Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 6, 2006, Pages

  Ge, Yuqiang ^a   Bagnall, Alan ^b   Stricklett, Peter K ^a   Strait, Kevin ^a   Webb, David J ^b   Kotelevtsev, Yuri ^b   Kohan, Donald E ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Blood pressure; Cell specific gene targeting; Urinary sodium excretion

Indexed keywords

ALDOSTERONE; AQUAPORIN 2; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; RENIN; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HYPERTENSION; KIDNEY COLLECTING TUBULE; KIDNEY FUNCTION; LOXP SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; SALT LOADING; SODIUM EXCRETION; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE;

EID: 33845423984     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00190.2006     Document Type: Article

References (55)

1. Ahn D, Ge Y, Stricklett P, Gill P, Taylor D, Hughes A, Yanagisawa M, Miller L, Nelson R, and Kohan D. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest 114: 504-511, 2004.
2. Ajayi A, Ogungbade G, Hercule H, Oyekan A, and Mutembei L. Alteration in endothelin receptor subtype responsiveness and in the edntoehlin-TXA2 mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats. Diabetes Res Clin Pract 63: 155-169, 2004.
3. Battistini B, Berthiaume N, Kelland N, Webb D, and Kohan D. Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug. Exp Biol Med 231: 653-695, 2006.
4. Brodsky S, Abassi Z, Wessale J, Ramadan R, Winaver J, and Hoffman A. Effects of A192621.1, a specific endothelin-B antagonist, on intrarenal hemodynamic responses to endothelin-1. J Cardiovasc Pharmacol 36, Suppl 1: S311-S313, 2000.
5. B receptor subtypes in the dog kidney. J Cardiovasc Pharmacol 26: S322-S325, 1995.
6. Brooks DP, DePalma PD, Pullen M, and Nambi P. Characterization of canine renal endothelin receptor subtypes and their function. J Pharmacol Exp Ther 268: 1091-1097, 1994.
7. Cernacek P, Legault L, Stewart DJ, and Levy M. Specific endothelin binding sites in renal medullary collecting duct cells: lack of interaction with ANP binding and cGMP signalling. Can J Physiol Pharmacol 70: 1167-1174, 1992.
8. Chen M, Todd-Turla K, Wang WH, Cao X, Smart A, Brosius FC, Killen PD, Keiser JA, Briggs JP, and Schnermann J. Endothelin-1 mRNA in glomerular and epithelial cells of kidney. Am J Physiol Renal Fluid Electrolyte Physiol 265: F542-F550, 1993.
9. Chou SY and Porush JG. Renal actions of endothelin-1 and endothelin-3: interactions with the prostaglandin system and nitric oxide. Am J Kidney Dis 26: 116-123, 1995.
10. Chow LH, Subramanian S, Nuovo GJ, Miller F, and Nord EP. Endothelin receptor mRNA expression in renal medulla identified by in situ PT-PCR. Am J Physiol Renal Fluid Electrolyte Physiol 269: F449-F457, 1995.
11. Clavell AL, Stingo AJ, Margulies KB, Brandt RR, and Burnett JC Jr. Role of endothelin receptor subtypes in the in vivo regulation of renal function. Am J Physiol Renal Fluid Electrolyte Physiol 268: F455-F460, 1995.
12. B receptor. J Pharmacol Exp Ther 267: 1028-1033, 1993.
13. Evans R, Madden A, Oliver J, and Lewis T. Effects of ETA- and ETB-receptor antagonists on regional kidney blood flow, and response to intravenous endothelin-1, in anaesthetized rabbits. J Hypertens 19: 1789-1799, 2001.
14. Gallego MS and Ling BN. Regulation of amiloride-sensitive sodium channels by endothelin-1 in distal nephron cells. Am J Physiol Renal Fluid Electrolyte Physiol 271: F451-F460, 1996.
15. Gariepy CE, Ohuchi T, Williams SC, Richardson JA, and Yanagisawa M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest 105: 925-933, 2000.
16. Gariepy CE, Williams SC, Richardson JA, Hammer RE, and Yanagisawa H. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest 102: 1092-1101, 1998.
17. Ge Y, Ahn D, Stricklett P, Hughes A, Yangisawa M, Verbalis J, and Kohan D. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol 288: F912-F920, 2005.
18. Ge Y, Stricklett P, Hughes A, Yang T, Yanagisawa M, and Kohan D. Effect of collecting duct-specific knockout of the endothelin A receptor on salt and water metabolism. Am J Physiol Renal Physiol 289: F692-F698, 2005.
19. Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, and Breyer MD. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 11: 861-866, 2005.
20. Hoffman A, Grossman E, Goldstein DS, Gill JR Jr, and Keiser HR. Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity. Kidney Int 45: 556-560, 1993.
21. Hosoda K, Hammer RE, Richardson JA, Baynash AG, Cheung JC, Giaid A, and Yanagisawa M. Targeted and natural (Piebald-Lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 80: 1267-1276, 1994.
22. Karet FE and Davenport AP. Localization of endothelin peptides in human kidney. Kidney Int 49: 382-387, 1996.
23. Karet FE, Kuc RE, and Davenport AP. Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney. Kidney Int 44: 36-42, 1993.
24. Kitamura K, Tanaka T, Kato J, Eto T, and Tanaka K. Regional distribution of immunoreactive endothelin in porcine tissue: abundance in inner medulla of kidney. Biochem Biophys Res Commun 161: 348-352, 1989.
25. Kohan DE and Fiedorek FTJ. Endothelin synthesis by rat inner medullary collecting duct cells. J Am Soc Nephrol 2: 150-155, 1991.
26. Kohan DE, Hughes AK, and Perkins SP. Characterization of endothelin receptors in the inner medullary collecting duct of the rat. J Biol Chem 267: 12336-12340, 1992.
27. Kohan DE and Padilla E. Endothelin-1 is an autocrine factor in rat inner medullary collecting ducts. Am J Physiol Renal Fluid Electrolyte Physiol 263: F607-F612, 1992.
28. Kohan DE and Padilla E. Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct. J Clin Invest 91: 1235-1240, 1993.
29. 2 accumulation in rat IMCD. Am J Physiol Renal Fluid Electrolyte Physiol 265: F670-F676, 1993.
30. i in M-1 mouse cortical collecting duct cells by a dual mechanism. Am J Physiol Cell Physiol 265: C349-C357, 1993.
31. Kurokawa K, Yoshitomi K, Ikeda M, Uchida S, Naruse M, and Imai M. Regulation of cortical collecting duct function: effect of endothelin. Am Heart J 125: 582-588, 1993.
32. - channels in cultured rabbit CCT principal cells. J Am Soc Nephrol 5: 292, 1994.
33. Nadler SP, Zimplemann JA, and Hebert RL. Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct. J Clin Invest 90: 1458-1466, 1992.
34. Naruse M, Uchida S, Ogata E, and Kurokawa K. Endothelin-1 increases cell calcium in mouse collecting tubule cells. Am J Physiol Renal Fluid Electrolyte Physiol 261: F720-F725, 1991.
35. Ohkita M, Wang Y, Nguyen ND, Tsai YH, Williams SC, Wiseman RC, Killen PD, Li S, Yanagisawa M, and Gariepy CE. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats. Hypertension 45: 940-946, 2005.
36. Oishi R, Nonoguchi H, Tomita K, and Marumo F. Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 261: F951-F956, 1991.
37. Omatsu S and Tomoyoshi T. Immunohistochemical study on endothelin in rat kidney. Hinyokika Kiyo 43: 109-114, 1997.
38. Ortiz PA and Garvin JL. Role of nitric oxide in the regulation of nephron transport. Am J Physiol Renal Physiol 282: F777-F784, 2002.
39. Pallone TL, Zhang Z, and Rhinehart K. Physiology of the renal medullary microcirculation. Am J Physiol Renal Physiol 284: F253-F266, 2003.
40. Plato C, Pollock D, and Garvin J. Endothelin inhibits thick ascending limb chloride flux via ETB receptor-mediated NO release. Am J Physiol Renal Physiol 279: F326-F333, 2000.
41. Pupilli C, Brunori M, Misciglia N, Selli C, Ianni L, Yanagisawa M, Mannelli M, and Serio M. Presence and distribution of endothelin-1 gene expression in human kidney. Am J Physiol Renal Fluid Electrolyte Physiol 267: F679-F687, 1994.
42. Stricklett PK, Hughes AK, and Kohan DE. Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways. Am J Physiol Renal Physiol 290: F1315-F1319, 2006.
43. Takemoto F, Uchida S, Ogata E, and Kurokawa K. Endothelin-1 and endothelin-3 binding to rat nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 264: F827-F832, 1993.
44. Taylor TA, Gariepy CE, Pollock DM, and Pollock JS. Unique endothelin receptor binding in kidneys of ETB receptor deficient rats. Am J Physiol Regul Integr Comp Physiol 284: R674-R681, 2003.
45. Terada Y, Tomita K, Nonoguchi H, and Marumo F. Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay. J Clin Invest 90: 107-112, 1992.
46. Tomita K, Nonguchi H, Terada Y, and Marumo F. Effects of ET-1 on water and chloride transport in cortical collecting ducts of the rat. Am J Physiol Renal Fluid Electrolyte Physiol 264: F690-F696, 1993.
47. Tomita K, Nonoguchi H, and Marumo F. Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat. J Clin Invest 85: 2014-2018, 1990.
48. Uchida S, Takemoto F, Ogata E, and Kurokawa K. Detection of endothelin-1 mRNA by RT-PCR in isolated rat renal tubules. Biochem Biophys Res Commun 188: 108-113, 1992.
49. Ujiie K, Terada Y, Nonoguchi H, Shinohara M, Tomita K, and Marumo F. Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments. J Clin Invest 90: 1043-1048, 1992.
50. Wong BPH and Wong NLM. Mechanisms of vasopressin-induced endothelin receptor desensitization. J Am Soc Nephrol 7: 1575, 1996.
51. Ye Q, Chen S, and Gardner DG. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension 41: 675-681, 2003.
52. B receptor agonist, IRL1620. Eur J Pharmacol 264: 399-405, 1994.
53. +-ATPase in intact tubular epithelial cells. Am J Physiol Cell Physiol 257: C1101-C1107, 1989.
54. Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, and Yang T. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci USA 102: 9406-9411, 2005.
55. Zhou J. Renomedullary interstitial cells: a target for endocrine and paracrine actions of vasoactive peptides in the renal medulla. Clin Exp Pharmacol Physiol 27: 465-473, 2000.