-
1
-
-
21744445077
-
Nrf2, a multi-organ protector?
-
Lee, J.M., Li, J., Johnson, D.A., Stein, T.D., Kraft, A.D., Calkins, M.J., Jakel, R.J. and Johnson, J.A. (2005) Nrf2, a multi-organ protector? FASEB J. 19, 1061-1066
-
(2005)
FASEB J
, vol.19
, pp. 1061-1066
-
-
Lee, J.M.1
Li, J.2
Johnson, D.A.3
Stein, T.D.4
Kraft, A.D.5
Calkins, M.J.6
Jakel, R.J.7
Johnson, J.A.8
-
2
-
-
67649402187
-
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
-
Nguyen, T., Nioi, P. and Pickett, C.B. (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 13291-13295
-
(2009)
J. Biol. Chem
, vol.284
, pp. 13291-13295
-
-
Nguyen, T.1
Nioi, P.2
Pickett, C.B.3
-
3
-
-
74049120454
-
Nrf2: friend or foe for chemoprevention?
-
Kensler, T.W. and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99
-
(2010)
Carcinogenesis
, vol.31
, pp. 90-99
-
-
Kensler, T.W.1
Wakabayashi, N.2
-
4
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
Zhang, D.D. (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 38, 769-789
-
(2006)
Drug Metab. Rev
, vol.38
, pp. 769-789
-
-
Zhang, D.D.1
-
6
-
-
84896714242
-
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy
-
Ishimura, R., Tanaka, K. and Komatsu, M. (2014) Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy. FEBS Lett. 588, 822-828
-
(2014)
FEBS Lett
, vol.588
, pp. 822-828
-
-
Ishimura, R.1
Tanaka, K.2
Komatsu, M.3
-
7
-
-
77954599053
-
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain, A., Lamark, T., Sjottem, E., Larsen, K.B., Awuh, J.A., Øvervatn, A., McMahon, M., Hayes, J.D. and Johansen, T. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285, 22576-22591
-
(2010)
J. Biol. Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
Øvervatn, A.6
McMahon, M.7
Hayes, J.D.8
Johansen, T.9
-
8
-
-
79952256187
-
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
-
Rada, P., Rojo, A.I., Chowdhry, S., McMahon, M., Hayes, J.D. and Cuadrado, A. (2011) SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol. Cell. Biol. 31, 1121-1133
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 1121-1133
-
-
Rada, P.1
Rojo, A.I.2
Chowdhry, S.3
McMahon, M.4
Hayes, J.D.5
Cuadrado, A.6
-
9
-
-
34447526197
-
GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
-
Jain, A.K. and Jaiswal, A.K. (2007) GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J. Biol. Chem. 282, 16502-16510
-
(2007)
J. Biol. Chem
, vol.282
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
10
-
-
83355174048
-
Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia
-
Kweider, N., Fragoulis, A., Rosen, C., Pecks, U., Rath, W., Pufe, T. and Wruck, C.J. (2011) Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia. J. Biol. Chem. 286, 42863-42872
-
(2011)
J. Biol. Chem
, vol.286
, pp. 42863-42872
-
-
Kweider, N.1
Fragoulis, A.2
Rosen, C.3
Pecks, U.4
Rath, W.5
Pufe, T.6
Wruck, C.J.7
-
11
-
-
84867055462
-
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
-
Liby, K.T. and Sporn, M.B. (2012) Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacol. Rev. 64, 972-1003
-
(2012)
Pharmacol. Rev
, vol.64
, pp. 972-1003
-
-
Liby, K.T.1
Sporn, M.B.2
-
12
-
-
33846786713
-
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
-
Yates, M.S., Tauchi, M., Katsuoka, F., Flanders, K.C., Liby, K.T., Honda, T., Gribble, G.W., Johnson, D.A., Johnson, J.A., Burton, N.C. et al. (2007) Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol. Cancer Ther. 6, 154-162
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 154-162
-
-
Yates, M.S.1
Tauchi, M.2
Katsuoka, F.3
Flanders, K.C.4
Liby, K.T.5
Honda, T.6
Gribble, G.W.7
Johnson, D.A.8
Johnson, J.A.9
Burton, N.C.10
-
13
-
-
33845976705
-
Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179
-
Ahmad, R., Raina, D., Meyer, C., Kharbanda, S. and Kufe, D. (2006) Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179. J. Biol. Chem. 281, 35764-35769
-
(2006)
J. Biol. Chem
, vol.281
, pp. 35764-35769
-
-
Ahmad, R.1
Raina, D.2
Meyer, C.3
Kharbanda, S.4
Kufe, D.5
-
14
-
-
34547129333
-
Treatment of psoriasis with fumaric acid esters (Fumaderm)
-
Mrowietz, U., Altmeyer, P., Bieber, T., Rocken, M., Schopf, R.E. and Sterry, W. (2007) Treatment of psoriasis with fumaric acid esters (Fumaderm). J. Dtsch. Dermatol. Ges. 5, 716-717
-
(2007)
J. Dtsch. Dermatol. Ges
, vol.5
, pp. 716-717
-
-
Mrowietz, U.1
Altmeyer, P.2
Bieber, T.3
Rocken, M.4
Schopf, R.E.5
Sterry, W.6
-
15
-
-
33947265597
-
Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1
-
Lehmann, J.C., Listopad, J.J., Rentzsch, C.U., Igney, F.H., von Bonin, A., Hennekes, H.H., Asadullah, K. and Docke, W.D. (2007) Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. J. Invest. Dermatol. 127, 835-845
-
(2007)
J. Invest. Dermatol
, vol.127
, pp. 835-845
-
-
Lehmann, J.C.1
Listopad, J.J.2
Rentzsch, C.U.3
Igney, F.H.4
von Bonin, A.5
Hennekes, H.H.6
Asadullah, K.7
Docke, W.D.8
-
16
-
-
84860447071
-
Protective effect of sulforaphane against oxidative stress: recent advances
-
Guerrero-Beltran, C.E., Calderon-Oliver, M., Pedraza-Chaverri, J. and Chirino, Y.I. (2012) Protective effect of sulforaphane against oxidative stress: recent advances. Exp. Toxicol. Pathol. 64, 503-508
-
(2012)
Exp. Toxicol. Pathol
, vol.64
, pp. 503-508
-
-
Guerrero-Beltran, C.E.1
Calderon-Oliver, M.2
Pedraza-Chaverri, J.3
Chirino, Y.I.4
-
17
-
-
0026577605
-
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
-
Zhang, Y., Talalay, P., Cho, C.G. and Posner, G.H. (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. U.S.A. 89, 2399-2403
-
(1992)
Proc. Natl. Acad. Sci. U.S.A
, vol.89
, pp. 2399-2403
-
-
Zhang, Y.1
Talalay, P.2
Cho, C.G.3
Posner, G.H.4
-
18
-
-
84867409491
-
Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
-
Fragoulis, A., Laufs, J., Müller, S., Soppa, U., Siegl, S., Reiss, L.K., Tohidnezhad, M., Rosen, C., Tenbrock, K., Varoga, D., et al. (2012) Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes. Arthritis Res. Ther. 14, R220
-
(2012)
Arthritis Res. Ther
, vol.14
-
-
Fragoulis, A.1
Laufs, J.2
Müller, S.3
Soppa, U.4
Siegl, S.5
Reiss, L.K.6
Tohidnezhad, M.7
Rosen, C.8
Tenbrock, K.9
Varoga, D.10
-
19
-
-
67649637824
-
Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling
-
Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B.M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G. et al. (2009) Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling. Gut 58, 949-963
-
(2009)
Gut
, vol.58
, pp. 949-963
-
-
Kallifatidis, G.1
Rausch, V.2
Baumann, B.3
Apel, A.4
Beckermann, B.M.5
Groth, A.6
Mattern, J.7
Li, Z.8
Kolb, A.9
Moldenhauer, G.10
-
20
-
-
79952122321
-
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
-
Ren, D., Villeneuve, N.F., Jiang, T., Wu, T., Lau, A., Toppin, H.A. and Zhang, D.D. (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc. Natl. Acad. Sci. U.S.A. 108, 1433-1438
-
(2011)
Proc. Natl. Acad. Sci. U.S.A
, vol.108
, pp. 1433-1438
-
-
Ren, D.1
Villeneuve, N.F.2
Jiang, T.3
Wu, T.4
Lau, A.5
Toppin, H.A.6
Zhang, D.D.7
-
21
-
-
57349126748
-
Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
-
Azarenko, O., Okouneva, T., Singletary, K.W., Jordan, M.A. and Wilson, L. (2008) Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane. Carcinogenesis 29, 2360-2368
-
(2008)
Carcinogenesis
, vol.29
, pp. 2360-2368
-
-
Azarenko, O.1
Okouneva, T.2
Singletary, K.W.3
Jordan, M.A.4
Wilson, L.5
-
22
-
-
84970951874
-
Roles of NRF2 in cell proliferation and differentiation
-
Murakami, S. and Motohashi, H. (2015) Roles of NRF2 in cell proliferation and differentiation. Free Radic. Biol. Med.
-
(2015)
Free Radic. Biol. Med
-
-
Murakami, S.1
Motohashi, H.2
-
23
-
-
84864348569
-
NRF2 and cancer: the good, the bad and the importance of context
-
Sporn, M.B. and Liby, K.T. (2012) NRF2 and cancer: the good, the bad and the importance of context. Nat. Rev. Cancer 12, 564-571
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 564-571
-
-
Sporn, M.B.1
Liby, K.T.2
-
24
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
Lau, A., Villeneuve, N.F., Sun, Z., Wong, P.K. and Zhang, D.D. (2008) Dual roles of Nrf2 in cancer. Pharmacol. Res. 58, 262-270
-
(2008)
Pharmacol. Res
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
25
-
-
84929614470
-
Targeting Nrf2 signaling to combat chemoresistance
-
No, J.H., Kim, Y.B. and Song, Y.S. (2014) Targeting Nrf2 signaling to combat chemoresistance. J. Cancer Prev. 19, 111-117
-
(2014)
J. Cancer Prev
, vol.19
, pp. 111-117
-
-
No, J.H.1
Kim, Y.B.2
Song, Y.S.3
-
26
-
-
84885177241
-
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
-
Arlt, A., Sebens, S., Krebs, S., Geismann, C., Grossmann, M., Kruse, M.L., Schreiber, S. and Schafer, H. (2013) Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene 32, 4825-4835
-
(2013)
Oncogene
, vol.32
, pp. 4825-4835
-
-
Arlt, A.1
Sebens, S.2
Krebs, S.3
Geismann, C.4
Grossmann, M.5
Kruse, M.L.6
Schreiber, S.7
Schafer, H.8
-
27
-
-
79952122321
-
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
-
Ren, D.M., Villeneuve, N.F., Jiang, T., Wu, T.D., Lau, A., Toppin, H.A. and Zhang, D.D. (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc. Natl. Acad. Sci. U.S.A. 108, 1433-1438
-
(2011)
Proc. Natl. Acad. Sci. U.S.A
, vol.108
, pp. 1433-1438
-
-
Ren, D.M.1
Villeneuve, N.F.2
Jiang, T.3
Wu, T.D.4
Lau, A.5
Toppin, H.A.6
Zhang, D.D.7
-
28
-
-
84863764507
-
Oxidative stress and liver disease
-
Zhu, R.Z., Wang, Y.J., Zhang, L.Q. and Guo, Q.L. (2012) Oxidative stress and liver disease. Hepatol. Res. 42, 741-749
-
(2012)
Hepatol. Res
, vol.42
, pp. 741-749
-
-
Zhu, R.Z.1
Wang, Y.J.2
Zhang, L.Q.3
Guo, Q.L.4
-
30
-
-
14944375587
-
Immunology of hepatitis B virus and hepatitis C virus infection
-
Rehermann, B. and Nascimbeni, M. (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5, 215-229
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 215-229
-
-
Rehermann, B.1
Nascimbeni, M.2
-
31
-
-
0034774463
-
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress
-
Waris, G., Huh, K.W. and Siddiqui, A. (2001) Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress. Mol. Cell. Biol. 21, 7721-7730
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 7721-7730
-
-
Waris, G.1
Huh, K.W.2
Siddiqui, A.3
-
32
-
-
76849085285
-
Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway
-
Burdette, D., Olivarez, M. and Waris, G. (2010) Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway. J. Gen. Virol. 91, 681-690
-
(2010)
J. Gen. Virol
, vol.91
, pp. 681-690
-
-
Burdette, D.1
Olivarez, M.2
Waris, G.3
-
33
-
-
71749098743
-
Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells
-
Hou, W.H., Rossi, L., Shan, Y., Zheng, J.Y., Lambrecht, R.W. and Bonkovsky, H.L. (2009) Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. World J. Gastroenterol. 15, 4499-4510
-
(2009)
World J. Gastroenterol
, vol.15
, pp. 4499-4510
-
-
Hou, W.H.1
Rossi, L.2
Shan, Y.3
Zheng, J.Y.4
Lambrecht, R.W.5
Bonkovsky, H.L.6
-
34
-
-
84877809314
-
New player on an old field: the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome
-
Chartoumpekis, D.V. and Kensler, T.W. (2013) New player on an old field: the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Curr. Diabetes Rev. 9, 137-145
-
(2013)
Curr. Diabetes Rev
, vol.9
, pp. 137-145
-
-
Chartoumpekis, D.V.1
Kensler, T.W.2
-
35
-
-
84877798095
-
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis
-
Endo, H., Niioka, M., Kobayashi, N., Tanaka, M. and Watanabe, T. (2013) Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis. PLoS One 8, e63388
-
(2013)
PLoS One
, vol.8
-
-
Endo, H.1
Niioka, M.2
Kobayashi, N.3
Tanaka, M.4
Watanabe, T.5
-
36
-
-
67649968443
-
Oxidative stress and alcoholic liver disease
-
Wu, D.F. and Cederbaum, A.I. (2009) Oxidative stress and alcoholic liver disease. Semin. Liver Dis. 29, 141-154
-
(2009)
Semin. Liver Dis
, vol.29
, pp. 141-154
-
-
Wu, D.F.1
Cederbaum, A.I.2
-
37
-
-
54449093352
-
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system
-
Copple, I.M., Goldring, C.E., Jenkins, R.E., Chia, A.J.L., Randle, L.E., Hayes, J.D., Kitteringham, N.R. and Park, B.K. (2008) The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. Hepatology 48, 1292-1301
-
(2008)
Hepatology
, vol.48
, pp. 1292-1301
-
-
Copple, I.M.1
Goldring, C.E.2
Jenkins, R.E.3
Chia, A.J.L.4
Randle, L.E.5
Hayes, J.D.6
Kitteringham, N.R.7
Park, B.K.8
-
38
-
-
84856302591
-
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
-
Oh, C.J., Kim, J.Y., Min, A.K., Park, K.G., Harris, R.A., Kim, H.J. and Lee, I.K. (2012) Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. Free Radic. Biol. Med. 52, 671-682
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 671-682
-
-
Oh, C.J.1
Kim, J.Y.2
Min, A.K.3
Park, K.G.4
Harris, R.A.5
Kim, H.J.6
Lee, I.K.7
-
39
-
-
84879090781
-
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model
-
Shimozono, R., Asaoka, Y., Yoshizawa, Y., Aoki, T., Noda, H., Yamada, M., Kaino, M. and Mochizuki, H. (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol. Pharmacol. 84, 62-70
-
(2013)
Mol. Pharmacol
, vol.84
, pp. 62-70
-
-
Shimozono, R.1
Asaoka, Y.2
Yoshizawa, Y.3
Aoki, T.4
Noda, H.5
Yamada, M.6
Kaino, M.7
Mochizuki, H.8
-
40
-
-
84906315540
-
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy
-
Ni, H.M., Woolbright, B.L., Williams, J., Copple, B., Cui, W., Luyendyk, J.P., Jaeschke, H. and Ding, W.X. (2014) Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J. Hepatol. 61, 617-625
-
(2014)
J. Hepatol
, vol.61
, pp. 617-625
-
-
Ni, H.M.1
Woolbright, B.L.2
Williams, J.3
Copple, B.4
Cui, W.5
Luyendyk, J.P.6
Jaeschke, H.7
Ding, W.X.8
-
41
-
-
84862786878
-
Somatic mutations of the KEAP1 gene in common solid cancers
-
Yoo, N.J., Kim, H.R., Kim, Y.R., An, C.H. and Lee, S.H. (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60, 943-952
-
(2012)
Histopathology
, vol.60
, pp. 943-952
-
-
Yoo, N.J.1
Kim, H.R.2
Kim, Y.R.3
An, C.H.4
Lee, S.H.5
-
42
-
-
80755168955
-
Nrf2 activators as attractive therapeutics for diabetic nephropathy
-
de Haan, J.B. (2011) Nrf2 activators as attractive therapeutics for diabetic nephropathy. Diabetes 60, 2683-2684
-
(2011)
Diabetes
, vol.60
, pp. 2683-2684
-
-
de Haan, J.B.1
-
43
-
-
77951199503
-
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
-
Jiang, T., Huang, Z., Lin, Y., Zhang, Z., Fang, D. and Zhang, D.D. (2010) The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59, 850-860
-
(2010)
Diabetes
, vol.59
, pp. 850-860
-
-
Jiang, T.1
Huang, Z.2
Lin, Y.3
Zhang, Z.4
Fang, D.5
Zhang, D.D.6
-
44
-
-
84874085595
-
Loss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK)
-
Chang, J., Ma, J.Z., Zeng, Q., Cechova, S., Gantz, A., Nievergelt, C., O'Connor, D., Lipkowitz, M. and Le, T.H. (2013) Loss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK). Am. J. Physiol. Renal Physiol. 304, F348-F355
-
(2013)
Am. J. Physiol. Renal Physiol
, vol.304
, pp. F348-F355
-
-
Chang, J.1
Ma, J.Z.2
Zeng, Q.3
Cechova, S.4
Gantz, A.5
Nievergelt, C.6
O'Connor, D.7
Lipkowitz, M.8
Le, T.H.9
-
45
-
-
79956214470
-
Role of intrarenal angiotensin system activation, oxidative stress, inflammation, and impaired nuclear factor-erythroid-2-related factor 2 activity in the progression of focal glomerulosclerosis
-
Kim, H.J., Sato, T., Rodriguez-Iturbe, B. and Vaziri, N.D. (2011) Role of intrarenal angiotensin system activation, oxidative stress, inflammation, and impaired nuclear factor-erythroid-2-related factor 2 activity in the progression of focal glomerulosclerosis. J. Pharmacol. Exp. Ther. 337, 583-590
-
(2011)
J. Pharmacol. Exp. Ther
, vol.337
, pp. 583-590
-
-
Kim, H.J.1
Sato, T.2
Rodriguez-Iturbe, B.3
Vaziri, N.D.4
-
46
-
-
84867324847
-
Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
-
Oh, C.J., Kim, J.Y., Choi, Y.K., Kim, H.J., Jeong, J.Y., Bae, K.H., Park, K.G. and Lee, I.K. (2012) Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. PLoS One 7, e45870
-
(2012)
PLoS One
, vol.7
-
-
Oh, C.J.1
Kim, J.Y.2
Choi, Y.K.3
Kim, H.J.4
Jeong, J.Y.5
Bae, K.H.6
Park, K.G.7
Lee, I.K.8
-
47
-
-
0034785941
-
Nrf2-deficient female mice develop lupus-like autoimmune nephritis
-
Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Koyama, A., Yamamoto, M. and Takahashi, S. (2001) Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int. 60, 1343-1353
-
(2001)
Kidney Int
, vol.60
, pp. 1343-1353
-
-
Yoh, K.1
Itoh, K.2
Enomoto, A.3
Hirayama, A.4
Yamaguchi, N.5
Kobayashi, M.6
Morito, N.7
Koyama, A.8
Yamamoto, M.9
Takahashi, S.10
-
48
-
-
0036176161
-
K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification
-
National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am. J. Kidney Dis. 39 Suppl. 1, S1-S266
-
(2002)
Am. J. Kidney Dis
, vol.39
, pp. S1-S266
-
-
-
49
-
-
84862557429
-
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
-
Hong, D.S., Kurzrock, R., Supko, J.G., He, X., Naing, A., Wheler, J., Lawrence, D., Eder, J.P., Meyer, C.J., Ferguson, D.A. et al. (2012) A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin. Cancer Res. 18, 3396-3406
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 3396-3406
-
-
Hong, D.S.1
Kurzrock, R.2
Supko, J.G.3
He, X.4
Naing, A.5
Wheler, J.6
Lawrence, D.7
Eder, J.P.8
Meyer, C.J.9
Ferguson, D.A.10
-
50
-
-
79960855656
-
Bardoxolone methyl and kidney function in CKD with type 2 diabetes
-
Pergola, P.E., Raskin, P., Toto, R.D., Meyer, C.J., Huff, J.W., Grossman, E.B., Krauth, M., Ruiz, S., Audhya, P., Christ-Schmidt, H. et al. (2011) Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N. Engl. J. Med. 365, 327-336
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 327-336
-
-
Pergola, P.E.1
Raskin, P.2
Toto, R.D.3
Meyer, C.J.4
Huff, J.W.5
Grossman, E.B.6
Krauth, M.7
Ruiz, S.8
Audhya, P.9
Christ-Schmidt, H.10
-
51
-
-
84874615691
-
Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON)
-
de Zeeuw, D., Akizawa, T., Agarwal, R., Audhya, P., Bakrise, G.L., Chin, M., Krauth, M., Heerspink, H.J.L., Meyer, C.J., McMurray, J.J. et al. (2013) Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON). Am. J. Nephrol. 37, 212-222
-
(2013)
Am. J. Nephrol
, vol.37
, pp. 212-222
-
-
de Zeeuw, D.1
Akizawa, T.2
Agarwal, R.3
Audhya, P.4
Bakrise, G.L.5
Chin, M.6
Krauth, M.7
Heerspink, H.J.L.8
Meyer, C.J.9
McMurray, J.J.10
-
52
-
-
84890946148
-
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease
-
de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G.L., Chin, M., Christ-Schmidt, H., Goldsberry, A., Houser, M., Krauth, M., Heerspink, H.J.L. et al. (2013) Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. New Engl. J. Med. 369, 2492-2503
-
(2013)
New Engl. J. Med
, vol.369
, pp. 2492-2503
-
-
de Zeeuw, D.1
Akizawa, T.2
Audhya, P.3
Bakris, G.L.4
Chin, M.5
Christ-Schmidt, H.6
Goldsberry, A.7
Houser, M.8
Krauth, M.9
Heerspink, H.J.L.10
-
53
-
-
84901734541
-
Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl
-
Chin, M.P., Reisman, S.A., Bakris, G.L., O'Grady, M., Linde, P.G., McCullough, P.A., Packham, D., Vaziri, N.D., Ward, K.W., Warnock, D.G. et al. (2014) Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. Am. J. Nephrol. 39, 499-508
-
(2014)
Am. J. Nephrol
, vol.39
, pp. 499-508
-
-
Chin, M.P.1
Reisman, S.A.2
Bakris, G.L.3
O'Grady, M.4
Linde, P.G.5
McCullough, P.A.6
Packham, D.7
Vaziri, N.D.8
Ward, K.W.9
Warnock, D.G.10
-
54
-
-
0034806025
-
B-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits
-
B-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits. J. Hypertens. 19, 1789-1799
-
(2001)
J. Hypertens
, vol.19
, pp. 1789-1799
-
-
Evans, R.G.1
Madden, A.C.2
Oliver, J.J.3
Lewis, T.V.4
-
55
-
-
33845423984
-
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
-
Ge, Y., Bagnall, A., Stricklett, P.K., Strait, K., Webb, D.J., Kotelevtsev, Y. and Kohan, D.E. (2006) Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am. J. Physiol. Renal Physiol. 291, F1274-F1280
-
(2006)
Am. J. Physiol. Renal Physiol
, vol.291
, pp. F1274-F1280
-
-
Ge, Y.1
Bagnall, A.2
Stricklett, P.K.3
Strait, K.4
Webb, D.J.5
Kotelevtsev, Y.6
Kohan, D.E.7
-
56
-
-
73449127260
-
The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses
-
Vachiery, J.L. and Davenport, A. (2009) The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses. Eur. Respir. Rev. 18, 260-271
-
(2009)
Eur. Respir. Rev
, vol.18
, pp. 260-271
-
-
Vachiery, J.L.1
Davenport, A.2
-
57
-
-
84904041193
-
Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl
-
Chin, M.P., Wrolstad, D., Bakris, G.L., Chertow, G.M., de Zeeuw, D., Goldsberry, A., Linde, P.G., McCullough, P.A., McMurray, J.J., Wittes, J. et al. (2014) Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. J. Card. Fail. 20, 953-958
-
(2014)
J. Card. Fail
, vol.20
, pp. 953-958
-
-
Chin, M.P.1
Wrolstad, D.2
Bakris, G.L.3
Chertow, G.M.4
de Zeeuw, D.5
Goldsberry, A.6
Linde, P.G.7
McCullough, P.A.8
McMurray, J.J.9
Wittes, J.10
-
58
-
-
84890067870
-
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial
-
Lambers Heerspink, H.J., Chertow, G.M., Akizawa, T., Audhya, P., Bakris, G.L., Goldsberry, A., Krauth, M., Linde, P., McMurray, J.J., Meyer, C.J. et al. (2013) Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. Nephrol. Dial. Transplant. 28, 2841-2850
-
(2013)
Nephrol. Dial. Transplant
, vol.28
, pp. 2841-2850
-
-
Lambers Heerspink, H.J.1
Chertow, G.M.2
Akizawa, T.3
Audhya, P.4
Bakris, G.L.5
Goldsberry, A.6
Krauth, M.7
Linde, P.8
McMurray, J.J.9
Meyer, C.J.10
-
59
-
-
84887822325
-
Nuclear factor-κB-mediated endothelin receptor up-regulation increases renal artery contractility in rats
-
Xie, Y.H., Wang, S.W., Zhang, Y., Edvinsson, L. and Xu, C.B. (2013) Nuclear factor-κB-mediated endothelin receptor up-regulation increases renal artery contractility in rats. Basic Clin. Pharmacol. Toxicol. 113, 401-410
-
(2013)
Basic Clin. Pharmacol. Toxicol
, vol.113
, pp. 401-410
-
-
Xie, Y.H.1
Wang, S.W.2
Zhang, Y.3
Edvinsson, L.4
Xu, C.B.5
-
60
-
-
84867910411
-
Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl
-
McCullough, P.A. and Ali, S. (2012) Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl. Drug Des. Devel. Ther. 6, 141-149
-
(2012)
Drug Des. Devel. Ther
, vol.6
, pp. 141-149
-
-
McCullough, P.A.1
Ali, S.2
-
61
-
-
66149093072
-
The pathology of chronic obstructive pulmonary disease
-
Hogg, J.C. and Timens, W. (2009) The pathology of chronic obstructive pulmonary disease. Annu. Rev. Pathol. 4, 435-459
-
(2009)
Annu. Rev. Pathol
, vol.4
, pp. 435-459
-
-
Hogg, J.C.1
Timens, W.2
-
62
-
-
53349129571
-
Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells
-
Adair-Kirk, T.L., Atkinson, J.J., Griffin, G.L., Watson, M.A., Kelley, D.G., DeMello, D., Senior, R.M. and Betsuyaku, T. (2008) Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am. J. Respir. Cell Mol. Biol. 39, 400-411
-
(2008)
Am. J. Respir. Cell Mol. Biol
, vol.39
, pp. 400-411
-
-
Adair-Kirk, T.L.1
Atkinson, J.J.2
Griffin, G.L.3
Watson, M.A.4
Kelley, D.G.5
DeMello, D.6
Senior, R.M.7
Betsuyaku, T.8
-
63
-
-
29244473882
-
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema
-
Iizuka, T., Ishii, Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A.E., Homma, S., Nomura, A. et al. (2005) Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells 10, 1113-1125
-
(2005)
Genes Cells
, vol.10
, pp. 1113-1125
-
-
Iizuka, T.1
Ishii, Y.2
Itoh, K.3
Kiwamoto, T.4
Kimura, T.5
Matsuno, Y.6
Morishima, Y.7
Hegab, A.E.8
Homma, S.9
Nomura, A.10
-
64
-
-
27744450995
-
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
-
Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T., Iizuka, T., Hegab, A.E., Hosoya, T., Nomura, A., Sakamoto, T. et al. (2005) Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J. Immunol. 175, 6968-6975
-
(2005)
J. Immunol
, vol.175
, pp. 6968-6975
-
-
Ishii, Y.1
Itoh, K.2
Morishima, Y.3
Kimura, T.4
Kiwamoto, T.5
Iizuka, T.6
Hegab, A.E.7
Hosoya, T.8
Nomura, A.9
Sakamoto, T.10
-
65
-
-
37549071817
-
Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2
-
Walters, D.M., Cho, H.Y. and Kleeberger, S.R. (2008) Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. Antioxid. Redox Signal. 10, 321-332
-
(2008)
Antioxid. Redox Signal
, vol.10
, pp. 321-332
-
-
Walters, D.M.1
Cho, H.Y.2
Kleeberger, S.R.3
-
66
-
-
84875941102
-
Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?
-
Voelkel, N.F., Bogaard, H.J., Al Husseini, A., Farkas, L., Gomez-Arroyo, J. and Natarajan, R. (2013) Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension? Antioxid. Redox Signal. 18, 1810-1817
-
(2013)
Antioxid. Redox Signal
, vol.18
, pp. 1810-1817
-
-
Voelkel, N.F.1
Bogaard, H.J.2
Al Husseini, A.3
Farkas, L.4
Gomez-Arroyo, J.5
Natarajan, R.6
-
67
-
-
84914154132
-
Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation
-
Reiss, L.K., Fragoulis, A., Siegl, S., Platen, C., Kan, Y.W., Nautiyal, J., Parker, M., Pufe, T., Uhlig, U., Martin, C. et al. (2014) Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation. Am. J. Respir. Cell Mol. Biol. 51, 668-677
-
(2014)
Am. J. Respir. Cell Mol. Biol
, vol.51
, pp. 668-677
-
-
Reiss, L.K.1
Fragoulis, A.2
Siegl, S.3
Platen, C.4
Kan, Y.W.5
Nautiyal, J.6
Parker, M.7
Pufe, T.8
Uhlig, U.9
Martin, C.10
-
68
-
-
84934436070
-
Effects of mechanical ventilation with different tidal volume on oxidative stress and antioxidant in lung
-
Sun, Z.T., Yang, C.Y., Miao, L.J., Zhang, S.F., Han, X.P., Ren, S.E., Sun, X.Q. and Cao, Y.N. (2015) Effects of mechanical ventilation with different tidal volume on oxidative stress and antioxidant in lung. J. Anesth. 29, 346-351
-
(2015)
J. Anesth
, vol.29
, pp. 346-351
-
-
Sun, Z.T.1
Yang, C.Y.2
Miao, L.J.3
Zhang, S.F.4
Han, X.P.5
Ren, S.E.6
Sun, X.Q.7
Cao, Y.N.8
-
69
-
-
0035734736
-
Oxygen-induced pulmonary injury in γ-glutamyl transpeptidase-deficient mice
-
Barrios, R., Shi, Z.Z., Kala, S.V., Wiseman, A.L., Welty, S.E., Kala, G., Bahler, A.A., Ou, C.N. and Lieberman, M.W. (2001) Oxygen-induced pulmonary injury in γ-glutamyl transpeptidase-deficient mice. Lung 179, 319-330
-
(2001)
Lung
, vol.179
, pp. 319-330
-
-
Barrios, R.1
Shi, Z.Z.2
Kala, S.V.3
Wiseman, A.L.4
Welty, S.E.5
Kala, G.6
Bahler, A.A.7
Ou, C.N.8
Lieberman, M.W.9
-
70
-
-
13044304201
-
Nrf2 is essential for protection against acute pulmonary injury in mice
-
Chan, K.M. and Kan, Y.W. (1999) Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. U.S.A. 96, 12731-12736
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 12731-12736
-
-
Chan, K.M.1
Kan, Y.W.2
-
71
-
-
0036784377
-
γ-Glutamyl transferase deficiency results in lung oxidant stress in normoxia
-
Jean, J.C., Liu, Y., Brown, L.A., Marc, R.E., Klings, E. and Joyce-Brady, M. (2002) γ-Glutamyl transferase deficiency results in lung oxidant stress in normoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 283, L766-L776
-
(2002)
Am. J. Physiol. Lung Cell. Mol. Physiol
, vol.283
, pp. L766-L776
-
-
Jean, J.C.1
Liu, Y.2
Brown, L.A.3
Marc, R.E.4
Klings, E.5
Joyce-Brady, M.6
-
72
-
-
84922502827
-
Pulmonary hypertension in valvular disease: a comprehensive review on pathophysiology to therapy from the HAVEC Group
-
Magne, J., Pibarot, P., Sengupta, P.P., Donal, E., Rosenhek, R. and Lancellotti, P. (2015) Pulmonary hypertension in valvular disease: a comprehensive review on pathophysiology to therapy from the HAVEC Group. JACC Cardiovasc. Imaging 8, 83-99
-
(2015)
JACC Cardiovasc. Imaging
, vol.8
, pp. 83-99
-
-
Magne, J.1
Pibarot, P.2
Sengupta, P.P.3
Donal, E.4
Rosenhek, R.5
Lancellotti, P.6
-
73
-
-
84923250517
-
Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
-
Carri, M.T., Valle, C., Bozzo, F. and Cozzolino, M. (2015) Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Front. Cell Neurosci. 9, 41
-
(2015)
Front. Cell Neurosci
, vol.9
, pp. 41
-
-
Carri, M.T.1
Valle, C.2
Bozzo, F.3
Cozzolino, M.4
-
74
-
-
84899895001
-
Oxidative stress in Alzheimer's disease
-
Chen, Z. and Zhong, C. (2014) Oxidative stress in Alzheimer's disease. Neurosci. Bull. 30, 271-281
-
(2014)
Neurosci. Bull
, vol.30
, pp. 271-281
-
-
Chen, Z.1
Zhong, C.2
-
75
-
-
53049093018
-
Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity
-
Gonsette, R.E. (2008) Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J. Neurol. Sci. 274, 48-53
-
(2008)
J. Neurol. Sci
, vol.274
, pp. 48-53
-
-
Gonsette, R.E.1
-
76
-
-
84930000141
-
Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress
-
Nataraj, J., Manivasagam, T., Thenmozhi, A.J. and Essa, M.M. (2015) Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress. Nutr. Neurosci.
-
(2015)
Nutr. Neurosci
-
-
Nataraj, J.1
Manivasagam, T.2
Thenmozhi, A.J.3
Essa, M.M.4
-
77
-
-
84910040404
-
Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis
-
Wang, P., Xie, K., Wang, C. and Bi, J. (2014) Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis. Eur. Neurol. 72, 249-254
-
(2014)
Eur. Neurol
, vol.72
, pp. 249-254
-
-
Wang, P.1
Xie, K.2
Wang, C.3
Bi, J.4
-
78
-
-
84912571285
-
Apoptosis and oxidative stress in neurodegenerative diseases
-
Radi, E., Formichi, P., Battisti, C. and Federico, A. (2014) Apoptosis and oxidative stress in neurodegenerative diseases. J. Alzheimers Dis. 42 Suppl. 3, S125-S152
-
(2014)
J. Alzheimers Dis
, vol.42
, pp. S125-S152
-
-
Radi, E.1
Formichi, P.2
Battisti, C.3
Federico, A.4
-
79
-
-
79957515007
-
Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental Parkinsonism
-
Jazwa, A., Rojo, A.I., Innamorato, N.G., Hesse, M., Fernandez-Ruiz, J. and Cuadrado, A. (2011) Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental Parkinsonism. Antioxid. Redox Signal. 14, 2347-2360
-
(2011)
Antioxid. Redox Signal
, vol.14
, pp. 2347-2360
-
-
Jazwa, A.1
Rojo, A.I.2
Innamorato, N.G.3
Hesse, M.4
Fernandez-Ruiz, J.5
Cuadrado, A.6
-
80
-
-
84874159254
-
Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model
-
Kim, H.V., Kim, H.Y., Ehrlich, H.Y., Choi, S.Y., Kim, D.J. and Kim, Y. (2013) Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model. Amyloid 20, 7-12
-
(2013)
Amyloid
, vol.20
, pp. 7-12
-
-
Kim, H.V.1
Kim, H.Y.2
Ehrlich, H.Y.3
Choi, S.Y.4
Kim, D.J.5
Kim, Y.6
-
81
-
-
38449086141
-
Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway
-
Wruck, C.J., Claussen, M., Fuhrmann, G., Romer, L., Schulz, A., Pufe, T., Waetzig, V., Peipp, M., Herdegen, T. and Gotz, M.E. (2007) Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J. Neural Transm. Suppl. 57-67
-
(2007)
J. Neural Transm
, pp. 57-67
-
-
Wruck, C.J.1
Claussen, M.2
Fuhrmann, G.3
Romer, L.4
Schulz, A.5
Pufe, T.6
Waetzig, V.7
Peipp, M.8
Herdegen, T.9
Gotz, M.E.10
-
82
-
-
44249103744
-
Kavalactones protect neural cells against amyloid β peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
-
Wruck, C.J., Gotz, M.E., Herdegen, T., Varoga, D., Brandenburg, L.O. and Pufe, T. (2008) Kavalactones protect neural cells against amyloid β peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol. Pharmacol. 73, 1785-1795
-
(2008)
Mol. Pharmacol
, vol.73
, pp. 1785-1795
-
-
Wruck, C.J.1
Gotz, M.E.2
Herdegen, T.3
Varoga, D.4
Brandenburg, L.O.5
Pufe, T.6
-
83
-
-
64249161639
-
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia
-
Paupe, V., Dassa, E.P., Goncalves, S., Auchère, F., Lönn, M., Holmgren, A. and Rustin, P. (2009) Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. Plos One 4, e4253
-
(2009)
Plos One
, vol.4
-
-
Paupe, V.1
Dassa, E.P.2
Goncalves, S.3
Auchère, F.4
Lönn, M.5
Holmgren, A.6
Rustin, P.7
-
84
-
-
84925751210
-
Mitochondrial myopathies in adults and children: management and therapy development
-
Pitceathly, R.D.S. and McFarland, R. (2014) Mitochondrial myopathies in adults and children: management and therapy development. Curr. Opin. Neurol. 27, 576-582
-
(2014)
Curr. Opin. Neurol
, vol.27
, pp. 576-582
-
-
Pitceathly, R.D.S.1
McFarland, R.2
-
85
-
-
85000580279
-
Interferons-β versus glatiramer acetate for relapsing-remitting multiple sclerosis
-
La Mantia, L., Di Pietrantonj, C., Rovaris, M., Rigon, G., Frau, S., Berardo, F., Gandini, A., Longobardi, A., Weinstock-Guttman, B. and Vaona, A. (2014) Interferons-β versus glatiramer acetate for relapsing-remitting multiple sclerosis. Cochrane Database Syst. Rev. 7, CD009333
-
(2014)
Cochrane Database Syst. Rev
, vol.7
-
-
La Mantia, L.1
Di Pietrantonj, C.2
Rovaris, M.3
Rigon, G.4
Frau, S.5
Berardo, F.6
Gandini, A.7
Longobardi, A.8
Weinstock-Guttman, B.9
Vaona, A.10
-
86
-
-
1642264093
-
The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy
-
Gilgun-Sherki, Y., Melamed, E. and Offen, D. (2004) The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J. Neurol. 251, 261-268
-
(2004)
J. Neurol
, vol.251
, pp. 261-268
-
-
Gilgun-Sherki, Y.1
Melamed, E.2
Offen, D.3
-
87
-
-
84868535759
-
Progressive multiple sclerosis: pathology and pathogenesis
-
Lassmann, H., van Horssen, J. and Mahad, D. (2012) Progressive multiple sclerosis: pathology and pathogenesis. Nat. Rev. Neurol. 8, 647-656
-
(2012)
Nat. Rev. Neurol
, vol.8
, pp. 647-656
-
-
Lassmann, H.1
van Horssen, J.2
Mahad, D.3
-
88
-
-
84897026062
-
Established and novel disease-modifying treatments in multiple sclerosis
-
Cross, A.H. and Naismith, R.T. (2014) Established and novel disease-modifying treatments in multiple sclerosis. J. Intern. Med. 275, 350-363
-
(2014)
J. Intern. Med
, vol.275
, pp. 350-363
-
-
Cross, A.H.1
Naismith, R.T.2
-
89
-
-
79952136166
-
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
-
Linker, R.A., Lee, D.H., Ryan, S., van Dam, A.M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S. et al. (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134, 678-692
-
(2011)
Brain
, vol.134
, pp. 678-692
-
-
Linker, R.A.1
Lee, D.H.2
Ryan, S.3
van Dam, A.M.4
Conrad, R.5
Bista, P.6
Zeng, W.7
Hronowsky, X.8
Buko, A.9
Chollate, S.10
-
90
-
-
84866355653
-
Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
-
Fox, R.J., Miller, D.H., Phillips, J.T., Hutchinson, M., Havrdova, E., Kita, M., Yang, M., Raghupathi, K., Novas, M., Sweetser, M.T. et al. (2012) Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N. Engl. J. Med. 367, 1087-1097
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 1087-1097
-
-
Fox, R.J.1
Miller, D.H.2
Phillips, J.T.3
Hutchinson, M.4
Havrdova, E.5
Kita, M.6
Yang, M.7
Raghupathi, K.8
Novas, M.9
Sweetser, M.T.10
-
91
-
-
84866423965
-
Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
-
Gold, R., Kappos, L., Arnold, D.L., Bar-Or, A., Giovannoni, G., Selmaj, K., Tornatore, C., Sweetser, M.T., Yang, M., Sheikh, S.I. et al. (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N. Engl. J. Med. 367, 1098-1107
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 1098-1107
-
-
Gold, R.1
Kappos, L.2
Arnold, D.L.3
Bar-Or, A.4
Giovannoni, G.5
Selmaj, K.6
Tornatore, C.7
Sweetser, M.T.8
Yang, M.9
Sheikh, S.I.10
-
92
-
-
84884554385
-
Oral BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis: a review of DEFINE and CONFIRM
-
Havrdova, E., Hutchinson, M., Kurukulasuriya, N.C., Raghupathi, K., Sweetser, M.T., Dawson, K.T. and Gold, R. (2013) Oral BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis: a review of DEFINE and CONFIRM. Expert Opin. Pharmacother. 14, 2145-2156
-
(2013)
Expert Opin. Pharmacother
, vol.14
, pp. 2145-2156
-
-
Havrdova, E.1
Hutchinson, M.2
Kurukulasuriya, N.C.3
Raghupathi, K.4
Sweetser, M.T.5
Dawson, K.T.6
Gold, R.7
-
93
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi, K., Motohashi, H. and Yamamoto, M. (2011) Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16, 123-140
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
94
-
-
84878572136
-
Toward clinical application of the Keap1-Nrf2 pathway
-
Suzuki, T., Motohashi, H. and Yamamoto, M. (2013) Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol. Sci. 34, 340-346
-
(2013)
Trends Pharmacol. Sci
, vol.34
, pp. 340-346
-
-
Suzuki, T.1
Motohashi, H.2
Yamamoto, M.3
-
95
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M. and Biswal, S. (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62, 5196-5203
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
96
-
-
34248591499
-
Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro
-
Tanito, M., Agbaga, M.P. and Anderson, R.E. (2007) Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radic. Biol. Med. 42, 1838-1850
-
(2007)
Free Radic. Biol. Med
, vol.42
, pp. 1838-1850
-
-
Tanito, M.1
Agbaga, M.P.2
Anderson, R.E.3
-
97
-
-
58649100237
-
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
-
Harvey, C.J., Thimmulappa, R.K., Singh, A., Blake, D.J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. and Biswal, S. (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic. Biol. Med. 46, 443-453
-
(2009)
Free Radic. Biol. Med
, vol.46
, pp. 443-453
-
-
Harvey, C.J.1
Thimmulappa, R.K.2
Singh, A.3
Blake, D.J.4
Ling, G.5
Wakabayashi, N.6
Fujii, J.7
Myers, A.8
Biswal, S.9
-
98
-
-
84883326543
-
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4
-
Huang, B.W., Ray, P.D., Iwasaki, K. and Tsuji, Y. (2013) Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J. 27, 3763-3774
-
(2013)
FASEB J
, vol.27
, pp. 3763-3774
-
-
Huang, B.W.1
Ray, P.D.2
Iwasaki, K.3
Tsuji, Y.4
-
99
-
-
0042330074
-
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
-
Nioi, P., McMahon, M., Itohm, K., Yamamoto, M. and Hayes, J.D. (2003) Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem. J. 374, 337-348
-
(2003)
Biochem. J
, vol.374
, pp. 337-348
-
-
Nioi, P.1
McMahon, M.2
Itohm, K.3
Yamamoto, M.4
Hayes, J.D.5
-
100
-
-
0033543566
-
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
-
Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A.M. and Cook, J.L. (1999) Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol. Chem. 274, 26071-26078
-
(1999)
J. Biol. Chem
, vol.274
, pp. 26071-26078
-
-
Alam, J.1
Stewart, D.2
Touchard, C.3
Boinapally, S.4
Choi, A.M.5
Cook, J.L.6
-
101
-
-
0036854702
-
The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element
-
Park, E.Y. and Rho, H.M. (2002) The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element. Mol. Cell. Biochem. 240, 47-55
-
(2002)
Mol. Cell. Biochem
, vol.240
, pp. 47-55
-
-
Park, E.Y.1
Rho, H.M.2
-
102
-
-
77956640097
-
Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration
-
Wakabayashi, N., Shin, S., Slocum, S.L., Agoston, E.S., Wakabayashi, J., Kwak, M.K., Misra, V., Biswal, S., Yamamoto, M. and Kensler, T.W. (2010) Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration. Sci. Signal. 3, ra52
-
(2010)
Sci. Signal
, vol.3
-
-
Wakabayashi, N.1
Shin, S.2
Slocum, S.L.3
Agoston, E.S.4
Wakabayashi, J.5
Kwak, M.K.6
Misra, V.7
Biswal, S.8
Yamamoto, M.9
Kensler, T.W.10
-
103
-
-
84910606993
-
Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury
-
Al-Sawaf, O., Fragoulis, A., Rosen, C., Keimes, N., Liehn, E.A., Holzle, F., Kan, Y.W., Pufe, T., Sonmez, T.T. and Wruck, C.J. (2014) Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury. J. Pathol. 234, 538-547
-
(2014)
J. Pathol
, vol.234
, pp. 538-547
-
-
Al-Sawaf, O.1
Fragoulis, A.2
Rosen, C.3
Keimes, N.4
Liehn, E.A.5
Holzle, F.6
Kan, Y.W.7
Pufe, T.8
Sonmez, T.T.9
Wruck, C.J.10
-
104
-
-
79952997672
-
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
-
Wruck, C.J., Streetz, K., Pavic, G., Gotz, M.E., Tohidnezhad, M., Brandenburg, L.O., Varoga, D., Eickelberg, O., Herdegen, T., Trautwein, C. et al. (2011) Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J. Biol. Chem. 286, 4493-4499
-
(2011)
J. Biol. Chem
, vol.286
, pp. 4493-4499
-
-
Wruck, C.J.1
Streetz, K.2
Pavic, G.3
Gotz, M.E.4
Tohidnezhad, M.5
Brandenburg, L.O.6
Varoga, D.7
Eickelberg, O.8
Herdegen, T.9
Trautwein, C.10
-
105
-
-
84910681905
-
Nrf2 induces fibroblast growth factor 21 in diabetic mice
-
Furusawa, Y., Uruno, A., Yagishita, Y., Higashi, C. and Yamamoto, M. (2014) Nrf2 induces fibroblast growth factor 21 in diabetic mice. Genes Cells 19, 864-878.
-
(2014)
Genes Cells
, vol.19
, pp. 864-878
-
-
Furusawa, Y.1
Uruno, A.2
Yagishita, Y.3
Higashi, C.4
Yamamoto, M.5
-
106
-
-
84936124241
-
Regulated genes in psoriatic skin during treatment with fumaric acid esters
-
Onderdijk, A.J., Balak, D.M., Baerveldt, E.M., Florencia, E.F., Kant, M., Laman, J.D., van IJcken, W.F., Racz, E., de Ridder, D., Thio, H.B. et al. (2014) Regulated genes in psoriatic skin during treatment with fumaric acid esters. Br J Dermatol. 171, 732-741
-
(2014)
Br J Dermatol
, vol.171
, pp. 732-741
-
-
Onderdijk, A.J.1
Balak, D.M.2
Baerveldt, E.M.3
Florencia, E.F.4
Kant, M.5
Laman, J.D.6
van IJcken, W.F.7
Racz, E.8
de Ridder, D.9
Thio, H.B.10
-
107
-
-
84921047168
-
Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview
-
Bomprezzi, R. (2015) Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview. Ther. Adv. Neurol. Disord. 8, 20-30
-
(2015)
Ther. Adv. Neurol. Disord
, vol.8
, pp. 20-30
-
-
Bomprezzi, R.1
-
108
-
-
84906690102
-
Effect of redox modulating NRF2 activators on chronic kidney disease
-
Choi, B.H., Kang, K.S. and Kwak, M.K. (2014) Effect of redox modulating NRF2 activators on chronic kidney disease. Molecules 19, 12727-12759
-
(2014)
Molecules
, vol.19
, pp. 12727-12759
-
-
Choi, B.H.1
Kang, K.S.2
Kwak, M.K.3
-
109
-
-
84856541000
-
Proliferative capacity of corneal endothelial cells
-
Joyce, N.C. (2012) Proliferative capacity of corneal endothelial cells. Exp. Eye Res. 95, 16-23
-
(2012)
Exp. Eye Res
, vol.95
, pp. 16-23
-
-
Joyce, N.C.1
|