Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 696, Issue 2, 2010, Pages 130-138

  Chattopadhyay, Indranil ^a   Singh, Avninder ^a   Phukan, Rupkumar ^c   Purkayastha, Joydeep ^b   Kataki, Amal ^b   Mahanta, Jagadish ^c   Saxena, Sunita ^a   Kapur, Sujala ^a  

^a SAFDARJUNG HOSPITAL CAMPUS   (India)

^b DR B BOROOAH CANCER INSTITUTE   (India)

^c Regional Medical Research Center   (India)

Author keywords

Esophageal cancer; Genomic alteration; SNP array

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CYCLIN DEPENDENT KINASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 12; MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE 1; PHOSPHOLIPASE A2; PROTEIN S 100; RAB27A PROTEIN; RGS PROTEIN; RGS1 PROTEIN; S100 A3 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT7A PROTEIN;

ALCOHOL CONSUMPTION; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; BETEL NUT; CANCER DIAGNOSIS; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHROMOSOME ARM; CHROMOSOME DELETION; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; EXPOSURE; FOCAL ADHESION; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENOME ANALYSIS; GERM LINE; HUMAN; HUMAN TISSUE; INDIA; METASTASIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TIGHT JUNCTION; TISSUE MICROARRAY; TOBACCO; TUMOR CELL; TUMOR SUPPRESSOR GENE; VALIDATION STUDY;

ARECA; CARCINOMA, SQUAMOUS CELL; CHROMOSOME ABERRATIONS; DNA COPY NUMBER VARIATIONS; ESOPHAGEAL NEOPLASMS; GENE AMPLIFICATION; GENE DELETION; HUMANS; INDIA; MUTAGENS; RISK; SIGNAL TRANSDUCTION; TOBACCO;

NICOTIANA TABACUM; PIPER BETEL;

EID: 77249109757     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.01.001     Document Type: Article

References (74)

1. Chen J., Guo L., Peiffer D.A., Zhou L., Chan O.T., Bibikova M., Wickham-Garcia E., Lu S.H., Zhan Q., Wang-Rodriguez J., Jiang W., and Fan J.B. Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. Int. J. Cancer 122 (2008) 2249-2254
2. Wiech T., Nikolopoulos E., Weis R., Langer R., Bartholomé K., Timmer J., Walch A.K., Höfler H., and Werner M. Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. Lab. Invest. 89 (2009) 385-397
3. Hu N., Wang C., Hu Y., Yang H.H., Kong L.H., Lu N., Su H., Wang Q.H., Goldstein A.M., Buetow K.H., Emmert-Buck M.R., Taylor P.R., and Lee M.P. Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10K array. BMC Genomics 7 (2006) 299
4. Murtaza I., Mushtaq D., Margoob M.A., Dutt A., Wani N.A., Ahmad I., and Bhat M.L. A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World J. Gastroenterol. 12 (2006) 4033-4037
5. Stoner G.D., and Gupta A. Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis 22 (2001) 1737-1746
6. Phukan R.K., Ali M.S., Chetia C.K., and Mahanta J. Betel nut and tobacco chewing; potential risk factors of cancer of oesophagus in Assam, India. Br. J. Cancer 85 (2001) 661-667
7. Lee C.H., Lee J.M., Wu D.C., Hsu H.K., Kao E.L., Huang H.L., Wang T.N., Huang M.C., and Wu M.T. Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan. Int. J. Cancer 113 (2005) 475-482
8. Carneiro A., Isinger A., Karlsson A., Johansson J., Jönsson G., Bendahl P.O., Falkenback D., Halvarsson B., and Nilbert M. Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer. BMC Cancer 8 (2008) 98
9. Yen C.C., Chen Y.J., Chen J.T., Hsia J.Y., Chen P.M., Liu J.H., Fan F.S., Chiou T.J., Wang W.S., and Lin C.H. Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer 92 (2001) 2769-2777
10. Qin Y.R., Fu L., Sham P.C., Kwong D.L., Zhu C.L., Chu K.K., Li Y., and Guan X.Y. Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma. Int. J. Cancer 123 (2008) 826-830
11. Tørring N., Borre M., Sørensen K.D., Andersen C.L., Wiuf C., and Ørntoft T.F. Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br. J. Cancer 96 (2007) 499-506
12. Albertson D.G. Gene amplification in cancer. Trends Genet. 22 (2006) 447-455
13. Gorringe K.L., Jacobs S., Thompson E.R., Sridhar A., Qiu W., Choong D.Y., and Campbell I.G. High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications. Clin. Cancer Res. 13 (2007) 4731-4739
14. Mannello F., Qin W., Zhu W., Fabbri L., Tonti G.A., and Sauter E.R. Nipple aspirate fluids from women with breast cancer contain increased levels of group IIa secretory phospholipase A2. Breast Cancer Res. Treat. 111 (2008) 209-218
15. Tribler L., Jensen L.T., Jørgensen K., Brünner N., Gelb M.H., Nielsen H.J., and Jensen S.S. Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue. Anticancer Res. 27 (2007) 3179-3185
16. Fischer H., Stenling R., Rubio C., and Lindblom A. Colorectal carcinogenesis is associated with stromal expression of COL11A1 and COL5A2. Carcinogenesis 22 (2001) 875-878
17. Balakrishnan A., Bleeker F.E., Lamba S., Rodolfo M., Daniotti M., Scarpa A., van Tilborg A.A., Leenstra S., Zanon C., and Bardelli A. Novel somatic and germ line mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res. 67 (2007) 3545-3550
18. Voloshyna I., Besana A., Castillo M., Matos T., Weinstein I.B., Mansukhani M., Robinson R.B., Cordon-Cardo C., and Feinmark S.J. TREK-1 is a novel molecular target in prostate cancer. Cancer Res. 68 (2008) 1197-1203
19. Liu J., Li X., Dong G.L., Zhang H.W., Chen D.L., Du J.J., Zheng J.Y., Li J.P., and Wang W.Z. In silico analysis and verification of S100 gene expression in gastric cancer. BMC Cancer 8 (2008) 261
20. Di Modugno F., Mottolese M., Di Benedetto A., Conidi A., Novelli F., Perracchio L., Venturo I., Botti C., Jager E., Santoni A., Natali P.G., and Nisticò P. The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors. Clin. Cancer Res. 12 (2006) 1470-1478
21. Wong Y.F., Cheung T.H., Tsao G.S., Lo K.W., Yim S.F., Wang V.W., Heung M.M., Chan S.C., Chan L.K., Ho T.W., Wong K.W., Li C., Guo Y., Chung T.K., and Smith D.I. Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. Int. J. Cancer 118 (2006) 2461-2469
22. Ding X.W., Yan J.J., An P., Lü P., and Luo H.S. Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines. World J. Gastroenterol. 13 (2007) 1257-1261
23. Allin K.H., Bojesen S.E., and Nordestgaard B.G. Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J. Clin. Oncol. March 16 (2009)
24. Li C.G., Gruidl M., Eschrich S., McCarthy S., Wang H.G., Alexandrow M.G., and Yeatman T.J. Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. Int. J. Cancer 123 (2008) 273-282
25. Katoh M., and Katoh M. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int. J. Oncol. 31 (2007) 461-466
26. Chattopadhyay I., Kapur S., Purkayastha J., Phukan R., Kataki A., Mahanta J., and Saxena S. Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis. World J. Gastroenterol. 13 (2007) 1438-1444
27. Stewart G.D., Gray K., Pennington C.J., Edwards D.R., Riddick A.C., Ross J.A., and Habib F.K. Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score. Oncol. Rep. 20 (2008) 1561-1567
28. Zheng M., Simon R., Mirlacher M., Maurer R., Gasser T., Forster T., Diener P.A., Mihatsch M.J., Sauter G., and Schraml P. TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Am. J. Pathol. 165 (2004) 63-69
29. Sugito N., Ishiguro H., Kuwabara Y., Kimura M., Mitsui A., Kurehara H., Ando T., Mori R., Takashima N., Ogawa R., and Fujii Y. RNASEN regulates cell proliferation and affects survival in esophageal cancer patients. Clin. Cancer Res. 12 (2006) 7322-7328
30. Nomura S., Yoshitomi H., Takano S., Shida T., Kobayashi S., Ohtsuka M., Kimura F., Shimizu H., Yoshidome H., Kato A., and Miyazaki M. FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer. Br. J. Cancer 99 (2008) 305-313
31. Yu C., Zhang X., Sun G., Guo X., Li H., You Y., Jacobs J.L., Gardner K., Yuan D., Xu Z., Du Q., Dai C., Qian Z., Jiang K., Zhu Y., Li Q.Q., and Miao Y. RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells. J. Cell. Mol. Med. 12 (2008) 2334-2349
32. Hurst C.D., Tomlinson D.C., Williams S.V., Platt F.M., and Knowles M.A. Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. Oncogene 27 (2008) 2716-2727
33. Wang Y., Ma Y., Lü B., Xu E., Huang Q., and Lai M. Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study. Exp. Biol. Med. (Maywood) 232 (2007) 1152-1159
34. Bobryshev Y.V., Tran D., Killingsworth M.C., Buckland M., and Lord R.V. Dendritic cells in Barrett's esophagus and esophageal adenocarcinoma. J. Gastrointest. Surg. 13 (2009) 44-53
35. Bagnato A., and Catt K.J. Endothelins as autocrine regulators of tumor cell growth. Trends Endocrinol. Metab. 9 (1998) 378-383
36. Medina P.P., Castillo S.D., Blanco S., Sanz-Garcia M., Largo C., Alvarez S., Yokota J., Gonzalez-Neira A., Benitez J., Clevers H.C., Cigudosa J.C., Lazo P.A., and Sanchez-Cespedes M. The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum. Mol. Genet. 18 (2009) 1343-1352
37. Jin Y., Tian X., Shang Y., and Huang P. Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncol. Rep. 19 (2008) 669-674
38. Coe B.P., Lee E.H., Chi B., Girard L., Minna J.D., Gazdar A.F., Lam S., MacAulay C., and Lam W.L. Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines. Genes Chromosomes Cancer 45 (2006) 11-19
39. Valdés-Mora F., Gómez del Pulgar T., Bandrés E., Cejas P., Ramírez de Molina A., Pérez-Palacios R., Gallego-Ortega D., García-Cabezas M.A., Casado E., Larrauri J., Nistal M., González-Barón M., García-Foncillas J., and Lacal J.C. TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer. Ann. Surg. Oncol. 16 (2009) 78-87
40. Li J., Kleeff J., Abiatari I., Kayed H., Giese N.A., Felix K., Giese T., Büchler M.W., and Friess H. Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer. Mol. Cancer 4 (2005) 14
41. Mhawech-Fauceglia P., Alvarez V., Fischer G., Beck A., and Herrmann F.R. Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinoma. Am. J. Clin. Pathol. 129 (2008) 918-923
42. Degen M., Brellier F., Schenk S., Driscoll R., Zaman K., Stupp R., Tornillo L., Terracciano L., Chiquet-Ehrismann R., Rüegg C., Seelentag W., and Tenascin W. New marker of cancer stroma, is elevated in sera of colon and breast cancer patients. Int. J. Cancer 122 (2008) 2454-2461
43. Qiu L., Zhou C., Sun Y., Di W., Scheffler E., Healey S., Kouttab N., Chu W., and Wan Y. Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation. Int. J. Oncol. 29 (2006) 1003-1011
44. Kuo Y.C., Su C.H., Liu C.Y., Chen T.H., Chen C.P., and Wang H.S. Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. Int. J. Cancer 124 (2009) 2568-2576
45. Katoh M., and Katoh M. Comparative genomics on mammalian Fgf3-Fgf4 locus. Int. J. Oncol. 27 (2005) 281-285
46. Li Q., Mullins S.R., Sloane B.F., and Mattingly R.R. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 10 (2008) 314-329
47. Frame M.C., and Inman G.J. NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation. Dev. Cell 15 (2008) 494-496
48. Kosaka Y., Inoue H., Ohmachi T., Yokoe T., Matsumoto T., Mimori K., Tanaka F., Watanabe M., and Mori M. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann. Surg. Oncol. 14 (2007) 2543-2549
49. Wang J.S., Wang F.B., Zhang Q.G., Shen Z.Z., and Shao Z.M. Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II. Mol. Cancer Res. 6 (2008) 372-382
50. Sheng S., Barnett D.H., and Katzenellenbogen B.S. Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells. Mol. Cell. Endocrinol. 296 (2008) 1-9
51. Wu M., Soler D.R., Abba M.C., Nunez M.I., Baer R., Hatzis C., Llombart-Cussac A., Llombart-Bosch A., and Aldaz C.M. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol. Cancer Res. 5 (2007) 1285-1295
52. Liang J., Wang J.B., Pan Y.L., Wang J., Liu L.L., Guo X.Y., Sun L., Lin T., Han S., Xie H.H., Yin F., Guo X.G., and Fan D. High frequency occurrence of 1-OPRD variant of PRNP gene in gastric cancer cell lines and Chinese population with gastric cancer. Cell Biol. Int. 30 (2006) 920-923
53. Fujiwara I., Yashiro M., Kubo N., Maeda K., and Hirakawa K. Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. Dis. Colon Rectum 51 (2008) 1387-1394
54. Yi C.H., Smith D.J., West W.W., and Hollingsworth M.A. Loss of fibulin-2 expression is associated with breast cancer progression. Am. J. Pathol. 170 (2007) 1535-1545
55. Ohira T., Gemmill R.M., Ferguson K., Kusy S., Roche J., Brambilla E., Zeng C., Baron A., Bemis L., Erickson P., Wilder E., Rustgi A., Kitajewski J., Gabrielson E., Bremnes R., Franklin W., and Drabkin H.A. WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 10429-10434
56. Cecener G., Tunca B., Egeli U., Karadag M., Vatan O., Uzaslan E., and Tolunay S. Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer. Tumori 94 (2008) 845-848
57. Tokumaru Y., Yamashita K., Kim M.S., Park H.L., Osada M., Mori M., and Sidransky D. The role of PGP9.5 as a tumor suppressor gene in human cancer. Int. J. Cancer 123 (2008) 753-759
58. Ullmannova-Benson V., Guan M., Zhou X., Tripathi V., Yang X.Y., Zimonjic D.B., and Popescu N.C. DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway. Leukemia 23 (2009) 383-390
59. Nonaka D., Fabbri A., Roz L., Mariani L., Vecchione A., Moore G.W., Tavecchio L., Croce C.M., and Sozzi G. Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Cancer Res. 65 (2005) 1207-1212
60. Frank B., Bermejo J.L., Hemminki K., Sutter C., Wappenschmidt B., Meindl A., Kiechle-Bahat M., Bugert P., Schmutzler R.K., Bartram C.R., and Burwinkel B. Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis 28 (2007) 1442-1445
61. Hagemann C., Anacker J., Gerngras S., Kühnel S., Said H.M., Patel R., Kämmerer U., Vordermark D., Roosen K., and Vince G.H. Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas. Oncol. Rep. 20 (2008) 301-308
62. Chaplet M., Rai R., Jackson-Bernitsas D., Li K., and Lin S.Y. BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle 5 (2006) 2579-2583
63. Pils D., Horak P., Gleiss A., Sax C., Fabjani G., Moebus V.J., Zielinski C., Reinthaller A., Zeillinger R., and Krainer M. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Cancer 104 (2005) 2417-2429
64. Sowd G., Lei M., and Opresko P.L. Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase. Nucleic Acids Res. 36 (2008) 4242-4256
65. Qin Y.R., Wang L.D., Fan Z.M., Kwong D., and Guan X.Y. Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China. World J. Gastroenterol. 14 (2008) 1828-1835
66. Wu K., Katiyar S., Witkiewicz A., Li A., McCue P., Song L.N., Tian L., Jin M., and Pestell R.G. The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res. 69 (2009) 3347-3355
67. Zhu Z., Friess H., Kleeff J., Wang L., Wirtz M., Zimmermann A., Kore M., and Buchler M.W. Glypican-3 expression is markedly decreased in human gastric cancer but not in esophageal cancer. Am. J. Surg. 184 (2002) 78-83
68. Huang Y., Fan J., Yang J., and Zhu G.Z. Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Mol. Cell. Biochem. 308 (2008) 133-139
69. Park H.L., Kim M.S., Yamashita K., Westra W., Carvalho A.L., Lee J., Jiang W.W., Baek J.H., Liu J., Osada M., Moon C.S., Califano J.A., Mori M., and Sidransky D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int. J. Cancer 122 (2008) 2498-2502
70. Furne C., Rama N., Corset V., Chédotal A., and Mehlen P. Netrin-1 is a survival factor during commissural neuron navigation. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 14465-14470
71. Hu X.Y., Xu Y.M., Fu Q., Yu J.J., and Huang J. Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia. Eur. J. Surg. Oncol. 35 (2009) 527-531
72. Kim S.K., Jang H.R., Kim J.H., Kim M., Noh S.M., Song K.S., Kang G.H., Kim H.J., Kim S.Y., Yoo H.S., and Kim Y.S. CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers. Carcinogenesis 29 (2008) 1623-1631
73. Suhr M.L., Dysvik B., Bruland O., Warnakulasuriya S., Amaratunga A.N., Jonaseen I., Vasstrand E.N., and Ibrahim S.O. Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid users. Oncol. Rep. 18 (2007) 1061-1075
74. Cheong S.C., Chandramouli G.V., Saleh A., Zain R.B., Lau S.H., Sivakumaren S., Pathmanathan R., Prime S.S., Teo S.H., Patel V., and Gutkind J.S. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol. 45 (2009) 712-719