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER STAGING; CAUCASIAN; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INFLAMMATION; MALE; MELANOMA CELL; PROTEIN EXPRESSION; VERY ELDERLY; AGONISTS; CELL MOTION; DRUG EFFECTS; GENETICS; MELANOMA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MELANOMA; MYELOID DIFFERENTIATION FACTOR 88; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84919383679     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.234.57     Document Type: Article

References (21)

1. Akira, S. & Takeda, K. (2004) Toll-like receptor signalling. Nat. Rev. Immunol., 4, 499-511.
2. Andreani, V., Gatti, G., Simonella, L., Rivero, V. & Maccioni, M. (2007) Activation of Toll-like receptor 4 on tumor cells in vitro inhibits subsequent tumor growth in vivo. Cancer Res., 67, 10519-10527.
3. Eiro, N., Ovies, C., Fernandez-Garcia, B., Alvarez-Cuesta, C.C., Gonzalez, L., Gonzalez, L.O. & Vizoso, F.J. (2013) Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis. Arch. Dermatol. Res., 305, 59-67.
4. Fan, J. & Malik, A.B. (2003) Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat. Med., 9, 315-321.
5. Furumoto, K., Soares, L., Engleman, E.G. & Merad, M. (2004) Induction of potent antitumor immunity by in situ targeting of intratumoral DCs. J. Clin. Invest., 113, 774-783.
6. Goto, Y., Arigami, T., Kitago, M., Nguyen, S.L., Narita, N., Ferrone, S., Morton, D.L., Irie, R.F. & Hoon, D.S. (2008) Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol. Cancer Ther., 7, 3642-3653.
7. Hiratsuka, S., Watanabe, A., Sakurai, Y., Akashi-Takamura, S., Ishibashi, S., Miyake, K., Shibuya, M., Akira, S., Aburatani, H. & Maru, Y. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol., 10, 1349-1355.
8. Huang, B., Zhao, J., Li, H., He, K.L., Chen, Y., Chen, S.H., Mayer, L., Unkeless, J.C. & Xiong, H. (2005) Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res., 65, 5009-5014.
9. Kasturi, S.P., Skountzou, I., Albrecht, R.A., Koutsonanos, D., Hua, T., Nakaya, H.I., Ravindran, R., Stewart, S., Alam, M., Kwissa, M., Villinger, F., Murthy, N., Steel, J., Jacob, J., Hogan, R.J., et al.(2011) Programming the magnitude and persistence of antibody responses with innate immunity. Nature, 470, 543-547.
10. Kirkwood, J.M., Wilson, J., Whiteside, T.L., Donnelly, S. & Herberman, R.B. (1997) Phase IB trial of picibanil (OK-432) as an immunomodulator in patients with resected high-risk melanoma. Cancer Immunol. Immunother., 44, 137-149.
11. Medzhitov, R. & Janeway, C.A. Jr. (2002) Decoding the patterns of self and nonself by the innate immune system. Science, 296, 298-300.
12. Nunez, N.G., Andreani, V., Crespo, M.I., Nocera, D.A., Breser, M.L., Moron, G., Dejager, L., Libert, C., Rivero, V. & Maccioni, M. (2012) IFNbeta produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response. Cancer Res., 72, 592-603.
13. Okamoto, M., Oshikawa, T., Tano, T., Ahmed, S.U., Kan, S., Sasai, A., Akashi, S., Miyake, K., Moriya, Y., Ryoma, Y., Saito, M. & Sato, M.(2006) Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling. J. Immuno-ther., 29, 78-86.
14. Pasare, C. & Medzhitov, R. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science, 299, 1033-1036.
15. Saint-Jean, M., Knol, A.C., Nguyen, J.M., Khammari, A. & Dreno, B. (2011) TLR expression in human melanoma cells. Eur. J. Dermatol., 21, 899-905.
16. Sato, Y., Goto, Y., Narita, N. & Hoon, D.S. (2009) Cancer Cells Expressing Toll-like Receptors and the Tumor Microenviron-ment. Cancer Microenviron., 2 Suppl 1, 205-214.
17. Shingu, K., Kruschinski, C., Luhrmann, A., Grote, K., Tschernig, T., Von Horsten, S. & Pabst, R. (2003) Intratracheal macro-phage-activating lipopeptide-2 reduces metastasis in the rat lung. Am. J. Respir. Cell Mol. Biol., 28, 316-321.
18. Tanami, H., Imoto, I., Hirasawa, A., Yuki, Y., Sonoda, I., Inoue, J., Yasui, K., Misawa-Furihata, A., Kawakami, Y. & Inazawa, J. (2004) Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene, 23, 8796-8804.
19. Voelcker, V., Gebhardt, C., Averbeck, M., Saalbach, A., Wolf, V., Weih, F., Sleeman, J., Anderegg, U. & Simon, J. (2008) Hyal-uronan fragments induce cytokine and metalloprotease upreg-ulation in human melanoma cells in part by signalling via TLR4. Exp. Dermatol., 17, 100-107.
20. Wang, E.L., Qian, Z.R., Nakasono, M., Tanahashi, T., Yoshimoto, K., Bando, Y., Kudo, E., Shimada, M. & Sano, T. (2010) High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br. J. Cancer, 102, 908-915.
21. Yu, N., Zhang, S., Zuo, F., Kang, K., Guan, M. & Xiang, L. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci., 56, 113-120.