Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia

PLoS ONE

Volumn 4, Issue 1, 2009, Pages

  Paupe, Vincent ^a,b   Dassa, Emmanuel P ^a,b   Goncalves, Sergio ^a,b   Auchère, Françoise ^c   Lönn, Maria ^d   Holmgren, Arne ^d   Rustin, Pierre ^a,b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT JACQUES MONOD   (France)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; IRON SULFUR PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; HYDROGEN PEROXIDE; NFE2L2 PROTEIN, HUMAN;

ARTICLE; BRAIN MITOCHONDRION; CELL LINE; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; FIBROBLAST CULTURE; FRIEDREICH ATAXIA; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERSENSITIVITY; IRON METABOLISM DISORDER; NERVE CELL NECROSIS; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; ACTIVE TRANSPORT; BIOLOGICAL MODEL; CHEMISTRY; FIBROBLAST; GENE EXPRESSION REGULATION; METABOLISM; NERVE CELL; OXIDATION REDUCTION REACTION; PATHOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIOXIDANTS; DISEASE PROGRESSION; FIBROBLASTS; FRIEDREICH ATAXIA; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; IRON-SULFUR PROTEINS; MODELS, BIOLOGICAL; NEURONS; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 64249161639     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004253     Document Type: Article

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