Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesis

Journal of Pathology

Volumn 237, Issue 4, 2015, Pages 508-519

  McCleland, Mark L ^a   Soukup, Tim M ^a   Liu, Scot D ^a   Esensten, Jonathan H ^a,b   De Sousa E Melo, Felipe ^a   Yaylaoglu, Murat ^a   Warming, Soren ^a   Roose Girma, Merone ^a   Firestein, Ron ^a,c  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

ApcMin; Cdk8; colon cancer; cyclin C

Indexed keywords

CYCLIN DEPENDENT KINASE 8; HISTONE H3; POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR EZH2; CDK8 PROTEIN, MOUSE; EZH2 PROTEIN, MOUSE; POLYCOMB REPRESSIVE COMPLEX 2;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL MIGRATION; COLON CANCER; COLORECTAL CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FRAMESHIFT MUTATION; GENE EXPRESSION; GENOTYPE; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE TUMOR; MELANOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR MODEL; TUMOR VOLUME; UPREGULATION; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; COLON TUMOR; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE 8; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; GENES, TUMOR SUPPRESSOR; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; POLYCOMB REPRESSIVE COMPLEX 2; POLYMERASE CHAIN REACTION;

EID: 84951180291     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4596     Document Type: Article

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