Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer

Cancer Research

Volumn 72, Issue 24, 2012, Pages 6512-6523

  Ren, Shun X ^a   Cheng, Alfred S L ^a   To, Ka F ^a   Tong, Joanna H M ^a   Li, May S ^a   Shen, Jin ^a   Wong, Clover C M ^a   Zhang, Lin ^a   Chan, Ruby L Y ^a   Wang, Xiao J ^a   Ng, Simon S M ^a   Chiu, Lawrence C M ^a   Marquez, Victor E ^b   Gallo, Richard L ^c   Chan, Francis K L ^a   Yu, Jun ^a   Sung, Joseph J Y ^a   Wu, William K K ^a   Cho, Chi H ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA NUCLEOTIDYLEXOTRANSFERASE; ENDONUCLEASE G; G PROTEIN COUPLED RECEPTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CANCER TISSUE; CELL NUCLEUS TRANSPLANTATION; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ADAPTIVE IMMUNITY; ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; CASE-CONTROL STUDIES; CASPASES; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; FEMALE; HCT116 CELLS; HT29 CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED;

EID: 84871188238     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2359     Document Type: Article

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