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Volumn 14, Issue 12, 2011, Pages 2347-2360

Pharmacological targeting of the transcription factor NRf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; HEME OXYGENASE 1; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

EID: 79957515007     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3731     Document Type: Article
Times cited : (275)

References (35)
  • 1
    • 33751503096 scopus 로고    scopus 로고
    • In vivo modulation of the Parkinsonian phenotype by Nrf2
    • DOI 10.1016/j.neuro.2006.07.019, PII S0161813X06001884
    • Burton NC, Kensler TW, and Guilarte TR. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology 27: 1094-100, 2006. (Pubitemid 44838961)
    • (2006) NeuroToxicology , vol.27 , Issue.6 , pp. 1094-1100
    • Burton, N.C.1    Kensler, T.W.2    Guilarte, T.R.3
  • 2
    • 65549095883 scopus 로고    scopus 로고
    • The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
    • Cuadrado A, Moreno-Murciano P, and Pedraza-Chaverri J. The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opin Ther Targets 13: 319-329, 2009.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 319-329
    • Cuadrado, A.1    Moreno-Murciano, P.2    Pedraza-Chaverri, J.3
  • 3
    • 0034046911 scopus 로고    scopus 로고
    • Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death
    • DOI 10.1046/j.1471-4159.2000.0750304.x
    • Chen K, Gunter K, and Maines MD. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem 75: 304-13, 2000. (Pubitemid 30418197)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.1 , pp. 304-313
    • Chen, K.1    Gunter, K.2    Maines, M.D.3
  • 5
    • 48349084189 scopus 로고    scopus 로고
    • Dietary agents as histone deacetylase inhibitors: Sulforaphane and structurally related isothiocyanates
    • Dashwood RH and Ho E. Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev 66 Suppl 1: S36-8, 2008.
    • (2008) Nutr Rev , vol.66 , Issue.SUPPL. 1
    • Dashwood, R.H.1    Ho, E.2
  • 6
    • 52449089630 scopus 로고    scopus 로고
    • Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    • Dinkova-Kostova AT and Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52 Suppl 1: S128-38, 2008.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Dinkova-Kostova, A.T.1    Talalay, P.2
  • 7
    • 77950521629 scopus 로고    scopus 로고
    • Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated antiinflammatory activity in vascular endothelium
    • Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP, and Mason JC. Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated antiinflammatory activity in vascular endothelium. Free Radic Biol Med 48: 1013-23, 2010.
    • (2010) Free Radic Biol Med , vol.48 , pp. 1013-1023
    • Hamdulay, S.S.1    Wang, B.2    Birdsey, G.M.3    Ali, F.4    Dumont, O.5    Evans, P.C.6    Haskard, D.O.7    Wheeler-Jones, C.P.8    Mason, J.C.9
  • 8
    • 67349247003 scopus 로고    scopus 로고
    • Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    • Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, and Hayes JD. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol 237: 267-80, 2009.
    • (2009) Toxicol Appl Pharmacol , vol.237 , pp. 267-280
    • Higgins, L.G.1    Kelleher, M.O.2    Eggleston, I.M.3    Itoh, K.4    Yamamoto, M.5    Hayes, J.D.6
  • 9
    • 77955608828 scopus 로고    scopus 로고
    • Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1
    • Innamorato NG, Jazwa A, Rojo AI, García C, Fernández-Ruiz J, Grochot-Przeczek A, Stachurska A, Jozkowicz A, Dulak J, and Cuadrado A. Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One 5: e11838, 2010.
    • (2010) PLoS One , vol.5
    • Innamorato Ng, J.1
  • 10
    • 67049100713 scopus 로고    scopus 로고
    • Role of microglial redox balance in modulation of neuroinflammation
    • Innamorato NG, Lastres-Becker I, and Cuadrado A. Role of microglial redox balance in modulation of neuroinflammation. Curr Opin Neurol 22: 308-14, 2009.
    • (2009) Curr Opin Neurol , vol.22 , pp. 308-314
    • Innamorato, N.G.1    Lastres-Becker, I.2    Cuadrado, A.3
  • 13
    • 0032827002 scopus 로고    scopus 로고
    • Regulatory mechanisms of cellular response to oxidative stress
    • DOI 10.1080/10715769900300881
    • Itoh K, Ishii T, Wakabayashi N, and Yamamoto M. Regulatory mechanisms of cellular response to oxidative stress. Free Radic Res 31: 319-24, 1999. (Pubitemid 29452857)
    • (1999) Free Radical Research , vol.31 , Issue.4 , pp. 319-324
    • Itoh, K.1    Ishii, T.2    Wakabayashi, N.3    Yamamoto, M.4
  • 14
    • 67649329442 scopus 로고    scopus 로고
    • Oxidative stress and Parkinson's disease
    • Jenner P. Oxidative stress and Parkinson's disease. Handb Clin Neurol 83: 507-20, 2007.
    • (2007) Handb Clin Neurol , vol.83 , pp. 507-520
    • Jenner, P.1
  • 15
    • 0036319473 scopus 로고    scopus 로고
    • Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice
    • DOI 10.1046/j.1471-4159.2002.00913.x
    • Johnson DA, Andrews GK, Xu W, and Johnson JA. Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice. J Neurochem 81: 1233-41, 2002. (Pubitemid 34809257)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.6 , pp. 1233-1241
    • Johnson, D.A.1    Andrews, G.K.2    Xu, W.3    Johnson, J.A.4
  • 16
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, and Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116, 2007.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 17
    • 0038146898 scopus 로고    scopus 로고
    • Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    • DOI 10.1074/jbc.M211558200
    • Lee JM, Calkins MJ, Chan K, Kan YW, and Johnson JA. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278: 12029-38, 2003. (Pubitemid 36800179)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12029-12038
    • Lee, J.-M.1    Calkins, M.J.2    Chan, K.3    Kan, Y.W.4    Johnson, J.A.5
  • 19
    • 77649271223 scopus 로고    scopus 로고
    • The rise of antioxidant signaling-the evolution and hormetic actions of Nrf2
    • Maher J and Yamamoto M. The rise of antioxidant signaling-the evolution and hormetic actions of Nrf2. Toxicol Appl Pharmacol 244: 4-15, 2010.
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 4-15
    • Maher, J.1    Yamamoto, M.2
  • 21
    • 77953160513 scopus 로고    scopus 로고
    • Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli (Brassica oleracea L.) sprouts
    • Moon JK, Kim JR, Ahn YJ, and Shibamoto T. Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli (Brassica oleracea L.) sprouts. J Agric Food Chem 58: 6672-7, 2010.
    • (2010) J Agric Food Chem , vol.58 , pp. 6672-6677
    • Moon, J.K.1    Kim, J.R.2    Ahn, Y.J.3    Shibamoto, T.4
  • 23
    • 35349007965 scopus 로고    scopus 로고
    • Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats
    • DOI 10.1016/j.expneurol.2007.07.022, PII S0014488607003007
    • Rojo AI, Cavada C, de Sagarra MR, and Cuadrado A. Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Exp Neurol 208: 120-6, 2007. (Pubitemid 47600154)
    • (2007) Experimental Neurology , vol.208 , Issue.1 , pp. 120-126
    • Rojo, A.I.1    Cavada, C.2    De Sagarra, M.R.3    Cuadrado, A.4
  • 26
    • 77954675751 scopus 로고    scopus 로고
    • Inhibition of PI3K/ AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
    • Roy SK, Srivastava RK, and Shankar S. Inhibition of PI3K/ AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 5: 10, 2010.
    • (2010) J Mol Signal , vol.5 , pp. 10
    • Roy, S.K.1    Srivastava, R.K.2    Shankar, S.3
  • 28
    • 67349112729 scopus 로고    scopus 로고
    • Iron, the substantia nigra and related neurological disorders
    • Snyder AM and Connor JR. Iron, the substantia nigra and related neurological disorders. Biochim Biophys Acta 1790: 606-14, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 606-614
    • Snyder, A.M.1    Connor, J.R.2
  • 29
    • 31944431573 scopus 로고    scopus 로고
    • Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia
    • DOI 10.1002/jcp.20509
    • Song W, Su H, Song S, Paudel HK, and Schipper HM. Overexpression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia. J Cell Physiol 206: 655-63, 2006. (Pubitemid 43191040)
    • (2006) Journal of Cellular Physiology , vol.206 , Issue.3 , pp. 655-663
    • Song, W.1    Su, H.2    Song, S.3    Paudel, H.K.4    Schipper, H.M.5
  • 30
    • 77953012548 scopus 로고    scopus 로고
    • Stress-activated cap'n'collar transcription factors in aging and human disease
    • Sykiotis GP and Bohmann D. Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal 3: re3, 2010.
    • (2010) Sci Signal , vol.3
    • Sykiotis, G.P.1    Bohmann, D.2
  • 31
    • 70349333698 scopus 로고    scopus 로고
    • The Nrf2-ARE cytoprotective pathway in astrocytes
    • Vargas MR and Johnson JA. The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev Mol Med 11: e17, 2009.
    • (2009) Expert Rev Mol Med , vol.11
    • Vargas, M.R.1    Johnson, J.A.2
  • 33
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • DOI 10.1016/0197-4580(93)90112-O
    • West MJ. New stereological methods for counting neurons. Neurobiol Aging 14: 275-85, 1993. (Pubitemid 23214693)
    • (1993) Neurobiology of Aging , vol.14 , Issue.4 , pp. 275-285
    • West, M.J.1
  • 34
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang Y, Talalay P, Cho CG, and Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-403, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4


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