Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes

Journal of Biochemistry

Volumn 152, Issue 3, 2012, Pages 241-249

  Fukasawa, Rikiya ^a   Tsutsui, Taiki ^a   Hirose, Yutaka ^a   Tanaka, Aki ^a   Ohkuma, Yoshiaki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

CDK interacting proteins; chromatin regulation; Mediator; transcriptional cofactors; transcriptional regulation

Indexed keywords

BRG1 PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 19; CYCLIN DEPENDENT KINASE 8; MEDIATOR COMPLEX; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN BCL 6; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SUZ12; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CONTROLLED STUDY; HUMAN; HYBRIDIZATION; MOLECULAR CLONING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SUBUNIT; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

CHROMATIN; CYCLIN-DEPENDENT KINASES; DNA HELICASES; DNA-BINDING PROTEINS; HUMANS; MEDIATOR COMPLEX; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

EID: 84865783466     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs065     Document Type: Article

References (38)

1. Malik, S. and Roeder, R.G. (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11, 761-772
2. Li, G. and Reinberg, D. (2011) Chromatin higher-order structures and gene regulation. Curr. Opin. Genet. Dev. 21, 175-186
3. Roeder, R.G. (2005) Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579, 909-915
4. Tsutsui, T., Umemura, H., Tanaka, A., Mizuki, F., Hirose, Y., and Ohkuma, Y. (2008) Human Mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcription. Genes Cells 13, 817-826
5. Knuesel, M.T., Meyer, K.D., Bernecky, C, and Taatjes, D.J. (2009) The human CDK8 subcomplex is a molecular switch that controls Mediator activator function. Genes Dev. 23, 439-451
6. Malik, S. and Roeder, R.G. (2005) Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci. 30, 256-263
7. Conaway, R.C., Sato, S., Tomomori-Sato, C, Yao, T., and Conaway, J.W. (2005) The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 30, 250-255
8. Liu, Y., Ranish, J.A., Aebersold, R., and Hahn, S. (2001) Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes. J. Biol. Chem. 276, 7169-7175
9. Takahashi, H., Parmely, T.J., Sato, S., Tomomori-Sato, C, Banks, C.A., Kong, S.E., Szutorisz, H., Swanson, S.K., Martin-Brown, S., Washburn, M.P., Florens, L., Seidel, C.W., Lin, C, Smith, E.R., Shilatifard, A., Conaway, R.C., and Conaway, J.W. (2011) Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 146, 92-104
10. Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F., and Ohkuma, Y. (2007) A kinase sub-unit of the human Mediator complex, CDK8, positively regulates transcriptional activation. Genes Cells 12, 119-132
11. Hengartner, C.J., Myer, V.E., Liao, S.M., Wilson, C.J., Koh, S.S., and Young, R.A. (1998) Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol. Cell 2, 43-53
12. Akoulitchev, S., Chuikov, S., and Reinberg, D. (2000) TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 407, 102-106
13. Chi, Y., Huddleston, M.J., Zhang, X., Young, R.A., Annan, R.S., Carr, S.A., and Deshaies, R.J. (2001) Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15, 1078-1092
14. Sato, S., Tomomori-Sato, C, Parmely, T.J., Florens, L., Zybailov, B., Swanson, S.K., Banks, C.A., Jin, J., Cai, Y., Washburn, M.P., Conaway, J.W., and Conaway, R.C. (2004) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol. Cell 14, 685-691
15. Tsutsui, T., Fukasawa, R., Tanaka, A., Hirose, Y., and Ohkuma, Y. (2011) Identification of target genes for the CDK subunits of the Mediator complex. Genes Cells 15, in press
16. Galbraith, M.D., Donner, A.J., and Espinosa, J.M. (2010) CDK8: a positive regulator of transcription. Transcription 1, 4-12
17. Conaway, R.C. and Conaway, J.W. (2011) Funation and regulation of the Mediator complex. Curr. Opin. Genet. Dev. 21, 225-230
18. Meyer, K.D., Donner, A.J., Knuesel, M.T., York, A.G, Espinosa, J.M., and Taatjes, D.J. (2008) Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 27, 1447-1457
19. Chakraborty, T., Martin, J., and Olson, E.N. (1992) Analysis of the oligomerization of myogenin and E2A products in vivo usinf a two-hybrid assay system. J. Biol. Chem. 267, 17496-17501
20. Khavari, P.A., Peterson, C.L., Tamkun, J.W., Mendel, D.B., and Crabtree, GR. (1993) BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature 366, 170-174
21. Dhordain, P., Lin, R.J., Quief, S., Lantoine, D., Kerckaert, J.P., Evans, R.M., and Albagli, O. (1998) The LAZ3 (BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucl. Acids Res. 26, 2899-2907
22. Cao, R. and Zhang, Y. (2004) SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67
23. Ito, T., Nakamura, R., Sumimoto, H., Takeshige, K, and Sakaki, Y. (1996) An SH3 domain-mediated interaction between the phagocyte NADPH oxidase factors p40phox and p47phox. FEBS Lett. 385, 229-232
24. Kubota, H., Ota, K, Sakaki, Y., and Ito, T. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J. Biol. Chem. 276, 17591-17596
25. Okamoto, T., Yamamoto, S., Watanabe, Y., Ohta, T., Hanaoka, F., Roeder, R.G, and Ohkuma, Y. (1998) Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit. J. Biol. Chem. 273, 19866-19876
26. Trotter, K.W. and Archer, T.K. (2008) The BRG1 transcriptional coregulator. Nucl. Recept. Signal. 6, e004
27. Linggi, B.E., Brandt, S.J., Sun, Z.W., and Hiebert, S.W. (2005) Translating the histone code into leukemia. J. Cell. Biochem. 96, 938-950
28. Ochiai, K, Muto, A., Tanaka, H., Takahashi, S., and Igarashi, K. (2008) Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int. Immunol. 20, 453-460
29. Levine, M. and Tjian, R. (2003) Transcription regulation and animal diversity. Nature 424, 147-151
30. Donner, A.J., Szostek, S., Hoover, J.M., and Espinosa, J.M. (2007) CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol. Cell 27, 121-133
31. Belakavadi, M. and Fondell, J.D. (2010) Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol. Cell. Biol. 30, 2437-2448
32. Reisman, D., Glaros, S., and Thompson, E.A. (2009) The SWI/SNF complex and cancer. Oncogene 28, 1653-1668
33. Kuzmichev, A., Zhang, Y., Erdjument-Bromage, H, Tempst, P., and Reinberg, D. (2002) Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33 (ING1). Mol. Cell. Biol. 22, 835-848
34. Igarashi, K., Ochiai, K., and Muto, A. (2007) Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation. J. Biochem. 141, 783-789
35. Martins, G. and Calame, K. (2008) Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol. 26, 133-169
36. Ghetu, A.F., Corcoran, CM., Cerchietti, L., Bardwell, V.J., Melnick, A., and Prive, G.G. (2008) Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol. Cell 29, 384-391
37. Ahmad, K.F., Melnick, A., Lax, S., Bouchard, D., Liu, J., Kiang, C.L., Mayer, S., Takahashi, S., Licht, J.D., and Prive, G.G. (2003) Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol. Cell 12, 1551-1564
38. Margueron, R. and Reinberg, D. (2011) The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349