The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity

Molecular Cancer Research

Volumn 7, Issue 5, 2009, Pages 689-702

  Mader, Jamie S ^a   Mookherjee, Neeloffer ^b   Hancock, Robert E W ^c   Bleackley, R Chris ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CALPAIN; CASPASE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; PROTEIN BAK; PROTEIN BAX;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CHELATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; HOST RESISTANCE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T CELL LEUKEMIA;

AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CALPAIN; CASPASE 9; CELL NUCLEUS; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 66349099109     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0274     Document Type: Article

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